-
1
-
-
33846821916
-
High TGFb-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
-
Bruna A, Darken RS, Rojo F, et al. High TGFb-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell. 2007;11(2):147-160.
-
(2007)
Cancer Cell.
, vol.11
, Issue.2
, pp. 147-160
-
-
Bruna, A.1
Darken, R.S.2
Rojo, F.3
-
2
-
-
0031717878
-
Decorin gene transfer-mediated suppression of TGF-b synthesis abrogates experimental malignant glioma growth in vivo
-
Ständer M, Naumann U, Dumitrescu L, et al. Decorin gene transfer-mediated suppression of TGF-b synthesis abrogates experimental malignant glioma growth in vivo. Gene Ther. 1998; 5(9):1187-1194.
-
(1998)
Gene Ther.
, vol.5
, Issue.9
, pp. 1187-1194
-
-
Ständer, M.1
Naumann, U.2
Dumitrescu, L.3
-
3
-
-
5644248080
-
RNA interference targeting transforming growth factor-b enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo
-
Friese MA, Wischhusen J, Wick W, et al. RNA interference targeting transforming growth factor-b enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo. Cancer Res. 2004;64(20):7596-7603.
-
(2004)
Cancer Res.
, vol.64
, Issue.20
, pp. 7596-7603
-
-
Friese, M.A.1
Wischhusen, J.2
Wick, W.3
-
4
-
-
7444226411
-
SD-208, a novel transforming growth factor beta receptor i kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo
-
Uhl M, Aulwurm S, Wischhusen J, et al. SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res. 2004;64(21):7954-7961.
-
(2004)
Cancer Res.
, vol.64
, Issue.21
, pp. 7954-7961
-
-
Uhl, M.1
Aulwurm, S.2
Wischhusen, J.3
-
5
-
-
34547475192
-
Inhibiting TGF-b signaling restores immune surveillance in the SMA-560 glioma model
-
Tran TT, Uhl M, Ma JY, et al. Inhibiting TGF-b signaling restores immune surveillance in the SMA-560 glioma model. Neuro Oncol. 2007;9(3):259-270.
-
(2007)
Neuro Oncol.
, vol.9
, Issue.3
, pp. 259-270
-
-
Tran, T.T.1
Uhl, M.2
Ma, J.Y.3
-
6
-
-
79951602633
-
Targeted therapy for high-grade glioma with the TGF-b2 inhibitor trabedersen: Results of a randomized and controlled phase IIb study
-
Bogdahn U, Hau P, Stockhammer G, et al. Targeted therapy for high-grade glioma with the TGF-b2 inhibitor trabedersen: results of a randomized and controlled phase IIb study. Neuro Oncol. 2011;13(1):132-142.
-
(2011)
Neuro Oncol.
, vol.13
, Issue.1
, pp. 132-142
-
-
Bogdahn, U.1
Hau, P.2
Stockhammer, G.3
-
7
-
-
84924993459
-
Safety interim data from a three-arm phase II study evaluating safety and pharmakokinetics of the oral transforming growth factor-beta (TGF-b) receptor i kinase inhibitor LY2157299 monohydrate in patients with glioblastoma at first progression [abstract 2061]
-
Carpentier A, Brandes A, Kesari S, et al. Safety interim data from a three-arm phase II study evaluating safety and pharmakokinetics of the oral transforming growth factor-beta (TGF-b) receptor I kinase inhibitor LY2157299 monohydrate in patients with glioblastoma at first progression [abstract 2061]. J Clin Oncol 2013;31:(suppl).
-
(2013)
J Clin Oncol
, vol.31
-
-
Carpentier, A.1
Brandes, A.2
Kesari, S.3
-
8
-
-
38649088246
-
Cooperative assembly of TGF-b superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding
-
Groppe J, Hinck CS, Samavarchi-Tehrani P, et al. Cooperative assembly of TGF-b superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol Cell. 2008;29(2):157-168.
-
(2008)
Mol Cell.
, vol.29
, Issue.2
, pp. 157-168
-
-
Groppe, J.1
Hinck, C.S.2
Samavarchi-Tehrani, P.3
-
10
-
-
82655181475
-
Blockade of TGF-b signaling by the TGFbR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma
-
Zhang M, Kleber S, Rohrich M, et al. Blockade of TGF-b signaling by the TGFbR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. Cancer Res. 2011;71(23):7155-7167.
-
(2011)
Cancer Res.
, vol.71
, Issue.23
, pp. 7155-7167
-
-
Zhang, M.1
Kleber, S.2
Rohrich, M.3
-
11
-
-
0242330126
-
Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFb/ALK5 signaling
-
Goumans MJ, Valdimarsdottir G, Itoh S, et al. Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFb/ALK5 signaling. Mol Cell. 2003;12(4):817-828.
-
(2003)
Mol Cell.
, vol.12
, Issue.4
, pp. 817-828
-
-
Goumans, M.J.1
Valdimarsdottir, G.2
Itoh, S.3
-
12
-
-
11144246285
-
Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-b1 activity in endothelial cells
-
Boström K, Zebboudj AF, Yao Y, et al. Matrix GLA protein stimulates VEGF expression through increased transforming growth factor-b1 activity in endothelial cells. J Biol Chem. 2004;279(51): 52904-52913.
-
(2004)
J Biol Chem.
, vol.279
, Issue.51
, pp. 52904-52913
-
-
Boström, K.1
Zebboudj, A.F.2
Yao, Y.3
-
13
-
-
70350418644
-
VEGFand inhibitors of TGFb type-I receptor kinase synergistically promote blood-vessel formation by inducing alpha5-integrin expression
-
Liu Z, Kobayashi K, van Dinther M, et al. VEGFand inhibitors of TGFb type-I receptor kinase synergistically promote blood-vessel formation by inducing alpha5-integrin expression. J Cell Sci. 2009;122(Pt 18):3294-3302.
-
(2009)
J Cell Sci.
, vol.122
, pp. 3294-3302
-
-
Liu, Z.1
Kobayashi, K.2
Van Dinther, M.3
-
14
-
-
0029871064
-
Vascular endothelial growth factor production is stimulated by gangliosides and TGF-b isoforms in human glioma cells in vitro
-
Koochekpour S, Merzak A, Pilkington GJ. Vascular endothelial growth factor production is stimulated by gangliosides and TGF-b isoforms in human glioma cells in vitro. Cancer Lett. 1996; 102(1-2):209-215.
-
(1996)
Cancer Lett.
, vol.102
, Issue.1-2
, pp. 209-215
-
-
Koochekpour, S.1
Merzak, A.2
Pilkington, G.J.3
-
15
-
-
54949138122
-
VEGF-dependent induction of CD62E on endothelial cells mediates glioma tropism of adult haematopoietic progenitor cells
-
Tabatabai G, Herrmann C, von Kurthy G, et al. VEGF-dependent induction of CD62E on endothelial cells mediates glioma tropism of adult haematopoietic progenitor cells. Brain. 2008; 131(Pt 10):2579-2595.
-
(2008)
Brain.
, vol.131
, pp. 2579-2595
-
-
Tabatabai, G.1
Herrmann, C.2
Von Kurthy, G.3
-
16
-
-
4444341835
-
SB-431542, a small molecule transforming growth factor-b-receptor antagonist, inhibits human glioma cell line proliferation and motility
-
Hjelmeland MD, Hjelmeland AB, Sathornsumetee S, et al. SB-431542, a small molecule transforming growth factor-b-receptor antagonist, inhibits human glioma cell line proliferation and motility. Mol Cancer Ther. 2004;3(6):737-745.
-
(2004)
Mol Cancer Ther.
, vol.3
, Issue.6
, pp. 737-745
-
-
Hjelmeland, M.D.1
Hjelmeland, A.B.2
Sathornsumetee, S.3
-
17
-
-
0031767393
-
Predicting chemoresistance in human malignant glioma cells: The role of molecular genetic analyses
-
Weller M, Rieger J, Grimmel C, et al. Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses. Int J Cancer. 1998;79(6):640-644.
-
(1998)
Int J Cancer.
, vol.79
, Issue.6
, pp. 640-644
-
-
Weller, M.1
Rieger, J.2
Grimmel, C.3
-
18
-
-
50849095153
-
Enzastaurin-induced apoptosis in glioma cells is caspase-dependent and inhibited by BCL-XL
-
Rieger J, Lemke D, Maurer G, et al. Enzastaurin-induced apoptosis in glioma cells is caspase-dependent and inhibited by BCL-XL. J Neurochem. 2008;106(6):2436-2448.
-
(2008)
J Neurochem.
, vol.106
, Issue.6
, pp. 2436-2448
-
-
Rieger, J.1
Lemke, D.2
Maurer, G.3
-
19
-
-
84874739414
-
Suppression of proinvasive RGS4 by mTOR inhibition optimizes glioma treatment
-
Weiler M, Pfenning PN, Thiepold AL, et al. Suppression of proinvasive RGS4 by mTOR inhibition optimizes glioma treatment. Oncogene. 2013;32(9):1099-1109.
-
(2013)
Oncogene.
, vol.32
, Issue.9
, pp. 1099-1109
-
-
Weiler, M.1
Pfenning, P.N.2
Thiepold, A.L.3
-
20
-
-
27744460321
-
Blood-brain barrier-specific properties of a human adult brain endothelial cell line
-
Weksler BB, Subileau EA, Perriere N, et al. Blood-brain barrier-specific properties of a human adult brain endothelial cell line. FASEB J. 2005;19(13):1872-1874.
-
(2005)
FASEB J.
, vol.19
, Issue.13
, pp. 1872-1874
-
-
Weksler, B.B.1
Subileau, E.A.2
Perriere, N.3
-
21
-
-
0032014216
-
Human Smad3 and Smad4 are sequence-specific transcription activators
-
Zawel L, Dai JL, Buckhaults P, et al. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell. 1998;1(4): 611-617.
-
(1998)
Mol Cell.
, vol.1
, Issue.4
, pp. 611-617
-
-
Zawel, L.1
Dai, J.L.2
Buckhaults, P.3
-
22
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996;16(9):4604-4613.
-
(1996)
Mol Cell Biol.
, vol.16
, Issue.9
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
-
23
-
-
77949891455
-
Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma
-
Wick W, Puduvalli VK, Chamberlain MC, et al. Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J Clin Oncol. 2010;28(7): 1168-1174.
-
(2010)
J Clin Oncol.
, vol.28
, Issue.7
, pp. 1168-1174
-
-
Wick, W.1
Puduvalli, V.K.2
Chamberlain, M.C.3
-
24
-
-
84887116872
-
Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma
-
Batchelor TT, Mulholland P, Neyns B, et al. Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. J Clin Oncol. 2013;31(26): 3212-3218.
-
(2013)
J Clin Oncol.
, vol.31
, Issue.26
, pp. 3212-3218
-
-
Batchelor, T.T.1
Mulholland, P.2
Neyns, B.3
-
25
-
-
84924962619
-
Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma and methylated O6-methylguanine-DNA methyltransferase (MGMT) gene promoter: Key results of the multicenter, randomized, open-label, controlled, phase III CENTRIC study [abstract LBA2009]
-
Stupp R, Hegi M, Gorlia T, et al. Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma and methylated O6-methylguanine-DNA methyltransferase (MGMT) gene promoter: Key results of the multicenter, randomized, open-label, controlled, phase III CENTRIC study [abstract LBA2009]. J Clin Oncol 2013;31:(suppl).
-
(2013)
J Clin Oncol
, vol.31
-
-
Stupp, R.1
Hegi, M.2
Gorlia, T.3
-
26
-
-
70350461699
-
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
-
Friedman HS, Prados MD, Wen PY, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol. 2009;27(28):4733-4740.
-
(2009)
J Clin Oncol.
, vol.27
, Issue.28
, pp. 4733-4740
-
-
Friedman, H.S.1
Prados, M.D.2
Wen, P.Y.3
-
27
-
-
59949083263
-
Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
-
Kreisl TN, Kim L, Moore K, et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol. 2009;27(5): 740-745.
-
(2009)
J Clin Oncol.
, vol.27
, Issue.5
, pp. 740-745
-
-
Kreisl, T.N.1
Kim, L.2
Moore, K.3
-
28
-
-
84894114159
-
A randomized trial of bevacizumab for newly diagnosed glioblastoma
-
Gilbert MR, Dignam JJ, Armstrong TS, et al. A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med. 2014;370(8):699-708.
-
(2014)
N Engl J Med.
, vol.370
, Issue.8
, pp. 699-708
-
-
Gilbert, M.R.1
Dignam, J.J.2
Armstrong, T.S.3
-
29
-
-
84894194756
-
Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma
-
Chinot OL, Wick W, Mason W, et al. Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med. 2014;370(8):709-722.
-
(2014)
N Engl J Med.
, vol.370
, Issue.8
, pp. 709-722
-
-
Chinot, O.L.1
Wick, W.2
Mason, W.3
-
30
-
-
79953840934
-
A review of VEGF/VEGFR-targeted therapeutics for recurrent glioblastoma
-
Reardon DA, Turner S, Peters KB, et al. A review of VEGF/VEGFR-targeted therapeutics for recurrent glioblastoma. J Natl Compr Canc Netw. 2011;9(4):414-427.
-
(2011)
J Natl Compr Canc Netw.
, vol.9
, Issue.4
, pp. 414-427
-
-
Reardon, D.A.1
Turner, S.2
Peters, K.B.3
-
31
-
-
84876817355
-
Beyond TGFb: Roles of other TGFb superfamily members in cancer
-
Wakefield LM, Hill CS. Beyond TGFb: roles of other TGFb superfamily members in cancer. Nat Rev Cancer. 2013;13(5): 328-341.
-
(2013)
Nat Rev Cancer.
, vol.13
, Issue.5
, pp. 328-341
-
-
Wakefield, L.M.1
Hill, C.S.2
-
32
-
-
65649105437
-
Transforming Growth Factor b Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors
-
Wrighton KH, Lin X, Yu PB, et al. Transforming Growth Factor b Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors. J Biol Chem. 2009;284(15): 9755-9763.
-
(2009)
J Biol Chem.
, vol.284
, Issue.15
, pp. 9755-9763
-
-
Wrighton, K.H.1
Lin, X.2
Yu, P.B.3
-
33
-
-
0021344432
-
Glioblastoma cells release interleukin 1 and factors inhibiting interleukin 2-mediated effects
-
Fontana A, Hengartner H, de Tribolet N, et al. Glioblastoma cells release interleukin 1 and factors inhibiting interleukin 2-mediated effects. J Immunol. 1984;132(4):1837-1844.
-
(1984)
J Immunol.
, vol.132
, Issue.4
, pp. 1837-1844
-
-
Fontana, A.1
Hengartner, H.2
De Tribolet, N.3
-
34
-
-
0035877007
-
Processing of immunosuppressive pro-TGF-b1, 2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases
-
Leitlein J, Aulwurm S, Waltereit R, et al. Processing of immunosuppressive pro-TGF-b1, 2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases. J Immunol. 2001;166(12):7238-7243.
-
(2001)
J Immunol.
, vol.166
, Issue.12
, pp. 7238-7243
-
-
Leitlein, J.1
Aulwurm, S.2
Waltereit, R.3
-
35
-
-
79251620102
-
Hypoxia potentiates glioma-mediated immunosuppression
-
Wei J, Wu A, Kong LY, et al. Hypoxia potentiates glioma-mediated immunosuppression. PLoS One. 2011;6(1):e16195.
-
(2011)
PLoS One.
, vol.6
, Issue.1
, pp. e16195
-
-
Wei, J.1
Wu, A.2
Kong, L.Y.3
-
36
-
-
1242328762
-
Transforming growth factor beta receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells
-
Chattopadhyay N, T-Felt Hansen J, Godbole MM, et al. Transforming growth factor beta receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells. Brain Res Mol Brain Res. 2004;121(1-2): 146-150.
-
(2004)
Brain Res Mol Brain Res.
, vol.121
, Issue.1-2
, pp. 146-150
-
-
Chattopadhyay, N.1
T-Felt Hansen, J.2
Godbole, M.M.3
-
37
-
-
67749142355
-
Molecular mechanisms of HIF-1a modulation induced by oxygen tension and BMP2 in glioblastoma derived cells
-
Pistollato F, Rampazzo E, Abbadi S, et al. Molecular mechanisms of HIF-1a modulation induced by oxygen tension and BMP2 in glioblastoma derived cells. PLoS One. 2009;4(7):e6206.
-
(2009)
PLoS One.
, vol.4
, Issue.7
, pp. e6206
-
-
Pistollato, F.1
Rampazzo, E.2
Abbadi, S.3
-
38
-
-
70349260659
-
Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells
-
Shao ES, Lin L, Yao Y, et al. Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells. Blood. 2009;114(10): 2197-2206.
-
(2009)
Blood.
, vol.114
, Issue.10
, pp. 2197-2206
-
-
Shao, E.S.1
Lin, L.2
Yao, Y.3
-
39
-
-
84858004513
-
USP15 stabilizes TGF-b receptor i and promotes oncogenesis through the activation of TGF-beta signaling in glioblastoma
-
Eichhorn PJ, Rodon L, Gonzalez-Junca A, et al. USP15 stabilizes TGF-b receptor I and promotes oncogenesis through the activation of TGF-beta signaling in glioblastoma. Nat Med. 2012; 18(3):429-435.
-
(2012)
Nat Med.
, vol.18
, Issue.3
, pp. 429-435
-
-
Eichhorn, P.J.1
Rodon, L.2
Gonzalez-Junca, A.3
-
40
-
-
12344287138
-
Transcriptional regulation of the Vascular Endothelial Growth Factor gene-a concert of activating factors
-
Pagès G, Pouyssegur J. Transcriptional regulation of the Vascular Endothelial Growth Factor gene-a concert of activating factors. Cardiovasc Res. 2005;65(3):564-573.
-
(2005)
Cardiovasc Res.
, vol.65
, Issue.3
, pp. 564-573
-
-
Pagès, G.1
Pouyssegur, J.2
-
41
-
-
0035914297
-
Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression
-
Sanchez-Elsner T, Botella LM, Velasco B, et al. Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression. J Biol Chem. 2001;276(42):38527-38535.
-
(2001)
J Biol Chem.
, vol.276
, Issue.42
, pp. 38527-38535
-
-
Sanchez-Elsner, T.1
Botella, L.M.2
Velasco, B.3
-
42
-
-
84874318559
-
Integrin control of the transforming growth factor-b pathway in glioblastoma
-
Roth P, Silginer M, Goodman SL, et al. Integrin control of the transforming growth factor-b pathway in glioblastoma. Brain. 2013;136(Pt 2):564-576.
-
(2013)
Brain.
, vol.136
, pp. 564-576
-
-
Roth, P.1
Silginer, M.2
Goodman, S.L.3
|