메뉴 건너뛰기




Volumn 5, Issue 10, 2014, Pages

TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; SMAD2 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA; HOMEODOMAIN PROTEIN; SMAD2 PROTEIN, HUMAN; TGFB1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1; ZEB1 PROTEIN, HUMAN;

EID: 84919949972     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.395     Document Type: Article
Times cited : (149)

References (39)
  • 5
    • 54549108740 scopus 로고    scopus 로고
    • Cancer genome atlas research network, comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network, Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008; 455:1061-1068.
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 6
    • 84867606428 scopus 로고    scopus 로고
    • Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
    • Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DT, Konermann C et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 2012; 22: 425-437.
    • (2012) Cancer Cell , vol.22 , pp. 425-437
    • Sturm, D.1    Witt, H.2    Hovestadt, V.3    Khuong-Quang, D.A.4    Jones, D.T.5    Konermann, C.6
  • 7
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    • Phillips HS, Kharbanda S, Chen R, Forrest WF, Soriano RH, Wu TD et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006; 9: 157-173.
    • (2006) Cancer Cell , vol.9 , pp. 157-173
    • Phillips, H.S.1    Kharbanda, S.2    Chen, R.3    Forrest, W.F.4    Soriano, R.H.5    Wu, T.D.6
  • 8
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010;17: 98-110.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6
  • 9
    • 79957905986 scopus 로고    scopus 로고
    • Molecular subclassification of diffuse gliomas: Seeing order in the chaos
    • Huse JT, Phillips HS, Brennan CW. Molecular subclassification of diffuse gliomas: seeing order in the chaos. Glia 2011; 59: 1190-1199.
    • (2011) Glia , vol.59 , pp. 1190-1199
    • Huse, J.T.1    Phillips, H.S.2    Brennan, C.W.3
  • 11
    • 16444373329 scopus 로고    scopus 로고
    • YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma
    • Pelloski CE, Mahajan A, Maor M, Chang EL, Woo S, Gilbert M et al. YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma. Clin Cancer Res 2005; 11: 3326-3334.
    • (2005) Clin Cancer Res , vol.11 , pp. 3326-3334
    • Pelloski, C.E.1    Mahajan, A.2    Maor, M.3    Chang, E.L.4    Woo, S.5    Gilbert, M.6
  • 12
  • 13
    • 75149195336 scopus 로고    scopus 로고
    • The transcriptional network for mesenchymal transformation of brain tumours
    • Carro MS, Lim WK, Alvarez MJ, Bollo RJ, Zhao X, Snyder EY et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 2010; 463: 318-325.
    • (2010) Nature , vol.463 , pp. 318-325
    • Carro, M.S.1    Lim, W.K.2    Alvarez, M.J.3    Bollo, R.J.4    Zhao, X.5    Snyder, E.Y.6
  • 16
    • 0042634444 scopus 로고    scopus 로고
    • The role of transforming growth factor-beta in primary brain tumors
    • Rich JN. The role of transforming growth factor-beta in primary brain tumors. Front Biosci 2003; 8: e245-e260.
    • (2003) Front Biosci , vol.8 , pp. e245-e260
    • Rich, J.N.1
  • 17
    • 0035865158 scopus 로고    scopus 로고
    • Malignant glioma biology: Role for TGF-beta in growth, motility, angiogenesis, and immune escape
    • Platten M, Wick W, Weller M. Malignant glioma biology: role for TGF-beta in growth, motility, angiogenesis, and immune escape. Microsc Res Tech 2001; 52:401-410.
    • (2001) Microsc Res Tech , vol.52 , pp. 401-410
    • Platten, M.1    Wick, W.2    Weller, M.3
  • 18
    • 84872684798 scopus 로고    scopus 로고
    • TGF-ß as a therapeutic target in high grade gliomas - promises and challenges
    • Joseph JV, Balasubramaniyan V, Walenkamp A, Kruyt FA. TGF-ß as a therapeutic target in high grade gliomas - promises and challenges. Biochem Pharmacol 2013; 85:478-485.
    • (2013) Biochem Pharmacol , vol.85 , pp. 478-485
    • Joseph, J.V.1    Balasubramaniyan, V.2    Walenkamp, A.3    Kruyt, F.A.4
  • 19
    • 82655181475 scopus 로고    scopus 로고
    • Blockade of TGF-ß signaling by the TGFßR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma
    • Zhang M, Kleber S, Rfhrich M, Timke C, Han N, Tuettenberg J et al. Blockade of TGF-ß signaling by the TGFßR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma. Cancer Res 2011; 71:7155-7167.
    • (2011) Cancer Res , vol.71 , pp. 7155-7167
    • Zhang, M.1    Kleber, S.2    Röhrich, M.3    Timke, C.4    Han, N.5    Tuettenberg, J.6
  • 20
    • 84865140762 scopus 로고    scopus 로고
    • Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-ß
    • Hardee ME, Marciscano AE, Medina-Ramirez CM, Zagzag D, Narayana A, Lonning SM et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-ß. Cancer Res 2012; 72:4119-4129.
    • (2012) Cancer Res , vol.72 , pp. 4119-4129
    • Hardee, M.E.1    Marciscano, A.E.2    Medina-Ramirez, C.M.3    Zagzag, D.4    Narayana, A.5    Lonning, S.M.6
  • 21
    • 84866985855 scopus 로고    scopus 로고
    • Targeting the TGFß signalling pathway in disease
    • Akhurst RJ, Hata A. Targeting the TGFß signalling pathway in disease. Nat Rev Drug Discov 2012; 11: 790-811.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 790-811
    • Akhurst, R.J.1    Hata, A.2
  • 22
    • 79951602633 scopus 로고    scopus 로고
    • Targeted therapy for high-grade glioma with the TGF-ß2 inhibitor trabedersen: Results of a randomized and controlled phase IIb study
    • Bogdahn U, Hau P, Stockhammer G, Venkataramana NK, Mahapatra AK, Suri A. Targeted therapy for high-grade glioma with the TGF-ß2 inhibitor trabedersen: results of a randomized and controlled phase IIb study. Neuro Oncol 2011; 13: 132-142.
    • (2011) Neuro Oncol , vol.13 , pp. 132-142
    • Bogdahn, U.1    Hau, P.2    Stockhammer, G.3    Venkataramana, N.K.4    Mahapatra, A.K.5    Suri, A.6
  • 23
    • 78649986150 scopus 로고    scopus 로고
    • TGF-ß receptor inhibitors target the CD44(high)/Id1(high) glioma-initiating cell population in human glioblastoma
    • Anido J, Sáez-Borderías A, Gonzàlez-Juncà A, Rodósn L, Folch G, Carmona MA. TGF-ß receptor inhibitors target the CD44(high)/Id1(high) glioma-initiating cell population in human glioblastoma. Cancer Cell 2010; 18: 655-668.
    • (2010) Cancer Cell , vol.18 , pp. 655-668
    • Anido, J.1    Sáez-Borderías, A.2    Gonzàlez-Juncà, A.3    Rodón, L.4    Folch, G.5    Carmona, M.A.6
  • 24
    • 43049165453 scopus 로고    scopus 로고
    • The epithelialmesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY et al. The epithelialmesenchymal transition generates cells with properties of stem cells. Cell 2008; 133:704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 25
    • 84868327473 scopus 로고    scopus 로고
    • Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer
    • Hance MW, Dole K, Gopal U, Bohonowych JE, Jezierska-Drutel A, Neumann CA et al. Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer. J Biol Chem 2012; 287: 37732-37744.
    • (2012) J Biol Chem , vol.287 , pp. 37732-37744
    • Hance, M.W.1    Dole, K.2    Gopal, U.3    Bohonowych, J.E.4    Jezierska-Drutel, A.5    Neumann, C.A.6
  • 26
    • 80053535498 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and lung cancer
    • Xiao D, He J. Epithelial mesenchymal transition and lung cancer. J Thorac Dis 2010; 2:154-159.
    • (2010) J Thorac Dis , vol.2 , pp. 154-159
    • Xiao, D.1    He, J.2
  • 27
    • 79955862101 scopus 로고    scopus 로고
    • TGF-ß1 signaling targets metastasis-associated protein 1, a new effector in epithelial cells
    • Pakala SB, Singh K, Reddy SD, Ohshiro K, Li DQ, Mishra L et al. TGF-ß1 signaling targets metastasis-associated protein 1, a new effector in epithelial cells. Oncogene 2011; 30:2230-2241.
    • (2011) Oncogene , vol.30 , pp. 2230-2241
    • Pakala, S.B.1    Singh, K.2    Reddy, S.D.3    Ohshiro, K.4    Li, D.Q.5    Mishra, L.6
  • 28
    • 59449090107 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial to mesenchymal transition
    • Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res 2009; 19: 156-172.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 29
    • 29644443725 scopus 로고    scopus 로고
    • The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to mesenchymal transition by transforming growth factor-beta
    • Tojo M, Hamashima Y, Hanyu A, Kajimoto T, Saitoh M, Miyazono K et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to mesenchymal transition by transforming growth factor-beta. Cancer Sci 2005; 96: 791-800.
    • (2005) Cancer Sci , vol.96 , pp. 791-800
    • Tojo, M.1    Hamashima, Y.2    Hanyu, A.3    Kajimoto, T.4    Saitoh, M.5    Miyazono, K.6
  • 30
    • 65549145501 scopus 로고    scopus 로고
    • Neutrophils: Key mediators of tumour angiogenesis
    • Tazzyman S, Lewis CE, Murdoch C. Neutrophils: key mediators of tumour angiogenesis. Int J Exp Pathol 2009; 90: 222-231.
    • (2009) Int J Exp Pathol , vol.90 , pp. 222-231
    • Tazzyman, S.1    Lewis, C.E.2    Murdoch, C.3
  • 31
    • 79952283482 scopus 로고    scopus 로고
    • P53 regulates epithelialmesenchymal transition and stem cell properties through modulating miRNAs
    • Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW et al. p53 regulates epithelialmesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol 2011; 13: 317-323.
    • (2011) Nat Cell Biol , vol.13 , pp. 317-323
    • Chang, C.J.1    Chao, C.H.2    Xia, W.3    Yang, J.Y.4    Xiong, Y.5    Li, C.W.6
  • 32
    • 82755198488 scopus 로고    scopus 로고
    • ß-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)- Activator ZEB1 to regulate tumor invasiveness
    • Sánchez-Tilló E, de Barrios O, Siles L, Cuatrecasas M, Castells A, Postigo A. ß-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)- activator ZEB1 to regulate tumor invasiveness. Proc Natl Acad Sci USA 2011; 108:19204-19209.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 19204-19209
    • Sánchez-Tilló, E.1    De Barrios, O.2    Siles, L.3    Cuatrecasas, M.4    Castells, A.5    Postigo, A.6
  • 33
    • 63249123273 scopus 로고    scopus 로고
    • TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma
    • Peñuelas S, Anido J, Prieto-Sánchez RM, Folch G, Barba I, Cuartas I et al. TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma. Cancer Cell 2009; 15: 315-327.
    • (2009) Cancer Cell , vol.15 , pp. 315-327
    • Peñuelas, S.1    Anido, J.2    Prieto-Sánchez, R.M.3    Folch, G.4    Barba, I.5    Cuartas, I.6
  • 35
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009;119: 1420-1428.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 37
    • 84887040380 scopus 로고    scopus 로고
    • Transforming growth factor beta signalling controls human breast cancer metastasis in a zebrafish xenograft model
    • Drabsch Y, He S, Zhang L, Snaar-Jagalska BE, Ten Dijke P. Transforming growth factor beta signalling controls human breast cancer metastasis in a zebrafish xenograft model. Breast Cancer Res 2013; 15: R106.
    • (2013) Breast Cancer Res , vol.15 , pp. R106
    • Drabsch, Y.1    He, S.2    Zhang, L.3    Snaar-Jagalska, B.E.4    Ten Dijke, P.5
  • 38
    • 0021992459 scopus 로고
    • Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines
    • Massagué J, Like B. Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines. J Biol Chem 1985; 260: 2636-2645.
    • (1985) J Biol Chem , vol.260 , pp. 2636-2645
    • Massagué, J.1    Like, B.2
  • 39
    • 84879983245 scopus 로고    scopus 로고
    • Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity
    • Chaffer CL, Marjanovic ND, Lee T, Bell G, Kleer CG, Reinhardt F et al. Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell 2013; 154: 61-74.
    • (2013) Cell , vol.154 , pp. 61-74
    • Chaffer, C.L.1    Marjanovic, N.D.2    Lee, T.3    Bell, G.4    Kleer, C.G.5    Reinhardt, F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.