메뉴 건너뛰기




Volumn 6, Issue , 2015, Pages

Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; DOXORUBICIN; MESSENGER RNA; PROTEIN UPF1; RNA HELICASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CYCLOHEXIMIDE; ETOPOSIDE; PROTEIN SYNTHESIS INHIBITOR; STOP CODON; TRANSACTIVATOR PROTEIN; UPF1 PROTEIN, HUMAN;

EID: 84925831393     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7632     Document Type: Article
Times cited : (64)

References (70)
  • 1
    • 84888617099 scopus 로고    scopus 로고
    • Organizing principles of mammalian nonsensemediated mRNA decay
    • Popp, M. W. & Maquat, L. E. Organizing principles of mammalian nonsensemediated mRNA decay. Annu. Rev. Genet. 47, 139-165 (2013).
    • (2013) Annu. Rev. Genet. , vol.47 , pp. 139-165
    • Popp, M.W.1    Maquat, L.E.2
  • 2
    • 32044454232 scopus 로고    scopus 로고
    • HUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay
    • Wittmann, J., Hol, E. M. & Jäck, H. M. hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay. Mol. Cell. Biol. 26, 1272-1287 (2006).
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 1272-1287
    • Wittmann, J.1    Hol, E.M.2    Jäck, H.M.3
  • 3
    • 6944256813 scopus 로고    scopus 로고
    • Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise
    • Mendell, J. T., Sharifi, N. A., Meyers, J. L., Martinez-Murillo, F. & Dietz, H. C. Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise. Nat. Genet. 36, 1073-1078 (2004).
    • (2004) Nat. Genet. , vol.36 , pp. 1073-1078
    • Mendell, J.T.1    Sharifi, N.A.2    Meyers, J.L.3    Martinez-Murillo, F.4    Dietz, H.C.5
  • 4
    • 84861461351 scopus 로고    scopus 로고
    • Staufen1-mediated mRNA decay functions in adipogenesis
    • Cho, H. et al. Staufen1-mediated mRNA decay functions in adipogenesis. Mol. Cell 46, 495-506 (2012).
    • (2012) Mol. Cell , vol.46 , pp. 495-506
    • Cho, H.1
  • 5
    • 79955964537 scopus 로고    scopus 로고
    • Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay
    • Bruno, I. G. et al. Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. Mol. Cell 42, 500-510 (2011).
    • (2011) Mol. Cell , vol.42 , pp. 500-510
    • Bruno, I.G.1
  • 6
    • 0032825494 scopus 로고    scopus 로고
    • Yeast Upf proteins required for RNA surveillance affect global expression of the yeast transcriptome
    • Lelivelt, M. J. & Culbertson, M. R. Yeast Upf proteins required for RNA surveillance affect global expression of the yeast transcriptome. Mol. Cell. Biol. 19, 6710-6719 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6710-6719
    • Lelivelt, M.J.1    Culbertson, M.R.2
  • 7
    • 84906885914 scopus 로고    scopus 로고
    • A post-translational regulatory switch on UPF1 controls targeted mRNA degradation
    • Kurosaki, T. et al. A post-translational regulatory switch on UPF1 controls targeted mRNA degradation. Genes Dev. 28, 1900-1916 (2014).
    • (2014) Genes Dev. , vol.28 , pp. 1900-1916
    • Kurosaki, T.1
  • 8
    • 58149520665 scopus 로고    scopus 로고
    • SMD and NMD are competitive pathways that contribute to myogenesis: Effects on PAX3 and myogenin mRNAs
    • Gong, C., Kim, Y. K., Woeller, C. F., Tang, Y. & Maquat, L. E. SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs. Genes Dev. 23, 54-66 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 54-66
    • Gong, C.1    Kim, Y.K.2    Woeller, C.F.3    Tang, Y.4    Maquat, L.E.5
  • 9
    • 84876240496 scopus 로고    scopus 로고
    • Control of myogenesis by rodent SINE-containing lncRNAs
    • Wang, J., Gong, C. & Maquat, L. E. Control of myogenesis by rodent SINE-containing lncRNAs. Genes Dev. 27, 793-804 (2013).
    • (2013) Genes Dev. , vol.27 , pp. 793-804
    • Wang, J.1    Gong, C.2    Maquat, L.E.3
  • 10
    • 80052331341 scopus 로고    scopus 로고
    • Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis
    • Wang, D. et al. Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis. Mol. Cell. Biol. 31, 3670-3680 (2011).
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 3670-3680
    • Wang, D.1
  • 11
    • 81155126104 scopus 로고    scopus 로고
    • Overexpression of the c-myc oncogene inhibits nonsense-mediated RNA decay in B lymphocytes
    • Wang, D., Wengrod, J. & Gardner, L. B. Overexpression of the c-myc oncogene inhibits nonsense-mediated RNA decay in B lymphocytes. J. Biol. Chem. 286, 40038-40043 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 40038-40043
    • Wang, D.1    Wengrod, J.2    Gardner, L.B.3
  • 12
    • 84877830445 scopus 로고    scopus 로고
    • Regulation of nonsense-mediated mRNA decay: Implications for physiology and disease
    • Karam, R., Wengrod, J., Gardner, L. B. & Wilkinson, M. F. Regulation of nonsense-mediated mRNA decay: implications for physiology and disease. Biochim. Biophys. Acta 1829, 624-633 (2013).
    • (2013) Biochim. Biophys. Acta , vol.1829 , pp. 624-633
    • Karam, R.1    Wengrod, J.2    Gardner, L.B.3    Wilkinson, M.F.4
  • 13
    • 84896723059 scopus 로고    scopus 로고
    • Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway
    • Lou, C. H. et al. Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway. Cell Rep. 6, 748-764 (2014).
    • (2014) Cell Rep. , vol.6 , pp. 748-764
    • Lou, C.H.1
  • 14
    • 84901437738 scopus 로고    scopus 로고
    • The dharma of nonsense-mediated mRNA decay in mammalian cells
    • Popp, M. W. & Maquat, L. E. The dharma of nonsense-mediated mRNA decay in mammalian cells. Mol. Cells 37, 1-8 (2014).
    • (2014) Mol. Cells , vol.37 , pp. 1-8
    • Popp, M.W.1    Maquat, L.E.2
  • 15
    • 32044435368 scopus 로고    scopus 로고
    • Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsensemediated mRNA decay
    • Kashima, I. et al. Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsensemediated mRNA decay. Genes Dev. 20, 355-367 (2006).
    • (2006) Genes Dev. , vol.20 , pp. 355-367
    • Kashima, I.1
  • 16
    • 37849005006 scopus 로고    scopus 로고
    • NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity
    • Chamieh, H., Ballut, L., Bonneau, F. & Le Hir, H. NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity. Nat. Struct. Mol. Biol. 15, 85-93 (2008).
    • (2008) Nat. Struct. Mol. Biol. , vol.15 , pp. 85-93
    • Chamieh, H.1    Ballut, L.2    Bonneau, F.3    Le Hir, H.4
  • 17
    • 79952686670 scopus 로고    scopus 로고
    • Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2
    • Chakrabarti, S. et al. Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2. Mol. Cell 41, 693-703 (2011).
    • (2011) Mol. Cell , vol.41 , pp. 693-703
    • Chakrabarti, S.1
  • 18
    • 0035449691 scopus 로고    scopus 로고
    • Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
    • Yamashita, A., Ohnishi, T., Kashima, I., Taya, Y. & Ohno, S. Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes Dev. 15, 2215-2228 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 2215-2228
    • Yamashita, A.1    Ohnishi, T.2    Kashima, I.3    Taya, Y.4    Ohno, S.5
  • 19
    • 65449178454 scopus 로고    scopus 로고
    • SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay
    • Yamashita, A. et al. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Genes Dev. 23, 1091-1105 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 1091-1105
    • Yamashita, A.1
  • 20
    • 57049126216 scopus 로고    scopus 로고
    • SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan
    • Huntzinger, E., Kashima, I., Fauser, M., Saulière, J. & Izaurralde, E. SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. RNA 14, 2609-2617 (2008).
    • (2008) RNA , vol.14 , pp. 2609-2617
    • Huntzinger, E.1    Kashima, I.2    Fauser, M.3    Saulière, J.4    Izaurralde, E.5
  • 21
    • 78649949096 scopus 로고    scopus 로고
    • Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense-mediated mRNA decay
    • Franks, T. M., Singh, G. & Lykke-Andersen, J. Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense-mediated mRNA decay. Cell 143, 938-950 (2010).
    • (2010) Cell , vol.143 , pp. 938-950
    • Franks, T.M.1    Singh, G.2    Lykke-Andersen, J.3
  • 23
    • 8844245615 scopus 로고    scopus 로고
    • SMG7 acts as a molecular link between mRNA surveillance and mRNA decay
    • Unterholzner, L. & Izaurralde, E. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Mol. Cell 16, 587-596 (2004).
    • (2004) Mol. Cell , vol.16 , pp. 587-596
    • Unterholzner, L.1    Izaurralde, E.2
  • 24
    • 84873026843 scopus 로고    scopus 로고
    • An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay
    • Jonas, S., Weichenrieder, O. & Izaurralde, E. An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes Dev. 27, 211-225 (2013).
    • (2013) Genes Dev. , vol.27 , pp. 211-225
    • Jonas, S.1    Weichenrieder, O.2    Izaurralde, E.3
  • 25
    • 84874720941 scopus 로고    scopus 로고
    • SMG5-PNRC2 is functionally dominant compared with SMG5-SMG7 in mammalian nonsense-mediated mRNA decay
    • Cho, H. et al. SMG5-PNRC2 is functionally dominant compared with SMG5-SMG7 in mammalian nonsense-mediated mRNA decay. Nucleic Acids Res. 41, 1319-1328 (2013).
    • (2013) Nucleic Acids Res. , vol.41 , pp. 1319-1328
    • Cho, H.1
  • 26
    • 0141819096 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities
    • Lejeune, F., Li, X. & Maquat, L. E. Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol. Cell 12, 675-687 (2003).
    • (2003) Mol. Cell , vol.12 , pp. 675-687
    • Lejeune, F.1    Li, X.2    Maquat, L.E.3
  • 27
    • 13944259434 scopus 로고    scopus 로고
    • SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
    • Fukuhara, N. et al. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Mol. Cell 17, 537-547 (2005).
    • (2005) Mol. Cell , vol.17 , pp. 537-547
    • Fukuhara, N.1
  • 28
  • 29
    • 84887331394 scopus 로고    scopus 로고
    • Global cellular response to chemotherapy-induced apoptosis
    • Wiita, A. P. et al. Global cellular response to chemotherapy-induced apoptosis. Elife 2, e01236 (2013).
    • (2013) Elife , vol.2 , pp. e01236
    • Wiita, A.P.1
  • 30
    • 0036883882 scopus 로고    scopus 로고
    • Degradation of cellular mRNA is a general early apoptosis-induced event
    • Del Prete, M. J. et al. Degradation of cellular mRNA is a general early apoptosis-induced event. FASEB J. 16, 2003-2005 (2002).
    • (2002) FASEB J. , vol.16 , pp. 2003-2005
    • Del Prete, M.J.1
  • 31
    • 4344630346 scopus 로고    scopus 로고
    • Translation inhibition during the induction of apoptosis: RNA or protein degradation?
    • Bushell, M., Stoneley, M., Sarnow, P. & Willis, A. E. Translation inhibition during the induction of apoptosis: RNA or protein degradation? Biochem. Soc. Trans. 32, 606-610 (2004).
    • (2004) Biochem. Soc. Trans. , vol.32 , pp. 606-610
    • Bushell, M.1    Stoneley, M.2    Sarnow, P.3    Willis, A.E.4
  • 32
    • 52649141086 scopus 로고    scopus 로고
    • Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini
    • Mahrus, S. et al. Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini. Cell 134, 866-876 (2008).
    • (2008) Cell , vol.134 , pp. 866-876
    • Mahrus, S.1
  • 33
    • 79959461070 scopus 로고    scopus 로고
    • Caspase substrates and cellular remodeling
    • Crawford, E. D. & Wells, J. A. Caspase substrates and cellular remodeling. Annu. Rev. Biochem. 80, 1055-1087 (2011).
    • (2011) Annu. Rev. Biochem. , vol.80 , pp. 1055-1087
    • Crawford, E.D.1    Wells, J.A.2
  • 34
    • 84873828345 scopus 로고    scopus 로고
    • Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability
    • Tani, H. et al. Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability. RNA Biol. 9, 1370-1379 (2012).
    • (2012) RNA Biol. , vol.9 , pp. 1370-1379
    • Tani, H.1
  • 35
    • 80052979901 scopus 로고    scopus 로고
    • RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD
    • Huang, L. et al. RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD. Mol. Cell 43, 950-961 (2011).
    • (2011) Mol. Cell , vol.43 , pp. 950-961
    • Huang, L.1
  • 36
    • 34547838641 scopus 로고    scopus 로고
    • The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the nonsense mediated decay pathway
    • Viegas, M. H., Gehring, N. H., Breit, S., Hentze, M. W. & Kulozik, A. E. The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the nonsense mediated decay pathway. Nucleic Acids Res. 35, 4542-4551 (2007).
    • (2007) Nucleic Acids Res. , vol.35 , pp. 4542-4551
    • Viegas, M.H.1    Gehring, N.H.2    Breit, S.3    Hentze, M.W.4    Kulozik, A.E.5
  • 37
    • 84863760251 scopus 로고    scopus 로고
    • The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1
    • Mocquet, V. et al. The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1. J. Virol. 86, 7530-7543 (2012).
    • (2012) J. Virol. , vol.86 , pp. 7530-7543
    • Mocquet, V.1
  • 38
    • 84864751261 scopus 로고    scopus 로고
    • The upstream open reading frame of cyclindependent kinase inhibitor 1A mRNA negatively regulates translation of the downstream main open reading frame
    • Kim, K. M., Cho, H. & Kim, Y. K. The upstream open reading frame of cyclindependent kinase inhibitor 1A mRNA negatively regulates translation of the downstream main open reading frame. Biochem. Biophys. Res. Commun. 424, 469-475 (2012).
    • (2012) Biochem. Biophys. Res. Commun. , vol.424 , pp. 469-475
    • Kim, K.M.1    Cho, H.2    Kim, Y.K.3
  • 39
    • 84874504687 scopus 로고    scopus 로고
    • Rules that govern UPF1 binding to mRNA 3′ UTRs
    • Kurosaki, T. & Maquat, L. E. Rules that govern UPF1 binding to mRNA 3′ UTRs. Proc. Natl Acad. Sci. USA 110, 3357-3362 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 3357-3362
    • Kurosaki, T.1    Maquat, L.E.2
  • 40
    • 43249084802 scopus 로고    scopus 로고
    • A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay
    • Singh, G., Rebbapragada, I. & Lykke-Andersen, J. A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. PLoS Biol. 6, e111 (2008).
    • (2008) PLoS Biol. , vol.6 , pp. e111
    • Singh, G.1    Rebbapragada, I.2    Lykke-Andersen, J.3
  • 41
    • 84856858152 scopus 로고    scopus 로고
    • N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD
    • Okada-Katsuhata, Y. et al. N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD. Nucleic Acids Res. 40, 1251-1266 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. 1251-1266
    • Okada-Katsuhata, Y.1
  • 42
    • 41949113083 scopus 로고    scopus 로고
    • Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay
    • Isken, O. et al. Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell 133, 314-327 (2008).
    • (2008) Cell , vol.133 , pp. 314-327
    • Isken, O.1
  • 43
    • 33750354408 scopus 로고    scopus 로고
    • Analysis of cycloheximide-induced apoptosis in human leukocytes: Fluorescence microscopy using annexin V/propidium iodide versus acridin orange/ethidium bromide
    • Baskic, D., Popovic, S., Ristic, P. & Arsenijevic, N. N. Analysis of cycloheximide-induced apoptosis in human leukocytes: fluorescence microscopy using annexin V/propidium iodide versus acridin orange/ethidium bromide. Cell Biol. Int. 30, 924-932 (2006).
    • (2006) Cell Biol. Int. , vol.30 , pp. 924-932
    • Baskic, D.1    Popovic, S.2    Ristic, P.3    Arsenijevic, N.N.4
  • 44
    • 84940570573 scopus 로고    scopus 로고
    • Proteases implicated in apoptosis: Old and new
    • Moffitt, K. L., Martin, S. L. & Walker, B. Proteases implicated in apoptosis: old and new. J. Pharm. Pharmacol. 62, 563-576 (2010).
    • (2010) J. Pharm. Pharmacol. , vol.62 , pp. 563-576
    • Moffitt, K.L.1    Martin, S.L.2    Walker, B.3
  • 45
    • 0035038083 scopus 로고    scopus 로고
    • Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway
    • Pal, M., Ishigaki, Y., Nagy, E. & Maquat, L. E. Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway. RNA 7, 5-15 (2001).
    • (2001) RNA , vol.7 , pp. 5-15
    • Pal, M.1    Ishigaki, Y.2    Nagy, E.3    Maquat, L.E.4
  • 46
    • 0034704104 scopus 로고    scopus 로고
    • Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system
    • Smith, L. et al. Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system. J. Biol. Chem. 275, 40620-40627 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 40620-40627
    • Smith, L.1
  • 47
    • 0033174072 scopus 로고    scopus 로고
    • Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappa B loop
    • Levkau, B., Scatena, M., Giachelli, C. M., Ross, R. & Raines, E. W. Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappa B loop. Nat. Cell Biol. 1, 227-233 (1999).
    • (1999) Nat. Cell Biol. , vol.1 , pp. 227-233
    • Levkau, B.1    Scatena, M.2    Giachelli, C.M.3    Ross, R.4    Raines, E.W.5
  • 48
    • 84889099630 scopus 로고    scopus 로고
    • Phosphorylation of the N- and C-terminal UPF1 domains plays a critical role in plant nonsensemediated mRNA decay
    • Kerenyi, F., Wawer, I., Sikorski, P. J., Kufel, J. & Silhavy, D. Phosphorylation of the N- and C-terminal UPF1 domains plays a critical role in plant nonsensemediated mRNA decay. Plant J. 76, 836-848 (2013).
    • (2013) Plant J. , vol.76 , pp. 836-848
    • Kerenyi, F.1    Wawer, I.2    Sikorski, P.J.3    Kufel, J.4    Silhavy, D.5
  • 49
    • 84864933811 scopus 로고    scopus 로고
    • Evidence that the Upf1-related molecular motor scans the 3′-UTR to ensure mRNA integrity
    • Shigeoka, T., Kato, S., Kawaichi, M. & Ishida, Y. Evidence that the Upf1-related molecular motor scans the 3′-UTR to ensure mRNA integrity. Nucleic Acids Res. 40, 6887-6897 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , pp. 6887-6897
    • Shigeoka, T.1    Kato, S.2    Kawaichi, M.3    Ishida, Y.4
  • 50
    • 0032544062 scopus 로고    scopus 로고
    • A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells
    • Sun, X., Perlick, H. A., Dietz, H. C. & Maquat, L. E. A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells. Proc. Natl Acad. Sci. USA 95, 10009-10014 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 10009-10014
    • Sun, X.1    Perlick, H.A.2    Dietz, H.C.3    Maquat, L.E.4
  • 52
    • 84906239869 scopus 로고    scopus 로고
    • A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD
    • Nicholson, P., Josi, C., Kurosawa, H., Yamashita, A. & Mühlemann, O. A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD. Nucleic Acids Res. 42, 9217-9235 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. 9217-9235
    • Nicholson, P.1    Josi, C.2    Kurosawa, H.3    Yamashita, A.4    Mühlemann, O.5
  • 53
    • 84906218594 scopus 로고    scopus 로고
    • Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6
    • Chakrabarti, S., Bonneau, F., Schussler, S., Eppinger, E. & Conti, E. Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6. Nucleic Acids Res. 42, 9447-9460 (2014).
    • (2014) Nucleic Acids Res. , vol.42 , pp. 9447-9460
    • Chakrabarti, S.1    Bonneau, F.2    Schussler, S.3    Eppinger, E.4    Conti, E.5
  • 54
    • 4644303124 scopus 로고    scopus 로고
    • Gadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress
    • Mak, S. K. & Kultz, D. Gadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress. J. Biol. Chem. 279, 39075-39084 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 39075-39084
    • Mak, S.K.1    Kultz, D.2
  • 55
    • 77955620283 scopus 로고    scopus 로고
    • Activation of specific apoptotic caspases with an engineered small-molecule-activated protease
    • Gray, D. C., Mahrus, S. & Wells, J. A. Activation of specific apoptotic caspases with an engineered small-molecule-activated protease. Cell 142, 637-646 (2010).
    • (2010) Cell , vol.142 , pp. 637-646
    • Gray, D.C.1    Mahrus, S.2    Wells, J.A.3
  • 56
    • 84873850861 scopus 로고    scopus 로고
    • The RNA degradation pathway regulates the function of GAS5 a non-coding RNA in mammalian cells
    • Tani, H., Torimura, M. & Akimitsu, N. The RNA degradation pathway regulates the function of GAS5 a non-coding RNA in mammalian cells. PLoS ONE 8, e55684 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e55684
    • Tani, H.1    Torimura, M.2    Akimitsu, N.3
  • 57
    • 84876059532 scopus 로고    scopus 로고
    • Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression
    • Keeling, K. M. et al. Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression. PLoS ONE 8, e60478 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e60478
    • Keeling, K.M.1
  • 58
    • 34547625136 scopus 로고    scopus 로고
    • Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies
    • Durand, S. et al. Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies. J. Cell Biol. 178, 1145-1160 (2007).
    • (2007) J. Cell Biol. , vol.178 , pp. 1145-1160
    • Durand, S.1
  • 59
    • 84860851412 scopus 로고    scopus 로고
    • Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks
    • Lee, M. J. et al. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell 149, 780-794 (2012).
    • (2012) Cell , vol.149 , pp. 780-794
    • Lee, M.J.1
  • 60
    • 34547659166 scopus 로고    scopus 로고
    • Human INT6/eIF3e is required for nonsense-mediated mRNA decay
    • Morris, C., Wittmann, J., Jäck, H. M. & Jalinot, P. Human INT6/eIF3e is required for nonsense-mediated mRNA decay. EMBO Rep. 8, 596-602 (2007).
    • (2007) EMBO Rep. , vol.8 , pp. 596-602
    • Morris, C.1    Wittmann, J.2    Jäck, H.M.3    Jalinot, P.4
  • 61
    • 84902125654 scopus 로고    scopus 로고
    • Identification and characterization of small molecules that inhibit nonsense-mediated rna decay and suppress nonsense p53 mutations
    • Martin, L. et al. Identification and characterization of small molecules that inhibit nonsense-mediated rna decay and suppress nonsense p53 mutations. Cancer Res. 74, 3104-3113 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 3104-3113
    • Martin, L.1
  • 62
    • 84874483832 scopus 로고    scopus 로고
    • Temporal and spatial characterization of nonsense-mediated mRNA decay
    • Trcek, T., Sato, H., Singer, R. H. & Maquat, L. E. Temporal and spatial characterization of nonsense-mediated mRNA decay. Genes Dev. 27, 541-551 (2013).
    • (2013) Genes Dev. , vol.27 , pp. 541-551
    • Trcek, T.1    Sato, H.2    Singer, R.H.3    Maquat, L.E.4
  • 63
    • 0034595967 scopus 로고    scopus 로고
    • The GADD45 inhibition of Cdc2 kinase correlates with GADD45- mediated growth suppression
    • Jin, S. et al. The GADD45 inhibition of Cdc2 kinase correlates with GADD45- mediated growth suppression. J. Biol. Chem. 275, 16602-16608 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 16602-16608
    • Jin, S.1
  • 64
    • 21044444012 scopus 로고    scopus 로고
    • Gadd45a expression induces Bim dissociation from the cytoskeleton and translocation to mitochondria
    • Tong, T. et al. Gadd45a expression induces Bim dissociation from the cytoskeleton and translocation to mitochondria. Mol. Cell. Biol. 25, 4488-4500 (2005).
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 4488-4500
    • Tong, T.1
  • 65
    • 77955499212 scopus 로고    scopus 로고
    • Gadd45b mediates Fas-induced apoptosis by enhancing the interaction between p38 and retinoblastoma tumor suppressor
    • Cho, H. J. et al. Gadd45b mediates Fas-induced apoptosis by enhancing the interaction between p38 and retinoblastoma tumor suppressor. J. Biol. Chem. 285, 25500-25505 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 25500-25505
    • Cho, H.J.1
  • 66
    • 0028832667 scopus 로고
    • A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions
    • Chittenden, T. et al. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J. 14, 5589-5596 (1995).
    • (1995) EMBO J. , vol.14 , pp. 5589-5596
    • Chittenden, T.1
  • 67
    • 84890017364 scopus 로고    scopus 로고
    • Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5
    • Mourtada-Maarabouni, M. & Williams, G. T. Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5. Biomed. Res. Int. 2013, 358015 (2013).
    • (2013) Biomed. Res. Int. , vol.2013 , pp. 358015
    • Mourtada-Maarabouni, M.1    Williams, G.T.2
  • 68
    • 0033556151 scopus 로고    scopus 로고
    • Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death
    • Kissil, J. L., Cohen, O., Raveh, T. & Kimchi, A. Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death. EMBO J. 18, 353-362 (1999).
    • (1999) EMBO J. , vol.18 , pp. 353-362
    • Kissil, J.L.1    Cohen, O.2    Raveh, T.3    Kimchi, A.4
  • 69
    • 0037417281 scopus 로고    scopus 로고
    • PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression
    • Yin, Y., Liu, Y. X., Jin, Y. J., Hall, E. J. & Barrett, J. C. PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression. Nature 422, 527-531 (2003).
    • (2003) Nature , vol.422 , pp. 527-531
    • Yin, Y.1    Liu, Y.X.2    Jin, Y.J.3    Hall, E.J.4    Barrett, J.C.5
  • 70
    • 33751336068 scopus 로고    scopus 로고
    • BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription
    • Brocke-Heidrich, K. et al. BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription. Oncogene 25, 7297-7304 (2006).
    • (2006) Oncogene , vol.25 , pp. 7297-7304
    • Brocke-Heidrich, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.