Human INT6/eIF3e is required for nonsense-mediated mRNA decay

EMBO Reports

Volumn 8, Issue 6, 2007, Pages 596-602

  Morris, Christelle ^a   Wittmann, Jürgen ^b   Jäck, Hans Martin ^b   Jalinot, Pierre ^a  

^a UNIVERSITÉ DE LYON   (France)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ASPARTATE AMMONIA LIGASE; BETA GLOBIN; CAP BINDING PROTEIN; CYSTEINE TRANSFER RNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; INITIATION FACTOR 3; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN SUBUNIT; SERINE TRANSFER RNA LIGASE; SLIT2 PROTEIN; TRANSLATION TERMINATION FACTOR;

ARTICLE; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PURIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA DEGRADATION; RNA INTERFERENCE; SEQUENCE ANALYSIS; STOP CODON; TRANSCRIPTION REGULATION;

CODON, NONSENSE; EUKARYOTIC INITIATION FACTOR-3; GENE SILENCING; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; NUCLEAR CAP-BINDING PROTEIN COMPLEX; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA STABILITY; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 34547659166     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7400955     Document Type: Article

References (34)

1. Akiyoshi Y, Clayton J, Phan L, Yamamoto M, Hinnebusch AG, Watanabe Y, Asano K (2001) Fission yeast homolog of murine Int-6 protein, encoded by mouse mammary tumor virus integration site, is associated with the conserved core subunits of eukaryotic translation initiation factor 3. J Biol Chem 276: 10056-10062
2. Applequist SE, Selg M, Raman C, Jack HM (1997) Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein. Nucleic Acids Res 25: 814-821
3. Asano K, Merrick WC, Hershey JW (1997) The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome. J Biol Chem 272: 23477-23480
4. Asano K, Phan L, Anderson J, Hinnebusch AG (1998) Complex formation by all five homologues of mammalian translation initiation factor 3 subunits from yeast Saccharomyces cerevisiae. J Biol Chem 273 18573-18585
5. Baker KE, Parker R (2004) Nonsense-mediated mRNA decay: Terminating erroneous gene expression. Curr Opin Cell Biol 16: 293-299
6. Bandyopadhyay A, Matsumoto T, Maitra U (2000) Fission yeast Int6 is not essential for global translation initiation, but deletion of int6(+) causes hypersensitivity to caffeine and affects spore formation. Mol Biol Cell 11: 4005-4018
7. Belgrader P, Cheng J, Maquat LE (1993) Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA. Proc Natl Acad Sci USA 90: 482-486
8. Chiu SY, Lejeune F, Ranganathan AC, Maquat LE (2004) The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex. Genes Dev 18: 745-754
9. Conti E, Izaurralde E (2005) Nonsense-mediated mRNA decay: Molecular insights and mechanistic variations across species. Curr Opin Cell Biol 17: 316-325
10. Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP (2001) Cloning of a novel phosphatidylinositol kinase-related kinase: Characterization of the human SMG-1 RNA surveillance protein. J Biol Chem 276 22709-22714
11. Hoareau Alves K, Bochard V, Rety S, Jalinot P (2002) Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. FEBS Left 527: 15-21
12. Ishigaki Y, Li X, Serin G, Maquat LE (2001) Evidence for a pioneer round of mRNA translation: MRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20. Cell 106: 607-617
13. Izaurralde E, Lewis J, McGuigar C, Jankowska M, Darzynkiewicz E, Mattaj IW (1994) A nuclear cap binding protein complex involved in pre-mRNA splicing. Cell 78: 657-668
14. Karniol B, Yahalom A, Kwok S, Tsuge T, Matsui M, Deng XW, Charnovitz DA (1998) The Arabidopsis homologue of an eIF3 complex subunit associates with the COP9 complex. FEBS Left 439: 173-179
15. Kim TH, Kim BH, Yahalom A, Chamovitz DA, von Amim AG (2004) Translational regulation via 5′ mRNA leader sequences revealed by mutational analysis of the Arabidopsis translation initiation factor subunit eIF3h. Plant Cell 16: 3341-3356
16. LeFebvre AK, Korneeva NL, Trutschl M, Cvek U, Duzan RD, Bradley CA, Hershey JW, Rhoads RE (2006) Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit. J Biol Chem 281: 22917-22932
17. Maquat LE (2004) Nonsense-mediated mRNA decay: Splicing, translation and mRNP dynamics. Nat Rev Mol Cell Biol 5: 89-99
18. Marchetti A, Buttitta F, Miyazaki S, Gallahan D, Smith GH, Callahan R (1995) Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia. J Virol 69 1932-1938
19. Mendell JT, Sharifi NA, Meyers JL, Martinez-Murillo F, Dietz HC (2004) Nonsense surveillance regilates expression of diverse classes of mammalian transcripts and mutes genomic noise. Nat Genet 36: 1073-1078
20. Morley SJ, McKendrick L (19971 Involvement of stress-activated protein kinase and p38/RK mitogen-activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells. J Biol Chem 272: 17887-17893
21. Morris C, Jalinot P (2005) Silencing of human Int-6 impairs mitosis progression and inhibits cyclin B-Cdk1 activation. Oncogene 24 1203-1211
22. Morris-Desbois C, Bochard V, Reynaud C, Jalinot P (1999) Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies. J Cell Sci 112: 3331-3342
23. Morris-Desbois C, Rety S, Ferro M, Garin J, Jalinot P (2001) The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3. J Biol Chem 276: 45988-45995
24. Pal M, Ishigaki Y, Nagy E, Maquat LE (2001) Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway. RNA 7: 5-15
25. Phan L, Zhang X, Asano K, Anderson J, Vornlocher HP, Greenberg JR, Qin J, Hinnebusch AG (1998) Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol 18: 4935-4946
26. Seither P, Iben S, Thiry M, Grummt I (2001) PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I. Biol Chem 382: 1163-1170
27. Thermann R, Neu-Yilik G, Deters A, Frede U, Wehr K, Hagemeier C, Hentze MW, Kulozik AE (1998) Binary specification of nonsense codons by splicing and cytoplasmic translation. EMBO J 17: 3484-3494
28. Welch EM, Jacobson A (1999) An internal open reading frame triggers nonsense-mediated decay of the yeast SPT10 mRNA. EMBO J 18: 6134-6145
29. Wittmann J, Hol EM, Jack HM (2006) hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay. Mol Cell Biol 26: 1272-1287
30. Yahalom A, Kim TH, Winter E, Karniol B, von Arnim AG, Chamovitz DA (2001) Arabidopsis eIF3e (INT-6) associates with both eIF3c and the COP9 signalosome subunit CSN7. J Biol Chem 276: 334-340
31. Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S (2001) Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. Genes Dev 15: 2215-2228
32. Yen HC, Gordon C, Chang EC (2003) Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome. Cell 112: 207-217
33. Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I (2002) Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. EMBO Rep 3: 1082-1087
34. Zhou C, Arslan F, Wee S, Krishnan S, Ivanov AR, Oliva A, Leatherwood J, Wolf DA (2005) PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes. BMC Biol 3: 14