-
1
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp R, Mason WP, van den Bent MJ, et al: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987-996, 2005
-
(2005)
N Engl J Med
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
Van Den Bent, M.J.3
-
2
-
-
34047238978
-
The relationship between six-month progressionfree survival and 12-month overall survival end points for phase II trials in patients with glioblastoma multiforme
-
Ballman KV, Buckner JC, Brown PD, et al: The relationship between six-month progressionfree survival and 12-month overall survival end points for phase II trials in patients with glioblastoma multiforme. Neuro Oncol 9:29-38, 2007
-
(2007)
Neuro Oncol
, vol.9
, pp. 29-38
-
-
Ballman, K.V.1
Buckner, J.C.2
Brown, P.D.3
-
3
-
-
44849138808
-
Progression-free survival: An important end point in evaluating therapy for recurrent high-grade gliomas
-
Lamborn KR, Yung WK, Chang SM, et al: Progression-free survival: An important end point in evaluating therapy for recurrent high-grade gliomas. Neuro Oncol 10:162-170, 2008
-
(2008)
Neuro Oncol
, vol.10
, pp. 162-170
-
-
Lamborn, K.R.1
Yung, W.K.2
Chang, S.M.3
-
4
-
-
0032767387
-
Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials
-
Wong ET, Hess KR, Gleason MJ, et al: Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials. J Clin Oncol 17:2572-2578, 1999
-
(1999)
J Clin Oncol
, vol.17
, pp. 2572-2578
-
-
Wong, E.T.1
Hess, K.R.2
Gleason, M.J.3
-
5
-
-
73649123907
-
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
-
Verhaak RG, Hoadley KA, Purdom E, et al: Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17:98-110, 2010
-
(2010)
Cancer Cell
, vol.17
, pp. 98-110
-
-
Verhaak, R.G.1
Hoadley, K.A.2
Purdom, E.3
-
6
-
-
84876993950
-
Normalizing tumor microenvironment to treat cancer: Bench to bedside to biomarkers
-
Jain RK: Normalizing tumor microenvironment to treat cancer: Bench to bedside to biomarkers. J Clin Oncol 31:2205-2218, 2013
-
(2013)
J Clin Oncol
, vol.31
, pp. 2205-2218
-
-
Jain, R.K.1
-
8
-
-
2442621619
-
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
-
Ferrara N, Hillan KJ, Gerber HP, et al: Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 3:391-400, 2004
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 391-400
-
-
Ferrara, N.1
Hillan, K.J.2
Gerber, H.P.3
-
9
-
-
70350461699
-
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
-
Friedman HS, Prados MD, Wen PY, et al: Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol 27:4733-4740, 2009
-
(2009)
J Clin Oncol
, vol.27
, pp. 4733-4740
-
-
Friedman, H.S.1
Prados, M.D.2
Wen, P.Y.3
-
10
-
-
59949083263
-
Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
-
Kreisl TN, Kim L, Moore K, et al: Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol 27:740-745, 2009
-
(2009)
J Clin Oncol
, vol.27
, pp. 740-745
-
-
Kreisl, T.N.1
Kim, L.2
Moore, K.3
-
11
-
-
36049037819
-
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
-
Vredenburgh JJ, Desjardins A, Herndon JE 2nd, et al: Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol 25:4722-4729, 2007
-
(2007)
J Clin Oncol
, vol.25
, pp. 4722-4729
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Herndon, J.E.3
-
12
-
-
84894194756
-
Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma
-
Chinot OL, Wick W, Mason W, et al: Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med 370:709-722, 2014
-
(2014)
N Engl J Med
, vol.370
, pp. 709-722
-
-
Chinot, O.L.1
Wick, W.2
Mason, W.3
-
13
-
-
84894114159
-
A randomized trial of bevacizumab for newly diagnosed glioblastoma
-
Gilbert MR, Dignam JJ, Armstrong TS, et al: A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med 370:699-708, 2014
-
(2014)
N Engl J Med
, vol.370
, pp. 699-708
-
-
Gilbert, M.R.1
Dignam, J.J.2
Armstrong, T.S.3
-
14
-
-
84887116872
-
Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma
-
Batchelor TT, Mulholland P, Neyns B, et al: Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. J Clin Oncol 31:3212-3218, 2013
-
(2013)
J Clin Oncol
, vol.31
, pp. 3212-3218
-
-
Batchelor, T.T.1
Mulholland, P.2
Neyns, B.3
-
15
-
-
77949891455
-
Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma
-
Wick W, Puduvalli VK, Chamberlain MC, et al: Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J Clin Oncol 28:1168-1174, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 1168-1174
-
-
Wick, W.1
Puduvalli, V.K.2
Chamberlain, M.C.3
-
16
-
-
84887419886
-
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation
-
Batchelor TT, Gerstner ER, Emblem KE, et al: Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation. Proc Natl Acad Sci U S A 110:19059-19064, 2013
-
(2013)
Proc Natl Acad Sci u S a
, vol.110
, pp. 19059-19064
-
-
Batchelor, T.T.1
Gerstner, E.R.2
Emblem, K.E.3
-
17
-
-
84862907876
-
Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion
-
Sorensen AG, Emblem KE, Polaskova P, et al: Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion. Cancer Res 72:402-407, 2012
-
(2012)
Cancer Res
, vol.72
, pp. 402-407
-
-
Sorensen, A.G.1
Emblem, K.E.2
Polaskova, P.3
-
18
-
-
16844382092
-
A phase I/II trial of single-agent PTK 787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM)
-
Conrad C, Friedman H, Reardon D, et al: A phase I/II trial of single-agent PTK 787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM). J Clin Oncol 22:15s, 2004 (suppl; abstr 1512)
-
(2004)
J Clin Oncol
, vol.22
, pp. 15s
-
-
Conrad, C.1
Friedman, H.2
Reardon, D.3
-
19
-
-
84899842077
-
Parametric response maps of perfusion MRI may identify recurrent glioblastomas responsive to bevacizumab and irinotecan
-
Aquino D, Di Stefano AL, Scotti A, et al: Parametric response maps of perfusion MRI may identify recurrent glioblastomas responsive to bevacizumab and irinotecan. PLoS One 9:e90535, 2014
-
(2014)
PLoS One
, vol.9
, pp. e90535
-
-
Aquino, D.1
Di Stefano, A.L.2
Scotti, A.3
-
20
-
-
79956328903
-
Molecular mechanisms and clinical applications of angiogenesis
-
Carmeliet P, Jain RK: Molecular mechanisms and clinical applications of angiogenesis. Nature 473:298-307, 2011
-
(2011)
Nature
, vol.473
, pp. 298-307
-
-
Carmeliet, P.1
Jain, R.K.2
-
21
-
-
17844405022
-
Endogenous inhibitors of angiogenesis in malignant gliomas: Nature's antiangiogenic therapy
-
Rege TA, Fears CY, Gladson CL: Endogenous inhibitors of angiogenesis in malignant gliomas: Nature's antiangiogenic therapy. Neuro Oncol 7:106-121, 2005
-
(2005)
Neuro Oncol
, vol.7
, pp. 106-121
-
-
Rege, T.A.1
Fears, C.Y.2
Gladson, C.L.3
-
22
-
-
0344837389
-
Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment
-
Guo P, Hu B, Gu W, et al: Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment. Am J Pathol 162:1083-1093, 2003
-
(2003)
Am J Pathol
, vol.162
, pp. 1083-1093
-
-
Guo, P.1
Hu, B.2
Gu, W.3
-
23
-
-
0038376002
-
Molecular regulation of vessel maturation
-
Jain RK: Molecular regulation of vessel maturation. Nat Med 9:685-693, 2003
-
(2003)
Nat Med
, vol.9
, pp. 685-693
-
-
Jain, R.K.1
-
24
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain RK: Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 307:58-62, 2005
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
25
-
-
0029010597
-
Vascular morphology and angiogenesis in glial tumors
-
Plate KH, Mennel HD: Vascular morphology and angiogenesis in glial tumors. Exp Toxicol Pathol 47:89-94, 1995
-
(1995)
Exp Toxicol Pathol
, vol.47
, pp. 89-94
-
-
Plate, K.H.1
Mennel, H.D.2
-
26
-
-
19944422751
-
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases
-
Winkler F, Kozin SV, Tong RT, et al: Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 6:553-563, 2004
-
(2004)
Cancer Cell
, vol.6
, pp. 553-563
-
-
Winkler, F.1
Kozin, S.V.2
Tong, R.T.3
-
28
-
-
34047260282
-
Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: Insights from a mathematical model
-
Jain RK, Tong RT, Munn LL: Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: Insights from a mathematical model. Cancer Res 67:2729-2735, 2007
-
(2007)
Cancer Res
, vol.67
, pp. 2729-2735
-
-
Jain, R.K.1
Tong, R.T.2
Munn, L.L.3
-
29
-
-
0034796595
-
Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
-
Jain RK: Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy. Nat Med 7:987-989, 2001
-
(2001)
Nat Med
, vol.7
, pp. 987-989
-
-
Jain, R.K.1
-
30
-
-
2542628099
-
Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
-
Tong RT, Boucher Y, Kozin SV, et al: Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 64:3731-3736, 2004
-
(2004)
Cancer Res
, vol.64
, pp. 3731-3736
-
-
Tong, R.T.1
Boucher, Y.2
Kozin, S.V.3
-
31
-
-
0029949160
-
Timedependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/ vascular permeability factor antibody
-
Yuan F, Chen Y, Dellian M, et al: Timedependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/ vascular permeability factor antibody. Proc Natl Acad Sci U S A 93:14765-14770, 1996
-
(1996)
Proc Natl Acad Sci u S a
, vol.93
, pp. 14765-14770
-
-
Yuan, F.1
Chen, Y.2
Dellian, M.3
-
32
-
-
33846149645
-
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
-
Batchelor TT, Sorensen AG, di Tomaso E, et al: AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11:83-95, 2007
-
(2007)
Cancer Cell
, vol.11
, pp. 83-95
-
-
Batchelor, T.T.1
Sorensen, A.G.2
Di Tomaso, E.3
-
33
-
-
84877870613
-
Vascular normalization as an emerging strategy to enhance cancer immunotherapy
-
Huang Y, Goel S, Duda DG, et al: Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Res 73:2943-2948, 2013
-
(2013)
Cancer Res
, vol.73
, pp. 2943-2948
-
-
Huang, Y.1
Goel, S.2
Duda, D.G.3
-
34
-
-
9244241576
-
Identification of human brain tumour initiating cells
-
Singh SK, Hawkins C, Clarke ID, et al: Identification of human brain tumour initiating cells. Nature 432:396-401, 2004
-
(2004)
Nature
, vol.432
, pp. 396-401
-
-
Singh, S.K.1
Hawkins, C.2
Clarke, I.D.3
-
35
-
-
33846029123
-
A perivascular niche for brain tumor stem cells
-
Calabrese C, Poppleton H, Kocak M, et al: A perivascular niche for brain tumor stem cells. Cancer Cell 11:69-82, 2007
-
(2007)
Cancer Cell
, vol.11
, pp. 69-82
-
-
Calabrese, C.1
Poppleton, H.2
Kocak, M.3
-
36
-
-
84890812467
-
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
-
Lotti F, Jarrar AM, Pai RK, et al: Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A. J Exp Med 210:2851-2872, 2013
-
(2013)
J Exp Med
, vol.210
, pp. 2851-2872
-
-
Lotti, F.1
Jarrar, A.M.2
Pai, R.K.3
-
38
-
-
79957916805
-
Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma
-
Kim H, Catana C, Ratai EM, et al: Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma. Cancer Res 71:3745-3752, 2011
-
(2011)
Cancer Res
, vol.71
, pp. 3745-3752
-
-
Kim, H.1
Catana, C.2
Ratai, E.M.3
-
39
-
-
77950804823
-
A new alternative mechanism in glioblastoma vascularization: Tubular vasculogenic mimicry
-
El Hallani S, Boisselier B, Peglion F, et al: A new alternative mechanism in glioblastoma vascularization: Tubular vasculogenic mimicry. Brain 133: 973-982, 2010
-
(2010)
Brain
, vol.133
, pp. 973-982
-
-
El Hallani, S.1
Boisselier, B.2
Peglion, F.3
-
40
-
-
78650153633
-
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
-
Ricci-Vitiani L, Pallini R, Biffoni M, et al: Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature 468:824-828, 2010
-
(2010)
Nature
, vol.468
, pp. 824-828
-
-
Ricci-Vitiani, L.1
Pallini, R.2
Biffoni, M.3
-
41
-
-
58149456505
-
Efficacy, safety and patterns of response and recurrence in patients with recurrent high-grade gliomas treated with bevacizumab plus irinotecan
-
Zuniga RM, Torcuator R, Jain R, et al: Efficacy, safety and patterns of response and recurrence in patients with recurrent high-grade gliomas treated with bevacizumab plus irinotecan. J Neurooncol 91:329-336, 2009
-
(2009)
J Neurooncol
, vol.91
, pp. 329-336
-
-
Zuniga, R.M.1
Torcuator, R.2
Jain, R.3
-
42
-
-
79952721477
-
Transdifferentiation of glioblastoma cells into vascular endothelial cells
-
Soda Y, Marumoto T, Friedmann-Morvinski D, et al: Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc Natl Acad Sci U S A 108:4274-4280, 2011
-
(2011)
Proc Natl Acad Sci u S a
, vol.108
, pp. 4274-4280
-
-
Soda, Y.1
Marumoto, T.2
Friedmann-Morvinski, D.3
-
43
-
-
26944437515
-
PDGFRbeta + perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
-
Song S, Ewald AJ, Stallcup W, et al: PDGFRbeta + perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol 7:870-879, 2005
-
(2005)
Nat Cell Biol
, vol.7
, pp. 870-879
-
-
Song, S.1
Ewald, A.J.2
Stallcup, W.3
-
44
-
-
79959812904
-
Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy
-
Reardon DA, Desjardins A, Peters K, et al: Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy. J Neurooncol 103:371-379, 2011
-
(2011)
J Neurooncol
, vol.103
, pp. 371-379
-
-
Reardon, D.A.1
Desjardins, A.2
Peters, K.3
-
45
-
-
84861312289
-
Phase II study of carboplatin, irinotecan, and bevacizumab for bevacizumab naïve, recurrent glioblastoma
-
Reardon DA, Desjardins A, Peters KB, et al: Phase II study of carboplatin, irinotecan, and bevacizumab for bevacizumab naïve, recurrent glioblastoma. J Neurooncol 107:155-164, 2012
-
(2012)
J Neurooncol
, vol.107
, pp. 155-164
-
-
Reardon, D.A.1
Desjardins, A.2
Peters, K.B.3
-
46
-
-
71649094684
-
Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: A phase II study
-
Reardon DA, Desjardins A, Vredenburgh JJ, et al: Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: A phase II study. Br J Cancer 101:1986-1994, 2009
-
(2009)
Br J Cancer
, vol.101
, pp. 1986-1994
-
-
Reardon, D.A.1
Desjardins, A.2
Vredenburgh, J.J.3
-
47
-
-
84857373272
-
Bevacizumab and daily temozolomide for recurrent glioblastoma
-
Desjardins A, Reardon DA, Coan A, et al: Bevacizumab and daily temozolomide for recurrent glioblastoma. Cancer 118:1302-1312, 2012
-
(2012)
Cancer
, vol.118
, pp. 1302-1312
-
-
Desjardins, A.1
Reardon, D.A.2
Coan, A.3
-
48
-
-
17844397949
-
The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis
-
Brat DJ, Bellail AC, Van Meir EG: The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol 7:122-133, 2005
-
(2005)
Neuro Oncol
, vol.7
, pp. 122-133
-
-
Brat, D.J.1
Bellail, A.C.2
Van Meir, E.G.3
-
49
-
-
84904913239
-
Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): A randomised controlled phase 2 trial
-
Taal W, Oosterkamp HM, Walenkamp AM, et al: Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial. Lancet Oncol 15:943-953, 2014
-
(2014)
Lancet Oncol
, vol.15
, pp. 943-953
-
-
Taal, W.1
Oosterkamp, H.M.2
Walenkamp, A.M.3
-
50
-
-
84862555221
-
Relation between bevacizumab dose intensity and highgrade glioma survival: A retrospective study in two large cohorts
-
Lorgis V, Maura G, Coppa G, et al: Relation between bevacizumab dose intensity and highgrade glioma survival: A retrospective study in two large cohorts. J Neurooncol 107:351-358, 2012
-
(2012)
J Neurooncol
, vol.107
, pp. 351-358
-
-
Lorgis, V.1
Maura, G.2
Coppa, G.3
-
51
-
-
78650098659
-
Glioblastoma stem-like cells give rise to tumor endothelium
-
Wang R, Chadalavada K, Wilshire J, et al: Glioblastoma stem-like cells give rise to tumor endothelium. Nature 468:829-833, 2010
-
(2010)
Nature
, vol.468
, pp. 829-833
-
-
Wang, R.1
Chadalavada, K.2
Wilshire, J.3
-
52
-
-
78449274656
-
A phase 2 trial of single-agent bevacizumab given in an every-3-week schedule for patients with recurrent high-grade gliomas
-
Raizer JJ, Grimm S, Chamberlain MC, et al: A phase 2 trial of single-agent bevacizumab given in an every-3-week schedule for patients with recurrent high-grade gliomas. Cancer 116:5297-5305, 2010
-
(2010)
Cancer
, vol.116
, pp. 5297-5305
-
-
Raizer, J.J.1
Grimm, S.2
Chamberlain, M.C.3
-
53
-
-
77954748580
-
Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: A phase II trial
-
Hasselbalch B, Lassen U, Hansen S, et al: Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: A phase II trial. Neuro Oncol 12:508-516, 2010
-
(2010)
Neuro Oncol
, vol.12
, pp. 508-516
-
-
Hasselbalch, B.1
Lassen, U.2
Hansen, S.3
-
54
-
-
78650102866
-
Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma
-
Sathornsumetee S, Desjardins A, Vredenburgh JJ, et al: Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma. Neuro Oncol 12:1300-1310, 2010
-
(2010)
Neuro Oncol
, vol.12
, pp. 1300-1310
-
-
Sathornsumetee, S.1
Desjardins, A.2
Vredenburgh, J.J.3
-
55
-
-
79951984402
-
Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme
-
Lai A, Tran A, Nghiemphu PL, et al: Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J Clin Oncol 29:142-148, 2011
-
(2011)
J Clin Oncol
, vol.29
, pp. 142-148
-
-
Lai, A.1
Tran, A.2
Nghiemphu, P.L.3
-
56
-
-
84856806386
-
A clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastoma
-
Narayana A, Gruber D, Kunnakkat S, et al: A clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastoma. J Neurosurg 116:341-345, 2012
-
(2012)
J Neurosurg
, vol.116
, pp. 341-345
-
-
Narayana, A.1
Gruber, D.2
Kunnakkat, S.3
-
57
-
-
79959213028
-
The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide, and irinotecan for newly diagnosed glioblastoma
-
Vredenburgh JJ, Desjardins A, Reardon DA, et al: The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide, and irinotecan for newly diagnosed glioblastoma. Clin Cancer Res 17:4119-4124, 2011
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4119-4124
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Reardon, D.A.3
-
58
-
-
84880683534
-
Tumor response based on adapted Macdonald criteria and assessment of pseudoprogression (PsPD) in the phase III AVAglio trial of bevacizumab (Bv) plus temozolomide (T) plus radiotherapy (RT) in newly diagnosed glioblastoma (GBM)
-
15s2002
-
Wick W, Cloughesy TF, Nishikawa R, et al: Tumor response based on adapted Macdonald criteria and assessment of pseudoprogression (PsPD) in the phase III AVAglio trial of bevacizumab (Bv) plus temozolomide (T) plus radiotherapy (RT) in newly diagnosed glioblastoma (GBM). J Clin Oncol 31:114s, 2013 (suppl 15s; abstr 2002)
-
(2013)
J Clin Oncol
, vol.31
, pp. 114s
-
-
Wick, W.1
Cloughesy, T.F.2
Nishikawa, R.3
-
60
-
-
7444261960
-
Use of soluble recombinant decoy receptor vascular endothelial growth factor trap (VEGF Trap) to inhibit vascular endothelial growth factor activity
-
Konner J, Dupont J: Use of soluble recombinant decoy receptor vascular endothelial growth factor trap (VEGF Trap) to inhibit vascular endothelial growth factor activity. Clin Colorectal Cancer 4:S81-S85, 2004
-
(2004)
Clin Colorectal Cancer
, vol.4
, pp. S81-S85
-
-
Konner, J.1
Dupont, J.2
-
61
-
-
60549106878
-
VEGF trap induces antiglioma effect at different stages of disease
-
Gomez-Manzano C, Holash J, Fueyo J, et al: VEGF trap induces antiglioma effect at different stages of disease. Neuro Oncol 10:940-945, 2008
-
(2008)
Neuro Oncol
, vol.10
, pp. 940-945
-
-
Gomez-Manzano, C.1
Holash, J.2
Fueyo, J.3
-
62
-
-
79960111080
-
Phase II study of aflibercept in recurrent malignant glioma: A North American Brain Tumor Consortium study
-
de Groot JF, Lamborn KR, Chang SM, et al: Phase II study of aflibercept in recurrent malignant glioma: A North American Brain Tumor Consortium study. J Clin Oncol 29:2689-2695, 2011
-
(2011)
J Clin Oncol
, vol.29
, pp. 2689-2695
-
-
De Groot, J.F.1
Lamborn, K.R.2
Chang, S.M.3
-
63
-
-
76249126427
-
Rationale for the development of IMC-3G3, a fully human immunoglobulin G subclass 1 monoclonal antibody targeting the platelet-derived growth factor receptor alpha
-
Shah GD, Loizos N, Youssoufian H, et al: Rationale for the development of IMC-3G3, a fully human immunoglobulin G subclass 1 monoclonal antibody targeting the platelet-derived growth factor receptor alpha. Cancer 116:1018-1026, 2010
-
(2010)
Cancer
, vol.116
, pp. 1018-1026
-
-
Shah, G.D.1
Loizos, N.2
Youssoufian, H.3
-
64
-
-
67649685004
-
Phase 1 study of IMC-3G3, an IgG1 monoclonal antibody targeting PDGFR {alpha} in patients with advanced solid malignancies
-
Youssoufian H, Amato RJ, Sweeney CJ, et al: Phase 1 study of IMC-3G3, an IgG1 monoclonal antibody targeting PDGFR {alpha} in patients with advanced solid malignancies. J Clin Oncol 26:636s, 2008 (suppl; abstr 14617)
-
(2008)
J Clin Oncol
, vol.26
, pp. 636s
-
-
Youssoufian, H.1
Amato, R.J.2
Sweeney, C.J.3
-
65
-
-
79955798791
-
Ramucirumab (IMC-1121B): Monoclonal antibody inhibition of vascular endothelial growth factor receptor-2
-
Spratlin J: Ramucirumab (IMC-1121B): Monoclonal antibody inhibition of vascular endothelial growth factor receptor-2. Curr Oncol Rep 13:97-102, 2011
-
(2011)
Curr Oncol Rep
, vol.13
, pp. 97-102
-
-
Spratlin, J.1
-
66
-
-
33646812605
-
Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue
-
Kopp HG, Ramos CA, Rafii S: Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue. Curr Opin Hematol 13:175-181, 2006
-
(2006)
Curr Opin Hematol
, vol.13
, pp. 175-181
-
-
Kopp, H.G.1
Ramos, C.A.2
Rafii, S.3
-
67
-
-
27644543354
-
Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis
-
Abounader R, Laterra J: Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis. Neuro Oncol 7:436-451, 2005
-
(2005)
Neuro Oncol
, vol.7
, pp. 436-451
-
-
Abounader, R.1
Laterra, J.2
-
68
-
-
20144370978
-
AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
-
Wedge SR, Kendrew J, Hennequin LF, et al: AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 65:4389-4400, 2005
-
(2005)
Cancer Res
, vol.65
, pp. 4389-4400
-
-
Wedge, S.R.1
Kendrew, J.2
Hennequin, L.F.3
-
69
-
-
77954720781
-
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma
-
Batchelor TT, Duda DG, di Tomaso E, et al: Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol 28:2817-2823, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 2817-2823
-
-
Batchelor, T.T.1
Duda, D.G.2
Di Tomaso, E.3
-
70
-
-
67649092660
-
Role of a second chemotherapy in recurrent malignant glioma patients who progress on bevacizumab
-
Quant EC, Norden AD, Drappatz J, et al: Role of a second chemotherapy in recurrent malignant glioma patients who progress on bevacizumab. Neuro Oncol 11:550-555, 2009
-
(2009)
Neuro Oncol
, vol.11
, pp. 550-555
-
-
Quant, E.C.1
Norden, A.D.2
Drappatz, J.3
-
71
-
-
3543028023
-
PTK787/ZK222584, an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, decreases glioma growth and vascularization
-
Goldbrunner RH, Bendszus M, Wood J, et al: PTK787/ZK222584, an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, decreases glioma growth and vascularization. Neurosurgery 55:426-432, 2004
-
(2004)
Neurosurgery
, vol.55
, pp. 426-432
-
-
Goldbrunner, R.H.1
Bendszus, M.2
Wood, J.3
-
72
-
-
65649146868
-
Phase I pharmacokinetic study of the vascular endothelial growth factor receptor tyrosine kinase inhibitor vatalanib (PTK787) plus imatinib and hydroxyurea for malignant glioma
-
Reardon DA, Egorin MJ, Desjardins A, et al: Phase I pharmacokinetic study of the vascular endothelial growth factor receptor tyrosine kinase inhibitor vatalanib (PTK787) plus imatinib and hydroxyurea for malignant glioma. Cancer 115:2188-2198, 2009
-
(2009)
Cancer
, vol.115
, pp. 2188-2198
-
-
Reardon, D.A.1
Egorin, M.J.2
Desjardins, A.3
-
73
-
-
79959841782
-
Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide
-
Gerstner ER, Eichler AF, Plotkin SR, et al: Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide. J Neurooncol 103:325-332, 2010
-
(2010)
J Neurooncol
, vol.103
, pp. 325-332
-
-
Gerstner, E.R.1
Eichler, A.F.2
Plotkin, S.R.3
-
74
-
-
72449155176
-
EORTC study 26041-22041: Phase I/II study on concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) with PTK787/ZK222584 (PTK/ZK) in newly diagnosed glioblastoma
-
Brandes AA, Stupp R, Hau P, et al: EORTC study 26041-22041: Phase I/II study on concomitant and adjuvant temozolomide (TMZ) and radiotherapy (RT) with PTK787/ZK222584 (PTK/ZK) in newly diagnosed glioblastoma. Eur J Cancer 46:348-354, 2010
-
(2010)
Eur J Cancer
, vol.46
, pp. 348-354
-
-
Brandes, A.A.1
Stupp, R.2
Hau, P.3
-
75
-
-
78149492402
-
Phase II trial of pazopanib (GW786034), an oral multitargeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02)
-
Iwamoto FM, Lamborn KR, Robins HI, et al: Phase II trial of pazopanib (GW786034), an oral multitargeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02). Neuro Oncol 12:855-861, 2010
-
(2010)
Neuro Oncol
, vol.12
, pp. 855-861
-
-
Iwamoto, F.M.1
Lamborn, K.R.2
Robins, H.I.3
-
76
-
-
84871816644
-
Continuous daily sunitinib for recurrent glioblastoma
-
Kreisl TN, Smith P, Sul J, et al: Continuous daily sunitinib for recurrent glioblastoma. J Neurooncol 111:41-48, 2013
-
(2013)
J Neurooncol
, vol.111
, pp. 41-48
-
-
Kreisl, T.N.1
Smith, P.2
Sul, J.3
-
77
-
-
79959795987
-
Phase II study of sunitinib malate in patients with recurrent high-grade glioma
-
Neyns B, Sadones J, Chaskis C, et al: Phase II study of sunitinib malate in patients with recurrent high-grade glioma. J Neurooncol 103:491-501, 2011
-
(2011)
J Neurooncol
, vol.103
, pp. 491-501
-
-
Neyns, B.1
Sadones, J.2
Chaskis, C.3
-
78
-
-
84866364645
-
A prospective phase II single-institution trial of sunitinib for recurrent malignant glioma
-
Pan E, Yu D, Yue B, et al: A prospective phase II single-institution trial of sunitinib for recurrent malignant glioma. J Neurooncol 110:111-118, 2012
-
(2012)
J Neurooncol
, vol.110
, pp. 111-118
-
-
Pan, E.1
Yu, D.2
Yue, B.3
-
79
-
-
82955232920
-
Phase I study of sunitinib and irinotecan for patients with recurrent malignant glioma
-
Reardon DA, Vredenburgh JJ, Coan A, et al: Phase I study of sunitinib and irinotecan for patients with recurrent malignant glioma. J Neurooncol 105: 621-627, 2011
-
(2011)
J Neurooncol
, vol.105
, pp. 621-627
-
-
Reardon, D.A.1
Vredenburgh, J.J.2
Coan, A.3
-
80
-
-
84869188311
-
Phase I/II study of sorafenib in combination with temsirolimus for recurrent glioblastoma or gliosarcoma: North American Brain Tumor Consortium study 05-02
-
Lee EQ, Kuhn J, Lamborn KR, et al: Phase I/II study of sorafenib in combination with temsirolimus for recurrent glioblastoma or gliosarcoma: North American Brain Tumor Consortium study 05-02. Neuro Oncol 14:1511-1518, 2012
-
(2012)
Neuro Oncol
, vol.14
, pp. 1511-1518
-
-
Lee, E.Q.1
Kuhn, J.2
Lamborn, K.R.3
-
81
-
-
84875740755
-
NABTT 0502: A phase II and pharmacokinetic study of erlotinib and sorafenib for patients with progressive or recurrent glioblastoma multiforme
-
Peereboom DM, Ahluwalia MS, Ye X, et al: NABTT 0502: A phase II and pharmacokinetic study of erlotinib and sorafenib for patients with progressive or recurrent glioblastoma multiforme. Neuro Oncol 15:490-496, 2013
-
(2013)
Neuro Oncol
, vol.15
, pp. 490-496
-
-
Peereboom, D.M.1
Ahluwalia, M.S.2
Ye, X.3
-
82
-
-
27944446867
-
The role of angiopoietins during angiogenesis in gliomas
-
Reiss Y, Machein MR, Plate KH: The role of angiopoietins during angiogenesis in gliomas. Brain Pathol 15:311-317, 2005
-
(2005)
Brain Pathol
, vol.15
, pp. 311-317
-
-
Reiss, Y.1
Machein, M.R.2
Plate, K.H.3
-
83
-
-
84875456598
-
Angiopoietin-2: An attractive target for improved antiangiogenic tumor therapy
-
Gerald D, Chintharlapalli S, Augustin HG, et al: Angiopoietin-2: An attractive target for improved antiangiogenic tumor therapy. Cancer Res 73:1649-1657, 2013
-
(2013)
Cancer Res
, vol.73
, pp. 1649-1657
-
-
Gerald, D.1
Chintharlapalli, S.2
Augustin, H.G.3
-
84
-
-
77954699789
-
Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas
-
Chae SS, Kamoun WS, Farrar CT, et al: Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas. Clin Cancer Res 16:3618-3627, 2010
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3618-3627
-
-
Chae, S.S.1
Kamoun, W.S.2
Farrar, C.T.3
-
85
-
-
77950254591
-
Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth
-
Hashizume H, Falcón BL, Kuroda T, et al: Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res 70:2213-2223, 2010
-
(2010)
Cancer Res
, vol.70
, pp. 2213-2223
-
-
Hashizume, H.1
Falcón, B.L.2
Kuroda, T.3
-
86
-
-
84898748271
-
Molecular predictors of outcome and response to bevacizumab (BEV) based on analysis of RTOG 0825, a phase III trial comparing chemoradiation (CRT) with and without BEV in patients with newly diagnosed glioblastoma (GBM)
-
15sLBA2010
-
Sulman EP, Won M, Blumenthal DT, et al: Molecular predictors of outcome and response to bevacizumab (BEV) based on analysis of RTOG 0825, a phase III trial comparing chemoradiation (CRT) with and without BEV in patients with newly diagnosed glioblastoma (GBM). J Clin Oncol 31: 116s, 2013 (suppl 15s; abstr LBA2010)
-
(2013)
J Clin Oncol
, vol.31
, pp. 116s
-
-
Sulman, E.P.1
Won, M.2
Blumenthal, D.T.3
-
87
-
-
38349155463
-
Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan
-
Sathornsumetee S, Cao Y, Marcello JE, et al: Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan. J Clin Oncol 26:271-278, 2008
-
(2008)
J Clin Oncol
, vol.26
, pp. 271-278
-
-
Sathornsumetee, S.1
Cao, Y.2
Marcello, J.E.3
-
88
-
-
76749103247
-
Correlative tumor molecular profiling and plasma biomarker analysis in a phase II study of XL184 in patients with progressive or recurrent glioblastoma multiforme
-
DePrimo S, Wu B, Huang S, et al: Correlative tumor molecular profiling and plasma biomarker analysis in a phase II study of XL184 in patients with progressive or recurrent glioblastoma multiforme. J Clin Oncol 27:99s, 2009 (suppl; abstr 2049)
-
(2009)
J Clin Oncol
, vol.27
, pp. 99s
-
-
DePrimo, S.1
Wu, B.2
Huang, S.3
-
89
-
-
80053602712
-
Preliminary results from a multicenter, phase II, randomized, noncomparative clinical trial of radiation and temozolomide with or without vandetanib in newly diagnosed glioblastoma
-
Quant EC, Batchelor T, Lassman AB, et al: Preliminary results from a multicenter, phase II, randomized, noncomparative clinical trial of radiation and temozolomide with or without vandetanib in newly diagnosed glioblastoma. J Clin Oncol 29: 157s, 2011 (suppl; abstr 2069)
-
(2011)
J Clin Oncol
, vol.29
, pp. 157s
-
-
Quant, E.C.1
Batchelor, T.2
Lassman, A.B.3
-
90
-
-
84918566143
-
Biomarker (BM) evaluations in the phase III AVAglio study of bevacizumab (Bv) plus standard radiotherapy (RT) and temozolomide (T) for newly diagnosed glioblastoma (GBM)
-
15s2023
-
Nishikawa R, Saran F, Mason W, et al: Biomarker (BM) evaluations in the phase III AVAglio study of bevacizumab (Bv) plus standard radiotherapy (RT) and temozolomide (T) for newly diagnosed glioblastoma (GBM). J Clin Oncol 31:119s, 2013 (suppl 15s; abstr 2023)
-
(2013)
J Clin Oncol
, vol.31
, pp. 119s
-
-
Nishikawa, R.1
Saran, F.2
Mason, W.3
-
91
-
-
79960406166
-
Myeloid biomarkers associated with glioblastoma response to anti-VEGF therapy with aflibercept
-
de Groot JF, Piao Y, Tran H, et al: Myeloid biomarkers associated with glioblastoma response to anti-VEGF therapy with aflibercept. Clin Cancer Res 17:4872-4881, 2011
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4872-4881
-
-
De Groot, J.F.1
Piao, Y.2
Tran, H.3
-
92
-
-
67650463119
-
A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients
-
Sorensen AG, Batchelor TT, Zhang WT, et al: A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients. Cancer Res 69:5296-5300, 2009
-
(2009)
Cancer Res
, vol.69
, pp. 5296-5300
-
-
Sorensen, A.G.1
Batchelor, T.T.2
Zhang, W.T.3
-
93
-
-
67650380136
-
Biomarkers of response and resistance to antiangiogenic therapy
-
Jain RK, Duda DG, Willett CG, et al: Biomarkers of response and resistance to antiangiogenic therapy. Nat Rev Clin Oncol 6:327-338, 2009
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 327-338
-
-
Jain, R.K.1
Duda, D.G.2
Willett, C.G.3
-
94
-
-
77951457560
-
Glioblastoma: A method for predicting response to antiangiogenic chemotherapy by using MR perfusion imaging-Pilot study
-
Sawlani RN, Raizer J, Horowitz SW, et al: Glioblastoma: A method for predicting response to antiangiogenic chemotherapy by using MR perfusion imaging-Pilot study. Radiology 255:622-628, 2010
-
(2010)
Radiology
, vol.255
, pp. 622-628
-
-
Sawlani, R.N.1
Raizer, J.2
Horowitz, S.W.3
-
95
-
-
0032941495
-
Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis
-
Schmidt NO, Westphal M, Hagel C, et al: Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis. Int J Cancer 84:10-18, 1999
-
(1999)
Int J Cancer
, vol.84
, pp. 10-18
-
-
Schmidt, N.O.1
Westphal, M.2
Hagel, C.3
-
96
-
-
0026409737
-
Acidic and basic fibroblast growth factors are present in glioblastoma multiforme and normal brain
-
Stefanik DF, Rizkalla LR, Soi A, et al: Acidic and basic fibroblast growth factors are present in glioblastoma multiforme and normal brain. Ann N Y Acad Sci 638:477-480, 1991
-
(1991)
Ann N y Acad Sci
, vol.638
, pp. 477-480
-
-
Stefanik, D.F.1
Rizkalla, L.R.2
Soi, A.3
-
97
-
-
0034648793
-
Vascular-specific growth factors and blood vessel formation
-
Yancopoulos GD, Davis S, Gale NW, et al: Vascular-specific growth factors and blood vessel formation. Nature 407:242-248, 2000
-
(2000)
Nature
, vol.407
, pp. 242-248
-
-
Yancopoulos, G.D.1
Davis, S.2
Gale, N.W.3
-
98
-
-
0037234235
-
Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis
-
Gomez-Manzano C, Fueyo J, Jiang H, et al: Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis. Ann Neurol 53:109-117, 2003
-
(2003)
Ann Neurol
, vol.53
, pp. 109-117
-
-
Gomez-Manzano, C.1
Fueyo, J.2
Jiang, H.3
-
99
-
-
0025214980
-
Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line
-
Morrison RS, Gross JL, Herblin WF, et al: Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line. Cancer Res 50:2524-2529, 1990
-
(1990)
Cancer Res
, vol.50
, pp. 2524-2529
-
-
Morrison, R.S.1
Gross, J.L.2
Herblin, W.F.3
-
100
-
-
74949119167
-
Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors
-
Lockhart AC, Rothenberg ML, Dupont J, et al: Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors. J Clin Oncol 28:207-214, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 207-214
-
-
Lockhart, A.C.1
Rothenberg, M.L.2
Dupont, J.3
-
101
-
-
77049108176
-
Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: Contrasting, overlapping and compensatory functions
-
Deryugina EI, Quigley JP: Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: Contrasting, overlapping and compensatory functions. Biochim Biophys Acta 1803:103-120, 2010
-
(2010)
Biochim Biophys Acta
, vol.1803
, pp. 103-120
-
-
Deryugina, E.I.1
Quigley, J.P.2
-
102
-
-
38949165993
-
Microglia-derived TGF-beta as an important regulator of glioblastoma invasion: An inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II receptor
-
Wesolowska A, Kwiatkowska A, Slomnicki L, et al: Microglia-derived TGF-beta as an important regulator of glioblastoma invasion: An inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II receptor. Oncogene 27:918-930, 2008
-
(2008)
Oncogene
, vol.27
, pp. 918-930
-
-
Wesolowska, A.1
Kwiatkowska, A.2
Slomnicki, L.3
-
103
-
-
79951602633
-
Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: Results of a randomized and controlled phase IIb study
-
Bogdahn U, Hau P, Stockhammer G, et al: Targeted therapy for high-grade glioma with the TGF-β2 inhibitor trabedersen: Results of a randomized and controlled phase IIb study. Neuro Oncol 13:132-142, 2011
-
(2011)
Neuro Oncol
, vol.13
, pp. 132-142
-
-
Bogdahn, U.1
Hau, P.2
Stockhammer, G.3
-
104
-
-
33947191055
-
Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
-
Vredenburgh JJ, Desjardins A, Herndon JE 2nd, et al: Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res 13:1253-1259, 2007
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1253-1259
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Herndon, J.E.3
-
105
-
-
77955922743
-
Phase I study of vandetanib with radiotherapy and temozolomide for newly diagnosed glioblastoma
-
Drappatz J, Norden AD, Wong ET, et al: Phase I study of vandetanib with radiotherapy and temozolomide for newly diagnosed glioblastoma. Int J Radiat Oncol Biol Phys 78:85-90, 2010
-
(2010)
Int J Radiat Oncol Biol Phys
, vol.78
, pp. 85-90
-
-
Drappatz, J.1
Norden, A.D.2
Wong, E.T.3
-
106
-
-
84863796631
-
Phase I study of AEE788, a novel multitarget inhibitor of ErbB- and VEGF-receptor-family tyrosine kinases, in recurrent glioblastoma patients
-
Reardon DA, Conrad CA, Cloughesy T, et al: Phase I study of AEE788, a novel multitarget inhibitor of ErbB- and VEGF-receptor-family tyrosine kinases, in recurrent glioblastoma patients. Cancer Chemother Pharmacol 69:1507-1518, 2012
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, pp. 1507-1518
-
-
Reardon, D.A.1
Conrad, C.A.2
Cloughesy, T.3
-
107
-
-
37349105704
-
E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition
-
Matsui J, Yamamoto Y, Funahashi Y, et al: E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition. Int J Cancer 122:664-671, 2008
-
(2008)
Int J Cancer
, vol.122
, pp. 664-671
-
-
Matsui, J.1
Yamamoto, Y.2
Funahashi, Y.3
-
108
-
-
23844521568
-
The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts
-
Graff JR, McNulty AM, Hanna KR, et al: The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res 65:7462-7469, 2005
-
(2005)
Cancer Res
, vol.65
, pp. 7462-7469
-
-
Graff, J.R.1
McNulty, A.M.2
Hanna, K.R.3
-
109
-
-
0034652392
-
Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
-
Jiang BH, Zheng JZ, Aoki M, et al: Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci U S A 97:1749-1753, 2000
-
(2000)
Proc Natl Acad Sci u S a
, vol.97
, pp. 1749-1753
-
-
Jiang, B.H.1
Zheng, J.Z.2
Aoki, M.3
-
110
-
-
0033199874
-
Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis
-
Yoshiji H, Kuriyama S, Ways DK, et al: Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis. Cancer Res 59: 4413-4418, 1999
-
(1999)
Cancer Res
, vol.59
, pp. 4413-4418
-
-
Yoshiji, H.1
Kuriyama, S.2
Ways, D.K.3
-
111
-
-
57649110848
-
A pilot safety study of lenalidomide and radiotherapy for patients with newly diagnosed glioblastoma multiforme
-
Drappatz J, Wong ET, Schiff D, et al: A pilot safety study of lenalidomide and radiotherapy for patients with newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys 73:222-227, 2009
-
(2009)
Int J Radiat Oncol Biol Phys
, vol.73
, pp. 222-227
-
-
Drappatz, J.1
Wong, E.T.2
Schiff, D.3
-
112
-
-
53349117686
-
A phase II study of thalidomide and irinotecan for treatment of glioblastoma multiforme
-
Fadul C, Kingman L, Meyer L, et al: A phase II study of thalidomide and irinotecan for treatment of glioblastoma multiforme. J Neurooncol 90:229-235, 2008
-
(2008)
J Neurooncol
, vol.90
, pp. 229-235
-
-
Fadul, C.1
Kingman, L.2
Meyer, L.3
-
113
-
-
0033954292
-
Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas
-
Fine HA, Figg WD, Jaeckle K, et al: Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas. J Clin Oncol 18:708-715, 2000
-
(2000)
J Clin Oncol
, vol.18
, pp. 708-715
-
-
Fine, H.A.1
Figg, W.D.2
Jaeckle, K.3
-
114
-
-
0037811745
-
Phase II trial of thalidomide and carmustine for patients with recurrent high-grade gliomas
-
Fine HA, Wen PY, Maher EA, et al: Phase II trial of thalidomide and carmustine for patients with recurrent high-grade gliomas. J Clin Oncol 21:2299-2304, 2003
-
(2003)
J Clin Oncol
, vol.21
, pp. 2299-2304
-
-
Fine, H.A.1
Wen, P.Y.2
Maher, E.A.3
-
115
-
-
34247166361
-
A phase I study of cisplatin, temozolomide and thalidomide in patients with malignant brain tumors
-
Zustovich F, Cartei G, Ceravolo R, et al: A phase I study of cisplatin, temozolomide and thalidomide in patients with malignant brain tumors. Anticancer Res 27:1019-1024, 2007
-
(2007)
Anticancer Res
, vol.27
, pp. 1019-1024
-
-
Zustovich, F.1
Cartei, G.2
Ceravolo, R.3
-
116
-
-
4544289953
-
Phase II study of temozolomide and thalidomide with radiation therapy for newly diagnosed glioblastoma multiforme
-
Chang SM, Lamborn KR, Malec M, et al: Phase II study of temozolomide and thalidomide with radiation therapy for newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys 60: 353-357, 2004
-
(2004)
Int J Radiat Oncol Biol Phys
, vol.60
, pp. 353-357
-
-
Chang, S.M.1
Lamborn, K.R.2
Malec, M.3
-
117
-
-
78650148102
-
A phase I factorial design study of dose-dense temozolomide alone and in combination with thalidomide, isotretinoin, and/or celecoxib as postchemoradiation adjuvant therapy for newly diagnosed glioblastoma
-
Gilbert MR, Gonzalez J, Hunter K, et al: A phase I factorial design study of dose-dense temozolomide alone and in combination with thalidomide, isotretinoin, and/or celecoxib as postchemoradiation adjuvant therapy for newly diagnosed glioblastoma. Neuro Oncol 12:1167-1172, 2010
-
(2010)
Neuro Oncol
, vol.12
, pp. 1167-1172
-
-
Gilbert, M.R.1
Gonzalez, J.2
Hunter, K.3
-
118
-
-
55849093794
-
Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults
-
Kesari S, Schiff D, Henson JW, et al: Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults. Neuro Oncol 10:300-308, 2008
-
(2008)
Neuro Oncol
, vol.10
, pp. 300-308
-
-
Kesari, S.1
Schiff, D.2
Henson, J.W.3
-
119
-
-
11244315274
-
Continuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme
-
Tuettenberg J, Grobholz R, Korn T, et al: Continuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme. J Cancer Res Clin Oncol 131:31-40, 2005
-
(2005)
J Cancer Res Clin Oncol
, vol.131
, pp. 31-40
-
-
Tuettenberg, J.1
Grobholz, R.2
Korn, T.3
-
120
-
-
77749332056
-
A phase 1 trial of ABT-510 concurrent with standard chemoradiotherapy for patients with newly diagnosed glioblastoma
-
Nabors LB, Fiveash JB, Markert JM, et al: A phase 1 trial of ABT-510 concurrent with standard chemoradiotherapy for patients with newly diagnosed glioblastoma. Arch Neurol 67:313-319, 2010
-
(2010)
Arch Neurol
, vol.67
, pp. 313-319
-
-
Nabors, L.B.1
Fiveash, J.B.2
Markert, J.M.3
-
121
-
-
84856316275
-
Intracranial hemorrhage in patients with cancer treated with bevacizumab: The Memorial Sloan-Kettering experience
-
Khasraw M, Holodny A, Goldlust SA, et al: Intracranial hemorrhage in patients with cancer treated with bevacizumab: The Memorial Sloan-Kettering experience. Ann Oncol 23:458-463, 2012
-
(2012)
Ann Oncol
, vol.23
, pp. 458-463
-
-
Khasraw, M.1
Holodny, A.2
Goldlust, S.A.3
-
122
-
-
80052781116
-
Bevacizumab-induced tumor calcifications as a surrogate marker of outcome in patients with glioblastoma
-
Bähr O, Hattingen E, Rieger J, et al: Bevacizumab-induced tumor calcifications as a surrogate marker of outcome in patients with glioblastoma. Neuro Oncol 13:1020-1029, 2011
-
(2011)
Neuro Oncol
, vol.13
, pp. 1020-1029
-
-
Bähr, O.1
Hattingen, E.2
Rieger, J.3
-
123
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
-
Therasse P, Arbuck SG, Eisenhauer EA, et al: New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92:205-216, 2000
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
-
124
-
-
0025281789
-
Response criteria for phase II studies of supratentorial malignant glioma
-
Macdonald DR, Cascino TL, Schold SC Jr, et al: Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 8:1277-1280, 1990
-
(1990)
J Clin Oncol
, vol.8
, pp. 1277-1280
-
-
Macdonald, D.R.1
Cascino, T.L.2
Schold, S.C.3
-
126
-
-
67649974030
-
End point assessment in gliomas: Novel treatments limit usefulness of classical Macdonald's Criteria
-
van den Bent MJ, Vogelbaum MA, Wen PY, et al: End point assessment in gliomas: Novel treatments limit usefulness of classical Macdonald's Criteria. J Clin Oncol 27:2905-2908, 2009
-
(2009)
J Clin Oncol
, vol.27
, pp. 2905-2908
-
-
Van Den Bent, M.J.1
Vogelbaum, M.A.2
Wen, P.Y.3
-
127
-
-
0035863501
-
Comparison of diameter and perimeter methods for tumor volume calculation
-
Sorensen AG, Patel S, Harmath C, et al: Comparison of diameter and perimeter methods for tumor volume calculation. J Clin Oncol 19:551-557, 2001
-
(2001)
J Clin Oncol
, vol.19
, pp. 551-557
-
-
Sorensen, A.G.1
Patel, S.2
Harmath, C.3
-
128
-
-
84875693725
-
MRI assessment of relapsed glioblastoma during treatment with bevacizumab: Volumetric measurement of enhanced and FLAIR lesions for evaluation of response and progression-A pilot study
-
Pichler J, Pachinger C, Pelz M, et al: MRI assessment of relapsed glioblastoma during treatment with bevacizumab: Volumetric measurement of enhanced and FLAIR lesions for evaluation of response and progression-A pilot study. Eur J Radiol 82:e240-e245, 2013
-
(2013)
Eur J Radiol
, vol.82
, pp. e240-e245
-
-
Pichler, J.1
Pachinger, C.2
Pelz, M.3
-
129
-
-
84871920938
-
Automatic multi-modal MR tissue classification for the assessment of response to bevacizumab in patients with glioblastoma
-
Liberman G, Louzoun Y, Aizenstein O, et al: Automatic multi-modal MR tissue classification for the assessment of response to bevacizumab in patients with glioblastoma. Eur J Radiol 82:e87-e94, 2013
-
(2013)
Eur J Radiol
, vol.82
, pp. e87-e94
-
-
Liberman, G.1
Louzoun, Y.2
Aizenstein, O.3
-
130
-
-
3543148964
-
Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression
-
de Wit MC, de Bruin HG, Eijkenboom W, et al: Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression. Neurology 63:535-537, 2004
-
(2004)
Neurology
, vol.63
, pp. 535-537
-
-
De Wit, M.C.1
De Bruin, H.G.2
Eijkenboom, W.3
-
131
-
-
42649106522
-
Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas
-
Brandsma D, Stalpers L, Taal W, et al: Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas. Lancet Oncol 9:453-461, 2008
-
(2008)
Lancet Oncol
, vol.9
, pp. 453-461
-
-
Brandsma, D.1
Stalpers, L.2
Taal, W.3
-
133
-
-
34548595378
-
Clinical applications of PET in brain tumors
-
Chen W: Clinical applications of PET in brain tumors. J Nucl Med 48:1468-1481, 2007
-
(2007)
J Nucl Med
, vol.48
, pp. 1468-1481
-
-
Chen, W.1
-
134
-
-
84855405944
-
3″-deoxy-3″-18F-fluorothymidine PET and MRI for early survival predictions in patients with recurrent malignant glioma treated with bevacizumab
-
Schwarzenberg J, Czernin J, Cloughesy TF, et al: 3″-deoxy-3″-18F-fluorothymidine PET and MRI for early survival predictions in patients with recurrent malignant glioma treated with bevacizumab. J Nucl Med 53:29-36, 2012
-
(2012)
J Nucl Med
, vol.53
, pp. 29-36
-
-
Schwarzenberg, J.1
Czernin, J.2
Cloughesy, T.F.3
-
135
-
-
84864683637
-
18F-FDOPA and 18F-FLT positron emission tomography parametric response maps predict response in recurrent malignant gliomas treated with bevacizumab
-
Harris RJ, Cloughesy TF, Pope WB, et al: 18F-FDOPA and 18F-FLT positron emission tomography parametric response maps predict response in recurrent malignant gliomas treated with bevacizumab. Neuro Oncol 14:1079-1089, 2012
-
(2012)
Neuro Oncol
, vol.14
, pp. 1079-1089
-
-
Harris, R.J.1
Cloughesy, T.F.2
Pope, W.B.3
-
136
-
-
77954712620
-
Prospective evaluation of angiogenic, hypoxic and EGFR-related biomarkers in recurrent glioblastoma multiforme treated with cetuximab, bevacizumab and irinotecan
-
Hasselbalch B, Eriksen JG, Broholm H, et al: Prospective evaluation of angiogenic, hypoxic and EGFR-related biomarkers in recurrent glioblastoma multiforme treated with cetuximab, bevacizumab and irinotecan. APMIS 118:585-594, 2010
-
(2010)
APMIS
, vol.118
, pp. 585-594
-
-
Hasselbalch, B.1
Eriksen, J.G.2
Broholm, H.3
-
137
-
-
84880667542
-
Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma
-
Lu-Emerson C, Snuderl M, Kirkpatrick ND, et al: Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma. Neuro Oncol 15:1079-1087, 2013
-
(2013)
Neuro Oncol
, vol.15
, pp. 1079-1087
-
-
Lu-Emerson, C.1
Snuderl, M.2
Kirkpatrick, N.D.3
-
138
-
-
84886581973
-
Recurrent high-grade glioma treated with bevacizumab: Prognostic value of MGMT methylation, EGFR status and pretreatment MRI in determining response and survival
-
Chen C, Huang R, MacLean A, et al: Recurrent high-grade glioma treated with bevacizumab: Prognostic value of MGMT methylation, EGFR status and pretreatment MRI in determining response and survival. J Neurooncol 115:267-276, 2013
-
(2013)
J Neurooncol
, vol.115
, pp. 267-276
-
-
Chen, C.1
Huang, R.2
MacLean, A.3
-
139
-
-
84855170315
-
Correlation between IDH1 gene mutation status and survival of patients treated for recurrent glioma
-
Lv S, Teugels E, Sadones J, et al: Correlation between IDH1 gene mutation status and survival of patients treated for recurrent glioma. Anticancer Res 31:4457-4463, 2011
-
(2011)
Anticancer Res
, vol.31
, pp. 4457-4463
-
-
Lv, S.1
Teugels, E.2
Sadones, J.3
-
140
-
-
84883474833
-
Phase II study of bevacizumab in combination with sorafenib in recurrent glioblastoma (N0776): A North Central Cancer Treatment Group trial
-
Galanis E, Anderson SK, Lafky JM, et al: Phase II study of bevacizumab in combination with sorafenib in recurrent glioblastoma (N0776): A North Central Cancer Treatment Group trial. Clin Cancer Res 19:4816-4823, 2013
-
(2013)
Clin Cancer Res
, vol.19
, pp. 4816-4823
-
-
Galanis, E.1
Anderson, S.K.2
Lafky, J.M.3
-
141
-
-
77954991606
-
Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer
-
Duda DG, Willett CG, Ancukiewicz M, et al: Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer. Oncologist 15:577-583, 2010
-
(2010)
Oncologist
, vol.15
, pp. 577-583
-
-
Duda, D.G.1
Willett, C.G.2
Ancukiewicz, M.3
-
142
-
-
84894246282
-
Association of matrix metalloproteinase 2 plasma level with response and survival in patients treated with bevacizumab for recurrent high-grade glioma
-
Tabouret E, Boudouresque F, Barrie M, et al: Association of matrix metalloproteinase 2 plasma level with response and survival in patients treated with bevacizumab for recurrent high-grade glioma. Neuro Oncol 16:392-399, 2014
-
(2014)
Neuro Oncol
, vol.16
, pp. 392-399
-
-
Tabouret, E.1
Boudouresque, F.2
Barrie, M.3
-
144
-
-
77958479632
-
Imaging and response criteria in gliomas
-
Gerstner ER, Batchelor TT: Imaging and response criteria in gliomas. Curr Opin Oncol 22:598-603, 2010
-
(2010)
Curr Opin Oncol
, vol.22
, pp. 598-603
-
-
Gerstner, E.R.1
Batchelor, T.T.2
-
145
-
-
84886948024
-
Molecular imaging in the development of a novel treatment paradigm for glioblastoma (GBM): An integrated multidisciplinary commentary
-
Jarzabek MA, Sweeney KJ, Evans RL, et al: Molecular imaging in the development of a novel treatment paradigm for glioblastoma (GBM): An integrated multidisciplinary commentary. Drug Discov Today 18:1052-1066, 2013
-
(2013)
Drug Discov Today
, vol.18
, pp. 1052-1066
-
-
Jarzabek, M.A.1
Sweeney, K.J.2
Evans, R.L.3
-
146
-
-
4944232432
-
Dynamic magnetic resonance perfusion imaging of brain tumors
-
Covarrubias DJ, Rosen BR, Lev MH: Dynamic magnetic resonance perfusion imaging of brain tumors. Oncologist 9:528-537, 2004
-
(2004)
Oncologist
, vol.9
, pp. 528-537
-
-
Covarrubias, D.J.1
Rosen, B.R.2
Lev, M.H.3
-
147
-
-
77951625266
-
Updated response assessment criteria for highgrade gliomas: Response assessment in Neuro-Oncology Working Group
-
Wen PY, Macdonald DR, Reardon DA, et al: Updated response assessment criteria for highgrade gliomas: Response assessment in Neuro-Oncology Working Group. J Clin Oncol 28:1963-1972, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. 1963-1972
-
-
Wen, P.Y.1
Macdonald, D.R.2
Reardon, D.A.3
-
148
-
-
79955759814
-
Quantitative volumetric analysis of conventional MRI response in recurrent glioblastoma treated with bevacizumab
-
Ellingson BM, Cloughesy TF, Lai A, et al: Quantitative volumetric analysis of conventional MRI response in recurrent glioblastoma treated with bevacizumab. Neuro Oncol 13:401-409, 2011
-
(2011)
Neuro Oncol
, vol.13
, pp. 401-409
-
-
Ellingson, B.M.1
Cloughesy, T.F.2
Lai, A.3
-
149
-
-
84860430771
-
New prognostic factors and calculators for outcome prediction in patients with recurrent glioblastoma: A pooled analysis of EORTC Brain Tumour Group phase I and II clinical trials
-
Gorlia T, Stupp R, Brandes AA, et al: New prognostic factors and calculators for outcome prediction in patients with recurrent glioblastoma: A pooled analysis of EORTC Brain Tumour Group phase I and II clinical trials. Eur J Cancer 48:1176-1184, 2012
-
(2012)
Eur J Cancer
, vol.48
, pp. 1176-1184
-
-
Gorlia, T.1
Stupp, R.2
Brandes, A.A.3
-
150
-
-
84857915848
-
Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies
-
O'Connor JP, Jackson A, Parker GJ, et al: Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies. Nat Rev Clin Oncol 9:167-177, 2012
-
(2012)
Nat Rev Clin Oncol
, vol.9
, pp. 167-177
-
-
O'Connor, J.P.1
Jackson, A.2
Parker, G.J.3
-
151
-
-
84883760198
-
Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy
-
Emblem KE, Mouridsen K, Bjornerud A, et al: Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy. Nat Med 19:1178-1183, 2013
-
(2013)
Nat Med
, vol.19
, pp. 1178-1183
-
-
Emblem, K.E.1
Mouridsen, K.2
Bjornerud, A.3
-
152
-
-
79952016080
-
Diffusion and diffusion tensor imaging in brain cancer
-
Gerstner ER, Sorensen AG: Diffusion and diffusion tensor imaging in brain cancer. Semin Radiat Oncol 21:141-146, 2011
-
(2011)
Semin Radiat Oncol
, vol.21
, pp. 141-146
-
-
Gerstner, E.R.1
Sorensen, A.G.2
-
153
-
-
20244364105
-
Functional diffusion map: A noninvasive MRI biomarker for early stratification of clinical brain tumor response
-
Moffat BA, Chenevert TL, Lawrence TS, et al: Functional diffusion map: A noninvasive MRI biomarker for early stratification of clinical brain tumor response. Proc Natl Acad Sci U S A 102:5524-5529, 2005
-
(2005)
Proc Natl Acad Sci u S a
, vol.102
, pp. 5524-5529
-
-
Moffat, B.A.1
Chenevert, T.L.2
Lawrence, T.S.3
-
154
-
-
49149113275
-
Functional diffusion map as an early imaging biomarker for high-grade glioma: Correlation with conventional radiologic response and overall survival
-
Hamstra DA, Galbán CJ, Meyer CR, et al: Functional diffusion map as an early imaging biomarker for high-grade glioma: Correlation with conventional radiologic response and overall survival. J Clin Oncol 26:3387-3394, 2008
-
(2008)
J Clin Oncol
, vol.26
, pp. 3387-3394
-
-
Hamstra, D.A.1
Galbán, C.J.2
Meyer, C.R.3
-
155
-
-
84864051629
-
Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: A multicenter study
-
Pope WB, Qiao XJ, Kim HJ, et al: Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: A multicenter study. J Neurooncol 108:491-498, 2012
-
(2012)
J Neurooncol
, vol.108
, pp. 491-498
-
-
Pope, W.B.1
Qiao, X.J.2
Kim, H.J.3
-
156
-
-
85047687115
-
Longitudinal restriction spectrum imaging is resistant to pseudoresponse in patients with high-grade gliomas treated with bevacizumab
-
Kothari PD, White NS, Farid N, et al: Longitudinal restriction spectrum imaging is resistant to pseudoresponse in patients with high-grade gliomas treated with bevacizumab. AJNR Am J Neuroradiol 34:1752-1757, 2013
-
(2013)
AJNR Am J Neuroradiol
, vol.34
, pp. 1752-1757
-
-
Kothari, P.D.1
White, N.S.2
Farid, N.3
-
157
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hanahan D: Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8:592-603, 2008
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
158
-
-
78651408563
-
Glioblastoma recurrence after cediranib therapy in patients: Lack of "rebound" revascularization as mode of escape
-
di Tomaso E, Snuderl M, Kamoun WS, et al: Glioblastoma recurrence after cediranib therapy in patients: Lack of "rebound" revascularization as mode of escape. Cancer Res 71:19-28, 2011
-
(2011)
Cancer Res
, vol.71
, pp. 19-28
-
-
Di Tomaso, E.1
Snuderl, M.2
Kamoun, W.S.3
-
159
-
-
77954730533
-
Infiltrative patterns of glioblastoma spread detected via diffusion MRI after treatment with cediranib
-
Gerstner ER, Chen PJ, Wen PY, et al: Infiltrative patterns of glioblastoma spread detected via diffusion MRI after treatment with cediranib. Neuro Oncol 12:466-472, 2010
-
(2010)
Neuro Oncol
, vol.12
, pp. 466-472
-
-
Gerstner, E.R.1
Chen, P.J.2
Wen, P.Y.3
-
160
-
-
77949911509
-
Diffusion magnetic resonance imaging detects pathologically confirmed, nonenhancing tumor progression in a patient with recurrent glioblastoma receiving bevacizumab
-
Gerstner ER, Frosch MP, Batchelor TT: Diffusion magnetic resonance imaging detects pathologically confirmed, nonenhancing tumor progression in a patient with recurrent glioblastoma receiving bevacizumab. J Clin Oncol 28:e91-e93, 2010
-
(2010)
J Clin Oncol
, vol.28
, pp. e91-e93
-
-
Gerstner, E.R.1
Frosch, M.P.2
Batchelor, T.T.3
-
161
-
-
77952309402
-
Tumor invasion after treatment of glioblastoma with bevacizumab: Radiographic and pathologic correlation in humans and mice
-
de Groot JF, Fuller G, Kumar AJ, et al: Tumor invasion after treatment of glioblastoma with bevacizumab: Radiographic and pathologic correlation in humans and mice. Neuro Oncol 12:233-242, 2010
-
(2010)
Neuro Oncol
, vol.12
, pp. 233-242
-
-
De Groot, J.F.1
Fuller, G.2
Kumar, A.J.3
-
162
-
-
84892385522
-
A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma
-
15s2054
-
Gerstner ER, Levine M, Ye X, et al: A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma. J Clin Oncol 31:127s, 2013 (suppl 15s; abstr 2054)
-
(2013)
J Clin Oncol
, vol.31
, pp. 127s
-
-
Gerstner, E.R.1
Levine, M.2
Ye, X.3
-
163
-
-
80052634162
-
Impact of therapy on quality of life, neurocognitive function and their correlates in glioblastoma multiforme: A review
-
Henriksson R, Asklund T, Poulsen HS: Impact of therapy on quality of life, neurocognitive function and their correlates in glioblastoma multiforme: A review. J Neurooncol 104:639-646, 2011
-
(2011)
J Neurooncol
, vol.104
, pp. 639-646
-
-
Henriksson, R.1
Asklund, T.2
Poulsen, H.S.3
-
164
-
-
77953872335
-
Carboplatin and etoposide combined with bevacizumab for the treatment of recurrent glioblastoma multiforme
-
Francesconi AB, Dupre S, Matos M, et al: Carboplatin and etoposide combined with bevacizumab for the treatment of recurrent glioblastoma multiforme. J Clin Neurosci 17:970-974, 2010
-
(2010)
J Clin Neurosci
, vol.17
, pp. 970-974
-
-
Francesconi, A.B.1
Dupre, S.2
Matos, M.3
-
165
-
-
75049085069
-
Salvage therapy with single agent bevacizumab for recurrent glioblastoma
-
Chamberlain MC, Johnston SK: Salvage therapy with single agent bevacizumab for recurrent glioblastoma. J Neurooncol 96:259-269, 2010
-
(2010)
J Neurooncol
, vol.96
, pp. 259-269
-
-
Chamberlain, M.C.1
Johnston, S.K.2
-
166
-
-
65249185501
-
Bevacizumab and chemotherapy for recurrent glioblastoma: A single-institution experience
-
Nghiemphu PL, Liu W, Lee Y, et al: Bevacizumab and chemotherapy for recurrent glioblastoma: A single-institution experience. Neurology 72: 1217-1222, 2009
-
(2009)
Neurology
, vol.72
, pp. 1217-1222
-
-
Nghiemphu, P.L.1
Liu, W.2
Lee, Y.3
-
167
-
-
51449122032
-
Bevacizumab and irinotecan therapy in glioblastoma multiforme: A series of 13 cases
-
Ali SA, McHayleh WM, Ahmad A, et al: Bevacizumab and irinotecan therapy in glioblastoma multiforme: A series of 13 cases. J Neurosurg 109:268-272, 2008
-
(2008)
J Neurosurg
, vol.109
, pp. 268-272
-
-
Ali, S.A.1
McHayleh, W.M.2
Ahmad, A.3
-
168
-
-
46949103217
-
Irinotecan and bevacizumab in progressive primary brain tumors, an evaluation of efficacy and safety
-
Kang TY, Jin T, Elinzano H, et al: Irinotecan and bevacizumab in progressive primary brain tumors, an evaluation of efficacy and safety. J Neurooncol 89:113-118, 2008
-
(2008)
J Neurooncol
, vol.89
, pp. 113-118
-
-
Kang, T.Y.1
Jin, T.2
Elinzano, H.3
-
169
-
-
43049124382
-
Treatment with bevacizumab and irinotecan for recurrent high-grade glial tumors
-
Bokstein F, Shpigel S, Blumenthal DT: Treatment with bevacizumab and irinotecan for recurrent high-grade glial tumors. Cancer 112:2267-2273, 2008
-
(2008)
Cancer
, vol.112
, pp. 2267-2273
-
-
Bokstein, F.1
Shpigel, S.2
Blumenthal, D.T.3
-
170
-
-
33646675851
-
MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy
-
Pope WB, Lai A, Nghiemphu P, et al: MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy. Neurology 66:1258-1260, 2006
-
(2006)
Neurology
, vol.66
, pp. 1258-1260
-
-
Pope, W.B.1
Lai, A.2
Nghiemphu, P.3
-
171
-
-
32944482137
-
Bevacizumab and CPT-11 in the treatment of relapsed malignant glioma
-
abstr 342
-
Stark-Vance V: Bevacizumab and CPT-11 in the treatment of relapsed malignant glioma. Neuro-Oncol 7:369, 2005 (abstr 342)
-
(2005)
Neuro-Oncol
, vol.7
, Issue.369
-
-
Stark-Vance, V.1
-
172
-
-
77952523530
-
Bevacizumab salvage therapy following progression in high-grade glioma patients treated with VEGF receptor tyrosine kinase inhibitors
-
Scott BJ, Quant EC, McNamara MB, et al: Bevacizumab salvage therapy following progression in high-grade glioma patients treated with VEGF receptor tyrosine kinase inhibitors. Neuro Oncol 12:603-607, 2010
-
(2010)
Neuro Oncol
, vol.12
, pp. 603-607
-
-
Scott, B.J.1
Quant, E.C.2
McNamara, M.B.3
-
173
-
-
84863600431
-
Bevacizumab for glioblastoma refractory to vascular endothelial growth factor receptor inhibitors
-
Goldlust SA, Cavaliere R, Newton HB, et al: Bevacizumab for glioblastoma refractory to vascular endothelial growth factor receptor inhibitors. J Neurooncol 107:407-411, 2012
-
(2012)
J Neurooncol
, vol.107
, pp. 407-411
-
-
Goldlust, S.A.1
Cavaliere, R.2
Newton, H.B.3
-
174
-
-
41649112610
-
Bevacizumab for recurrent malignant gliomas: Efficacy, toxicity, and patterns of recurrence
-
Norden AD, Young GS, Setayesh K, et al: Bevacizumab for recurrent malignant gliomas: Efficacy, toxicity, and patterns of recurrence. Neurology 70:779-787, 2008
-
(2008)
Neurology
, vol.70
, pp. 779-787
-
-
Norden, A.D.1
Young, G.S.2
Setayesh, K.3
-
175
-
-
16844371774
-
A phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM)
-
Reardon D, Friedman H, Yung WK, et al: A phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM). J Clin Oncol 22:28s, 2004 (suppl; abstr 1513)
-
(2004)
J Clin Oncol
, vol.22
, pp. 28s
-
-
Reardon, D.1
Friedman, H.2
Yung, W.K.3
-
176
-
-
84869155416
-
A phase I/II trial of vandetanib for patients with recurrent malignant glioma
-
Kreisl TN, McNeill KA, Sul J, et al: A phase I/II trial of vandetanib for patients with recurrent malignant glioma. Neuro Oncol 14:1519-1526, 2012
-
(2012)
Neuro Oncol
, vol.14
, pp. 1519-1526
-
-
Kreisl, T.N.1
McNeill, K.A.2
Sul, J.3
-
177
-
-
79751535045
-
Effect of CYP3A-inducing anti-epileptics on sorafenib exposure: Results of a phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma
-
Reardon DA, Vredenburgh JJ, Desjardins A, et al: Effect of CYP3A-inducing anti-epileptics on sorafenib exposure: Results of a phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma. J Neurooncol 101:57-66, 2011
-
(2011)
J Neurooncol
, vol.101
, pp. 57-66
-
-
Reardon, D.A.1
Vredenburgh, J.J.2
Desjardins, A.3
-
178
-
-
77955363593
-
Concurrent radiotherapy and temozolomide followed by temozolomide and sorafenib in the firstline treatment of patients with glioblastoma multiforme
-
Hainsworth JD, Ervin T, Friedman E, et al: Concurrent radiotherapy and temozolomide followed by temozolomide and sorafenib in the firstline treatment of patients with glioblastoma multiforme. Cancer 116:3663-3669, 2010
-
(2010)
Cancer
, vol.116
, pp. 3663-3669
-
-
Hainsworth, J.D.1
Ervin, T.2
Friedman, E.3
-
179
-
-
78049236224
-
ANG1005: Results of a phase I study in patients with recurrent malignant glioma
-
Drappatz J, Brenner AJ, Rosenfeld S, et al: ANG1005: Results of a phase I study in patients with recurrent malignant glioma. J Clin Oncol 28:182s, 2010 (suppl; abstr 2009)
-
(2010)
J Clin Oncol
, vol.28
, pp. 182s
-
-
Drappatz, J.1
Brenner, A.J.2
Rosenfeld, S.3
-
180
-
-
84912096468
-
Antiangiogenesis strategies revisted: From starving tumors to alleviating hypoxia
-
Jain RK: Antiangiogenesis strategies revisted: From starving tumors to alleviating hypoxia. Cancer Cell 26:605-622, 2014
-
(2014)
Cancer Cell
, vol.26
, pp. 605-622
-
-
Jain, R.K.1
-
181
-
-
77954382544
-
Bevacizumabinduced diffusion-restricted lesions in malignant glioma patients
-
Rieger J, Bähr O, Müller K, et al: Bevacizumabinduced diffusion-restricted lesions in malignant glioma patients. J Neurooncol 99:49-56, 2010
-
(2010)
J Neurooncol
, vol.99
, pp. 49-56
-
-
Rieger, J.1
Bähr, O.2
Müller, K.3
-
182
-
-
77955110523
-
An automated method for nonparametric kinetic analysis of clinical DCE-MRI data: Application to glioblastoma treated with bevacizumab
-
Ferl GZ, Xu L, Friesenhahn M, et al: An automated method for nonparametric kinetic analysis of clinical DCE-MRI data: Application to glioblastoma treated with bevacizumab. Magn Reson Med 63:1366-1375, 2010
-
(2010)
Magn Reson Med
, vol.63
, pp. 1366-1375
-
-
Ferl, G.Z.1
Xu, L.2
Friesenhahn, M.3
-
183
-
-
75049085441
-
Imaging response criteria for recurrent gliomas treated with bevacizumab: Role of diffusion weighted imaging as an imaging biomarker
-
Jain R, Scarpace LM, Ellika S, et al: Imaging response criteria for recurrent gliomas treated with bevacizumab: Role of diffusion weighted imaging as an imaging biomarker. J Neurooncol 96:423-431, 2010
-
(2010)
J Neurooncol
, vol.96
, pp. 423-431
-
-
Jain, R.1
Scarpace, L.M.2
Ellika, S.3
-
184
-
-
79954423425
-
ADC histograms predict response to anti-angiogenic therapy in patients with recurrent high-grade glioma
-
Nowosielski M, Recheis W, Goebel G, et al: ADC histograms predict response to anti-angiogenic therapy in patients with recurrent high-grade glioma. Neuroradiology 53:291-302, 2011
-
(2011)
Neuroradiology
, vol.53
, pp. 291-302
-
-
Nowosielski, M.1
Recheis, W.2
Goebel, G.3
-
185
-
-
84874957098
-
Longterm efficacy and toxicity of bevacizumab-based therapy in children with recurrent low-grade gliomas
-
Hwang EI, Jakacki RI, Fisher MJ, et al: Longterm efficacy and toxicity of bevacizumab-based therapy in children with recurrent low-grade gliomas. Pediatr Blood Cancer 60:776-782, 2013
-
(2013)
Pediatr Blood Cancer
, vol.60
, pp. 776-782
-
-
Hwang, E.I.1
Jakacki, R.I.2
Fisher, M.J.3
-
186
-
-
84879334593
-
Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN6677
-
Ratai EM, Zhang Z, Snyder BS, et al: Magnetic resonance spectroscopy as an early indicator of response to anti-angiogenic therapy in patients with recurrent glioblastoma: RTOG 0625/ACRIN6677. Neuro Oncol 15:936-944, 2013
-
(2013)
Neuro Oncol
, vol.15
, pp. 936-944
-
-
Ratai, E.M.1
Zhang, Z.2
Snyder, B.S.3
-
187
-
-
84876154750
-
GPU-accelerated nonparametric kinetic analysis of DCE-MRI data from glioblastoma patients treated with bevacizumab
-
Hsu YH, Ferl GZ, Ng CM: GPU-accelerated nonparametric kinetic analysis of DCE-MRI data from glioblastoma patients treated with bevacizumab. Magn Reson Imaging 31:618-623, 2013
-
(2013)
Magn Reson Imaging
, vol.31
, pp. 618-623
-
-
Hsu, Y.H.1
Ferl, G.Z.2
Ng, C.M.3
-
188
-
-
36949011682
-
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) evaluation in glioblastoma (GBM) patients treated with bevacizumab (BEV) and irinotecan (CPT-11)
-
Desjardins A, Barboriak DP, Herndon JE II, et al: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) evaluation in glioblastoma (GBM) patients treated with bevacizumab (BEV) and irinotecan (CPT-11). J Clin Oncol 25:82s, 2007 (suppl; abstr 2029)
-
(2007)
J Clin Oncol
, vol.25
, pp. 82s
-
-
Desjardins, A.1
Barboriak, D.P.2
Herndon, J.E.3
-
189
-
-
67650075305
-
Recurrent glioblastoma multiforme: ADC histogram analysis predicts response to bevacizumab treatment
-
Pope WB, Kim HJ, Huo J, et al: Recurrent glioblastoma multiforme: ADC histogram analysis predicts response to bevacizumab treatment. Radiology 252:182-189, 2009
-
(2009)
Radiology
, vol.252
, pp. 182-189
-
-
Pope, W.B.1
Kim, H.J.2
Huo, J.3
-
190
-
-
79952194217
-
Volumetric analysis of functional diffusion maps is a predictive imaging biomarker for cytotoxic and antiangiogenic treatments in malignant gliomas
-
Ellingson BM, Malkin MG, Rand SD, et al: Volumetric analysis of functional diffusion maps is a predictive imaging biomarker for cytotoxic and antiangiogenic treatments in malignant gliomas. J Neurooncol 102:95-103, 2011
-
(2011)
J Neurooncol
, vol.102
, pp. 95-103
-
-
Ellingson, B.M.1
Malkin, M.G.2
Rand, S.D.3
-
191
-
-
84355162260
-
Nonlinear registration of diffusion-weighted images improves clinical sensitivity of functional diffusion maps in recurrent glioblastoma treated with bevacizumab
-
Ellingson BM, Cloughesy TF, Lai A, et al: Nonlinear registration of diffusion-weighted images improves clinical sensitivity of functional diffusion maps in recurrent glioblastoma treated with bevacizumab. Magn Reson Med 67:237-245, 2012
-
(2012)
Magn Reson Med
, vol.67
, pp. 237-245
-
-
Ellingson, B.M.1
Cloughesy, T.F.2
Lai, A.3
-
192
-
-
84885038432
-
Early response evaluation for recurrent high grade gliomas treated with bevacizumab: A volumetric analysis using diffusion-weighted imaging
-
Hwang EJ, Cha Y, Lee AL, et al. Early response evaluation for recurrent high grade gliomas treated with bevacizumab: A volumetric analysis using diffusion-weighted imaging. J Neurooncol 112:427-435, 2013
-
(2013)
J Neurooncol
, vol.112
, pp. 427-435
-
-
Hwang, E.J.1
Cha, Y.2
Lee, A.L.3
-
193
-
-
36048955738
-
Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: A pilot study
-
Chen W, Delaloye S, Silverman DH, et al: Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: A pilot study. J Clin Oncol 25:4714-4721, 2007
-
(2007)
J Clin Oncol
, vol.25
, pp. 4714-4721
-
-
Chen, W.1
Delaloye, S.2
Silverman, D.H.3
-
194
-
-
77952298539
-
Kinetics of 3″-deoxy-3″-18F-fluorothymidine during treatment monitoring of recurrent high-grade glioma
-
Schiepers C, Dahlbom M, Chen W, et al: Kinetics of 3″-deoxy-3″-18F-fluorothymidine during treatment monitoring of recurrent high-grade glioma. J Nucl Med 51:720-727, 2010
-
(2010)
J Nucl Med
, vol.51
, pp. 720-727
-
-
Schiepers, C.1
Dahlbom, M.2
Chen, W.3
-
195
-
-
80054103544
-
Discriminant analysis of 18F-fluorothymidine kinetic parameters to predict survival in patients with recurrent high-grade glioma
-
Wardak M, Schiepers C, Dahlbom M, et al: Discriminant analysis of 18F-fluorothymidine kinetic parameters to predict survival in patients with recurrent high-grade glioma. Clin Cancer Res 17:6553-6562, 2011
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6553-6562
-
-
Wardak, M.1
Schiepers, C.2
Dahlbom, M.3
-
196
-
-
79958148395
-
O-(2-18F-fluoroethyl)-L-tyrosine PET predicts failure of antiangiogenic treatment in patients with recurrent high-grade glioma
-
Hutterer M, Nowosielski M, Putzer D, et al: O-(2-18F-fluoroethyl)-L-tyrosine PET predicts failure of antiangiogenic treatment in patients with recurrent high-grade glioma. J Nucl Med 52:856-864, 2011
-
(2011)
J Nucl Med
, vol.52
, pp. 856-864
-
-
Hutterer, M.1
Nowosielski, M.2
Putzer, D.3
-
197
-
-
84860370272
-
FDG-PET predicts survival in recurrent high-grade gliomas treated with bevacizumab and irinotecan
-
Colavolpe C, Chinot O, Metellus P, et al: FDG-PET predicts survival in recurrent high-grade gliomas treated with bevacizumab and irinotecan. Neuro Oncol 14:649-657, 2012
-
(2012)
Neuro Oncol
, vol.14
, pp. 649-657
-
-
Colavolpe, C.1
Chinot, O.2
Metellus, P.3
-
198
-
-
84873599039
-
Response assessment of bevacizumab in patients with recurrent malignant glioma using [18F]Fluoroethyl-Ltyrosine PET in comparison to MRI
-
Galldiks N, Rapp M, Stoffels G, et al: Response assessment of bevacizumab in patients with recurrent malignant glioma using [18F]Fluoroethyl-Ltyrosine PET in comparison to MRI. Eur J Nucl Med Mol Imaging 40:22-33, 2013
-
(2013)
Eur J Nucl Med Mol Imaging
, vol.40
, pp. 22-33
-
-
Galldiks, N.1
Rapp, M.2
Stoffels, G.3
-
199
-
-
84859512391
-
Early perfusion changes in patients with recurrent high-grade brain tumor treated with bevacizumab: Preliminary results by a quantitative evaluation
-
Vidiri A, Pace A, Fabi A, et al: Early perfusion changes in patients with recurrent high-grade brain tumor treated with bevacizumab: Preliminary results by a quantitative evaluation. J Exp Clin Cancer Res 31:33, 2012
-
(2012)
J Exp Clin Cancer Res
, vol.31
, pp. 33
-
-
Vidiri, A.1
Pace, A.2
Fabi, A.3
-
200
-
-
83055181491
-
Quantification of edema reduction using differential quantitative T2 (DQT2) relaxometry mapping in recurrent glioblastoma treated with bevacizumab
-
Ellingson BM, Cloughesy TF, Lai A, et al: Quantification of edema reduction using differential quantitative T2 (DQT2) relaxometry mapping in recurrent glioblastoma treated with bevacizumab. J Neurooncol 106:111-119, 2012
-
(2012)
J Neurooncol
, vol.106
, pp. 111-119
-
-
Ellingson, B.M.1
Cloughesy, T.F.2
Lai, A.3
-
201
-
-
80052001722
-
Isolated diffusion restriction precedes the development of enhancing tumor in a subset of patients with glioblastoma
-
Gupta A, Young RJ, Karimi S, et al: Isolated diffusion restriction precedes the development of enhancing tumor in a subset of patients with glioblastoma. AJNR Am J Neuroradiol 32:1301-1306, 2011
-
(2011)
AJNR Am J Neuroradiol
, vol.32
, pp. 1301-1306
-
-
Gupta, A.1
Young, R.J.2
Karimi, S.3
-
202
-
-
84867799455
-
Persistent diffusion-restricted lesions in bevacizumabtreated malignant gliomas are associated with improved survival compared with matched controls
-
Mong S, Ellingson BM, Nghiemphu PL, et al: Persistent diffusion-restricted lesions in bevacizumabtreated malignant gliomas are associated with improved survival compared with matched controls. AJNR Am J Neuroradiol 33:1763-1770, 2012
-
(2012)
AJNR Am J Neuroradiol
, vol.33
, pp. 1763-1770
-
-
Mong, S.1
Ellingson, B.M.2
Nghiemphu, P.L.3
-
203
-
-
84875717479
-
Vascular change measured with independent component analysis of dynamic susceptibility contrast MRI predicts bevacizumab response in high-grade glioma
-
LaViolette PS, Cohen AD, Prah MA, et al: Vascular change measured with independent component analysis of dynamic susceptibility contrast MRI predicts bevacizumab response in high-grade glioma. Neuro Oncol 15:442-450, 2013
-
(2013)
Neuro Oncol
, vol.15
, pp. 442-450
-
-
LaViolette, P.S.1
Cohen, A.D.2
Prah, M.A.3
-
204
-
-
84927651705
-
FLAIR, T1 contrast enhancement, MR perfusion, and FDG PET following hypofractionated stereotactic radiotherapy (HFSRT), bevacizumab (BEV), and temozolomide (TMZ) for glioblastoma (GBM)
-
Grommes C, Karimi S, Beal K, et al: FLAIR, T1 contrast enhancement, MR perfusion, and FDG PET following hypofractionated stereotactic radiotherapy (HFSRT), bevacizumab (BEV), and temozolomide (TMZ) for glioblastoma (GBM). J Clin Oncol 29:152s, 2011 (suppl; abstr 2048)
-
(2011)
J Clin Oncol
, vol.29
, pp. 152s
-
-
Grommes, C.1
Karimi, S.2
Beal, K.3
-
205
-
-
79955866104
-
Apparent diffusion coefficient histogram analysis stratifies progression-free survival in newly diagnosed bevacizumab-treated glioblastoma
-
Pope WB, Lai A, Mehta R, et al: Apparent diffusion coefficient histogram analysis stratifies progression-free survival in newly diagnosed bevacizumab-treated glioblastoma. AJNR Am J Neuroradiol 32:882-889, 2011
-
(2011)
AJNR Am J Neuroradiol
, vol.32
, pp. 882-889
-
-
Pope, W.B.1
Lai, A.2
Mehta, R.3
-
206
-
-
85027946336
-
T(1)- and T(2)()-dominant extravasation correction in DSC-MRI: Part II. Predicting patient outcome after a single dose of cediranib in recurrent glioblastoma patients
-
Emblem KE, Bjornerud A, Mouridsen K, et al: T(1)- and T(2)()-dominant extravasation correction in DSC-MRI: Part II. Predicting patient outcome after a single dose of cediranib in recurrent glioblastoma patients. Cereb Blood Flow Metab 31:2054-2064, 2011
-
(2011)
Cereb Blood Flow Metab
, vol.31
, pp. 2054-2064
-
-
Emblem, K.E.1
Bjornerud, A.2
Mouridsen, K.3
-
207
-
-
84927590667
-
Glioblastoma patients with arterio-venous normalization during anti-angiogenic therapy have prolonged survival
-
abstr MC13-0062
-
Emblem KE, Batchelor TT, Gerstner ER, et al: Glioblastoma patients with arterio-venous normalization during anti-angiogenic therapy have prolonged survival. Eur J Cancer 49:S29, 2013 (abstr MC13-0062)
-
(2013)
Eur J Cancer
, vol.49
, pp. S29
-
-
Emblem, K.E.1
Batchelor, T.T.2
Gerstner, E.R.3
-
208
-
-
57149108506
-
Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme
-
Reardon DA, Fink KL, Mikkelsen T, et al: Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. J Clin Oncol 26:5610-5617, 2008
-
(2008)
J Clin Oncol
, vol.26
, pp. 5610-5617
-
-
Reardon, D.A.1
Fink, K.L.2
Mikkelsen, T.3
-
209
-
-
84927618567
-
Imaging biomarkers of ramucirumab and olaratumab in patients with recurrent glioblastoma
-
15s2044
-
O'Neill Blakeley J, Fisher JD, Lieberman FS, et al: Imaging biomarkers of ramucirumab and olaratumab in patients with recurrent glioblastoma. J Clin Oncol 31:125s, 2013 (suppl 15s; abstr 2044)
-
(2013)
J Clin Oncol
, vol.31
, pp. 125s
-
-
O'Neill Blakeley, J.1
Fisher, J.D.2
Lieberman, F.S.3
-
210
-
-
76749172082
-
Use of neurovascular imaging in GBM patients (pts) to quantify early physiologic changes after treatment with XL184, an inhibitor of multiple receptor tyrosine kinases: Results from a phase II study
-
15S2048
-
Sorensen AG, Jenning D, Wang M, et al: Use of neurovascular imaging in GBM patients (pts) to quantify early physiologic changes after treatment with XL184, an inhibitor of multiple receptor tyrosine kinases: Results from a phase II study. J Clin Oncol 27:99s, 2009 (suppl 15S; abstr 2048)
-
(2009)
J Clin Oncol
, vol.27
, pp. 99s
-
-
Sorensen, A.G.1
Jenning, D.2
Wang, M.3
-
211
-
-
84875691055
-
Using susceptibility-weighted imaging to determine response to combined anti-angiogenic, cytotoxic, and radiation therapy in patients with glioblastoma multiforme
-
Lupo JM, Essock-Burns E, Molinaro AM, et al: Using susceptibility-weighted imaging to determine response to combined anti-angiogenic, cytotoxic, and radiation therapy in patients with glioblastoma multiforme. Neuro Oncol 15:480-489, 2013
-
(2013)
Neuro Oncol
, vol.15
, pp. 480-489
-
-
Lupo, J.M.1
Essock-Burns, E.2
Molinaro, A.M.3
-
212
-
-
79951606981
-
Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma
-
Essock-Burns E, Lupo JM, Cha S, et al: Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma. Neuro Oncol 13:119-131, 2011
-
(2011)
Neuro Oncol
, vol.13
, pp. 119-131
-
-
Essock-Burns, E.1
Lupo, J.M.2
Cha, S.3
-
213
-
-
0034019262
-
Dynamic contrast-enhanced T2-weighted MR imaging of recurrent malignant gliomas treated with thalidomide and carboplatin
-
Cha S, Knopp EA, Johnson G, et al: Dynamic contrast-enhanced T2-weighted MR imaging of recurrent malignant gliomas treated with thalidomide and carboplatin. AJNR Am J Neuroradiol 21:881-890, 2000
-
(2000)
AJNR Am J Neuroradiol
, vol.21
, pp. 881-890
-
-
Cha, S.1
Knopp, E.A.2
Johnson, G.3
-
214
-
-
9644281015
-
Assessment of brain tumor angiogenesis inhibitors using perfusion magnetic resonance imaging: Quality and analysis results of a phase I trial
-
Akella NS, Twieg DB, Mikkelsen T, et al: Assessment of brain tumor angiogenesis inhibitors using perfusion magnetic resonance imaging: Quality and analysis results of a phase I trial. J Magn Reson Imaging 20:913-922, 2004
-
(2004)
J Magn Reson Imaging
, vol.20
, pp. 913-922
-
-
Akella, N.S.1
Twieg, D.B.2
Mikkelsen, T.3
-
215
-
-
34249087162
-
Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma
-
Nabors LB, Mikkelsen T, Rosenfeld SS, et al: Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. J Clin Oncol 25:1651-1657, 2007
-
(2007)
J Clin Oncol
, vol.25
, pp. 1651-1657
-
-
Nabors, L.B.1
Mikkelsen, T.2
Rosenfeld, S.S.3
-
216
-
-
79959795987
-
A phase II trial of sunitinib malate in patients with recurrent highgrade glioma
-
Neyns B, Sadones J, Chaskis C, et al: A phase II trial of sunitinib malate in patients with recurrent highgrade glioma. J Neurooncol 103:491-501, 2011
-
(2011)
J Neurooncol
, vol.103
, pp. 491-501
-
-
Neyns, B.1
Sadones, J.2
Chaskis, C.3
-
217
-
-
72049108494
-
Phase II trial of sunitinib malate in patients with temozolomide refractory recurrent high-grade glioma
-
15S2038
-
Neyns B, Chaskis C, Dujardin M, et al: Phase II trial of sunitinib malate in patients with temozolomide refractory recurrent high-grade glioma. J Clin Oncol 27:96s, 2009 (suppl 15S; abstr 2038)
-
(2009)
J Clin Oncol
, vol.27
, pp. 96s
-
-
Neyns, B.1
Chaskis, C.2
Dujardin, M.3
-
218
-
-
77956700164
-
Phase II study of XL184 (BMS 907351), an inhibitor of MET, VEGFR2, and RET, in patients (pts) with progressive glioblastoma (GB)
-
Wen PY Prados M, Schiff D, et al: Phase II study of XL184 (BMS 907351), an inhibitor of MET, VEGFR2, and RET, in patients (pts) with progressive glioblastoma (GB). J Clin Oncol 28:181s, 2010 (suppl; abstr 2006)
-
(2010)
J Clin Oncol
, vol.28
, pp. 181s
-
-
Wen, P.Y.1
Prados, M.2
Schiff, D.3
|