-
1
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
15758009 10.1056/NEJMoa043330 1:CAS:528:DC%2BD2MXit1Wksbk%3D
-
Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987-996
-
(2005)
N Engl J Med
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
Van Den Bent, M.J.3
Weller, M.4
Fisher, B.5
Taphoorn, M.J.6
Belanger, K.7
Brandes, A.A.8
Marosi, C.9
Bogdahn, U.10
Curschmann, J.11
Janzer, R.C.12
Ludwin, S.K.13
Gorlia, T.14
Allgeier, A.15
Lacombe, D.16
Cairncross, J.G.17
Eisenhauer, E.18
Mirimanoff, R.O.19
-
2
-
-
73349134695
-
NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide
-
19901110 10.1200/JCO.2009.23.6497 1:CAS:528:DC%2BC3cXhtVWis7g%3D
-
Wick W, Hartmann C, Engel C, Stoffels M, Felsberg J, Stockhammer F, Sabel MC, Koeppen S, Ketter R, Meyermann R, Rapp M, Meisner C, Kortmann RD, Pietsch T, Wiestler OD, Ernemann U, Bamberg M, Reifenberger G, von Deimling A, Weller M (2009) NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. J Clin Oncol 27:5874-5880
-
(2009)
J Clin Oncol
, vol.27
, pp. 5874-5880
-
-
Wick, W.1
Hartmann, C.2
Engel, C.3
Stoffels, M.4
Felsberg, J.5
Stockhammer, F.6
Sabel, M.C.7
Koeppen, S.8
Ketter, R.9
Meyermann, R.10
Rapp, M.11
Meisner, C.12
Kortmann, R.D.13
Pietsch, T.14
Wiestler, O.D.15
Ernemann, U.16
Bamberg, M.17
Reifenberger, G.18
Von Deimling, A.19
Weller, M.20
more..
-
3
-
-
0032767387
-
Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials
-
10561324 1:STN:280:DC%2BD3c%2FjtVSmsQ%3D%3D
-
Wong ET, Hess KR, Gleason MJ, Jaeckle KA, Kyritsis AP, Prados MD, Levin VA, Yung WK (1999) Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials. J Clin Oncol 17:2572-2578
-
(1999)
J Clin Oncol
, vol.17
, pp. 2572-2578
-
-
Wong, E.T.1
Hess, K.R.2
Gleason, M.J.3
Jaeckle, K.A.4
Kyritsis, A.P.5
Prados, M.D.6
Levin, V.A.7
Yung, W.K.8
-
4
-
-
33846495120
-
A North American brain tumor consortium (NABTC 99-04) phase II trial of temozolomide plus thalidomide for recurrent glioblastoma multiforme
-
17031561 10.1007/s11060-006-9225-y 1:CAS:528:DC%2BD2sXktFWhtLY%3D
-
Groves MD, Puduvalli VK, Chang SM, Conrad CA, Gilbert MR, Tremont-Lukats IW, Liu TJ, Peterson P, Schiff D, Cloughesy TF, Wen PY, Greenberg H, Abrey LE, DeAngelis LM, Hess KR, Lamborn KR, Prados MD, Yung WK (2007) A North American brain tumor consortium (NABTC 99-04) phase II trial of temozolomide plus thalidomide for recurrent glioblastoma multiforme. J Neurooncol 81:271-277
-
(2007)
J Neurooncol
, vol.81
, pp. 271-277
-
-
Groves, M.D.1
Puduvalli, V.K.2
Chang, S.M.3
Conrad, C.A.4
Gilbert, M.R.5
Tremont-Lukats, I.W.6
Liu, T.J.7
Peterson, P.8
Schiff, D.9
Cloughesy, T.F.10
Wen, P.Y.11
Greenberg, H.12
Abrey, L.E.13
Deangelis, L.M.14
Hess, K.R.15
Lamborn, K.R.16
Prados, M.D.17
Yung, W.K.18
-
5
-
-
77949891455
-
Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma
-
20124186 10.1200/JCO.2009.23.2595 1:CAS:528:DC%2BC3cXktF2ltb4%3D
-
Wick W, Puduvalli VK, Chamberlain MC, van den Bent MJ, Carpentier AF, Cher LM, Mason W, Weller M, Hong S, Musib L, Liepa AM, Thornton DE, Fine HA (2010) Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J Clin Oncol 28:1168-1174
-
(2010)
J Clin Oncol
, vol.28
, pp. 1168-1174
-
-
Wick, W.1
Puduvalli, V.K.2
Chamberlain, M.C.3
Van Den Bent, M.J.4
Carpentier, A.F.5
Cher, L.M.6
Mason, W.7
Weller, M.8
Hong, S.9
Musib, L.10
Liepa, A.M.11
Thornton, D.E.12
Fine, H.A.13
-
6
-
-
2942707871
-
Hypoxia-inducible factor 1alpha/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis
-
15175080 10.1111/j.1365-2990.2003.00535.x 1:CAS:528:DC%2BD2cXlslymtbc%3D
-
Korkolopoulou P, Patsouris E, Konstantinidou AE, Pavlopoulos PM, Kavantzas N, Boviatsis E, Thymara I, Perdiki M, Thomas-Tsagli E, Angelidakis D, Rologis D, Sakkas D (2004) Hypoxia-inducible factor 1alpha/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis. Neuropathol Appl Neurobiol 30:267-278
-
(2004)
Neuropathol Appl Neurobiol
, vol.30
, pp. 267-278
-
-
Korkolopoulou, P.1
Patsouris, E.2
Konstantinidou, A.E.3
Pavlopoulos, P.M.4
Kavantzas, N.5
Boviatsis, E.6
Thymara, I.7
Perdiki, M.8
Thomas-Tsagli, E.9
Angelidakis, D.10
Rologis, D.11
Sakkas, D.12
-
7
-
-
0037389767
-
Levels of soluble vascular endothelial growth factor (VEGF) receptor 1 in astrocytic tumors and its relation to malignancy, vascularity, and VEGF-A
-
12684411 1:CAS:528:DC%2BD3sXislertL8%3D
-
Lamszus K, Ulbricht U, Matschke J, Brockmann MA, Fillbrandt R, Westphal M (2003) Levels of soluble vascular endothelial growth factor (VEGF) receptor 1 in astrocytic tumors and its relation to malignancy, vascularity, and VEGF-A. Clin Cancer Res 9:1399-1405
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1399-1405
-
-
Lamszus, K.1
Ulbricht, U.2
Matschke, J.3
Brockmann, M.A.4
Fillbrandt, R.5
Westphal, M.6
-
8
-
-
33947191055
-
Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma
-
17317837 10.1158/1078-0432.CCR-06-2309 1:CAS:528:DC%2BD2sXhvF2htr8%3D
-
Vredenburgh JJ, Desjardins A, Herndon JE II, Dowell JM, Reardon DA, Quinn JA, Rich JN, Sathornsumetee S, Gururangan S, Wagner M, Bigner DD, Friedman AH, Friedman HS (2007) Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res 13:1253-1259
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1253-1259
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Herndon, I.I.J.E.3
Dowell, J.M.4
Reardon, D.A.5
Quinn, J.A.6
Rich, J.N.7
Sathornsumetee, S.8
Gururangan, S.9
Wagner, M.10
Bigner, D.D.11
Friedman, A.H.12
Friedman, H.S.13
-
9
-
-
79953876016
-
Bevacizumab for recurrent glioblastoma multiforme: A meta-analysis
-
21464145 1:CAS:528:DC%2BC3MXmtl2isbY%3D
-
Wong ET, Gautam S, Malchow C, Lun M, Pan E, Brem S (2011) Bevacizumab for recurrent glioblastoma multiforme: a meta-analysis. J Natl Compr Canc Netw 9:403-407
-
(2011)
J Natl Compr Canc Netw
, vol.9
, pp. 403-407
-
-
Wong, E.T.1
Gautam, S.2
Malchow, C.3
Lun, M.4
Pan, E.5
Brem, S.6
-
10
-
-
59949083263
-
Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
-
19114704 10.1200/JCO.2008.16.3055 1:CAS:528:DC%2BD1MXjsVCjs7o%3D
-
Kreisl TN, Kim L, Moore K, Duic P, Royce C, Stroud I, Garren N, Mackey M, Butman JA, Camphausen K, Park J, Albert PS, Fine HA (2009) Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol 27:740-745
-
(2009)
J Clin Oncol
, vol.27
, pp. 740-745
-
-
Kreisl, T.N.1
Kim, L.2
Moore, K.3
Duic, P.4
Royce, C.5
Stroud, I.6
Garren, N.7
MacKey, M.8
Butman, J.A.9
Camphausen, K.10
Park, J.11
Albert, P.S.12
Fine, H.A.13
-
11
-
-
58149470640
-
Salvage chemotherapy with bevacizumab for recurrent alkylator-refractory anaplastic astrocytoma
-
18953491 10.1007/s11060-008-9722-2 1:CAS:528:DC%2BD1MXjvFelsg%3D%3D
-
Chamberlain MC, Johnston S (2009) Salvage chemotherapy with bevacizumab for recurrent alkylator-refractory anaplastic astrocytoma. J Neurooncol 91:359-367
-
(2009)
J Neurooncol
, vol.91
, pp. 359-367
-
-
Chamberlain, M.C.1
Johnston, S.2
-
12
-
-
41649112610
-
Bevacizumab for recurrent malignant gliomas: Efficacy, toxicity, and patterns of recurrence
-
18316689 10.1212/01.wnl.0000304121.57857.38 1:CAS:528: DC%2BD1cXitlyqs7o%3D
-
Norden AD, Young GS, Setayesh K, Muzikansky A, Klufas R, Ross GL, Ciampa AS, Ebbeling LG, Levy B, Drappatz J, Kesari S, Wen PY (2008) Bevacizumab for recurrent malignant gliomas: efficacy, toxicity, and patterns of recurrence. Neurology 70:779-787
-
(2008)
Neurology
, vol.70
, pp. 779-787
-
-
Norden, A.D.1
Young, G.S.2
Setayesh, K.3
Muzikansky, A.4
Klufas, R.5
Ross, G.L.6
Ciampa, A.S.7
Ebbeling, L.G.8
Levy, B.9
Drappatz, J.10
Kesari, S.11
Wen, P.Y.12
-
13
-
-
33947423448
-
Approval summary: Sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma
-
17332278 10.1158/1078-0432.CCR-06-2328 1:CAS:528:DC%2BD2sXitlSjsbc%3D
-
Goodman VL, Rock EP, Dagher R, Ramchandani RP, Abraham S, Gobburu JV, Booth BP, Verbois SL, Morse DE, Liang CY, Chidambaram N, Jiang JX, Tang S, Mahjoob K, Justice R, Pazdur R (2007) Approval summary: sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma. Clin Cancer Res 13:1367-1373
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1367-1373
-
-
Goodman, V.L.1
Rock, E.P.2
Dagher, R.3
Ramchandani, R.P.4
Abraham, S.5
Gobburu, J.V.6
Booth, B.P.7
Verbois, S.L.8
Morse, D.E.9
Liang, C.Y.10
Chidambaram, N.11
Jiang, J.X.12
Tang, S.13
Mahjoob, K.14
Justice, R.15
Pazdur, R.16
-
14
-
-
38449097166
-
Antiangiogenic and anti-invasive effects of sunitinib on experimental human glioblastoma
-
17622648 10.1215/15228517-2007-024
-
de Bouard S, Herlin P, Christensen JG, Lemoisson E, Gauduchon P, Raymond E, Guillamo JS (2007) Antiangiogenic and anti-invasive effects of sunitinib on experimental human glioblastoma. Neuro Oncol 9:412-423
-
(2007)
Neuro Oncol
, vol.9
, pp. 412-423
-
-
De Bouard, S.1
Herlin, P.2
Christensen, J.G.3
Lemoisson, E.4
Gauduchon, P.5
Raymond, E.6
Guillamo, J.S.7
-
15
-
-
0025281789
-
Response criteria for phase II studies of supratentorial malignant glioma
-
2358840 1:STN:280:DyaK3c3ptlyitQ%3D%3D
-
Macdonald DR, Cascino TL, Schold SC Jr, Cairncross JG (1990) Response criteria for phase II studies of supratentorial malignant glioma. J Clin Oncol 8:1277-1280
-
(1990)
J Clin Oncol
, vol.8
, pp. 1277-1280
-
-
MacDonald, D.R.1
Cascino, T.L.2
Schold, Jr.S.C.3
Cairncross, J.G.4
-
16
-
-
77951625266
-
Updated response assessment criteria for high-grade gliomas: Response assessment in neuro-oncology working group
-
20231676 10.1200/JCO.2009.26.3541
-
Wen PY, Macdonald DR, Reardon DA, Cloughesy TF, Sorensen AG, Galanis E, Degroot J, Wick W, Gilbert MR, Lassman AB, Tsien C, Mikkelsen T, Wong ET, Chamberlain MC, Stupp R, Lamborn KR, Vogelbaum MA, van den Bent MJ, Chang SM (2010) Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J Clin Oncol 28:1963-1972
-
(2010)
J Clin Oncol
, vol.28
, pp. 1963-1972
-
-
Wen, P.Y.1
MacDonald, D.R.2
Reardon, D.A.3
Cloughesy, T.F.4
Sorensen, A.G.5
Galanis, E.6
Degroot, J.7
Wick, W.8
Gilbert, M.R.9
Lassman, A.B.10
Tsien, C.11
Mikkelsen, T.12
Wong, E.T.13
Chamberlain, M.C.14
Stupp, R.15
Lamborn, K.R.16
Vogelbaum, M.A.17
Van Den Bent, M.J.18
Chang, S.M.19
-
17
-
-
0024536437
-
Optimal two-stage designs for phase II clinical trials
-
2702835 10.1016/0197-2456(89)90015-9 1:STN:280:DyaL1M7ps1SjsQ%3D%3D
-
Simon R (1989) Optimal two-stage designs for phase II clinical trials. Control Clin Trials 10:1-10
-
(1989)
Control Clin Trials
, vol.10
, pp. 1-10
-
-
Simon, R.1
-
18
-
-
0026793260
-
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors
-
1322795 1:CAS:528:DyaK38XlvV2ht7g%3D
-
Fleming TP, Saxena A, Clark WC, Robertson JT, Oldfield EH, Aaronson SA, Ali IU (1992) Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors. Cancer Res 52:4550-4553
-
(1992)
Cancer Res
, vol.52
, pp. 4550-4553
-
-
Fleming, T.P.1
Saxena, A.2
Clark, W.C.3
Robertson, J.T.4
Oldfield, E.H.5
Aaronson, S.A.6
Ali, I.U.7
-
19
-
-
0036242810
-
SU6668 inhibits Flk-1/KDR and PDGFRbeta in vivo, resulting in rapid apoptosis of tumor vasculature and tumor regression in mice
-
11978732 1:CAS:528:DC%2BD38XjsVChu7w%3D
-
Laird AD, Christensen JG, Li G, Carver J, Smith K, Xin X, Moss KG, Louie SG, Mendel DB, Cherrington JM (2002) SU6668 inhibits Flk-1/KDR and PDGFRbeta in vivo, resulting in rapid apoptosis of tumor vasculature and tumor regression in mice. FASEB J 16:681-690
-
(2002)
FASEB J
, vol.16
, pp. 681-690
-
-
Laird, A.D.1
Christensen, J.G.2
Li, G.3
Carver, J.4
Smith, K.5
Xin, X.6
Moss, K.G.7
Louie, S.G.8
Mendel, D.B.9
Cherrington, J.M.10
-
20
-
-
33846292596
-
Amplification of KIT, PDGFRA, VEGFR2, and EGFR in gliomas
-
17189383 10.1158/1541-7786.MCR-06-0085 1:CAS:528:DC%2BD28XhtlCrtr3I
-
Puputti M, Tynninen O, Sihto H, Blom T, Maenpaa H, Isola J, Paetau A, Joensuu H, Nupponen NN (2006) Amplification of KIT, PDGFRA, VEGFR2, and EGFR in gliomas. Mol Cancer Res 4:927-934
-
(2006)
Mol Cancer Res
, vol.4
, pp. 927-934
-
-
Puputti, M.1
Tynninen, O.2
Sihto, H.3
Blom, T.4
Maenpaa, H.5
Isola, J.6
Paetau, A.7
Joensuu, H.8
Nupponen, N.N.9
-
21
-
-
78149478057
-
MGMT modulates glioblastoma angiogenesis and response to the tyrosine kinase inhibitor sunitinib
-
20179017 10.1093/neuonc/noq017 1:CAS:528:DC%2BC3cXpvFSltL8%3D
-
Chahal M, Xu Y, Lesniak D, Graham K, Famulski K, Christensen JG, Aghi M, Jacques A, Murray D, Sabri S, Abdulkarim B (2010) MGMT modulates glioblastoma angiogenesis and response to the tyrosine kinase inhibitor sunitinib. Neuro Oncol 12:822-833
-
(2010)
Neuro Oncol
, vol.12
, pp. 822-833
-
-
Chahal, M.1
Xu, Y.2
Lesniak, D.3
Graham, K.4
Famulski, K.5
Christensen, J.G.6
Aghi, M.7
Jacques, A.8
Murray, D.9
Sabri, S.10
Abdulkarim, B.11
-
22
-
-
79959795987
-
Phase II study of sunitinib malate in patients with recurrent high-grade glioma
-
20872043 10.1007/s11060-010-0402-7 1:CAS:528:DC%2BC3MXnsFOjtb8%3D
-
Neyns B, Sadones J, Chaskis C, Dujardin M, Everaert H, Lv S, Duerinck J, Tynninen O, Nupponen N, Michotte A, De Greve J (2011) Phase II study of sunitinib malate in patients with recurrent high-grade glioma. J Neurooncol 103:491-501
-
(2011)
J Neurooncol
, vol.103
, pp. 491-501
-
-
Neyns, B.1
Sadones, J.2
Chaskis, C.3
Dujardin, M.4
Everaert, H.5
Lv, S.6
Duerinck, J.7
Tynninen, O.8
Nupponen, N.9
Michotte, A.10
De Greve, J.11
-
23
-
-
82955232920
-
Phase i study of sunitinib and irinotecan for patients with recurrent malignant glioma
-
21744079 10.1007/s11060-011-0631-4 1:CAS:528:DC%2BC3MXhsVyrtLfK
-
Reardon DA, Vredenburgh JJ, Coan A, Desjardins A, Peters KB, Gururangan S, Sathornsumetee S, Rich JN, Herndon JE, Friedman HS (2011) Phase I study of sunitinib and irinotecan for patients with recurrent malignant glioma. J Neurooncol 105:621-627
-
(2011)
J Neurooncol
, vol.105
, pp. 621-627
-
-
Reardon, D.A.1
Vredenburgh, J.J.2
Coan, A.3
Desjardins, A.4
Peters, K.B.5
Gururangan, S.6
Sathornsumetee, S.7
Rich, J.N.8
Herndon, J.E.9
Friedman, H.S.10
-
24
-
-
37549027153
-
Brain metastasis in renal cell cancer responding to sunitinib
-
18214028 1:CAS:528:DC%2BD1cXhtVOmu7o%3D
-
Koutras AK, Krikelis D, Alexandrou N, Starakis I, Kalofonos HP (2007) Brain metastasis in renal cell cancer responding to sunitinib. Anticancer Res 27:4255-4257
-
(2007)
Anticancer Res
, vol.27
, pp. 4255-4257
-
-
Koutras, A.K.1
Krikelis, D.2
Alexandrou, N.3
Starakis, I.4
Kalofonos, H.P.5
-
25
-
-
80054820244
-
Impact of tyrosine kinase inhibitors on the incidence of brain metastasis in metastatic renal cell carcinoma
-
21484781 10.1002/cncr.26138 1:CAS:528:DC%2BC3MXhtlaqu7zK
-
Verma J, Jonasch E, Allen P, Tannir N, Mahajan A (2011) Impact of tyrosine kinase inhibitors on the incidence of brain metastasis in metastatic renal cell carcinoma. Cancer 117:4958-4965
-
(2011)
Cancer
, vol.117
, pp. 4958-4965
-
-
Verma, J.1
Jonasch, E.2
Allen, P.3
Tannir, N.4
Mahajan, A.5
-
26
-
-
67649583236
-
Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model
-
18971416 10.1215/15228517-2008-088
-
Zhou Q, Gallo JM (2009) Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model. Neuro Oncol 11:301-310
-
(2009)
Neuro Oncol
, vol.11
, pp. 301-310
-
-
Zhou, Q.1
Gallo, J.M.2
|