Transdifferentiation of glioblastoma cells into vascular endothelial cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 11, 2011, Pages 4274-4280

  Soda, Yasushi ^a   Marumoto, Tomotoshi ^a,b   Friedmann Morvinski, Dinorah ^a   Soda, Mie ^a   Liu, Fei ^a   Michiue, Hiroyuki ^c   Pastorino, Sandra ^d   Yang, Meng ^e   Hoffman, Robert M ^e,f   Kesari, Santosh ^d   Verma, Inder M ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b KYUSHU UNIVERSITY   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e ANTICANCER INC   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Angiogenesis; Glioma; Hypoxia inducible factor 1; Mouse model

Indexed keywords

AG 28262; CRE RECOMBINASE; HYPOXIA INDUCIBLE FACTOR 1; LENTIVIRUS VECTOR; PROTEIN P53; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN MICROCIRCULATION; CANCER CELL; CELL FUSION; CELL HYPOXIA; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ANIMALS; CELL FUSION; CELL HYPOXIA; CELL TRANSDIFFERENTIATION; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; GLIOBLASTOMA; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; NEOVASCULARIZATION, PATHOLOGIC; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS;

EID: 79952721477     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1016030108     Document Type: Article

References (31)

1. Wen PY, Kesari S (2008) Malignant gliomas in adults. N Engl J Med 359:492-507.
2. Jain RK, et al. (2007) Angiogenesis in brain tumours. Nat Rev Neurosci 8:610-622. (Pubitemid 47093931)
3. Vredenburgh JJ, et al. (2007) Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma. Clin Cancer Res 13:1253-1259. (Pubitemid 46424067)
4. Bergers G, Hanahan D (2008) Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8:592-603.
5. Shojaei F, Ferrara N (2008) Refractoriness to antivascular endothelial growth factor treatment: Role of myeloid cells. Cancer Res 68:5501-5504.
6. Pope WB, Lai A, Nghiemphu P, Mischel P, Cloughesy TF (2006) MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy. Neurology 66:1258-1260. (Pubitemid 43739717)
7. Pàez-Ribes M, et al. (2009) Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15:220-231.
8. Gunsilius E, et al. (2000) Evidence from a leukaemia model for maintenance of vascular endothelium by bone-marrow-derived endothelial cells. Lancet 355:1688-1691. (Pubitemid 30248482)
9. Streubel B, et al. (2004) Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas. N Engl J Med 351:250-259. (Pubitemid 38916042)
10. Rigolin GM, et al. (2006) Neoplastic circulating endothelial cells in multiple myeloma with 13q14 deletion. Blood 107:2531-2535. (Pubitemid 43345578)
11. Pezzolo A, et al. (2007) Tumor origin of endothelial cells in human neuroblastoma. J Clin Oncol 25:376-383. (Pubitemid 350002985)
12. Bussolati B, Grange C, Sapino A, Camussi G (2009) Endothelial cell differentiation of human breast tumour stem/progenitor cells. J Cell Mol Med 13:309-319.
13. Marumoto T, et al. (2009) Development of a novel mouse glioma model using lentiviral vectors. Nat Med 15:110-116.
14. Dahlstrand J, Collins VP, Lendahl U (1992) Expression of the class VI intermediate filament nestin in human central nervous system tumors. Cancer Res 52:5334-5341.
15. Bergers G, Benjamin LE (2003) Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3:401-410. (Pubitemid 37328844)
16. Wurmser AE, et al. (2004) Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature 430:350-356. (Pubitemid 38937742)
17. Yang M, Reynoso J, Bouvet M, Hoffman RM (2009) A transgenic red fluorescent protein-expressing nude mouse for color-coded imaging of the tumor microenvironment. J Cell Biochem 106:279-284.
18. Ivan M, et al. (2001) HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science 292:464-468. (Pubitemid 32335941)
19. Jaakkola P, et al. (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292:468-472. (Pubitemid 32335942)
20. Zou HY, et al. (2004) AG-028262, a novel selective VEGFR tyrosine kinase antagonist that potently inhibits KDR signaling and angiogenesis in vitro and in vivo. Proc Am Assoc Cancer Res 45:A2578.
21. Chen J, et al. (2010) Inhibition of Notch Signaling Blocks Growth of Glioblastoma Cell Lines and Tumor Neurospheres. Genes Cancer 1:822-835.
22. Bertolini F, Shaked Y, Mancuso P, Kerbel RS (2006) The multifaceted circulating endothelial cell in cancer: Towards marker and target identification. Nat Rev Cancer 6:835-845. (Pubitemid 44629895)
23. Purhonen S, et al. (2008) Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci USA 105:6620-6625. (Pubitemid 351754556)
24. Hendrix MJ, Seftor EA, Hess AR, Seftor RE (2003) Vasculogenic mimicry and tumour-cell plasticity: Lessons from melanoma. Nat Rev Cancer 3:411-421. (Pubitemid 37328845)
25. Yue WY, Chen ZP (2005) Does vasculogenic mimicry exist in astrocytoma? J Histochem Cytochem 53:997-1002.
26. El Hallani S, et al. (2010) A new alternative mechanism in glioblastoma vascularization: Tubular vasculogenic mimicry. Brain 133:973-982.
27. Chang YS, et al. (2000) Mosaic blood vessels in tumors: Frequency of cancer cells in contact with flowing blood. Proc Natl Acad Sci USA 97:14608-14613. (Pubitemid 32016623)
28. Ricci-Vitiani L, et al. (2010) Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature 468:824-828.
29. Wang R, et al. (2010) Glioblastoma stem-like cells give rise to tumour endothelium. Nature 468:829-833.
30. Lee J, et al. (2006) Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9:391-403. (Pubitemid 43668737)
31. Moffat J, et al. (2006) A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124:1283-1298.