Computational selection of inhibitors of Aβ aggregation and neuronal toxicity

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 5189-5197

  Chen, Deliang ^a   Martin, Zane S ^a   Soto, Claudio ^a,b   Schein, Catherine H ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Aggregation inhibitors; Aggregation reversing; Alzheimer's disease; Amyloid fibrils; Database screening; Pharmacophore modeling

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[17-21]; BETA SHEET BREAKER PEPTIDE; LEUCYLPROLYLPHENYLALANYLPHENYLALANYLASPARTIC ACID; LEUCYLVALYLPHENYLALANYLPHENYLALANINE; PENTAPEPTIDE; PEPTIDOMIMETIC AGENT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BIOASSAY; CHEMICAL MODIFICATION; COMPUTER ANALYSIS; CONTROLLED STUDY; DATA BASE; DRUG BINDING SITE; DRUG SCREENING; DRUG SOLUBILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR WEIGHT; NERVE CELL; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOPHORE; STRUCTURE ANALYSIS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; COMPUTER SIMULATION; DATABASES, FACTUAL; DRUG DESIGN; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEURONS; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY;

EID: 67650091797     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.047     Document Type: Article

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