메뉴 건너뛰기




Volumn 6, Issue 8, 2015, Pages 5804-5817

EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma

Author keywords

Angiogenesis; DNAzyme; JNK; LMP1; NPC; Radiosensitivity

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; DEOXYRIBOZYME; DEOXYRIBOZYME 1; HYPOXIA INDUCIBLE FACTOR 1; LATENT MEMBRANE PROTEIN 1; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; EBV-ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN-BARR VIRUS; MATRIX PROTEIN;

EID: 84925590139     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3331     Document Type: Article
Times cited : (58)

References (47)
  • 1
    • 84862127941 scopus 로고    scopus 로고
    • Current management of nasopharyngeal cancer
    • Lee AW, Lin JC and Ng WT. Current management of nasopharyngeal cancer. Semin Radiat Oncol. 2012; 22(3):233-244.
    • (2012) Semin Radiat Oncol , vol.22 , Issue.3 , pp. 233-244
    • Lee, A.W.1    Lin, J.C.2    Ng, W.T.3
  • 3
    • 52049090124 scopus 로고    scopus 로고
    • EBV latent membrane protein 1 effects on plakoglobin, cell growth, and migration
    • Shair KH, Schnegg CI and Raab-Traub N. EBV latent membrane protein 1 effects on plakoglobin, cell growth, and migration. Cancer Res. 2008; 68(17):6997-7005.
    • (2008) Cancer Res , vol.68 , Issue.17 , pp. 6997-7005
    • Shair, K.H.1    Schnegg, C.I.2    Raab-Traub, N.3
  • 5
    • 77954337080 scopus 로고    scopus 로고
    • Evaluation of LMP1 of Epstein-Barr virus as a therapeutic target by its inhibition
    • Hannigan A and Wilson JB. Evaluation of LMP1 of Epstein-Barr virus as a therapeutic target by its inhibition. Mol Cancer. 2010; 9:184.
    • (2010) Mol Cancer , vol.9 , pp. 184
    • Hannigan, A.1    Wilson, J.B.2
  • 6
    • 33749358055 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus mediated RNA interference inhibits metastasis of nasopharyngeal cancer cells in vivo and in vitro by suppression of Epstein-Barr virus encoded LMP-1
    • Li X, Liu X, Li CY, Ding Y, Chau D, Li G, Kung HF, Lin MC and Peng Y. Recombinant adeno-associated virus mediated RNA interference inhibits metastasis of nasopharyngeal cancer cells in vivo and in vitro by suppression of Epstein-Barr virus encoded LMP-1. Int J Oncol. 2006; 29(3):595-603.
    • (2006) Int J Oncol , vol.29 , Issue.3 , pp. 595-603
    • Li, X.1    Liu, X.2    Li, C.Y.3    Ding, Y.4    Chau, D.5    Li, G.6    Kung, H.F.7    Lin, M.C.8    Peng, Y.9
  • 7
    • 0037657521 scopus 로고    scopus 로고
    • Antiviral agent cidofovir decreases Epstein-Barr virus (EBV) oncoproteins and enhances the radiosensitivity in EBV-related malignancies
    • Abdulkarim B, Sabri S, Zelenika D, Deutsch E, Frascogna V, Klijanienko J, Vainchenker W, Joab I and Bourhis J. Antiviral agent cidofovir decreases Epstein-Barr virus (EBV) oncoproteins and enhances the radiosensitivity in EBV-related malignancies. Oncogene. 2003; 22(15):2260-2271.
    • (2003) Oncogene , vol.22 , Issue.15 , pp. 2260-2271
    • Abdulkarim, B.1    Sabri, S.2    Zelenika, D.3    Deutsch, E.4    Frascogna, V.5    Klijanienko, J.6    Vainchenker, W.7    Joab, I.8    Bourhis, J.9
  • 8
    • 84867514301 scopus 로고    scopus 로고
    • Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy
    • Meijer TW, Kaanders JH, Span PN and Bussink J. Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy. Clin Cancer Res. 2012; 18(20):5585-5594.
    • (2012) Clin Cancer Res , vol.18 , Issue.20 , pp. 5585-5594
    • Meijer, T.W.1    Kaanders, J.H.2    Span, P.N.3    Bussink, J.4
  • 9
    • 0030659531 scopus 로고    scopus 로고
    • V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression
    • Jiang BH, Agani F, Passaniti A and Semenza GL. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res. 1997; 57(23):5328-5335.
    • (1997) Cancer Res , vol.57 , Issue.23 , pp. 5328-5335
    • Jiang, B.H.1    Agani, F.2    Passaniti, A.3    Semenza, G.L.4
  • 10
    • 59049088369 scopus 로고    scopus 로고
    • Blockade of an angiotensin type I receptor enhances effects of radiation on tumor growth and tumor-associated angiogenesis by reducing vascular endothelial growth factor expression
    • Ohnuma Y, Toda M, Fujita M, Hosono K, Suzuki T, Ogawa Y, Amano H, Kitasato H, Hayakawa K and Majima M. Blockade of an angiotensin type I receptor enhances effects of radiation on tumor growth and tumor-associated angiogenesis by reducing vascular endothelial growth factor expression. Biomed Pharmacother. 2009; 63(2):136-145.
    • (2009) Biomed Pharmacother , vol.63 , Issue.2 , pp. 136-145
    • Ohnuma, Y.1    Toda, M.2    Fujita, M.3    Hosono, K.4    Suzuki, T.5    Ogawa, Y.6    Amano, H.7    Kitasato, H.8    Hayakawa, K.9    Majima, M.10
  • 11
    • 84873524916 scopus 로고    scopus 로고
    • Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: novel prognostic factors of nasopharyngeal carcinoma
    • Kitagawa N, Kondo S, Wakisaka N, Zen Y, Nakanishi Y, Tsuji A, Endo K, Murono S and Yoshizaki T. Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: novel prognostic factors of nasopharyngeal carcinoma. Cancer Lett. 2013; 331(1):52-57.
    • (2013) Cancer Lett , vol.331 , Issue.1 , pp. 52-57
    • Kitagawa, N.1    Kondo, S.2    Wakisaka, N.3    Zen, Y.4    Nakanishi, Y.5    Tsuji, A.6    Endo, K.7    Murono, S.8    Yoshizaki, T.9
  • 13
    • 2542443138 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha
    • Wakisaka N, Kondo S, Yoshizaki T, Murono S, Furukawa M and Pagano JS. Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha. Mol Cell Biol. 2004; 24(12):5223-5234.
    • (2004) Mol Cell Biol , vol.24 , Issue.12 , pp. 5223-5234
    • Wakisaka, N.1    Kondo, S.2    Yoshizaki, T.3    Murono, S.4    Furukawa, M.5    Pagano, J.S.6
  • 14
    • 84881489334 scopus 로고    scopus 로고
    • The radiosensitizing effect of CpG ODN107 on human glioma cells is tightly related to its antiangiogenic activity via suppression of HIF-1alpha/VEGF pathway
    • Liu D, Cao G, Cen Y, Liu T, Peng W, Sun J, Li X and Zhou H. The radiosensitizing effect of CpG ODN107 on human glioma cells is tightly related to its antiangiogenic activity via suppression of HIF-1alpha/VEGF pathway. Int Immunopharmacol. 2013; 17(2):237-244.
    • (2013) Int Immunopharmacol , vol.17 , Issue.2 , pp. 237-244
    • Liu, D.1    Cao, G.2    Cen, Y.3    Liu, T.4    Peng, W.5    Sun, J.6    Li, X.7    Zhou, H.8
  • 15
    • 78049295535 scopus 로고    scopus 로고
    • STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling
    • Wang Z, Luo F, Li L, Yang L, Hu D, Ma X, Lu Z, Sun L and Cao Y. STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling. Eur J Cancer. 2010; 46(16):2996-3006.
    • (2010) Eur J Cancer , vol.46 , Issue.16 , pp. 2996-3006
    • Wang, Z.1    Luo, F.2    Li, L.3    Yang, L.4    Hu, D.5    Ma, X.6    Lu, Z.7    Sun, L.8    Cao, Y.9
  • 16
    • 39749165700 scopus 로고    scopus 로고
    • DNAzyme technology and cancer therapy: cleave and let die
    • Dass CR, Choong PF and Khachigian LM. DNAzyme technology and cancer therapy: cleave and let die. Mol Cancer Ther. 2008; 7(2):243-251.
    • (2008) Mol Cancer Ther , vol.7 , Issue.2 , pp. 243-251
    • Dass, C.R.1    Choong, P.F.2    Khachigian, L.M.3
  • 18
    • 43949113261 scopus 로고    scopus 로고
    • DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radiosensitivity in nasopharyngeal carcinoma
    • Lu ZX, Ma XQ, Yang LF, Wang ZL, Zeng L, Li ZJ, Li XN, Tang M, Yi W, Gong JP, Sun LQ and Cao Y. DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radiosensitivity in nasopharyngeal carcinoma. Cancer Lett. 2008; 265(2):226-238.
    • (2008) Cancer Lett , vol.265 , Issue.2 , pp. 226-238
    • Lu, Z.X.1    Ma, X.Q.2    Yang, L.F.3    Wang, Z.L.4    Zeng, L.5    Li, Z.J.6    Li, X.N.7    Tang, M.8    Yi, W.9    Gong, J.P.10    Sun, L.Q.11    Cao, Y.12
  • 19
    • 80655132010 scopus 로고    scopus 로고
    • Down-regulation of EBV-LMP1 radio-sensitizes nasal pharyngeal carcinoma cells via NF-kappaB regulated ATM expression
    • Ma X, Yang L, Xiao L, Tang M, Liu L, Li Z, Deng M, Sun L and Cao Y. Down-regulation of EBV-LMP1 radio-sensitizes nasal pharyngeal carcinoma cells via NF-kappaB regulated ATM expression. PLoS One. 2011; 6(11):e24647.
    • (2011) PLoS One , vol.6 , Issue.11
    • Ma, X.1    Yang, L.2    Xiao, L.3    Tang, M.4    Liu, L.5    Li, Z.6    Deng, M.7    Sun, L.8    Cao, Y.9
  • 21
    • 20344367537 scopus 로고    scopus 로고
    • Tumour vascular targeting
    • Neri D and Bicknell R. Tumour vascular targeting. Nat Rev Cancer. 2005; 5(6):436-446.
    • (2005) Nat Rev Cancer , vol.5 , Issue.6 , pp. 436-446
    • Neri, D.1    Bicknell, R.2
  • 22
    • 0033840389 scopus 로고    scopus 로고
    • Vasculogenic mimicry and tumor angiogenesis
    • Folberg R, Hendrix MJ and Maniotis AJ. Vasculogenic mimicry and tumor angiogenesis. Am J Pathol. 2000; 156(2):361-381.
    • (2000) Am J Pathol , vol.156 , Issue.2 , pp. 361-381
    • Folberg, R.1    Hendrix, M.J.2    Maniotis, A.J.3
  • 23
    • 84892608087 scopus 로고    scopus 로고
    • Antiangiogenic and antitumoral effects mediated by a vascular endothelial growth factor receptor 1 (VEGFR-1)-targeted DNAzyme
    • Shen L, Zhou Q, Wang Y, Liao W, Chen Y, Xu Z, Yang L and Sun LQ. Antiangiogenic and antitumoral effects mediated by a vascular endothelial growth factor receptor 1 (VEGFR-1)-targeted DNAzyme. Mol Med. 2013; 19:377-386.
    • (2013) Mol Med , vol.19 , pp. 377-386
    • Shen, L.1    Zhou, Q.2    Wang, Y.3    Liao, W.4    Chen, Y.5    Xu, Z.6    Yang, L.7    Sun, L.Q.8
  • 24
    • 2342611976 scopus 로고    scopus 로고
    • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules
    • Moeller BJ, Cao Y, Li CY and Dewhirst MW. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell. 2004; 5(5):429-441.
    • (2004) Cancer Cell , vol.5 , Issue.5 , pp. 429-441
    • Moeller, B.J.1    Cao, Y.2    Li, C.Y.3    Dewhirst, M.W.4
  • 26
    • 0036132872 scopus 로고    scopus 로고
    • c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription
    • Alfranca A, Gutierrez MD, Vara A, Aragones J, Vidal F and Landazuri MO. c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription. Mol Cell Biol. 2002; 22(1):12-22.
    • (2002) Mol Cell Biol , vol.22 , Issue.1 , pp. 12-22
    • Alfranca, A.1    Gutierrez, M.D.2    Vara, A.3    Aragones, J.4    Vidal, F.5    Landazuri, M.O.6
  • 27
    • 0142026222 scopus 로고    scopus 로고
    • Hepatocyte growth factor signaling regulates transactivation of genes belonging to the plasminogen activation system via hypoxia inducible factor-1
    • Tacchini L, Matteucci E, De Ponti C and Desiderio MA. Hepatocyte growth factor signaling regulates transactivation of genes belonging to the plasminogen activation system via hypoxia inducible factor-1. Exp Cell Res. 2003; 290(2):391-401.
    • (2003) Exp Cell Res , vol.290 , Issue.2 , pp. 391-401
    • Tacchini, L.1    Matteucci, E.2    De Ponti, C.3    Desiderio, M.A.4
  • 28
    • 0036183640 scopus 로고    scopus 로고
    • The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia
    • Salnikow K, Kluz T, Costa M, Piquemal D, Demidenko ZN, Xie K and Blagosklonny MV. The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia. Mol Cell Biol. 2002; 22(6):1734-1741.
    • (2002) Mol Cell Biol , vol.22 , Issue.6 , pp. 1734-1741
    • Salnikow, K.1    Kluz, T.2    Costa, M.3    Piquemal, D.4    Demidenko, Z.N.5    Xie, K.6    Blagosklonny, M.V.7
  • 29
    • 1642387020 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions
    • Lee JW, Bae SH, Jeong JW, Kim SH and Kim KW. Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions. Exp Mol Med. 2004; 36(1):1-12.
    • (2004) Exp Mol Med , vol.36 , Issue.1 , pp. 1-12
    • Lee, J.W.1    Bae, S.H.2    Jeong, J.W.3    Kim, S.H.4    Kim, K.W.5
  • 31
    • 10844278331 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxia
    • Comerford KM, Cummins EP and Taylor CT. c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1alpha-dependent P-glycoprotein expression in hypoxia. Cancer Res. 2004; 64(24):9057-9061.
    • (2004) Cancer Res , vol.64 , Issue.24 , pp. 9057-9061
    • Comerford, K.M.1    Cummins, E.P.2    Taylor, C.T.3
  • 33
    • 77952956071 scopus 로고    scopus 로고
    • Manganese-mediated up-regulation of HIF-1alpha protein in Hep2 human laryngeal epithelial cells via activation of the family of MAPKs
    • Shin HJ, Choi MS, Ryoo NH, Nam KY, Park GY, Bae JH, Suh SI, Baek WK, Park JW and Jang BC. Manganese-mediated up-regulation of HIF-1alpha protein in Hep2 human laryngeal epithelial cells via activation of the family of MAPKs. Toxicol In Vitro. 2010; 24(4):1208-1214.
    • (2010) Toxicol In Vitro , vol.24 , Issue.4 , pp. 1208-1214
    • Shin, H.J.1    Choi, M.S.2    Ryoo, N.H.3    Nam, K.Y.4    Park, G.Y.5    Bae, J.H.6    Suh, S.I.7    Baek, W.K.8    Park, J.W.9    Jang, B.C.10
  • 34
    • 49749091100 scopus 로고    scopus 로고
    • Salicylideneamino-2-thiophenol inhibits inflammatory mediator genes (RANTES, MCP-1, IL-8 and HIF-1alpha) expression induced by tert-butyl hydroperoxide via MAPK pathways in rat peritoneal macrophages
    • Chung J, Lee HS, Chung HY, Yoon TR and Kim HK. Salicylideneamino-2-thiophenol inhibits inflammatory mediator genes (RANTES, MCP-1, IL-8 and HIF-1alpha) expression induced by tert-butyl hydroperoxide via MAPK pathways in rat peritoneal macrophages. Biotechnol Lett. 2008; 30(9):1553-1558.
    • (2008) Biotechnol Lett , vol.30 , Issue.9 , pp. 1553-1558
    • Chung, J.1    Lee, H.S.2    Chung, H.Y.3    Yoon, T.R.4    Kim, H.K.5
  • 35
    • 0037470189 scopus 로고    scopus 로고
    • Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite
    • Duyndam MC, Hulscher ST, van der Wall E, Pinedo HM and Boven E. Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. J Biol Chem. 2003; 278(9):6885-6895.
    • (2003) J Biol Chem , vol.278 , Issue.9 , pp. 6885-6895
    • Duyndam, M.C.1    Hulscher, S.T.2    van der Wall, E.3    Pinedo, H.M.4    Boven, E.5
  • 36
    • 79951554462 scopus 로고    scopus 로고
    • Arsenite stabilizes HIF-1alpha protein through p85alpha-mediated up-regulation of inducible Hsp70 protein expression
    • Guo W, Yang Z, Xia Q, Liu J, Yu Y, Li J, Zuo Z, Zhang D, Li X, Shi X and Huang C. Arsenite stabilizes HIF-1alpha protein through p85alpha-mediated up-regulation of inducible Hsp70 protein expression. Cell Mol Life Sci. 2011; 68(3):475-488.
    • (2011) Cell Mol Life Sci , vol.68 , Issue.3 , pp. 475-488
    • Guo, W.1    Yang, Z.2    Xia, Q.3    Liu, J.4    Yu, Y.5    Li, J.6    Zuo, Z.7    Zhang, D.8    Li, X.9    Shi, X.10    Huang, C.11
  • 40
    • 84888013681 scopus 로고    scopus 로고
    • Tumour vasculogenic mimicry is associated with poor prognosis of human cancer patients: a systemic review and meta-analysis
    • Cao Z, Bao M, Miele L, Sarkar FH, Wang Z and Zhou Q. Tumour vasculogenic mimicry is associated with poor prognosis of human cancer patients: a systemic review and meta-analysis. Eur J Cancer. 2013; 49(18):3914-3923.
    • (2013) Eur J Cancer , vol.49 , Issue.18 , pp. 3914-3923
    • Cao, Z.1    Bao, M.2    Miele, L.3    Sarkar, F.H.4    Wang, Z.5    Zhou, Q.6
  • 41
    • 76249098330 scopus 로고    scopus 로고
    • Noninvasive evaluation of antiangiogenic effect in a mouse tumor model by DCE-MRI with Gd-DTPA cystamine copolymers
    • Wu X, Jeong EK, Emerson L, Hoffman J, Parker DL and Lu ZR. Noninvasive evaluation of antiangiogenic effect in a mouse tumor model by DCE-MRI with Gd-DTPA cystamine copolymers. Mol Pharm. 2010; 7(1):41-48.
    • (2010) Mol Pharm , vol.7 , Issue.1 , pp. 41-48
    • Wu, X.1    Jeong, E.K.2    Emerson, L.3    Hoffman, J.4    Parker, D.L.5    Lu, Z.R.6
  • 42
    • 77649333248 scopus 로고    scopus 로고
    • Changes in vascular permeability and expression of different angiogenic factors following anti-angiogenic treatment in rat glioma
    • Ali MM, Janic B, Babajani-Feremi A, Varma NR, Iskander AS, Anagli J and Arbab AS. Changes in vascular permeability and expression of different angiogenic factors following anti-angiogenic treatment in rat glioma. PLoS One. 2010; 5(1):e8727.
    • (2010) PLoS One , vol.5 , Issue.1
    • Ali, M.M.1    Janic, B.2    Babajani-Feremi, A.3    Varma, N.R.4    Iskander, A.S.5    Anagli, J.6    Arbab, A.S.7
  • 44
    • 2442466081 scopus 로고    scopus 로고
    • Interference effect of epigallocatechin-3-gallate on targets of nuclear factor kappaB signal transduction pathways activated by EB virus encoded latent membrane protein 1
    • Yan Z, Yong-Guang T, Fei-Jun L, Fa-Qing T, Min T and Ya C. Interference effect of epigallocatechin-3-gallate on targets of nuclear factor kappaB signal transduction pathways activated by EB virus encoded latent membrane protein 1. Int J Biochem Cell Biol. 2004; 36(8):1473-1481.
    • (2004) Int J Biochem Cell Biol , vol.36 , Issue.8 , pp. 1473-1481
    • Yan, Z.1    Yong-Guang, T.2    Fei-Jun, L.3    Fa-Qing, T.4    Min, T.5    Ya, C.6
  • 45
    • 21844454975 scopus 로고    scopus 로고
    • Epstein-Barr virus encoded latent membrane protein 1 modulates nuclear translocation of telomerase reverse transcriptase protein by activating nuclear factor-kappaB p65 in human nasopharyngeal carcinoma cells
    • Ding L, Li LL, Yang J, Tao YG, Ye M, Shi Y, Tang M, Yi W, Li XL, Gong JP and Cao Y. Epstein-Barr virus encoded latent membrane protein 1 modulates nuclear translocation of telomerase reverse transcriptase protein by activating nuclear factor-kappaB p65 in human nasopharyngeal carcinoma cells. Int J Biochem Cell Biol. 2005; 37(9):1881-1889.
    • (2005) Int J Biochem Cell Biol , vol.37 , Issue.9 , pp. 1881-1889
    • Ding, L.1    Li, L.L.2    Yang, J.3    Tao, Y.G.4    Ye, M.5    Shi, Y.6    Tang, M.7    Yi, W.8    Li, X.L.9    Gong, J.P.10    Cao, Y.11
  • 46
    • 84891800347 scopus 로고    scopus 로고
    • Targeting EBV-LMP1 DNAzyme enhances radiosensitivity of nasopharyngeal carcinoma cells by inhibiting telomerase activity
    • Yang L, Xu Z, Liu L, Luo X, Lu J, Sun L and Cao Y. Targeting EBV-LMP1 DNAzyme enhances radiosensitivity of nasopharyngeal carcinoma cells by inhibiting telomerase activity. Cancer biology & therapy. 2014; 15(1):61-68.
    • (2014) Cancer biology & therapy , vol.15 , Issue.1 , pp. 61-68
    • Yang, L.1    Xu, Z.2    Liu, L.3    Luo, X.4    Lu, J.5    Sun, L.6    Cao, Y.7
  • 47
    • 84882643175 scopus 로고    scopus 로고
    • XRCC3 and RAD51 expression are associated with clinical factors in breast cancer
    • Hu J, Wang N and Wang YJ. XRCC3 and RAD51 expression are associated with clinical factors in breast cancer. PLoS One. 2013; 8(8):e72104.
    • (2013) PLoS One , vol.8 , Issue.8
    • Hu, J.1    Wang, N.2    Wang, Y.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.