Arsenite stabilizes HIF-1α protein through p85α-mediated up-regulation of inducible Hsp70 protein expression

Cellular and Molecular Life Sciences

Volumn 68, Issue 3, 2011, Pages 475-488

  Guo, Wei ^a,b   Yang, Zhuo ^a   Xia, Qing ^a   Liu, Jinyi ^a   Yu, Yonghui ^a,b   Li, Jingxia ^a   Zuo, Zhenghong ^a   Zhang, Dongyun ^a   Li, Xueyong ^a   Shi, Xianglin ^c   Huang, Chuanshu ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WUHAN UNIVERSITY   (China)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Akt; Arsenite; HIF 1 ; Hsp70; p85

Indexed keywords

ARSENIC TRIOXIDE; HEAT SHOCK PROTEIN 70; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN P85; PROTEIN P85 ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; EMBRYO CELL; ENZYME ASSAY; EPIDERMIS CELL; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN STABILITY; PROTEIN TRANSPORT; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; ARSENITES; CARCINOGENS; CELL LINE; CELL NUCLEOLUS; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; DNA-BINDING PROTEINS; EPIDERMIS; FIBROBLASTS; GENE EXPRESSION REGULATION; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; PROTEIN STABILITY; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; TERATOGENS; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 79951554462     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0459-7     Document Type: Article

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