DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radiosensitivity in nasopharyngeal carcinoma

Cancer Letters

Volumn 265, Issue 2, 2008, Pages 226-238

  Lu, Zhong Xin ^a   Ma, Xiao Qian ^a   Yang, Li Fang ^a   Wang, Zhen Lian ^a   Zeng, Liang ^b   Li, Zi Jian ^a   Li, Xiao Nan ^c   Tang, Min ^a   Yi, Wei ^a   Gong, Jian Ping ^c   Sun, Lun Quan ^d   Cao, Ya ^a  

^a Central South University   (China)

^b People's Hospital of Hunan Province   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

DNAzymes; EBV associated carcinoma; Latent membrane protein; Radiosensitivity

Indexed keywords

CASPASE 3; CASPASE 9; DEOXYRIBOZYME; LATENT MEMBRANE PROTEIN 1; OLIGONUCLEOTIDE; ONCOPROTEIN; RADIOSENSITIZING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER MODEL; CANCER RADIOTHERAPY; CARCINOMA; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG DESIGN; DRUG EFFECT; DRUG MECHANISM; DRUG TUMOR LEVEL; EPSTEIN BARR VIRUS; FEMALE; GENE TARGETING; GENETIC MANIPULATION; HUMAN; HUMAN CELL; NASOPHARYNX CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; VIRUS ONCOGENE;

ANIMALS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DNA, CATALYTIC; FEASIBILITY STUDIES; HUMANS; MICE; MICE, NUDE; NASOPHARYNGEAL NEOPLASMS; RADIATION TOLERANCE; SIGNAL TRANSDUCTION; TRANSFECTION; VIRAL MATRIX PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

HUMAN HERPESVIRUS 4; MUS;

EID: 43949113261     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.02.019     Document Type: Article

References (36)

1. Hirayama T. Descriptive and analytical epidemiology of nasopharyngeal cancer. IARC Sci. Publ. 20 (1978) 167-189
2. Yu M.C., and Yuan J.M. Epidemiology of nasopharyngeal carcinoma. Semin. Cancer Biol. 12 (2002) 421-429
3. Pagano J.S. Epstein-Barr virus: the first human tumor virus and its role in cancer. Proc. Assoc. Am. Physicians 111 (1999) 573-580
4. Niedobitek G., Meru N., and Delecluse H.J. Epstein-Barr virus infection and human malignancies. Int. J. Exp. Pathol. 82 (2001) 149-170
5. Herrmann K., and Niedobitek G. Epstein-Barr virus-associated carcinomas: facts and fiction. J. Pathol. 199 (2003) 140-145
6. Wakisaka N., and Pagano J.S. Epstein-Barr virus induces invasion and metastasis factors. Anticancer Res. 23 (2003) 2133-2138
7. Kilger E., Kieser A., Baumann M., and Hammerschmidt W. Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor. EMBO J. 17 (1998) 1700-1709
8. Eliopoulos A.G., and Young L.S. Activation of the cJun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1). Oncogene 16 (1998) 1731-1742
9. Gires O., Kohlhuber F., Kilger E., Baumann M., Kieser A., Kaiser C., Zeidler R., Scheffer B., Ueffing M., and Hammerschmidt W. Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins. EMBO J. 18 (1999) 3064-3073
10. Tao T.G., Tan Y.N., Liu Y.P., Song X., Zeng L., Gu H.H., Tang M., Li W., and Cao Y. Epstein-Barr virus latent membrane protein 1 modulates epidermal growth factor receptor promoter activity in a nuclear factor kappa B-dependent manner. Cell. Signal. 16 (2004) 781-790
11. Tsao S.W., Tramoutanis G., Dawson C.W., Lo A.K., and Huang D.P. The significance of LMP1 expression in nasopharyngeal carcinoma. Semin. Cancer Biol. 12 (2002) 473-487
12. Masciarelli S., Mattioli B., and Galletti R. Antisense to Epstein-Barr Virus-encoded LMP1 does not affect the transcription of viral and cellular proliferation-related genes, but induces phenotypic effects on EBV-transformed B lymphocytes. Oncogene 21 (2002) 4166-4170
13. Li G., Li X.P., Peng Y., Liu X., and Li X.H. Effect of inhibition of EBV-encoded latent membrane protein-1 by small interfering RNA on EBV-positive nasopharyngeal carcinoma cell growth. J. First Mil. Med. Univ. 24 (2004) 241-246
14. Li X.P., Li G., Peng Y., Kung H.F., and Lin M.C. Suppression of Epstein-Barr virus-encoded latent membrane protein-1 by RNA interference inhibits the metastatic potential of nasopharyngeal carcinoma cells. Biochem. Biophys. Res. Commun. 315 (2004) 212-218
15. Sun L.Q., Cairns M.J., Saravolac E.G., Baker A., and Gerlach W.L. Catalytic nucleic acids: from lab to applications. Pharmacol. Rev. 52 (2000) 325-347
16. Schubert S., Gul D.C., Grunert H.P., Zeichhardt H., Erdmann V.A., and Kurreck J. RNA cleaving '10-23' DNAzymes with enhanced stability and activity. Nucleic Acids Res. 31 (2003) 5982-5992
17. Santoro S.W., and Joyce G.F. A general purpose RNA-cleaving DNA enzyme. Proc. Natl. Acad. Sci. USA 94 (1997) 4262-4266
18. Santiago F.S., Lowe H.C., and Kavurma M.M. New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth factor injury. Nat. Med. 5 (1999) 1264-1269
19. Fahmy F.G., Dass C.R., Sun L.Q., Chesterman C.N., and Khachigian L.M. Transcription factor Egr-1 supports FGF dependent angiogenesis during neovascularization and tumor growth. Nat. Med. 9 (2003) 1026-1032
20. Lu Z.X., Ye M., Yan G.R., Li Q., Tang M., Lee L.M., Sun L.Q., and Cao Y. Effect of EBV LMP1 targeted DNAzymes on cell proliferation and apoptosis. Cancer Gene Ther. 12 (2005) 647-654
21. Zhang L., Gasper W.J., Stass S.A., Ioffe O.B., Davis M.A., and Mixson A.J. Angiogenic inhibition mediated by a DNAzyme that targets vascular endothelial growth factor receptor 2. Cancer Res. 62 (2002) 5463-5469
22. Mitchell A., Dass C.R., Sun L.Q., and Khachigian L.M. Inhibition of human breast carcinoma proliferation, migration, chemoinvasion and solid tumor growth by DNAzymes targeting the zinc finger transcription factor EGR-1. Nucleic Acids Res. 32 (2004) 3065-3069
23. Zhang G., Dass C.R., Sumithran E., Girolamo N.D., Sun L.Q., and Khachigian L.M. Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents. J. Natl. Cancer Inst. 96 (2004) 683-696
24. Zhu H.C., Yao K.T., and Li G.Y. Establishment of 4 nasopharyngeal epidemic carcinoma cell lines and their biological characteristic involved. Bull. Hunan Med. Univ. 17 (1992) 103-106
25. Yan Z., Yong-Guang T., Fei-Jun L., Fa-Qing T., Min T., and Cao Y. Interference effect of epigallocatechin-3-gallate on targets of nuclear factor kappaB signal transduction pathways activated by EB virus encoded latent membrane protein 1. Int. J. Biochem. Cell Biol. 36 (2004) 1473-1481
26. Zhu H.C., Yao K.T., and Li G.Y. Establishment of 4 nasopharyngeal epidemic carcinoma cell lines and their biological characteristic involved. Bull. Hunan Med. Univ. 17 (1992) 103-106
27. Yan Z., Yong-Guang T., Fei-Jun L., Fa-Qing T., Min T., and Cao Y. Interference effect of epigallocatechin-3-gallate on targets of nuclear factor kappaB signal transduction pathways activated by EB virus encoded latent membrane protein 1. Int. J. Biochem. Cell Biol. 36 (2004) 1473-1481
28. Benimetskaya L., Takle G.B., Vilenchik M., Lebedeva I., Miller P., and Stein C.A. Cationic porphyrins: novel delivery vehicles for antisense oligodeoxynucleotides. Nucleic Acids Res. 26 (1998) 5310-5317
29. Turkson J., Bowman T., and Garcia R. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol. Cell. Biol. 18 (1998) 2545-2552
30. Chapman N.R., and Perkins N.D. Inhibition of the RelA (p65) NF-kappaB subunit by Egr-1. J. Biol. Chem. 275 (2000) 4719-4725
31. Kenney J.L., Guinness M.E., Reiss M., and Lacy L. Antisense to the Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP-1) sensitizes EBV-immortalized B cells to transforming growth factor-beta and chemotherapeutic agents. Int. J. Cancer 91 (2001) 89-98
32. Tang F., and Cao Y. Epstein-Barr virus LMP1 triggers the expression of inhibitor of apoptosis protein surviving via NF kappa B and AP-1 signaling pathways in nasopharyngeal carcinoma. Exp. Oncol. 25 (2003) 28-32
33. Higuchi M., Kieff E., and Izumi K.M. The Epstein-Barr virus latent membrane protein 1 putative Janus kinase 3 (JAK3) binding domain does not mediate JAK3 association or activation in B-lymphoma or lymphoblastoid cell lines. J. Virol. 76 (2002) 455-459
34. Chen H., Hutt-Fletcher L., Cao L., and Hayward S.D. A positive autoregulatory loop of LMP1 expression and STAT activation in epithelial cells latently infected with Epstein-Barr virus. J. Virol. 77 (2003) 4139-4148
35. Guo G., Wang T., Gao Q., Tamae D., Wong P., Chen T., Chen W.C., Shively J.E., Wong J.Y., and Li JJ J.J. Expression of ErbB2 enhances radiation-induced NF-kappaB activation. Oncogene 23 (2004) 535-545
36. Goldberg E.P., Hadba A.R., Almond B.A., and Marotta J.S. Intratumoral cancer chemotherapy and immunotherapy: opportunities for nonsystemic preoperative drug delivery. J. Pharm. Pharmacol. 54 (2002) 159-180