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Volumn 19, Issue 1, 2013, Pages 377-386

Antiangiogenic and antitumoral effects mediated by a vascular endothelial growth factor receptor 1 (VEGFR-1)-targeted DNAzyme

Author keywords

[No Author keywords available]

Indexed keywords

DNAZYME; DT18; GADOLINIUM PENTETATE; MATRIGEL; MESSENGER RNA; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1;

EID: 84892608087     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2013.00090     Document Type: Article
Times cited : (17)

References (34)
  • 2
    • 34249689753 scopus 로고    scopus 로고
    • Molecular regulation of angiogenesis and lymphangiogenesis
    • Adams RH, Alitalo K. (2007) Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell Biol. 8:464-78.
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 464-478
    • Adams, R.H.1    Alitalo, K.2
  • 3
    • 60749096085 scopus 로고    scopus 로고
    • Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    • Augustin HG, Koh GY, Thurston G, Alitalo K. (2009) Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat. Rev. Mol. Cell Biol. 10:165-77.
    • (2009) Nat. Rev. Mol. Cell Biol , vol.10 , pp. 165-177
    • Augustin, H.G.1    Koh, G.Y.2    Thurston, G.3    Alitalo, K.4
  • 4
    • 80052933197 scopus 로고    scopus 로고
    • Basic and therapeutic aspects of angiogenesis
    • Potente M, Gerhardt H, Carmeliet P. (2011) Basic and therapeutic aspects of angiogenesis. Cell. 146:873-87.
    • (2011) Cell , vol.146 , pp. 873-887
    • Potente, M.1    Gerhardt, H.2    Carmeliet, P.3
  • 5
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • Carmeliet P, Jain RK. (2011) Molecular mechanisms and clinical applications of angiogenesis. Nature. 473:298-307.
    • (2011) Nature , vol.473 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 6
    • 0029143960 scopus 로고
    • Molecular mechanisms of angiogenesis: Fibroblast growth factor signal transduction
    • Friesel RE, Maciag T. (1995) Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction. FASEB J. 9:919-25.
    • (1995) FASEB J , vol.9 , pp. 919-925
    • Friesel, R.E.1    Maciag, T.2
  • 7
    • 0030751493 scopus 로고    scopus 로고
    • Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes: Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia
    • Gerber HP, Condorelli F, Park J, Ferrara N. (1997) Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes: Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J. Biol. Chem. 272:23659-67.
    • (1997) J. Biol. Chem , vol.272 , pp. 23659-23667
    • Gerber, H.P.1    Condorelli, F.2    Park, J.3    Ferrara, N.4
  • 8
    • 19244379078 scopus 로고    scopus 로고
    • Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
    • Carmeliet P, et al. (2001) Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat. Med. 7:575-83.
    • (2001) Nat. Med , vol.7 , pp. 575-583
    • Carmeliet, P.1
  • 9
    • 0033650988 scopus 로고    scopus 로고
    • New paradigms for the treatment of cancer: The role of anti-angiogenesis agents
    • Cherrington JM, Strawn LM, Shawver LK. (2000) New paradigms for the treatment of cancer: the role of anti-angiogenesis agents. Adv. Cancer Res. 79:1-38.
    • (2000) Adv. Cancer Res , vol.79 , pp. 1-38
    • Cherrington, J.M.1    Strawn, L.M.2    Shawver, L.K.3
  • 10
    • 0000562664 scopus 로고    scopus 로고
    • The Role of Vascular Endothelial Growth Factor in the Regulation of Blood Vessel Growth
    • Bicknell R, Lewis CE, Ferrara N (eds.) Oxford University Press, New York
    • Ferrara N. (1997) The Role of Vascular Endothelial Growth Factor in the Regulation of Blood Vessel Growth. In: Tumour Angiogenesis. Bicknell R, Lewis CE, Ferrara N (eds.) Oxford University Press, New York, pp. 185-98.
    • (1997) Tumour Angiogenesis , pp. 185-198
    • Ferrara, N.1
  • 11
    • 0033998238 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in human colon cancer: Biology and therapeutic implications
    • Ellis LM, Takahashi Y, Liu W, Shaheen RM. (2000) Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications. Oncologist. 5 Suppl 1:11-15.
    • (2000) Oncologist , Issue.5 SUPPL. 1 , pp. 11-15
    • Ellis, L.M.1    Takahashi, Y.2    Liu, W.3    Shaheen, R.M.4
  • 12
    • 70349782389 scopus 로고    scopus 로고
    • An overview of small-molecule inhibitors of VEGFR signaling
    • Ivy SP, Wick JY, Kaufman BM. (2009) An overview of small-molecule inhibitors of VEGFR signaling. Nat. Rev. Clin. Oncol. 6:569-79.
    • (2009) Nat. Rev. Clin. Oncol , vol.6 , pp. 569-579
    • Ivy, S.P.1    Wick, J.Y.2    Kaufman, B.M.3
  • 13
    • 84970070220 scopus 로고
    • Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer
    • Takahashi Y, Kitadai Y, Bucana CD, Cleary KR, Ellis LM. (1995) Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res. 55:3964-8.
    • (1995) Cancer Res , vol.55 , pp. 3964-3968
    • Takahashi, Y.1    Kitadai, Y.2    Bucana, C.D.3    Cleary, K.R.4    Ellis, L.M.5
  • 14
    • 84878325052 scopus 로고    scopus 로고
    • Beyond anti-VEGF: Dual-targeting antiangiogenic and antiproliferative therapy
    • Chen CT, Hung MC. (2013) Beyond anti-VEGF: dual-targeting antiangiogenic and antiproliferative therapy. Am. J. Transl. Res. 5:393-403.
    • (2013) Am. J. Transl. Res , vol.5 , pp. 393-403
    • Chen, C.T.1    Hung, M.C.2
  • 17
    • 84862893498 scopus 로고    scopus 로고
    • Resurrecting DNAzymes as sequence-specific therapeutics
    • Rossi JJ. (2012) Resurrecting DNAzymes as sequence-specific therapeutics. Sci. Transl. Med. 4:139fs120.
    • (2012) Sci. Transl. Med , vol.4
    • Rossi, J.J.1
  • 18
    • 35348911812 scopus 로고    scopus 로고
    • Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based genesilencing strategies
    • Bhindi R, et al. (2007) Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based genesilencing strategies. Am. J. Pathol. 171:1079-88.
    • (2007) Am. J. Pathol , vol.171 , pp. 1079-1088
    • Bhindi, R.1
  • 20
    • 0032717640 scopus 로고    scopus 로고
    • New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury
    • Santiago FS, et al. (1999) New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury. Nat. Med. 5:1264-9.
    • (1999) Nat. Med , vol.5 , pp. 1264-1269
    • Santiago, F.S.1
  • 21
    • 77957325051 scopus 로고    scopus 로고
    • A therapeutic approach to nasopharyngeal carcinomas by DNAzymes targeting EBV LMP-1 gene
    • Yang L, Lu Z, Ma X, Cao Y, Sun LQ. (2010) A therapeutic approach to nasopharyngeal carcinomas by DNAzymes targeting EBV LMP-1 gene. Molecules. 15:6127-39.
    • (2010) Molecules , vol.15 , pp. 6127-6139
    • Yang, L.1    Lu, Z.2    Ma, X.3    Cao, Y.4    Sun, L.Q.5
  • 22
    • 84862841985 scopus 로고    scopus 로고
    • DNAzyme targeting c-jun suppresses skin cancer growth
    • Cai H, et al. (2012) DNAzyme targeting c-jun suppresses skin cancer growth. Sci. Transl. Med. 4:139ra182.
    • (2012) Sci. Transl. Med , vol.4
    • Cai, H.1
  • 23
    • 84878113156 scopus 로고    scopus 로고
    • Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: A phase 1 firstin-human trial (DISCOVER)
    • Cho EA, et al. (2013) Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 firstin-human trial (DISCOVER). Lancet. 381:1835-43.
    • (2013) Lancet , vol.381 , pp. 1835-1843
    • Cho, E.A.1
  • 24
    • 0024332127 scopus 로고
    • Two epithelial tumor cell lines (HNE-1 and HONE-1) latently infected with Epstein-Barr virus that were derived from nasopharyngeal carcinomas
    • Glaser R, et al. (1989) Two epithelial tumor cell lines (HNE-1 and HONE-1) latently infected with Epstein-Barr virus that were derived from nasopharyngeal carcinomas. Proc. Natl. Acad. Sci. U. S. A. 86:9524-8.
    • (1989) Proc. Natl. Acad. Sci. U. S. A , vol.86 , pp. 9524-9528
    • Glaser, R.1
  • 25
    • 0032558463 scopus 로고    scopus 로고
    • Mechanism and utility of an RNA-cleaving DNA enzyme
    • Santoro SW, Joyce GF. (1998) Mechanism and utility of an RNA-cleaving DNA enzyme. Biochemistry. 37:13330-42.
    • (1998) Biochemistry , vol.37 , pp. 13330-13342
    • Santoro, S.W.1    Joyce, G.F.2
  • 26
    • 0037930729 scopus 로고    scopus 로고
    • Optimisation of the 10-23 DNAzyme-substrate pairing interactions enhanced RNA cleavage activity at purinecytosine target sites
    • Cairns MJ, King A, Sun LQ. (2003) Optimisation of the 10-23 DNAzyme-substrate pairing interactions enhanced RNA cleavage activity at purinecytosine target sites. Nucleic Acids Res. 31:2883-9.
    • (2003) Nucleic Acids Res , vol.31 , pp. 2883-2889
    • Cairns, M.J.1    King, A.2    Sun, L.Q.3
  • 27
    • 0033168947 scopus 로고    scopus 로고
    • Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA
    • Parry TJ, et al. (1999) Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA. Nucleic Acids Res. 27:2569-77.
    • (1999) Nucleic Acids Res , vol.27 , pp. 2569-2577
    • Parry, T.J.1
  • 28
    • 0032404159 scopus 로고    scopus 로고
    • Cationic porphyrins: Novel delivery vehicles for antisense oligodeoxynucleotides
    • Benimetskaya L, et al. (1998) Cationic porphyrins: novel delivery vehicles for antisense oligodeoxynucleotides. Nucleic Acids Res. 26:5310-5317.
    • (1998) Nucleic Acids Res , vol.26 , pp. 5310-5317
    • Benimetskaya, L.1
  • 29
    • 34249338085 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced MRI in oncology drug development
    • Cheng HL. (2007) Dynamic contrast-enhanced MRI in oncology drug development. Curr. Clin. Pharmacol. 2:111-22.
    • (2007) Curr. Clin. Pharmacol , vol.2 , pp. 111-122
    • Cheng, H.L.1
  • 30
    • 0025743216 scopus 로고
    • Pharmacokinetics biodistribution and stability of oligonucleotide phosphorothioates in mice
    • Agrawal S, et al. (1991) Pharmacokinetics biodistribution and stability of oligonucleotide phosphorothioates in mice. Proc. Natl. Acad. Sci. U. S. A. 88:7595-9.
    • (1991) Proc. Natl. Acad. Sci. U. S. A , vol.88 , pp. 7595-7599
    • Agrawal, S.1
  • 31
  • 32
    • 15344342455 scopus 로고    scopus 로고
    • Genentech discloses safety concerns over Avastin
    • Ratner M. (2004) Genentech discloses safety concerns over Avastin. Nat. Biotechnol. 22:1198.
    • (2004) Nat. Biotechnol , vol.22 , pp. 1198
    • Ratner, M.1
  • 33
    • 33144459287 scopus 로고    scopus 로고
    • VEGFR-1 and VEGFR-2: Two non-identical twins with a unique physiognomy
    • Rahimi N. (2006) VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy. Front Biosci. 11:818-29.
    • (2006) Front Biosci , vol.11 , pp. 818-829
    • Rahimi, N.1
  • 34
    • 0036792125 scopus 로고    scopus 로고
    • Angiogenic inhibition mediated by a DNAzyme that targets vascular endothelial growth factor receptor 2
    • Zhang L, et al. (2002) Angiogenic inhibition mediated by a DNAzyme that targets vascular endothelial growth factor receptor 2. Cancer Res. 62:5463-9.
    • (2002) Cancer Res , vol.62 , pp. 5463-5469
    • Zhang, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.