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1
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37349061324
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HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty
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PID: 18000149
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Desquilbet L, Jacobson L, Fried LP, Phair JP, Williams CM, Jamieson BD, et al. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. J Gerontol A Biol Sci Med Sci. 2007;62:1279–86.
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J Gerontol A Biol Sci Med Sci
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Desquilbet, L.1
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Fried, L.P.3
Phair, J.P.4
Williams, C.M.5
Jamieson, B.D.6
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2
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84873100763
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Frailty, HIV infection, and mortality in an aging cohort of injection drug users
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COI: 1:CAS:528:DC%2BC3sXis1ymsbg%3D, PID: 23382997, This study demonstrated the prognostic import of frailty in a cohort of injection drug users with HIV infcction
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Piggott DA, Muzaale AD, Mehta SH, Brown TT, Patel KV, Leng SX, et al. Frailty, HIV infection, and mortality in an aging cohort of injection drug users. PLoS ONE. 2013;8(1):e54910. This study demonstrated the prognostic import of frailty in a cohort of injection drug users with HIV infcction.
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(2013)
PLoS ONE
, vol.8
, Issue.1
, pp. e54910
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Piggott, D.A.1
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Brown, T.T.4
Patel, K.V.5
Leng, S.X.6
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3
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63149194327
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Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-1 infected men
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This study illustrated the relationship between the frailty-related phenotype studied and the CD4 cell count in HIV-infected and -uninfected men who have sex with men
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Desquilbet L, Margolick JB, Fried LP, Phair JP, Jamieson BD, Holloway M, et al. Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-1 infected men. J Acquir Immun Defic Syndr. 2009;50:299–306. This study illustrated the relationship between the frailty-related phenotype studied and the CD4 cell count in HIV-infected and -uninfected men who have sex with men.
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(2009)
J Acquir Immun Defic Syndr
, vol.50
, pp. 299-306
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Desquilbet, L.1
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Fried, L.P.3
Phair, J.P.4
Jamieson, B.D.5
Holloway, M.6
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4
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77950361861
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Factors associated with preclinical disability and frailty among HIV-infected and HIV-uninfected women in the era of cART
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Terzian AS, Holman S, Nathwani N, Robison E, Weber K, Young M, et al. Factors associated with preclinical disability and frailty among HIV-infected and HIV-uninfected women in the era of cART. J Womens Health (Larchmt). 2009;18(12):1965–74.
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Terzian, A.S.1
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5
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84872075650
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Frailty in HIV-infected adults in South Africa
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PID: 23018372
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Pathai S, Gilbert C, Weiss HA, Cook C, Wood R, Bekker LG, et al. Frailty in HIV-infected adults in South Africa. J Acquir Immune Defic Syndr. 2013;62(1):43–51.
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J Acquir Immune Defic Syndr
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Pathai, S.1
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6
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84924263641
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An adapted frailty-related phenotype and the VACS index as predictors of hospitalization and mortality in HIV-infected and uninfected individuals
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PID: 25202921, Using a modified frailty phenotype, this study demonstrated the clinical import of frailty in HIV-infected and -unifected veterans
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Akgün KM, Tate JP, Crothers K, Crystal S, Leaf DA, Womack J, et al. An adapted frailty-related phenotype and the VACS index as predictors of hospitalization and mortality in HIV-infected and uninfected individuals. JAIDS. 2014;67:397–404. Using a modified frailty phenotype, this study demonstrated the clinical import of frailty in HIV-infected and -unifected veterans.
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(2014)
JAIDS
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, pp. 397-404
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Akgün, K.M.1
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Leaf, D.A.5
Womack, J.6
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7
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2442699834
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This paper described the frailty phenotype that has been most widely used and is focused on in the present review
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Fried L, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol Med Sci. 2001;56A:M146–56. This paper described the frailty phenotype that has been most widely used and is focused on in the present review.
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J Gerontol Med Sci
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Fried, L.1
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Gottdiener, J.6
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8
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33646014444
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Phenotype of frailty: characterization in the women’s health and aging studies
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PID: 16567375
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Bandeen-Roche K, Xue QL, Ferrucci L, Walston J, Guralnik JM, Chaves P, et al. Phenotype of frailty: characterization in the women’s health and aging studies. J Gerontol A Biol Sci Med Sci. 2006;61(3):262–6.
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J Gerontol A Biol Sci Med Sci
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Bandeen-Roche, K.1
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9
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0036197712
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Dynamics of stability: the physiologic basis of functional health and frailty
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Lipsitz LA. Dynamics of stability: the physiologic basis of functional health and frailty. J Gerontol A Biol Sci Med Sci. 2002;57(3):B115–25.
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Lipsitz, L.A.1
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10
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Fried LP, Hadley EC, Walston JD, Newman AB, Guralnik JM, Studenski S, et al. From bedside to bench: research agenda for frailty. Sci Aging Knowl Environ. 2005;2005(31):e24.
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Fried, L.P.1
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Studenski, S.6
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11
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33744913541
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Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults
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PID: 16776798
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Walston J, Hadley EC, Ferrucci L, Guralnik JM, Newman AB, Studenski SA, et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc. 2006;54(6):991–1001.
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Walston, J.1
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Studenski, S.A.6
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12
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78549269118
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Yao X, Li H, Leng SX. Inflammation and immune system alterations in frailty. Clin Geriatr Med. 2011;27(1):79–87.
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84878860296
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PID: 23764209, This paper reviews the basis for considering frailty as a clnical syndrome that merits attention in clinical care
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Morley JE, Vellas B, van Kan GA, Anker SD, Bauer JM, Bernabei R, et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14(6):392–7. This paper reviews the basis for considering frailty as a clnical syndrome that merits attention in clinical care.
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Morley, J.E.1
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Bernabei, R.6
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15
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69949102187
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Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment
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PID: 19567825, This paper explores the multisystem nature of frailty
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Fried LP, Xue QL, Cappola AR, Ferrucci L, Chaves P, Varadhan R, et al. Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci. 2009;64(10):1049–57. This paper explores the multisystem nature of frailty.
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J Gerontol A Biol Sci Med Sci
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Fried, L.P.1
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Varadhan, R.6
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Jones DM, Song X, Rockwood K. Operationalizing a frailty index from a standardized comprehensive geriatric assessment. J Am Geriatr Soc. 2004;52(11):1929–33.
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84910012937
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Frailty in people aging with human immunodeficiency virus (HIV) infection
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PID: 24903667, This paper reviews the clinical aspects of frailty and studies of frailty in people living with HIV infection
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Brothers TD, Kirkland S, Guaraldi G, Falutz J, Theou O, Johnston BL, et al. Frailty in people aging with human immunodeficiency virus (HIV) infection. J Infect Dis. 2014;210(8):1170–9. This paper reviews the clinical aspects of frailty and studies of frailty in people living with HIV infection.
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Brothers, T.D.1
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18
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Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci. 2004;59(3):255–63.
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20
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62149122567
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Alvarado BE, Zunzunegui MV, Beland F, Bamvita JM. Life course social and health conditions linked to frailty in Latin American older men and women. J Gerontol A Biol Sci Med Sci. 2008;63(12):1399–406.
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Buchman AS, Boyle PA, Wilson RS, Tang Y, Bennett DA. Frailty is associated with incident Alzheimer’s disease and cognitive decline in the elderly. Psychosom Med. 2007;69(5):483–9.
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COI: 1:CAS:528:DC%2BC3MXivVWht7Y%3D, PID: 21090961, This is a thorough review of evidence linking inflammation with aging in people with and without HIV infection
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Deeks SG. HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med. 2011;62:141–55. This is a thorough review of evidence linking inflammation with aging in people with and without HIV infection.
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Deeks, S.G.1
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Desquilbet L, Jacobson L, Fried LP, Phair JP, Jamieson BD, Holloway M, et al. A frailty-related phenotype before HAART initiation as an independent risk factor for AIDS or death after HAART among HIV-infected men. J Gerontol A Biol Sci Med Sci. 2011;66A:1030–8. This paper provides evidene that a frailty-related phenotype independently predicted onset of AIDS or death in a cohort of men who have sex with men.
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41
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84896743037
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Age, comorbidities and AIDS predict the frailty phenotype in men who have sex with men
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This paper reports data on the prevalence of the frailty phenotype in men who have sex with men, as well as factors associated with the incidence of this phenotype
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Althoff KN, Jacobson LP, Cranston RD, Detels R, Phair JP, Li X, et al. Age, comorbidities and AIDS predict the frailty phenotype in men who have sex with men. J Gerontol A Biol Sci Med Sci. 2014;69A:189–98. This paper reports data on the prevalence of the frailty phenotype in men who have sex with men, as well as factors associated with the incidence of this phenotype.
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J Gerontol A Biol Sci Med Sci
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Althoff, K.N.1
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42
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43
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47
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Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study
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PID: 12133023, This paper was the first reporting supportive evidence for chronic inflammation as indicated by elevated IL-6 levels in frailty in the geriatric population
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Leng S, Chaves P, Koenig K, Walston J. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study. J Am Geriatr Soc. 2002;50(7):1268–71. This paper was the first reporting supportive evidence for chronic inflammation as indicated by elevated IL-6 levels in frailty in the geriatric population.
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Walston J, McBurnie MA, Newman A, Tracy RP, Kop WJ, Hirsch CH, et al. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med. 2002;162(20):2333–41.
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49
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Schmaltz HN, Fried LP, Xue QL, Walston J, Leng SX, Semba RD. Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. J Am Geriatr Soc. 2005;53(5):747–54.
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PID: 17537086, This paper further describes chronic inflammation as indicated by both higher IL-6 levels and white blood cell counts in frailty in the geriatric population
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Leng SX, Xue QL, Tian J, Walston JD, Fried LP. Inflammation and frailty in older women. J Am Geriatr Soc. 2007;55(6):864–71. This paper further describes chronic inflammation as indicated by both higher IL-6 levels and white blood cell counts in frailty in the geriatric population.
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Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: results from the Women’s Health and Aging Studies I
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CCR5 is characteristic of Th1 lymphocytes
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Decreased cell proliferation and altered cytokine production in frail older adults
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Leng SX, Yang H, Walston JD. Decreased cell proliferation and altered cytokine production in frail older adults. Aging Clin Exp Res. 2004;16(3):249–52.
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Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14(+) monocytes in frail older adults
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Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty
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Qu T, Yang H, Walston JD, Fedarko NS, Leng SX. Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty. Cytokine. 2009;46(3):319–24.
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IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults
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Leng SX, Tian X, Matteini A, Li H, Hughes J, Jain A, et al. IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults. Age Ageing. 2011;40(4):475–81.
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Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels
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Impact of anemia and cardiovascular disease on frailty status of community-dwelling older women: the Women’s Health and Aging Studies I and II
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Leng SX, Cappola AR, Andersen RE, Blackman MR, Koenig K, Blair M, et al. Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty. Aging Clin Exp Res. 2004;16(2):153–7.
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Residual immune dysregulation syndrome in treated HIV infection
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COI: 1:CAS:528:DC%2BC3sXhs1CmsLjM, PID: 23886064, This paper reviews the mechanisms of immune activation that persists in people with well-treated HIV infection
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Lederman MM, Funderburg NT, Sekaly RP, Klatt NR, Hunt PW. Residual immune dysregulation syndrome in treated HIV infection. Adv Immunol. 2013;119:51–83. This paper reviews the mechanisms of immune activation that persists in people with well-treated HIV infection.
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Effect of highly active antiretroviral therapy on biomarkers of B-lymphocyte activation and inflammation
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Regidor DL, Detels R, Breen EC, Widney DP, Jacobson LP, Palella F, et al. Effect of highly active antiretroviral therapy on biomarkers of B-lymphocyte activation and inflammation. AIDS. 2011;25(3):303–14.
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Shiels MS, Pfeiffer RM, Engels EA. Age at cancer diagnosis among persons with AIDS in the United States. Ann Intern Med. 2010;153(7):452–60. This paper shows the effect of underlying age distributions in estimating relative rates of cancer (and by implication any disease) in groups that are not the same age.
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Association of functional impairment with inflammation and immune activation in HIV type 1-infected adults receiving effective antiretroviral therapy
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COI: 1:CAS:528:DC%2BC3sXhtVehsrnL, PID: 23559466, This is one of the few studies to examine inflammation and frailty in people with HIV infection
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Erlandson KM, Allshouse AA, Jankowski CM, Lee EJ, Rufner KM, Palmer BE, et al. Association of functional impairment with inflammation and immune activation in HIV type 1-infected adults receiving effective antiretroviral therapy. J Infect Dis. 2013;208(2):249–59. This is one of the few studies to examine inflammation and frailty in people with HIV infection.
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Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV?
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