A frailty-related phenotype before HAART initiation as an independent risk factor for AIDS or death after HAART among HIV-infected men

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 66 A, Issue 9, 2011, Pages 1030-1038

  Desquilbet, Loic ^a,b   Jacobson, Lisa P ^b   Fried, Linda P ^c   Phair, John P ^d,e   Jamieson, Beth D ^f   Holloway, Marcy ^g   Margolick, Joseph B ^b  

^a Alfort National Veterinary School (ENVA)   (France)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c Columbia University ^*  (United States)

^d HOWARD BROWN HEALTH CENTER   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Aging; Frailty; HAART response; HIV; Survival analysis

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AGED; ARTICLE; CD4 LYMPHOCYTE COUNT; CLINICAL TRIAL; FRAIL ELDERLY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; MORTALITY; MULTICENTER STUDY; PHENOTYPE; RISK FACTOR;

ACQUIRED IMMUNODEFICIENCY SYNDROME; AGED; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; FRAIL ELDERLY; HIV INFECTIONS; HUMANS; MALE; PHENOTYPE; RISK FACTORS;

EID: 80053537570     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glr097     Document Type: Article

References (46)

1. Fried LP. Conference on the physiologic basis of frailty. April 28, 1992, Baltimore, MD, U.S.A. Introduction. Aging (Milano). 1992;4:251-252.
2. Campbell AJ, Buchner DM. Unstable disability and the fluctuations of frailty. Age Ageing. 1997;26:315-318. (Pubitemid 27361648)
3. Ferrucci L, Cavazzini C, Corsi A, et al. Biomarkers of frailty in older persons. J Endocrinol Invest. 2002;25:10-15.
4. Bandeen-Roche K, Xue QL, Ferrucci L, et al. Phenotype of frailty: characterization in the Women's Health and Aging Studies. J Gerontol A Biol Sci Med Sci. 2006;61:62-66.
5. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Med Sci. 2001;56:M146-M156. (Pubitemid 32187141)
6. Fried LP, Walston J. Frailty and failure to thrive. In: Hazzard WR, Blass JP, Ettinger WH Jr, Halter JB, Ouslander J., eds. Principles of Geriatric Medicine and Gerontology. New York, NY: McGraw Hill; 1998:1387-1402.
7. Lipsitz LA. Physiological complexity, aging, and the path to frailty. Sci Aging Knowledge Environ. 2004;2004:16.
8. Fried LP, Hadley EC, Walston JD, et al. From bedside to bench: research agenda for frailty. Sci Aging Knowledge Environ. 2005;2005:24.
9. Kang HG, Costa MD, Priplata AA, et al. Frailty and the degradation of complex balance dynamics during a dual-task protocol. J Gerontol A Biol Sci Med Sci. 2009;64:1304-1311.
10. Fried LP, Xue QL, Cappola AR, et al. Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci. 2009;64:1049-1057.
11. Walston J, Hadley EC, Ferrucci L, et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc. 2006;54:991-1001. (Pubitemid 43847040)
12. Paganelli R, Di Iorio A, Cherubini A, et al. Frailty of older age: the role of the endocrine-immune interaction. Curr Pharm Des. 2006;12:3147-3159. (Pubitemid 44227575)
13. Resnicow K, Page SE. Embracing chaos and complexity: a quantum change for public health. Am J Public Health. 2008;98:1382-1389.
14. Fried LP. Response to: "understanding frailty". J Gerontol A Biol Sci Med Sci. 2010;65:257.
15. Bortz W. Understanding frailty. J Gerontol A Biol Sci Med Sci. 2010;65:255-256; discussion 257.
16. Klein BE, Klein R, Knudtson MD, Lee KE. Frailty, morbidity and survival. Arch Gerontol Geriatr. 2005;41:141-149. (Pubitemid 41115760)
17. Cawthon PM, Marshall LM, Michael Y, et al. Frailty in older men: prevalence, progression, and relationship with mortality. J Am Geriatr Soc. 2007;55:1216-1223. (Pubitemid 47106689)
18. Woods NF, LaCroix AZ, Gray SL, et al. Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc. 2005;53:1321-1330. (Pubitemid 41602477)
19. Ahmed N, Mandel R, Fain MJ. Frailty: an emerging geriatric syndrome. Am J Med. 2007;120:748-753. (Pubitemid 47313334)
20. Boyd CM, Xue QL, Simpson CF, Guralnik JM, Fried LP. Frailty, hospitalization, and progression of disability in a cohort of disabled older women. Am J Med. 2005;118:1225-1231. (Pubitemid 41566523)
21. Desquilbet L, Jacobson LP, Fried LP, et al. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. J Gerontol A Biol Sci Med Sci. 2007;62:1279-1286. (Pubitemid 350287617)
22. Desquilbet L, Margolick JB, Fried LP, et al. Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-infected men. J Acquir Immune Defic Syndr. 2009;50:299-306.
23. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci. 2004;59:255-263. (Pubitemid 38375339)
24. Topinkova E. Aging, disability and frailty. Ann Nutr Metab. 2008;52(suppl 1):6-11. (Pubitemid 351496697)
25. Kaslow RA, Ostrow DG, Detels R, Phair JP, Polk BF, Rinaldo CR Jr. The Multicenter AIDS Cohort Study: rationale, organization, and selected characteristics of the participants. Am J Epidemiol. 1987;126:310-318. (Pubitemid 17102758)
26. Jacobson LP, Kirby AJ, Polk S, et al. Changes in survival after acquired immunodeficiency syndrome (AIDS): 1984-1991. Am J Epidemiol. 1993;138:952-964. (Pubitemid 24002361)
27. McHorney CA, Ware JE Jr., Lu JF, Sherbourne CD. The MOS 36-item Short-Form Health Survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups. Med Care. 1994;32:40-66.
28. Radloff LS. The CES-D Scale: a self-report depression scale for research in the general population. Appl Psychol Meas. 1977;1:385-401.
29. Jacobson LP, Phair JP, Yamashita TE. Update on the virologic and immunologic response to highly active antiretroviral therapy. Curr Infect Dis Rep. 2004;6:325-332. (Pubitemid 39173566)
30. Schenker EL, Hultin LE, Bauer KD, Ferbas J, Margolick JB, Giorgi JV. Evaluation of a dual-color flow cytometry immunophenotyping panel in a multicenter quality assurance program. Cytometry. 1993;14:307-317. (Pubitemid 23089082)
31. Sterling RK, Lissen E, Clumeck N, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology. 2006;43:1317-1325. (Pubitemid 43980111)
32. Wai CT, Greenson JK, Fontana RJ, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology. 2003;38:518-526. (Pubitemid 36919874)
33. Levey AS, Coresh J, Greene T, et al. Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values. Clin Chem. 2007;53:766-772. (Pubitemid 46580250)
34. Dybul M, Fauci AS, Bartlett JG, Kaplan JE, Pau AK. Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Ann Intern Med. 2002;137:381-433.
35. Centers for Disease Control and Prevention. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Recomm Rep. 1992;41:1-19.
36. Durrleman S, Simon R. Flexible regression models with cubic splines. Stat Med. 1989;8:551-561. (Pubitemid 19116001)
37. Desquilbet L, Mariotti F. Dose-response analyses using restricted cubic spline functions in public health research. Stat Med. 2010;29:1037-1057.
38. Hammer SM, Eron JJ Jr, Reiss P, et al. Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel. JAMA. 2008;300:555-570.
39. May M, Sterne JA, Sabin C, et al. Prognosis of HIV-1-infected patients up to 5 years after initiation of HAART: collaborative analysis of prospective studies. AIDS. 2007;21:1185-1197. (Pubitemid 46763289)
40. Harris RJ, Sterne JA, Abgrall S, et al. Prognostic importance of anaemia in HIV type-1-infected patients starting antiretroviral therapy: collaborative analysis of prospective cohort studies. Antivir Ther. 2008;13:959-967.
41. Justice AC, McGinnis KA, Skanderson M, et al. Towards a combined prognostic index for survival in HIV infection: the role of 'non-HIV' biomarkers. HIV Med. 2010;11:143-151.
42. Bortz WM II. A conceptual framework of frailty: a review. J Gerontol A Med Sci. 2002;57:M283-M288.
43. Ferrucci L, Guralnik JM, Cavazzini C, et al. The frailty syndrome: a critical issue in geriatric oncology. Crit Rev Oncol Hematol. 2003;46:127-137. (Pubitemid 36444632)
44. Whitson HE, Purser JL, Cohen HJ. Frailty thy name is. Phrailty? J Gerontol A Biol Sci Med Sci. 2007;62:728-730.
45. Makary MA, Segev DL, Pronovost PJ, et al. Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg. 2010;210:901-908.
46. Turner RC, Millns H, Neil HA, Stratton IM, Manley SE, Matthews DR, Holman RR. Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23). BMJ. 1998;316:823-828. (Pubitemid 28112428)