Targeting 12-lipoxygenase as a novel strategy to combat the effects of inflammation on beta cells in diabetes

Diabetologia

Volumn 58, Issue 3, 2015, Pages 425-428

  Ehses, Jan A ^a   Donath, Marc Y ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

12 Lipoxygenase; Apoptosis; Cytokines; Diabetes; Hydroxyeicosatetraenoic acid; Inflammation; Insulin secretion; Pancreatic beta cell; Pancreatic islet

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; ANTIINFLAMMATORY AGENT; ARACHIDONATE 12 LIPOXYGENASE; CALCIUM INDEPENDENT PHOSPHOLIPASE A2; COPPER ZINC SUPEROXIDE DISMUTASE; GAMMA INTERFERON; GLUTATHIONE PEROXIDASE 1; INTERLEUKIN 12P40; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; SALSALATE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; ENZYME INHIBITOR;

ANTIINFLAMMATORY ACTIVITY; CLINICAL TRIAL (TOPIC); CYTOKINE RESPONSE; DIABETES MELLITUS; EDITORIAL; ENZYME ACTIVATION; HUMAN; IMMUNITY; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN TREATMENT; MACROPHAGE; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN TARGETING; ANIMAL; DRUG EFFECTS; MALE; METABOLISM;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ENZYME INHIBITORS; HUMANS; INSULIN-SECRETING CELLS; MALE;

EID: 84925494096     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3482-7     Document Type: Editorial

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