Inhibition of Ca2+-independent phospholipase A2β (iPLA2β) ameliorates islet infiltration and incidence of diabetes in NOD mice

Diabetes

Volumn 64, Issue 2, 2015, Pages 541-554

  Bone, Robert N ^a,b   Gai, Ying ^b,c   Magrioti, Victoria ^d   Kokotou, Maroula G ^d   Ali, Tomader ^b,c   Lei, Xiaoyong ^b,c   Tse, Hubert M ^b,e   Kokotos, George ^d   Ramanadham, Sasanka ^b,c  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF ATHENS   (Greece)

^e University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,8,11,14 ICOSATETRAYNOIC ACID; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONIC ACID; CALCIUM ION; CD4 ANTIGEN; FKGK 18; GAMMA INTERFERON; ICOSANOID; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INDOMETACIN; INSULIN; INTERLEUKIN 2; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; NORDIHYDROGUAIARETIC ACID; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PHOSPHOLIPASE A2BETA; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 1,1,1-TRIFLUORO-6-(NAPHTHALEN-2-YL)HEXAN-2-ONE; CALCIUM; GLUCOSE; ISOPROTEIN; KETONE; NAPHTHALENE DERIVATIVE; PHOSPHOLIPASE A2 GROUP VI; PLA2G6 PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; CELL DEATH; CELL FUNCTION; CELL INFILTRATION; CELL VIABILITY; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG BIOAVAILABILITY; ENZYME INHIBITION; FEMALE; GLUCOSE HOMEOSTASIS; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; INCIDENCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MALE; MOUSE; NONHUMAN; ORGAN PRESERVATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE; T LYMPHOCYTE; ANIMAL; B LYMPHOCYTE; BIOAVAILABILITY; CD4+ T LYMPHOCYTE; CHEMICAL STRUCTURE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; METABOLISM; NONOBESE DIABETIC MOUSE;

ANIMALS; B-LYMPHOCYTES; BIOLOGICAL AVAILABILITY; CALCIUM; CD4-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; GROUP VI PHOSPHOLIPASES A2; HOMEOSTASIS; INSULIN; INSULIN-SECRETING CELLS; KETONES; MICE; MICE, INBRED NOD; MOLECULAR STRUCTURE; NAPHTHALENES; PROTEIN ISOFORMS;

EID: 84921907797     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0097     Document Type: Article

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