-
1
-
-
84856718606
-
Fas death receptor signalling: Roles of Bid and XIAP
-
Kaufmann T, Strasser A, Jost PJ. Fas death receptor signalling: roles of Bid and XIAP. Cell Death Differ 2012; 19: 42-50.
-
(2012)
Cell Death Differ
, vol.19
, pp. 42-50
-
-
Kaufmann, T.1
Strasser, A.2
Jost, P.J.3
-
2
-
-
0033667778
-
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
-
Sprick MR, Weigand MA, Rieser E, Rauch CT, Juo P, Blenis J et al. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity 2000; 12: 599-609.
-
(2000)
Immunity
, vol.12
, pp. 599-609
-
-
Sprick, M.R.1
Weigand, M.A.2
Rieser, E.3
Rauch, C.T.4
Juo, P.5
Blenis, J.6
-
3
-
-
33845977959
-
Mitochondrial membrane permeabilization in cell death
-
Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol Rev 2007; 87: 99-163.
-
(2007)
Physiol Rev
, vol.87
, pp. 99-163
-
-
Kroemer, G.1
Galluzzi, L.2
Brenner, C.3
-
5
-
-
84890909335
-
Control of apoptosis by the BCL-2 protein family: Implications for physiology and therapy
-
Czabotar PE, Lessene G, Strasser A, Adams JM. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol 2014; 15: 49-63.
-
(2014)
Nat Rev Mol Cell Biol
, vol.15
, pp. 49-63
-
-
Czabotar, P.E.1
Lessene, G.2
Strasser, A.3
Adams, J.M.4
-
6
-
-
29144463145
-
The multidomain proapoptotic molecules Bax and Bak are directly activated by heat
-
Pagliari LJ, Kuwana T, Bonzon C, Newmeyer DD, Tu S, Beere HM et al. The multidomain proapoptotic molecules Bax and Bak are directly activated by heat. Proc Natl Acad Sci USA 2005; 102: 17975-17980.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17975-17980
-
-
Pagliari, L.J.1
Kuwana, T.2
Bonzon, C.3
Newmeyer, D.D.4
Tu, S.5
Beere, H.M.6
-
7
-
-
47249135572
-
Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis
-
Nie C, Tian C, Zhao L, Petit PX, Mehrpour M, Chen Q. Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis. J Biol Chem 2008; 283: 15359-15369.
-
(2008)
J Biol Chem
, vol.283
, pp. 15359-15369
-
-
Nie, C.1
Tian, C.2
Zhao, L.3
Petit, P.X.4
Mehrpour, M.5
Chen, Q.6
-
9
-
-
0031037897
-
The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
-
Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 1997; 275: 1132-1136.
-
(1997)
Science
, vol.275
, pp. 1132-1136
-
-
Kluck, R.M.1
Bossy-Wetzel, E.2
Green, D.R.3
Newmeyer, D.D.4
-
10
-
-
73349091842
-
The role of mitochondria in apoptosis
-
Wang C, Youle RJ. The role ofmitochondria in apoptosis. Annu Rev Genet 2009; 43: 95-118.
-
(2009)
Annu Rev Genet
, vol.43
, pp. 95-118
-
-
Wang, C.1
Youle, R.J.2
-
11
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91: 479-489.
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
Nijhawan, D.2
Budihardjo, I.3
Srinivasula, S.M.4
Ahmad, M.5
Alnemri, E.S.6
-
12
-
-
0030745646
-
Apaf-1a human protein homologous to C. Elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
-
Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 1997; 90: 405-413.
-
(1997)
Cell
, vol.90
, pp. 405-413
-
-
Zou, H.1
Henzel, W.J.2
Liu, X.3
Lutschg, A.4
Wang, X.5
-
13
-
-
67650642160
-
SnapShot: BCL-2 proteins
-
Hardwick JM, Youle RJ. SnapShot: BCL-2 proteins. Cell 2009; 138: 404 404.e1.
-
(2009)
Cell
, vol.138
, pp. 404-404e1
-
-
Hardwick, J.M.1
Youle, R.J.2
-
14
-
-
41149152733
-
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
-
Chipuk JE, Green DR. How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol 2008; 18: 157-164.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 157-164
-
-
Chipuk, J.E.1
Green, D.R.2
-
15
-
-
77958196417
-
Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition
-
Bachmann PS, Piazza RG, Janes ME, Wong NC, Davies C, Mogavero A et al. Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition. Blood 2010; 116: 3013-3022.
-
(2010)
Blood
, vol.116
, pp. 3013-3022
-
-
Bachmann, P.S.1
Piazza, R.G.2
Janes, M.E.3
Wong, N.C.4
Davies, C.5
Mogavero, A.6
-
16
-
-
0031785497
-
Bcl-2 but not Bax expression is associated with apoptosis in normal and transformed squamous epithelium
-
Drenning SD, Marcovitch AJ, Johnson DE, Melhem MF, Tweardy DJ, Grandis JR. Bcl-2 but not Bax expression is associated with apoptosis in normal and transformed squamous epithelium. Clin Cancer Res 1998; 4: 2913-2921.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 2913-2921
-
-
Drenning, S.D.1
Marcovitch, A.J.2
Johnson, D.E.3
Melhem, M.F.4
Tweardy, D.J.5
Grandis, J.R.6
-
17
-
-
0029868457
-
Bcl-2 protein expression correlates with recurrence and survival in early stage head and neck cancer treated by radiotherapy
-
Gallo O, Boddi V, Calzolari A, Simonetti L, Trovati M, Bianchi S. bcl-2 protein expression correlates with recurrence and survival in early stage head and neck cancer treated by radiotherapy. Clin Cancer Res 1996; 2: 261-267.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 261-267
-
-
Gallo, O.1
Boddi, V.2
Calzolari, A.3
Simonetti, L.4
Trovati, M.5
Bianchi, S.6
-
18
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005; 435: 677-681.
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
Armstrong, R.C.4
Augeri, D.J.5
Belli, B.A.6
-
19
-
-
44849112219
-
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
-
Tse C, Shoemaker AR, Adickes J, Anderson MG, Chen J, Jin S et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res 2008; 68: 3421-3428.
-
(2008)
Cancer Res
, vol.68
, pp. 3421-3428
-
-
Tse, C.1
Shoemaker, A.R.2
Adickes, J.3
Anderson, M.G.4
Chen, J.5
Jin, S.6
-
20
-
-
84873540049
-
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
-
Souers AJ, Leverson JD, Boghaert ER, Ackler SL, Catron ND, Chen J et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med 2013; 19: 202-208.
-
(2013)
Nat Med
, vol.19
, pp. 202-208
-
-
Souers, A.J.1
Leverson, J.D.2
Boghaert, E.R.3
Ackler, S.L.4
Catron, N.D.5
Chen, J.6
-
21
-
-
84899992324
-
The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells
-
Wang B, Ni Z, Dai X, Qin L, Li X, Xu L et al. The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells. Mol Cancer 2014; 13: 98.
-
(2014)
Mol Cancer
, vol.13
, pp. 98
-
-
Wang, B.1
Ni, Z.2
Dai, X.3
Qin, L.4
Li, X.5
Xu, L.6
-
22
-
-
79960119761
-
Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA
-
Albershardt TC, Salerni BL, Soderquist RS, Bates DJ, Pletnev AA, Kisselev AF et al. Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA. J Biol Chem 2011; 286: 24882-24895.
-
(2011)
J Biol Chem
, vol.286
, pp. 24882-24895
-
-
Albershardt, T.C.1
Salerni, B.L.2
Soderquist, R.S.3
Bates, D.J.4
Pletnev, A.A.5
Kisselev, A.F.6
-
23
-
-
37649023004
-
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
-
Nguyen M, Marcellus RC, Roulston A, Watson M, Serfass L, Murthy Madiraju SR et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci USA 2007; 104: 19512-19517.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19512-19517
-
-
Nguyen, M.1
Marcellus, R.C.2
Roulston, A.3
Watson, M.4
Serfass, L.5
Murthy Madiraju, S.R.6
-
24
-
-
76149104286
-
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
-
Geserick P, Hupe M, Moulin M, Wong WW, Feoktistova M, Kellert B et al. Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment. J Cell Biol 2009; 187: 1037-1054.
-
(2009)
J Cell Biol
, vol.187
, pp. 1037-1054
-
-
Geserick, P.1
Hupe, M.2
Moulin, M.3
Wong, W.W.4
Feoktistova, M.5
Kellert, B.6
-
25
-
-
0037305877
-
Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation
-
Leverkus M, Sprick MR, Wachter T, Mengling T, Baumann B, Serfling E et al. Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation. Mol Cell Biol 2003; 23: 777-790.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 777-790
-
-
Leverkus, M.1
Sprick, M.R.2
Wachter, T.3
Mengling, T.4
Baumann, B.5
Serfling, E.6
-
26
-
-
0034790570
-
Tumor progression of skin carcinoma cells in vivo promoted by clonal selection, mutagenesis, and autocrine growth regulation by granulocyte colony-stimulating factor and granulocytemacrophage colony-stimulating factor
-
Mueller MM, Peter W, Mappes M, Huelsen A, Steinbauer H, Boukamp P et al. Tumor progression of skin carcinoma cells in vivo promoted by clonal selection, mutagenesis, and autocrine growth regulation by granulocyte colony-stimulating factor and granulocytemacrophage colony-stimulating factor. Am J Pathol 2001; 159: 1567-1579.
-
(2001)
Am J Pathol
, vol.159
, pp. 1567-1579
-
-
Mueller, M.M.1
Peter, W.2
Mappes, M.3
Huelsen, A.4
Steinbauer, H.5
Boukamp, P.6
-
27
-
-
84255210700
-
Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012
-
Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 2012; 19: 107-120.
-
(2012)
Cell Death Differ
, vol.19
, pp. 107-120
-
-
Galluzzi, L.1
Vitale, I.2
Abrams, J.M.3
Alnemri, E.S.4
Baehrecke, E.H.5
Blagosklonny, M.V.6
-
29
-
-
77956095537
-
Mitochondria and cell death: Outer membrane permeabilization and beyond
-
Tait SW, Green DR. Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol 2010; 11: 621-632.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 621-632
-
-
Tait, S.W.1
Green, D.R.2
-
30
-
-
2942581328
-
Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex i of the electron transport chain
-
Ricci JE, Munoz-Pinedo C, Fitzgerald P, Bailly-Maitre B, Perkins GA, Yadava N et al. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell 2004; 117: 773-786.
-
(2004)
Cell
, vol.117
, pp. 773-786
-
-
Ricci, J.E.1
Munoz-Pinedo, C.2
Fitzgerald, P.3
Bailly-Maitre, B.4
Perkins, G.A.5
Yadava, N.6
-
31
-
-
0033601746
-
Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2,-3,-6,-7,-8, and-10 in a caspase-9-dependent manner
-
Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD et al. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2,-3,-6,-7,-8, and-10 in a caspase-9-dependent manner. J Cell Biol 1999; 144: 281-292.
-
(1999)
J Cell Biol
, vol.144
, pp. 281-292
-
-
Slee, E.A.1
Harte, M.T.2
Kluck, R.M.3
Wolf, B.B.4
Casiano, C.A.5
Newmeyer, D.D.6
-
32
-
-
54049145970
-
ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis
-
Song JH, Kandasamy K, Kraft AS. ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis. J Biol Chem 2008; 283: 25003-25013.
-
(2008)
J Biol Chem
, vol.283
, pp. 25003-25013
-
-
Song, J.H.1
Kandasamy, K.2
Kraft, A.S.3
-
33
-
-
67549141546
-
Different forms of cell death induced by putative BCL2 inhibitors
-
Vogler M, Weber K, Dinsdale D, Schmitz I, Schulze-Osthoff K, Dyer MJ et al. Different forms of cell death induced by putative BCL2 inhibitors. Cell Death Differ 2009; 16: 1030-1039.
-
(2009)
Cell Death Differ
, vol.16
, pp. 1030-1039
-
-
Vogler, M.1
Weber, K.2
Dinsdale, D.3
Schmitz, I.4
Schulze-Osthoff, K.5
Dyer, M.J.6
-
34
-
-
33646354381
-
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
-
Certo M, Del GMV, Nishino M, Wei G, Korsmeyer S, Armstrong SA et al. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 2006; 9: 351-365.
-
(2006)
Cancer Cell
, vol.9
, pp. 351-365
-
-
Certo, M.1
Del, G.M.V.2
Nishino, M.3
Wei, G.4
Korsmeyer, S.5
Armstrong, S.A.6
-
36
-
-
69249208481
-
XIAP discriminates between type i and type II FAS-induced apoptosis
-
Jost PJ, Grabow S, Gray D, McKenzie MD, Nachbur U, Huang DC et al. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature 2009; 460: 1035-1039.
-
(2009)
Nature
, vol.460
, pp. 1035-1039
-
-
Jost, P.J.1
Grabow, S.2
Gray, D.3
McKenzie, M.D.4
Nachbur, U.5
Huang, D.C.6
-
37
-
-
84876053292
-
Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma
-
He L, Torres-Lockhart K, Forster N, Ramakrishnan S, Greninger P, Garnett MJ et al. Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma. Cancer Discov 2013; 3: 324-337.
-
(2013)
Cancer Discov
, vol.3
, pp. 324-337
-
-
He, L.1
Torres-Lockhart, K.2
Forster, N.3
Ramakrishnan, S.4
Greninger, P.5
Garnett, M.J.6
-
38
-
-
84896744746
-
Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer
-
Nakajima W, Hicks MA, Tanaka N, Krystal GW, Harada H. Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung cancer. Cell Death Dis 2014; 5: e1052.
-
(2014)
Cell Death Dis
, vol.5
, pp. e1052
-
-
Nakajima, W.1
Hicks, M.A.2
Tanaka, N.3
Krystal, G.W.4
Harada, H.5
-
39
-
-
84884520490
-
BH3 mimetics: Status of the field and new developments
-
Billard C. BH3 mimetics: status of the field and new developments. Mol Cancer Ther 2013; 12: 1691-1700.
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 1691-1700
-
-
Billard, C.1
-
40
-
-
84862489317
-
Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells
-
Merino D, Khaw SL, Glaser SP, Anderson DJ, Belmont LD, Wong C et al. Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells. Blood 2012; 119: 5807-5816.
-
(2012)
Blood
, vol.119
, pp. 5807-5816
-
-
Merino, D.1
Khaw, S.L.2
Glaser, S.P.3
Anderson, D.J.4
Belmont, L.D.5
Wong, C.6
-
41
-
-
37249003222
-
The Bcl-2/Bcl-XL family inhibitor ABT-737 sensitizes ovarian cancer cells to carboplatin
-
Witham J, Valenti MR, De-Haven-Brandon AK, Vidot S, Eccles SA, Kaye SB et al. The Bcl-2/Bcl-XL family inhibitor ABT-737 sensitizes ovarian cancer cells to carboplatin. Clin Cancer Res 2007; 13: 7191-7198.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 7191-7198
-
-
Witham, J.1
Valenti, M.R.2
De-Haven-Brandon, A.K.3
Vidot, S.4
Eccles, S.A.5
Kaye, S.B.6
-
42
-
-
84862500662
-
P53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2/Bcl-XL inhibitor ABT-737
-
Tagscherer KE, Fassl A, Sinkovic T, Combs SE, Roth W. p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2/Bcl-XL inhibitor ABT-737. Apoptosis 2012; 17: 187-199.
-
(2012)
Apoptosis
, vol.17
, pp. 187-199
-
-
Tagscherer, K.E.1
Fassl, A.2
Sinkovic, T.3
Combs, S.E.4
Roth, W.5
-
43
-
-
42349098051
-
BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells
-
Huang S, Sinicrope FA. BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells. Cancer Res 2008; 68: 2944-2951.
-
(2008)
Cancer Res
, vol.68
, pp. 2944-2951
-
-
Huang, S.1
Sinicrope, F.A.2
-
44
-
-
44949186549
-
FLIP ing the coin? Death receptor-mediated signals during skin tumorigenesis
-
Leverkus M, Diessenbacher P, Geserick P. FLIP ing the coin? Death receptor-mediated signals during skin tumorigenesis. Exp Dermatol 2008; 17: 614-622.
-
(2008)
Exp Dermatol
, vol.17
, pp. 614-622
-
-
Leverkus, M.1
Diessenbacher, P.2
Geserick, P.3
-
46
-
-
84964575129
-
ABT-737 synergizes with Bortezomib to kill melanoma cells
-
Reuland SN, Goldstein NB, Partyka KA, Smith S, Luo Y, Fujita M et al. ABT-737 synergizes with Bortezomib to kill melanoma cells. Biol Open 2012; 1: 92-100.
-
(2012)
Biol Open
, vol.1
, pp. 92-100
-
-
Reuland, S.N.1
Goldstein, N.B.2
Partyka, K.A.3
Smith, S.4
Luo, Y.5
Fujita, M.6
-
47
-
-
84887670496
-
Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice
-
Meynet O, Zunino B, Happo L, Pradelli LA, Chiche J, Jacquin MA et al. Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice. Blood 2013; 122: 2402-2411.
-
(2013)
Blood
, vol.122
, pp. 2402-2411
-
-
Meynet, O.1
Zunino, B.2
Happo, L.3
Pradelli, L.A.4
Chiche, J.5
Jacquin, M.A.6
-
48
-
-
84892687335
-
The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA
-
Soderquist R, Pletnev AA, Danilov AV, Eastman A. The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA. Apoptosis 2014; 19: 201-209.
-
(2014)
Apoptosis
, vol.19
, pp. 201-209
-
-
Soderquist, R.1
Pletnev, A.A.2
Danilov, A.V.3
Eastman, A.4
-
49
-
-
58149331193
-
Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737
-
Okumura K, Huang S, Sinicrope FA. Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737. Clin Cancer Res 2008; 14: 8132-8142.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 8132-8142
-
-
Okumura, K.1
Huang, S.2
Sinicrope, F.A.3
-
50
-
-
44049083639
-
Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: A breakthrough in anticancer therapy?
-
Labi V, Grespi F, Baumgartner F, Villunger A. Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy? Cell Death Differ 2008; 15: 977-987.
-
(2008)
Cell Death Differ
, vol.15
, pp. 977-987
-
-
Labi, V.1
Grespi, F.2
Baumgartner, F.3
Villunger, A.4
-
51
-
-
63149186234
-
BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis
-
Miller LA, Goldstein NB, Johannes WU, Walton CH, Fujita M, Norris DA et al. BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis. J Invest Dermatol 2009; 129: 964-971.
-
(2009)
J Invest Dermatol
, vol.129
, pp. 964-971
-
-
Miller, L.A.1
Goldstein, N.B.2
Johannes, W.U.3
Walton, C.H.4
Fujita, M.5
Norris, D.A.6
-
52
-
-
84863082940
-
Modulation of NOXA and MCL-1 as a strategy for sensitizing melanoma cells to the BH3-mimetic ABT-737
-
Lucas KM, Mohana-Kumaran N, Lau D, Zhang XD, Hersey P, Huang DC et al. Modulation of NOXA and MCL-1 as a strategy for sensitizing melanoma cells to the BH3-mimetic ABT-737. Clin Cancer Res 2012; 18: 783-795.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 783-795
-
-
Lucas, K.M.1
Mohana-Kumaran, N.2
Lau, D.3
Zhang, X.D.4
Hersey, P.5
Huang, D.C.6
-
53
-
-
23144467530
-
Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: Role of wild-type p53 and Bcl-xL
-
Bauer JA, Trask DK, Kumar B, Los G, Castro J, Lee JS et al. Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL. Mol. Cancer Ther 2005l; 4: 1096-1104.
-
(2005)
Mol. Cancer Ther
, vol.4
, pp. 1096-1104
-
-
Bauer, J.A.1
Trask, D.K.2
Kumar, B.3
Los, G.4
Castro, J.5
Lee, J.S.6
-
54
-
-
78751513758
-
The BH3 mimetic ABT-737 induces cancer cell senescence
-
Song JH, Kandasamy K, Zemskova M, Lin YW, Kraft AS. The BH3 mimetic ABT-737 induces cancer cell senescence. Cancer Res 2011; 71: 506-515.
-
(2011)
Cancer Res
, vol.71
, pp. 506-515
-
-
Song, J.H.1
Kandasamy, K.2
Zemskova, M.3
Lin, Y.W.4
Kraft, A.S.5
-
55
-
-
80052714034
-
BH3 mimetics activate multiple pro-autophagic pathways
-
Malik SA, Orhon I, Morselli E, Criollo A, Shen S, Marino G et al. BH3 mimetics activate multiple pro-autophagic pathways. Oncogene 2011; 30: 3918-3929.
-
(2011)
Oncogene
, vol.30
, pp. 3918-3929
-
-
Malik, S.A.1
Orhon, I.2
Morselli, E.3
Criollo, A.4
Shen, S.5
Marino, G.6
-
56
-
-
84866654914
-
A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival
-
Cohen NA, Stewart ML, Gavathiotis E, Tepper JL, Bruekner SR, Koss B et al. A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem Biol 2012; 19: 1175-1186.
-
(2012)
Chem Biol
, vol.19
, pp. 1175-1186
-
-
Cohen, N.A.1
Stewart, M.L.2
Gavathiotis, E.3
Tepper, J.L.4
Bruekner, S.R.5
Koss, B.6
-
57
-
-
84858957737
-
Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation
-
Doi K, Li R, Sung SS, Wu H, Liu Y, Manieri W et al. Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. J Biol Chem 2012; 287: 10224-10235.
-
(2012)
J Biol Chem
, vol.287
, pp. 10224-10235
-
-
Doi, K.1
Li, R.2
Sung, S.S.3
Wu, H.4
Liu, Y.5
Manieri, W.6
-
58
-
-
0141569444
-
Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins
-
Kitada S, Leone M, Sareth S, Zhai D, Reed JC, Pellecchia M. Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem 2003; 46: 4259-4264.
-
(2003)
J Med Chem
, vol.46
, pp. 4259-4264
-
-
Kitada, S.1
Leone, M.2
Sareth, S.3
Zhai, D.4
Reed, J.C.5
Pellecchia, M.6
-
59
-
-
0034785591
-
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
-
Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell 2001; 8: 613-621.
-
(2001)
Mol Cell
, vol.8
, pp. 613-621
-
-
Suzuki, Y.1
Imai, Y.2
Nakayama, H.3
Takahashi, K.4
Takio, K.5
Takahashi, R.6
-
60
-
-
28044469866
-
Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance
-
Silke J, Kratina T, Chu D, Ekert PG, Day CL, Pakusch M et al. Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proc Natl Acad Sci USA 2005; 102: 16182-16187.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 16182-16187
-
-
Silke, J.1
Kratina, T.2
Chu, D.3
Ekert, P.G.4
Day, C.L.5
Pakusch, M.6
-
61
-
-
72149117664
-
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis
-
Vince JE, Pantaki D, Feltham R, Mace PD, Cordier SM, Schmukle AC et al. TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis. J Biol Chem 2009; 284: 35906-35915.
-
(2009)
J Biol Chem
, vol.284
, pp. 35906-35915
-
-
Vince, J.E.1
Pantaki, D.2
Feltham, R.3
Mace, P.D.4
Cordier, S.M.5
Schmukle, A.C.6
-
62
-
-
0034523634
-
Genetic characterization of a human skin carcinoma progression model: From primary tumor to metastasis
-
Popp S, Waltering S, Holtgreve-Grez H, Jauch A, Proby C, Leigh IM et al. Genetic characterization of a human skin carcinoma progression model: from primary tumor to metastasis. J Invest Dermatol 2000; 115: 1095-1103.
-
(2000)
J Invest Dermatol
, vol.115
, pp. 1095-1103
-
-
Popp, S.1
Waltering, S.2
Holtgreve-Grez, H.3
Jauch, A.4
Proby, C.5
Leigh, I.M.6
-
63
-
-
0023852747
-
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line
-
Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988; 106: 761-771.
-
(1988)
J Cell Biol
, vol.106
, pp. 761-771
-
-
Boukamp, P.1
Petrussevska, R.T.2
Breitkreutz, D.3
Hornung, J.4
Markham, A.5
Fusenig, N.E.6
-
64
-
-
0034030578
-
Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis
-
Proby CM, Purdie KJ, Sexton CJ, Purkis P, Navsaria HA, Stables JN et al. Spontaneous keratinocyte cell lines representing early and advanced stages of malignant transformation of the epidermis. Exp Dermatol 2000; 9: 104-117.
-
(2000)
Exp Dermatol
, vol.9
, pp. 104-117
-
-
Proby, C.M.1
Purdie, K.J.2
Sexton, C.J.3
Purkis, P.4
Navsaria, H.A.5
Stables, J.N.6
-
65
-
-
42149095910
-
NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2
-
Diessenbacher P, Hupe M, Sprick MR, Kerstan A, Geserick P, Haas TL et al. NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2. J Invest Dermatol 2008; 128: 1134-1147.
-
(2008)
J Invest Dermatol
, vol.128
, pp. 1134-1147
-
-
Diessenbacher, P.1
Hupe, M.2
Sprick, M.R.3
Kerstan, A.4
Geserick, P.5
Haas, T.L.6
-
66
-
-
33744944082
-
Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human
-
Bossen C, Ingold K, Tardivel A, Bodmer JL, Gaide O, Hertig S et al. Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J Biol Chem 2006; 281: 13964-13971.
-
(2006)
J Biol Chem
, vol.281
, pp. 13964-13971
-
-
Bossen, C.1
Ingold, K.2
Tardivel, A.3
Bodmer, J.L.4
Gaide, O.5
Hertig, S.6
-
67
-
-
43749119838
-
Suppression of cFLIP is sufficient to sensitize human melanoma cells to TRAIL-and CD95L-mediated apoptosis
-
Geserick P, Drewniok C, Hupe M, Haas TL, Diessenbacher P, Sprick MR et al. Suppression of cFLIP is sufficient to sensitize human melanoma cells to TRAIL-and CD95L-mediated apoptosis. Oncogene 2008; 27: 3211-3220.
-
(2008)
Oncogene
, vol.27
, pp. 3211-3220
-
-
Geserick, P.1
Drewniok, C.2
Hupe, M.3
Haas, T.L.4
Diessenbacher, P.5
Sprick, M.R.6
-
68
-
-
5944261448
-
Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins
-
Stassi G, Di LD, Todaro M, Zeuner A, Ricci-Vitiani L, Stoppacciaro A et al. Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins. Nat Immunol 2000; 1: 483-488.
-
(2000)
Nat Immunol
, vol.1
, pp. 483-488
-
-
Stassi, G.1
Di, L.D.2
Todaro, M.3
Zeuner, A.4
Ricci-Vitiani, L.5
Stoppacciaro, A.6
-
69
-
-
54249159248
-
Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic cancer growth in vitro and in vivo
-
Vogler M, Walczak H, Stadel D, Haas TL, Genze F, Jovanovic M et al. Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic cancer growth in vitro and in vivo. Cancer Res 2008; 68: 7956-7965.
-
(2008)
Cancer Res
, vol.68
, pp. 7956-7965
-
-
Vogler, M.1
Walczak, H.2
Stadel, D.3
Haas, T.L.4
Genze, F.5
Jovanovic, M.6
-
70
-
-
79955761920
-
Cellular FLICE-inhibitory protein (cFLIP) isoforms block
-
Kavuri SM, Geserick P, Berg D, Dimitrova DP, Feoktistova M, Siegmund D et al. Cellular FLICE-inhibitory protein (cFLIP) isoforms block. J Biol Chem 2011; 286: 16631-16646.
-
(2011)
J Biol Chem
, vol.286
, pp. 16631-16646
-
-
Kavuri, S.M.1
Geserick, P.2
Berg, D.3
Dimitrova, D.P.4
Feoktistova, M.5
Siegmund, D.6
-
71
-
-
0032415254
-
Simultaneous release of adenylate kinase and cytochrome c in cell death
-
Single B, Leist M, Nicotera P. Simultaneous release of adenylate kinase and cytochrome c in cell death. Cell Death Differ 1998; 5: 1001-1003.
-
(1998)
Cell Death Differ
, vol.5
, pp. 1001-1003
-
-
Single, B.1
Leist, M.2
Nicotera, P.3
|