bcl-2 protein expression correlates with recurrence and survival in early stage head and neck cancer treated by radiotherapy

Clinical Cancer Research

Volumn 2, Issue 2, 1996, Pages 261-267

  Gallo, Oreste ^a   Boddi, Vieri ^a   Calzolari, Anna ^a   Simonetti, Laura ^a   Trovati, Massimo ^a   Bianchi, Simonetta ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; EARLY CANCER; FEMALE; HEAD AND NECK CANCER; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SURVIVAL;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PROTO-ONCOGENE PROTEINS C-BCL-2; SURVIVAL RATE;

EID: 0029868457     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Parkin, D. M., Laara, E., and Muir, C. S. Estimates of the worldwide frequency of the sixteen major cancers in 1980. Int. J. Cancer, 41: 184-197, 1988.
2. Boring, C. C., Squires, T. S., and Tong, T. Cancer statistics, 1993. Cancer J. Clin., 43: 7-26, 1993.
3. Joseph, D. L , and Shumrick, D. A. Risks of head and neck surgery in previously irradiated patients. Arch. Otolaryngol., 104: 329-332, 1978.
4. Van den Bogaert, W., Ostyn, F., Lemkens, P., and Van der Schueren, E. Are postoperative complications more frequent and more serious after irradiation for laryngeal and hypopharyngeal cancers? Radiother. Oncol., 2: 31-36, 1984.
5. Suit, H. D. Local control and patient survival. Int. J. Radiat. Oncol. Biol. Phys., 23: 653-660, 1992.
6. Korsmeyer, S. J. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood, 80: 879-886, 1992.
7. Reed, J. C. Bcl-2 and the regulation of programmed cell death. J. Cell Biol., 124: 1-6, 1994.
8. Tsujimoto, Y., Yunis, J., Onorato-Showe, L., et al. Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(14;18) chromosome translocation. Science (Washington DC), 224: 1403-1406, 1984.
9. McDonnell, T. J., Troncoso, P., Brisbay, S. M., Logothetis, C. Chung, L. W. K., and Hsieh, J. T. Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res., 52: 6940-6944, 1992.
10. Silvestrini, R., Veneroni, S., Daidone, M. G., Benini, E., Boracchi, P., Mezzetti, M., Di Fronzo, G., Rilke, F., and Veronesi, U. The bcl-2 protein: a prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients. J. Natl. Cancer Inst., 86: 499-504, 1994.
11. Pezzella, F., Turley, H., Kuzu, I., Tungekar, M. F., Dunill, M. S., Pierce, C. B., Harris, A., Gatter, K. C., and Mason, D. Y. bcl-2 protein in non-small-cell lung carcinoma. N. Engl. J. Med., 329: 690-694, 1993.
12. Fontanini, G., Vignati, S., Mussi, A., Lucchi, M., Angeletti, C. A., Basolo, F., and Bevilacqua, G. Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer. Br. J. Cancer, 71: 1003-1007, 1995.
13. Reed, J. C., Meister, L., and Tanaka, S. Differential expression of bcl-2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin. Cancer Res., 51: 6529-6538, 1991.
14. Tron, V. A., Krajewski, S., Klein-Parker, G., Li, G., Ho, V. C., and Reed, J. C. Immunohistochemical analysis of bcl-2 protein regulation in cutaneous melanoma. Am. J. Pathol., 146: 643-650, 1995.
15. Hague, A., Moorghen, D., Hicks, M., et al. Bcl-2 expression in human colorectal adenomas and carcinomas. Oncogene, 9: 3367-3370, 1994.
16. Lowe, S. W., Ruley, H. E., Jacks, T., and Housman, D. E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74: 957-967, 1993.
17. Sentman, C. L., Shutter, J. R., Hockenbery, D., et al. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell, 67: 879-888, 1991.
18. Strasser, A., Harris, A. W., and Cory, S. Bcl-2 transgene inhibits T-cell death and perturbs thymic self-censorship. Cell, 67: 889-899, 1991.
19. Strasser, A., Harris, A. W., Jacks, T., and Cory, S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhabitable by bcl-2. Cell, 79: 329-339, 1994.
20. Dole, M., Nunez, G., Merchant, A., Maybaum, J., Rode, C. K., Bloch, C. A., and Castle, V. P. Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma. Cancer Res., 54: 3253-3259, 1994.
21. Kaplan, E. L., and Meier, P. Nonparametric estimations for incomplete observations. J. Am. Stat. Assoc., 53. 457-481, 1956.
22. Weichselbaum, R. R., Dahlberg, W., Beckett, M., Karrison, T., Miller, D., Clark, J., and Ervin, T. J. Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head and neck cancer patients. Proc. Natl. Acad. Sci. USA, 83: 2648-2688, 1986.
23. Weichselbaum, R. R., Beckett, M., Schwartz, J. L., and Dritschilo, A. Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy. Int. J. Radiat. Oncol. Biol. Phys., 15: 575-579, 1988.
24. Vaux, D., Cory, S., and Adams, J. Bcl-2 gene promotes haematopoietic cell survival and cooperates with c-myc to immortalize B-cells. Nature (Lond.), 335: 440-442, 1988.
25. Hockenbery, D. M , Zutter, M., Hickey, W., et al. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. USA, 88: 6961-6965, 1991.
26. Lu, Q., Elia, G., Lucas, S., and Thomas, J. A. BCL-2 protooncogene expression in Epstein-Barr virus associated nasopharyngeal carcinoma. Int. J. Cancer, 53: 29-35, 1993.
27. Gallo, O., Bianchi, S., and Porfirio, B. Bcl-2 overexpression and smoking history in head and neck cancer. J. Natl. Cancer Inst., 87: 1024-1025, 1995.
28. Castle, V. P., Heidelberg, K. P., Bromberg, J., et al. Expression of the apoptosis-suppressing protein bcl-2 in neuroblastoma is associated with unfavourable histology and N-myc amplification. Am J. Pathol., 143: 1543-1550, 1993.
29. Krajewski, S., Chatten, J., Hanada, M., and Reed, J. C. Immunohistochemical analysis of the bcl-2 oncoprotein in human neuroblastomas. Lab. Invest., 2: 42-54, 1995.
30. Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease. Science (Washington DC), 267: 1456-1462, 1995.