Role of the amino-terminal transmembrane domain of sulfonylurea receptor SUR2B for coupling to K IR6.2, ligand binding, and oligomerization

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 385, Issue 3, 2012, Pages 287-298

  Winkler, Marcus ^a,c   Kühner, Petra ^a   Russ, Ulrich ^a   Ortiz, David ^b   Bryan, Joseph ^b   Quast, Ulrich ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Allosteric coupling; Coupling K IR SUR; Ligand binding; Oligomerization of SUR2B; Sulfonylurea receptor 2; Transmembrane domain 0

Indexed keywords

2 CYANO 1 (1,1 DIMETHYLPROPYL) 3 (3 PYRIDYL)GUANIDINE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; GLIBENCLAMIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; REPAGLINIDE; SULFONYLUREA RECEPTOR; SULFONYLUREA RECEPTOR SUR2B; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIGAND BINDING; MOUSE; NONHUMAN; OLIGOMERIZATION; PROTEIN DOMAIN; RECEPTOR AFFINITY; SMOOTH MUSCLE;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; HEK293 CELLS; HUMANS; LIGANDS; MICE; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN STRUCTURE, TERTIARY; RADIOLIGAND ASSAY; RECEPTORS, DRUG;

EID: 84862879527     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-011-0708-9     Document Type: Article

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