AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 11, 2015, Pages 3511-3516

  Blair, Jessica M A ^a   Bavro, Vassiliy N ^a   Ricci, Vito ^a   Modi, Niraj ^b   Cacciotto, Pierpaolo ^c   Kleinekathöfer, Ulrich ^b   Ruggerone, Paolo ^c   Vargiu, Attilio V ^c   Baylay, Alison J ^a   Smith, Helen E ^a   Brandon, Yvonne ^a   Galloway, David ^a   Piddock, Laura J V ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b JACOBS UNIVERSITY BREMEN   (Germany)

^c UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

AcrB; Antimicrobial resistance; Efflux; Whole genome sequencing

Indexed keywords

CIPROFLOXACIN; TOLC PROTEIN; ACRB PROTEIN, E COLI; ACRB PROTEIN, SALMONELLA ENTERICA; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CARRIER PROTEIN; DOXORUBICIN; ESCHERICHIA COLI PROTEIN; MINOCYCLINE; MULTIDRUG RESISTANCE PROTEIN; WATER;

ACRB GENE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL THERAPY; ARTICLE; BACTERIAL GENOME; BACTERIAL INFECTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACCUMULATION; DRUG BINDING; DRUG DESIGN; DRUG TRANSPORT; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENE; GRAM NEGATIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; SURVIVAL RATE; WILD TYPE; AMINO ACID SUBSTITUTION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MICROBIAL SENSITIVITY TEST; MUTATION; REPRODUCTIVE FITNESS; SALMONELLA ENTERICA; SINGLE NUCLEOTIDE POLYMORPHISM;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; SALMONELLA; SALMONELLA TYPHIMURIUM;

AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; CIPROFLOXACIN; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENETIC FITNESS; GENOME, BACTERIAL; HUMANS; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; MINOCYCLINE; MODELS, MOLECULAR; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; SALMONELLA ENTERICA; SUBSTRATE SPECIFICITY; WATER;

EID: 84925310709     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1419939112     Document Type: Article

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