Skp2-Dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress

Molecular Cell

Volumn 57, Issue 6, 2015, Pages 1022-1033

  Lee, Szu Wei ^a,b   Li, Chien Feng ^e,f   Jin, Guoxiang ^b   Cai, Zhen ^b   Han, Fei ^a,b   Chan, Chia Hsin ^b,i   Yang, Wei Lei ^a,b   Li, Bin Kui ^b   Rezaeian, AbdolHossein ^b   Li, Hong Yu ^g   Huang, Hsuan Ying ^h   Lin, Hui Kuan ^a,b,c,d  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d ASIA UNIVERSITY   (Taiwan)

^e Chi Mei Foundational Medical Center   (Taiwan)

^f NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^g UNIVERSITY OF ARIZONA   (United States)

^h CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

ⁱ STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MO25 PROTEIN; ONCOPROTEIN; PROTEIN KINASE LKB1; RAS PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 2; STRAD PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; CALCIUM BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MO25 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; S PHASE KINASE ASSOCIATED PROTEIN; STK11 PROTEIN, HUMAN; STRAD PROTEIN, HUMAN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL SURVIVAL; CONTROLLED STUDY; ENERGY; FEMALE; GENE OVEREXPRESSION; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MEDIATOR; METABOLIC STRESS; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT; UBIQUITINATION; AGED; ANIMAL; DRUG SCREENING; GENETICS; LIVER TUMOR; MALE; METABOLISM; MIDDLE AGED; NUDE MOUSE; PATHOLOGY; PHYSIOLOGICAL STRESS; RETROSPECTIVE STUDY;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; AGED; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CALCIUM-BINDING PROTEINS; CELL SURVIVAL; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; MICE, NUDE; MIDDLE AGED; PROTEIN-SERINE-THREONINE KINASES; RAS PROTEINS; RETROSPECTIVE STUDIES; S-PHASE KINASE-ASSOCIATED PROTEINS; STRESS, PHYSIOLOGICAL; UBIQUITINATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84925272879     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.01.015     Document Type: Article

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