Integrating evolutionary and functional tests of adaptive hypotheses: A case study of altitudinal differentiation in hemoglobin function in an andean sparrow, zonotrichia capensis

Molecular Biology and Evolution

Volumn 31, Issue 11, 2014, Pages 2948-2962

  Cheviron, Zachary A ^a,b   Natarajan, Chandrasekhar ^b   Projecto Garcia, Joana ^b   Eddy, Douglas K ^a   Jones, Jennifer ^a   Carling, Matthew D ^c   Witt, Christopher C ^d   Moriyama, Hideaki ^b   Weber, Roy E ^e   Fago, Angela ^e   Storz, Jay F ^b  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF NEBRASKA   (United States)

^c UNIVERSITY OF WYOMING   (United States)

^d UNIVERSITY OF NEW MEXICO   (United States)

^e AARHUS UNIVERSITY   (Denmark)

Author keywords

adaptation; functional synthesis; high altitude adaptation; hypoxia; protein evolution

Indexed keywords

AMINO ACID; HEMOGLOBIN; HEMOGLOBIN A; HEMOGLOBIN ALPHA CHAIN; HEMOGLOBIN D; HEMOGLOBIN DELTA CHAIN; OXYGEN; RECOMBINANT HEMOGLOBIN; ISOPROTEIN; PROTEIN SUBUNIT; RECOMBINANT PROTEIN;

ADULT; ALTITUDE; ALTITUDE ACCLIMATIZATION; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DNA SEQUENCE; EMBRYO; EVOLUTIONARY ADAPTATION; EXPERIMENTAL TEST; GENE CLUSTER; GENE EXPRESSION; GENE FLOW; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOMICS; GENOTYPE; GLOBIN GENE; ISOELECTRIC FOCUSING; NONHUMAN; NUCLEOTIDE SEQUENCE; OXYGEN AFFINITY; OXYGEN BLOOD LEVEL; OXYGEN TENSION; OXYGEN TRANSPORT; PERUVIAN; POPULATION GENETIC STRUCTURE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN POLYMORPHISM; PROTEIN PURIFICATION; RESPIRATORY FUNCTION; SITE DIRECTED MUTAGENESIS; SPARROW; STRUCTURE ACTIVITY RELATION; TANDEM MASS SPECTROMETRY; TISSUE OXYGENATION; ZONOTRICHIA CAPENSIS; ADAPTATION; ALLELE; ANIMAL; ANOXIA; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN ENGINEERING; PROTEIN SUBUNIT; TRANSPORT AT THE CELLULAR LEVEL;

ZONOTRICHIA CAPENSIS;

ADAPTATION, PHYSIOLOGICAL; ALLELES; ALPHA-GLOBINS; ALTITUDE; ANIMALS; ANOXIA; BIOLOGICAL TRANSPORT; GENE EXPRESSION; GENE FREQUENCY; HEMOGLOBINS; MUTATION; OXYGEN; PROTEIN ENGINEERING; PROTEIN ISOFORMS; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; SPARROWS;

EID: 84910657559     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msu234     Document Type: Article

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