The use of nonhuman primates in research on seasonal, pandemic and avian influenza, 1893-2014

Antiviral Research

Volumn 117, Issue , 2015, Pages 75-98

  Davis, A Sally ^a,b   Taubenberger, Jeffery K ^a   Bray, Mike ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

Author keywords

Coinfection; Experimental infection; Influenza A virus; Nonhuman primate; Pathogenesis; Pneumonia

Indexed keywords

ANTIVIRUS AGENT; INFLUENZA VACCINE;

ANIMAL MODEL; ANTIVIRAL THERAPY; AVIAN INFLUENZA; AVIAN INFLUENZA VIRUS; BACTERIAL INFECTION; CERCOPITHECIDAE; CHRONOLOGY; CLINICAL EVALUATION; EXPERIMENTAL INFECTION; EXPERIMENTAL STUDY; FLU LIKE SYNDROME; HUMAN; INFECTION PREVENTION; INFLUENZA A (H5N1); INFLUENZA VACCINATION; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H5N1; INFLUENZA VIRUS A H7N7; INFLUENZA VIRUS A H7N9; INFLUENZA VIRUS A H9N2; INFLUENZA VIRUS B; LEMURIDAE; LUNG DISEASE; MIXED INFECTION; NEUROLOGICAL COMPLICATION; NONHUMAN; OBSERVATIONAL STUDY; PANDEMIC INFLUENZA; PLATYRRHINI; PREGNANT WOMAN; PRIMATE MODEL; PRIORITY JOURNAL; RESPIRATORY SYSTEM; REVIEW; SEASONAL INFLUENZA; SEROLOGY; SQUIRREL MONKEY; TERATOGENESIS; THORAX RADIOGRAPHY; VIRUS PATHOGENESIS; ANIMAL; ANIMAL EXPERIMENT; BIRD; DRUG EFFECTS; HISTORY; IMMUNOLOGY; INFLUENZA; INFLUENZA A VIRUS; INFLUENZA A VIRUS (H1N1); INFLUENZA A VIRUS (H5N1); ISOLATION AND PURIFICATION; ORTHOMYXOVIRUS INFECTION; PATHOGENICITY; PRIMATE; VIROLOGY; VIRUS REPLICATION; WILD ANIMAL;

ANIMALIA; AVES; AVIAN INFLUENZA VIRUS; BACTERIA (MICROORGANISMS); INFLUENZA A VIRUS; MUS; MUSTELA; ORTHOMYXOVIRIDAE; PRIMATES; SUIDAE;

ANIMAL EXPERIMENTATION; ANIMALS; ANIMALS, WILD; ANTIVIRAL AGENTS; BIRDS; HISTORY, 19TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA IN BIRDS; INFLUENZA VACCINES; INFLUENZA, HUMAN; OBSERVATIONAL STUDIES AS TOPIC; ORTHOMYXOVIRIDAE INFECTIONS; PRIMATES; VIRUS REPLICATION;

EID: 84925015179     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2015.02.011     Document Type: Review

References (250)

1. C.H. Andrewes, P.P. Laidlaw, and W. Smith The susceptibility of mice to the viruses of human and swine influenza Lancet 224 1934 859 862
2. Anonymous Does epidemic influenza affect the lower animals? Med. Standard 42 1919 29
3. Anonymous "Flu" Attacks Baboons 1919 Kilmore Free Press p. 1
4. Anonymous Medical influenza victims in South Africa Lancet 193 1919 78
5. R. Aspinall, J. Pido-Lopez, N. Imami, S.M. Henson, P.T. Ngom, M. Morre, H. Niphuis, E. Remarque, B. Rosenwirth, and J.L. Heeney Old rhesus macaques treated with interleukin-7 show increased TREC levels and respond well to influenza vaccination Rejuvenat. Res. 10 2007 5 17
6. T. Atoynatan, and G.D. Hsiung Epidemiologic studies of latent virus infections in captive monkeys baboons Am. J. Epidemiol. 89 1969 472 479
7. T. Baas, C.R. Baskin, D.L. Diamond, A. García-Sastre, H. Bielefeldt-Ohmann, T.M. Tumpey, M.J. Thomas, V.S. Carter, T.H. Teal, N. Van Hoeven, S. Proll, J.M. Jacobs, Z.R. Caldwell, M.A. Gritsenko, R.R. Hukkanen, D.G. Camp 2nd, R.D. Smith, and M.G. Katze Integrated molecular signature of disease: analysis of influenza virus-infected macaques through functional genomics and proteomics J. Virol. 80 2006 10813 10828
8. L.R. Baker Guidelines for nonhuman primate re-introductions Re-introduction News 21 2002 29 44
9. C.R. Baskin, A. García-Sastre, T.M. Tumpey, H. Bielefeldt-Ohmann, V.S. Carter, E. Nistal-Villan, and M.G. Katze Integration of clinical data, pathology, and cDNA microarrays in influenza virus-infected pigtailed macaques (Macaca nemestrina) J. Virol. 78 2004 10420 10432
10. C.R. Baskin, H. Bielefeldt-Ohmann, A. García-Sastre, T.M. Tumpey, N. Van Hoeven, V.S. Carter, M.J. Thomas, S. Proll, A. Solorzano, R. Billharz, J.L. Fornek, S. Thomas, C.H. Chen, E.A. Clark, K. Murali-Krishna, and M.G. Katze Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus J. Virol. 81 2007 11817 11827
11. C.R. Baskin, H. Bielefeldt-Ohmann, T.M. Tumpey, P.J. Sabourin, J.P. Long, A. García-Sastre, A.E. Tolnay, R. Albrecht, J.A. Pyles, P.H. Olson, L.D. Aicher, E.R. Rosenzweig, K. Murali-Krishna, E.A. Clark, M.S. Kotur, J.L. Fornek, S. Proll, R.E. Palermo, C.L. Sabourin, and M.G. Katze Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus PNAS 106 2009 3455 3460
12. A.S. Beare, and J.W. Craig Virulence for man of a human influenza-A virus antigenically similar to "classical" swine viruses Lancet 2 1976 4 5
13. R.F. Berendt Simian model for the evaluation of immunity to influenza Infect. Immun. 9 1974 101 105
14. R.F. Berendt, and W.C. Hall Reaction of squirrel monkeys to intratracheal inoculation with influenza/A/New Jersey/76 (swine) virus Infect. Immun. 16 1977 476 479
15. R.F. Berendt, and G.H. Scott Evaluation of commercially prepared vaccines for experimentally induced type A/New Jersey/8/76 influenza virus infections in mice and squirrel monkeys J. Infect. Dis. 136 Suppl. 1977 S712 S717
16. R.F. Berendt, W.E. Mcdonough, and J.S. Walker Persistence of Diplococcus pneumoniae after influenza virus infection in Macaca mulatta Infect. Immun. 10 1974 369 374
17. R.F. Berendt, G.G. Long, and J.S. Walker Influenza alone and in sequence with pneumonia due to Streptococcus pneumoniae in the squirrel monkey J. Infect. Dis. 132 1975 689 693
18. K.C. Bergmann, R.H. Waldman, W. Nordheim, H.T. Nguyen, P.L. Huynh, and H. Tischner Remote-site stimulation of influenza antibodies in monkeys following intestinal stimulation Immunol. Lett. 12 1986 65 67
19. P.N. Bhatt, C.D. Brandt, R.A. Weiss, J.P. Fox, and M.F. Shaffer Viral infections of monkeys in their natural habitat in south India Am. J. Trop. Med. Hyg. 15 1966 561 566
20. F.G. Blake, and R.L. Cecil Studies in experimental pneumonia: pathology of experimental influenza and of Bacillus influenzae pneumonia in monkeys J. Exp. Med. 32 1920 719 744
21. A. Bot, M. Shearer, S. Bot, C. Woods, J. Limmer, R. Kennedy, S. Casares, and C. Bona Induction of antibody response by DNA immunization of newborn baboons against influenza virus Viral Immunol. 12 1999 91 96
22. A. Bot, M. Shearer, S. Bot, M. Avriette, A. García Sastre, G. White, C. Woods, R. Kennedy, and C. Bona Induction of immunological memory in baboons primed with DNA vaccine as neonates Vaccine 19 2001 1960 1967
23. J.R. Bradford, E.F. Bashford, and J.A. Wilson The filter-passing virus of influenza Quart. J. Med. 12 1919 259 306
24. J.R. Bradford, E.F. Bashford, and J.A. Wilson Preliminary report of the presence of a "filter passing" virus in certain diseases with especial reference to trench fever, influenza, and nephritis Brit. Med. J. 1919 127 128
25. D.L. Brining, J.S. Mattoon, L. Kercher, R.A. Lacasse, D. Safronetz, H. Feldmann, and M.J. Parnell Thoracic radiography as a refinement methodology for the study of H1N1 influenza in cynomologus macaques (Macaca fascicularis) Comp. Med. 60 2010 389 395
26. J.N. Brown, R.E. Palermo, C.R. Baskin, M. Gritsenko, P.J. Sabourin, J.P. Long, C.L. Sabourin, H. Bielefeldt-Ohmann, A. García-Sastre, R. Albrecht, T.M. Tumpey, J.M. Jacobs, R.D. Smith, and M.G. Katze Macaque proteome response to highly pathogenic avian influenza and 1918 reassortant influenza virus infections J. Virol. 84 2010 12058 12068
27. H. Buitendijk, Z. Fabrouch, H. Niphuis, W.M. Bogers, K.S. Warren, and E.J. Verschoor Retrospective serology study of respiratory virus infections in captive great apes Viruses 6 2014 1442 1453
28. F.M. Burnet Propagation of the virus of epidemic influenza on the developing egg Med. J. Aust. 2 1935 687 689
29. F.M. Burnet Influenza virus "A" infections of cynomolgus monkeys Aust. J. Exp. Biol. Med. 19 1941 281 290
30. K.M. Butt, G.J. Smith, H. Chen, L.J. Zhang, Y.H. Leung, K.M. Xu, W. Lim, R.G. Webster, K.Y. Yuen, J.S. Peiris, and Y. Guan Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003 J. Clin. Microbiol. 43 2005 5760 5767
31. T.D. Carroll, S.R. Matzinger, M. Genesca, L. Fritts, R. Colon, M.B. Mcchesney, and C.J. Miller Interferon-induced expression of MxA in the respiratory tract of rhesus macaques is suppressed by influenza virus replication J. Immunol. 180 2008 2385 2395
32. T.D. Carroll, S.R. Matzinger, M. Barro, L. Fritts, M.B. Mcchesney, C.J. Miller, and R.E. Johnston Alphavirus replicon-based adjuvants enhance the immunogenicity and effectiveness of fluzone® in rhesus macaques Vaccine 29 2011 931 940
33. T.D. Carroll, S.R. Matzinger, L. Fritts, M.B. Mcchesney, and C.J. Miller Memory B cells and CD8(+) lymphocytes do not control seasonal influenza A virus replication after homologous re-challenge of rhesus macaques PLoS One 6 2011 e21756
34. T.D. Carroll, S.R. Matzinger, P.A. Barry, M.B. Mcchesney, J. Fairman, and C.J. Miller Efficacy of influenza vaccination of elderly rhesus macaques is dramatically improved by addition of a cationic lipid/DNA adjuvant J. Infect. Dis. 209 2014 24 33
35. CDC, 2013. Flu Symptoms & Severity. http://www.cdc.gov/flu/about/disease/symptoms.htm (access date May 7, 2014).
36. R. Cecil, and F. Blake Studies on experimental pneumonia: pathology of experimental influenza and of Bacillus influenzae pneumonia in monkeys J. Exp. Med. 32 1920 719 744
37. D. Chen, R. Endres, Y.F. Maa, C.R. Kensil, P. Whitaker-Dowling, A. Trichel, J.S. Youngner, and L.G. Payne Epidermal powder immunization of mice and monkeys with an influenza vaccine Vaccine 21 2003 2830 2836
38. Y. Chen, W. Deng, C. Jia, X. Dai, H. Zhu, Q. Kong, L. Huang, Y. Liu, C. Ma, J. Li, C. Xiao, Q. Wei, and C. Qin Pathological lesions and viral localization of influenza a (H5N1) virus in experimentally infected Chinese rhesus macaques: Implications for pathogenesis and viral transmission Arch. Virol. 154 2009 227 233
39. C. Cilloniz, K. Shinya, X. Peng, M.J. Korth, S.C. Proll, L.D. Aicher, V.S. Carter, J.H. Chang, D. Kobasa, F. Feldmann, J.E. Strong, H. Feldmann, Y. Kawaoka, and M.G. Katze Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes PLoS Pathog. 5 2009 e1000604
40. C.C. Clay, J.R. Reader, J.E. Gerriets, T.T. Wang, K.S. Harrod, and L.A. Miller Enhanced viral replication and modulated innate immune responses in infant airway epithelium following H1N1 infection J. Virol. 88 2014 7412 7425
41. M.L. Clements, M.H. Snyder, A.J. Buckler-White, E.L. Tierney, W.T. London, and B.R. Murphy Evaluation of avian-human reassortant influenza A/Washington/897/80 × A/pintail/119/79 virus in monkeys and adult volunteers J. Clin. Microbiol. 24 1986 47 51
42. M.L. Clements, E.K. Subbarao, L.F. Fries, R.A. Karron, W.T. London, and B.R. Murphy Use of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers J. Clin. Microbiol. 30 1992 655 662
43. Y. Clerc, B. Ricklin, M. Thibon, P. Coulanges, J. Andrianarivo, and T. Rahandraha Influenza and lemurs Arch. Inst. Pasteur Madagascar 48 1981 259 268
44. Y. Clerc, B. Ricklin, A. Gueguen, and P. Coulanges Trial of experimental infection of Lemur fulvus fulvus by the influenza virus A/USSR/90/77(H1N1) Arch. Inst. Pasteur Madagascar 49 1982 43 63
45. C.L. Coe, G.R. Lubach, and J. Kinnard Immune senescence in old and very old rhesus monkeys: reduced antibody response to influenza vaccination Age (Dordr) 34 2012 1169 1177
46. E. de Wit, A.L. Rasmussen, F. Feldmann, T. Bushmaker, C. Martellaro, E. Haddock, A. Okumura, S.C. Proll, J. Chang, D. Gardner, M.G. Katze, V.J. Munster, and H. Feldmann Influenza virus A/Anhui/1/2013 (H7N9) replicates efficiently in the upper and lower respiratory tracts of cynomolgus macaques MBio 5 4 2014 e01331
47. F. Deinhardt, A.W. Holmes, J. Devine, and J. Deinhardt Marmosets as laboratory animals Lab. Anim. Care 17 1967 48 70
48. E.C. Dick, and C.R. Dick Natural and experimental infections of nonhuman primates with respiratory viruses Lab. Anim. Sci. 24 1974 177 181
49. J.M. Dinapoli, L. Yang, A. Suguitan Jr., S. Elankumaran, D.W. Dorward, B.R. Murphy, S.K. Samal, P.L. Collins, and A. Bukreyev Immunization of primates with a newcastle disease virus-vectored vaccine via the respiratory tract induces a high titer of serum neutralizing antibodies against highly pathogenic avian influenza virus J. Virol. 81 2007 11560 11568
50. J.M. Dinapoli, B. Nayak, L. Yang, B.W. Finneyfrock, A. Cook, H. Andersen, F. Torres-Velez, B.R. Murphy, S.K. Samal, P.L. Collins, and A. Bukreyev Newcastle disease virus-vectored vaccines expressing the hemagglutinin or neuraminidase protein of H5N1 highly pathogenic avian influenza virus protext against virus challenge in monkeys J. Virol. 84 2010 1489 1503
51. C.A. Doan, S. Saslaw, M. Beard, O.C. Woolpert, J.L. Schwab, and C. Merino Reactions of monkeys to experimental respiratory infections. IV. Response to re-innoculation with Streptococcus hemolyticus Proc. Soc. Exp. Biol. Med. 48 1941 566 568
52. A.R. Dochez, G.S. Shibley, and K.C. Mills Studies in the common cold: IV. Experimental transmission of the common cold to anthropoid apes and human beings by means of a filtrable agent J. Exp. Med. 52 1930 701 716
53. A.R. Dochez, K.C. Mills, and Y. Kneeland Jr. Studies on the virus of influenza J. Exp. Med. 63 1936 581 598
54. J.J. Donnelly, A. Friedman, D. Martinez, D.L. Montgomery, J.W. Shiver, S.L. Motzel, J.B. Ulmer, and M.A. Liu Preclinical efficacy of a prototype DNA vaccine: enhanced protection against antigenic drift in influenza virus Nat. Med. 1 1995 583 587
55. G.W. Dunkin, and P.P. Laidlaw Studies in dog distemper: dog distemper in the ferret J. Comp. Pathol. 39 1926 201 212
56. C.J. Dutton, R.E. Junge, and E.E. Louis Biomedical evaluation of free-ranging ring-tailed lemurs (Lemur catta) in Tsimanampetsotsa strict nature reserve, Madagascar J. Zoo Wildl. Med. 34 2003 16 24
57. W.B. Ershler, C.L. Coe, S. Gravenstein, K.T. Schultz, and R.G. Klopp Specific antibody synthesis in vitro. IV. The correlation of in vitro and in vivo antibody response to influenza vaccine in rhesus monkeys Clin. Exp. Immunol. 73 1988 355 359
58. D.T. Evans, M.S. Piekarczyk, T.M. Allen, J.E. Boyson, M. Yeager, A.L. Hughes, F.M. Gotch, V.S. Hinshaw, and D.I. Watkins Immunodominance of a single CTL epitope in a primate species with limited MHC class I polymorphism J. Immunol. 159 1997 1374 1382
59. D.T. Evans, M.S. Piekarczyk, L. Cadavid, V.S. Hinshaw, and D.I. Watkins Two different primate species express an identical functional MHC class I allele Immunogenetics 47 1998 206 211
60. D.T. Evans, L.A. Knapp, P. Jing, M.S. Piekarczyk, V.S. Hinshaw, and D.I. Watkins Three different MHC class I molecules bind the same CTL epitope of the influenza virus in a primate species with limited MHC class I diversity J. Immunol. 162 1999 3970 3977
61. A.M. Falcon, A. Fernandez-Sesma, Y. Nakaya, T.M. Moran, J. Ortin, and A. García-Sastre Attenuation and immunogenicity in mice of temperature-sensitive influenza viruses expressing truncated NS1 proteins J. Gen. Virol. 86 2005 2817 2821
62. J. Fan, X. Liang, M.S. Horton, H.C. Perry, M.P. Citron, G.J. Heidecker, T.M. Fu, J. Joyce, C.T. Przysiecki, P.M. Keller, V.M. Garsky, R. Ionescu, Y. Rippeon, L. Shi, M.A. Chastain, J.H. Condra, M.E. Davies, J. Liao, E.A. Emini, and J.W. Shiver Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys Vaccine 22 2004 2993 3003
63. S. Fan, Y. Gao, K. Shinya, C.K. Li, Y. Li, J. Shi, Y. Jiang, Y. Suo, T. Tong, G. Zhong, J. Song, Y. Zhang, G. Tian, Y. Guan, X.N. Xu, Z. Bu, Y. Kawaoka, and H. Chen Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates PLoS Pathog. 5 2009 e1000409
64. L. Fejes Die Aetiologie der Influenza Dtsch. Med. Wochenschr. 45 1919 653 654
65. B. Ferko, J. Stasakova, J. Romanova, C. Kittel, S. Sereinig, H. Katinger, and A. Egorov Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes J. Virol. 78 2004 13037 13045
66. C.S.I. Fernandez, S. Jegaskanda, D.I. Godfrey, and S.J. Kent In-vivo stimulation of macaque natural killer T cells with α-galactosylceramide Clin. Exp. Immunol. 173 2013 480 492
67. N.W. Florek, J.T. Weinfurter, S. Jegaskanda, J.N. Brewoo, T.D. Powell, G.R. Young, S.C. Das, M. Hatta, K.W. Broman, O. Hungnes, S.G. Dudman, Y. Kawaoka, S.J. Kent, D.T. Stinchcomb, J.E. Osorio, and T.C. Friedrich Modified vaccinia Ankara encoding influenza virus hemagglutinin induces heterosubtypic immunity in macaques J. Virol. 88 2014 13418 13428
68. G.B. Foster The etiology of common colds J. Infect. Dis. 21 1917 451 475
69. R.A. Fouchier, P.M. Schneeberger, F.W. Rozendaal, J.M. Broekman, S.A. Kemink, V. Munster, T. Kuiken, G.F. Rimmelzwaan, M. Schutten, G.J. Van Doornum, G. Koch, A. Bosman, M. Koopmans, and A.D. Osterhaus Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome Proc. Natl. Acad. Sci. U.S.A 101 2004 1356 1361
70. A.M. Frace, A.I. Klimov, T. Rowe, R.A. Black, and J.M. Katz Modified M2 proteins produce heterotypic immunity against influenza A virus Vaccine 17 1999 2237 2244
71. T.M. Fu, K.M. Grimm, M.P. Citron, D.C. Freed, J. Fan, P.M. Keller, J.W. Shiver, X. Liang, and J.G. Joyce Comparative immunogenicity evaluations of influenza A virus M2 peptide as recombinant virus like particle or conjugate vaccines in mice and monkeys Vaccine 27 2009 1440 1447
72. T. Fujiyuki, M. Yoneda, F. Yasui, T. Kuraishi, S. Hattori, H.J. Kwon, K. Munekata, Y. Kiso, H. Kida, M. Kohara, and C. Kai Experimental infection of macaques with a wild water bird-derived highly pathogenic avian influenza virus (H5N1) PLoS One 8 2013 e83551
73. E.S. Gabitzsch, J.P. Balint-Junior, Y. Xu, S. Balcaitis, B. Sanders-Beer, J. Karl, K.J. Weinhold, S. Paessler, and F.R. Jones Control of SIV infection and subsequent induction of pandemic H1N1 immunity in rhesus macaques using an Ad5 [E1-, E2b-] vector platform Vaccine 30 2012 7265 7270
74. P. Gagneux, and A. Varki Genetic differences between humans and great apes Mol. Phylogenet. Evol. 18 2001 2 13
75. A. Gambotto, S.M. Barratt-Boyes, M.D. De Jong, G. Neumann, and Y. Kawaoka Human infection with highly pathogenic H5N1 influenza virus Lancet 371 2008 1464 1475
76. R. Gao, B. Cao, Y. Hu, Z. Feng, D. Wang, W. Hu, J. Chen, Z. Jie, H. Qiu, K. Xu, X. Xu, H. Lu, W. Zhu, Z. Gao, N. Xiang, Y. Shen, Z. He, Y. Gu, Z. Zhang, Y. Yang, X. Zhao, L. Zhou, X. Li, S. Zou, Y. Zhang, X. Li, L. Yang, J. Guo, J. Dong, Q. Li, L. Dong, Y. Zhu, T. Bai, S. Wang, P. Hao, W. Yang, Y. Zhang, J. Han, H. Yu, D. Li, G.F. Gao, G. Wu, Y. Wang, Z. Yuan, and Y. Shu Human infection with a novel avian-origin influenza A (H7N9) virus N. Engl. J. Med. 368 2013 1888 1897
77. H.G. Gibson, F.B. Bowman, and J.I. Connor The etiology of influenza: a filterable virus as the cause, with some notes on the culture of the virus by Noguchi's method Brit. Med. J. 1919 331 335
78. H.G. Gibson, F.B. Bowman, and J.I. Connor The etiology of influenza. A filterable virus as the cause, with some notes on the culture of the virus by the method of noguchi S.L. Cummins, Studies in the Etiology of Influenza 1919 National Health Insurance, Medical Research Committee
79. B.M. Giles, C.J. Crevar, D.M. Carter, S.J. Bissel, S. Schultz-Cherry, C.A. Wiley, and T.M. Ross A computationally optimized hemagglutinin virus-like particle vaccine elicits broadly reactive antibodies that protect nonhuman primates from H5N1 infection J. Infect. Dis. 205 2012 1562 1570
80. J.T. Go, S.E. Belisle, N. Tchitchek, T.M. Tumpey, W. Ma, J.A. Richt, D. Safronetz, H. Feldmann, and M.G. Katze 2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models BMC Genomics 13 2012 627
81. M.R. Gomaa, A.S. Kayed, M.A. Elabd, D.A. Zeid, S.A. Zaki, A.S. El Rifay, L.S. Sherif, P.P. McKenzie, R.G. Webster, R.J. Webby, M.A. Ali, and G. Kayali Avian Influenza A(H5N1) and A(H9N2) seroprevalence and risk factors for infection among Egyptians: a prospective controlled seroepidemiological study J. Infect. Dis. 2014
82. M.H. Gordon Influenza Lancet 221 1933 224
83. M.B. Grizzard, W.T. London, D.L. Sly, B.R. Murphy, W.D. James, W.P. Parnell, and R.M. Chanock Experimental production of respiratory tract disease in cebus monkeys after intratracheal or intranasal infection with influenza A/Victoria/3/75 or influenza A/New Jersey/76 virus Infect. Immun. 21 1978 201 205
84. J. Haensler, C. Verdelet, V. Sanchez, Y. Girerd-Chambaz, A. Bonnin, E. Trannoy, S. Krishnan, and P. Meulien Intradermal DNA immunization by using jet-injectors in mice and monkeys Vaccine 17 1999 628 638
85. R.L. Heberling, and S.S. Kalter Persistence and spread of influenza virus (A2-Hong Kong) in normal and poly I.C. Treated baboons (Papio cynophalus) Proc. Soc. Exp. Biol. Med. 135 1970 717 723
86. J.G. Heldens, H.L. Glansbeek, L.A. Hilgers, B. Haenen, K.J. Stittelaar, A.D. Osterhaus, and J.F. Van Den Bosch Feasibility of single-shot H5N1 influenza vaccine in ferrets, macaques and rabbits Vaccine 28 2010 8125 8131
87. S. Herfst, J.M. Van Den Brand, E.J. Schrauwen, E. De Wit, V.J. Munster, G. Van Amerongen, M. Linster, F. Zaaraoui, W.F. Van Ijcken, G.F. Rimmelzwaan, A.D. Osterhaus, R.A. Fouchier, A.C. Andeweg, and T. Kuiken Pandemic 2009 H1N1 influenza virus causes diffuse alveolar damage in cynomolgus macaques Vet. Pathol. 47 2010 1040 1047
88. B.C. Holbrook, S.L. Hayward, L.K. Blevins, N. Kock, T. Aycock, G.D. Parks, and M.A. Alexander-Miller Nonhuman primate infants have an impaired respiratory but not systemic IgG antibody response following influenza virus infection Virology 476 2015 124 133
89. B. Hubby, T. Talarico, M. Maughan, E.A. Reap, P. Berglund, K.I. Kamrud, L. Copp, W. Lewis, C. Cecil, P. Norberg, J. Wagner, A. Watson, S. Negri, B.K. Burnett, A. Graham, J.F. Smith, and J.D. Chulay Development and preclinical evaluation of an alphavirus replicon vaccine for influenza Vaccine 25 2007 8180 8189
90. T. Ichinohe, A. Ainai, Y. Ami, N. Nagata, N. Iwata, A. Kawaguchi, Y. Suzaki, T. Odagiri, M. Tashiro, H. Takahashi, D.R. Strayer, W.A. Carter, J. Chiba, S. Tamura, T. Sata, T. Kurata, and H. Hasegawa Intranasal administration of adjuvant-combined vaccine protects monkeys from challenge with the highly pathogenic influenza A H5N1 virus J. Med. Virol. 82 2010 1754 1761
91. M.T. Irwin, R.E. Junge, J.L. Raharison, and K.E. Samonds Variation in physiological health of diademed sifakas across intact and fragmented forest at Tsinjoarivo, eastern Madagascar Am. J. Primatol. 72 2010 1013 1025
92. T. Ishihara, S. Mue, T. Ohmi, G. Tamura, K. Yamauchi, S. Ida, T. Fuyuki, T. Chonan, C. Shindoh, and K. Sato et al. Bronchial responses to inhaled histamine and methacholine after influenza virus vaccination in monkeys Tohoku J. Exp. Med. 140 1983 335 336
93. Y. Itoh, H. Ozaki, H. Tsuchiya, K. Okamoto, R. Torii, Y. Sakoda, Y. Kawaoka, K. Ogasawara, and H. Kida A vaccine prepared from a non-pathogenic H5N1 avian influenza virus strain confers protective immunity against highly pathogenic avian influenza virus infection in cynomolgus macaques Vaccine 26 2008 562 572
94. Y. Itoh, K. Shinya, M. Kiso, T. Watanabe, Y. Sakoda, M. Hatta, Y. Muramoto, D. Tamura, Y. Sakai-Tagawa, T. Noda, S. Sakabe, M. Imai, Y. Hatta, S. Watanabe, C. Li, S. Yamada, K. Fujii, S. Murakami, H. Imai, S. Kakugawa, M. Ito, R. Takano, K. Iwatsuki-Horimoto, M. Shimojima, T. Horimoto, H. Goto, K. Takahashi, A. Makino, H. Ishigaki, M. Nakayama, M. Okamatsu, D. Warshauer, P.A. Shult, R. Saito, H. Suzuki, Y. Furuta, M. Yamashita, K. Mitamura, K. Nakano, M. Nakamura, R. Brockman-Schneider, H. Mitamura, M. Yamazaki, N. Sugaya, M. Suresh, M. Ozawa, G. Neumann, J. Gern, H. Kida, K. Ogasawara, and Y. Kawaoka In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses Nature 460 2009 1021 1025
95. Y. Itoh, H. Ozaki, H. Ishigaki, Y. Sakoda, T. Nagata, K. Soda, N. Isoda, T. Miyake, H. Ishida, K. Okamoto, M. Nakayama, H. Tsuchiya, R. Torii, H. Kida, and K. Ogasawara Subcutaneous inoculation of a whole virus particle vaccine prepared from a non-pathogenic virus library induces protective immunity against H7N7 highly pathogenic avian influenza virus in cynomolgus macaques Vaccine 28 2010 780 789
96. Y. Itoh, R. Yoshida, S. Shichinohe, M. Higuchi, H. Ishigaki, M. Nakayama, V.L. Pham, H. Ishida, M. Kitano, M. Arikata, N. Kitagawa, Y. Mitsuishi, K. Ogasawara, H. Tsuchiya, T. Hiono, M. Okamatsu, Y. Sakoda, H. Kida, M. Ito, L. Quynh Mai, Y. Kawaoka, H. Miyamoto, M. Ishijima, M. Igarashi, Y. Suzuki, and A. Takada Protective efficacy of passive immunization with monoclonal antibodies in animal models of H5N1 highly pathogenic avian influenza virus infection PLoS Pathog. 12 10 2014 e1004192
97. S. Jegaskanda, T.H. Amarasena, K.L. Laurie, H.X. Tan, J. Butler, M.S. Parsons, S. Alcantara, J. Petravic, M.P. Davenport, A.C. Hurt, P.C. Reading, and S.J. Kent Standard trivalent influenza virus protein vaccination does not prime antibody-dependent cellular cytotoxicity in macaques J. Virol. 87 2013 13706 13718
98. S. Jegaskanda, J.C. Reece, R. De Rose, J. Stambas, L. Sullivan, A.G. Brooks, S.J. Kent, and A. Sexton Comparison of influenza and SIV specific CD8 T cell responses in macaques PLoS One 7 2013 e32431
99. S. Jegaskanda, J.T. Weinfurter, T.C. Friedrich, and S.J. Kent Antibody-dependent cellular cytotoxicity is associated with control of pandemic H1N1 influenza virus infection of macaques J. Virol. 87 2013 5512 5522
100. Z. Jie, W. Sun, S. Wang, F. Koster, B. Li, and K.S. Harrod The rapid and sustained responses of dendritic cells to influenza virus infection in a non-human primate model Braz. J. Infect. Dis. 18 2014 406 413
101. R. Jin, Z. Lv, Q. Chen, Y. Quan, H. Zhang, S. Li, G. Chen, Q. Zheng, L. Jin, X. Wu, J. Chen, and Y. Zhang Safety and immunogenicity of H5N1 influenza vaccine based on baculovirus surface display system Bombyx mori PLoS One 3 2008 e3933
102. D.O. Johnsen, W.L. Woodling, P. Tanticharoenyos, and C. Karnjanaprakorn An epizootic of A/Hong Kong/68 influenza in gibbons J. Infect. Dis. 123 1971 365 370
103. E.E. Jones, P.L. Alford, A.L. Reingold, H. Russell, M.E. Keeling, and C.V. Broome Predisposition to invasive pneumococcal illness following parainfluenza type 3 virus infection in chimpanzees J. Am. Vet. Med. Assoc. 185 1984 1351 1353
104. L. Jones-Engel, G.A. Engel, M.A. Schillaci, R. Babo, and J. Froehlich Detection of antibodies to selected human pathogens among wild and pet macaques (Macaca tonkeana) in Sulawesi, Indonesia Am. J. Primatol. 54 2001 171 178
105. C.B. Jonsson, J.V. Camp, A. Wu, H. Zheng, J.L. Kraenzle, A.E. Biller, C.D. Vanover, Y.K. Chu, C.K. Ng, M. Proctor, L. Sherwood, M.C. Steffen, and D.J. Mollura Molecular imaging reveals a progressive pulmonary inflammation in lower airways in ferrets infected with 2009 H1N1 pandemic influenza virus PLoS One 2012 7 2012 e40094
106. J.O. Joslin Other primates excluding great apes M.E. Fowler, R.E. Miller, Zoo and Wild Animal Medicine 2003 Saunders St. Louis, MO
107. L. Josset, F. Engelmann, K. Haberthur, S. Kelly, B. Park, Y. Kawoaka, A. García-Sastre, M.G. Katze, and I. Messaoudi Increased viral loads and exacerbated innate host responses in aged macaques infected with the 2009 pandemic H1N1 influenza A virus J. Virol. 86 2012 11115 11127
108. R.E. Junge, and E.E. Louis Biomedical evaluation of two sympatric lemur species (Propithecus verreauxi deckeni and Eulemur fulvus rufus) in Tsiombokibo classified forest, Madagascar J. Zoo Wildl. Med. 36 2005 581 589
109. S.S. Kalter Nonhuman primates in viral research Ann. N. Y. Acad. Sci. 162 1969 499 528
110. S.S. Kalter, and R.L. Heberling Comparative virology of primates Bacteriol. Rev. 35 1971 319 364
111. S.S. Kalter, and R.L. Heberling Serologic response of primates to influenza viruses Proc. Soc. Exp. Biol. Med. 159 1978 414 417
112. S.S. Kalter, J. Ratner, G.V. Kalter, A.R. Rodrigues, and C.S. Kim A survey of primate sera for antibodies to viruses of human and simian origin Am. J. Epidemiol. 86 1967 552 568
113. S.S. Kalter, R.L. Heberling, T.E. Vice, F.S. Lief, and A.R. Rodriguez Influenza a2/Hong Kong/68 in the baboon (Papio sp.) Proc. Soc. Exp. Biol. Med. 132 1969 357 361
114. S.S. Kalter, J.J. Ratner, R.L. Rodriguez, R.L. Heberling, and N.B. Guilloud Antibodies to human and simian viruses in the gorilla (Gorilla gorilla) Lab. Anim. Care 19 1969 63 66
115. S.S. Kalter, R.L. Heberling, A.W. Cooke, J.D. Barry, P.Y. Tian, and W.J. Northam Viral infections of nonhuman primates Lab. Anim. Sci. 47 1997 461 467
116. E.A. Karlsson, G.A. Engel, M.M. Feeroz, S. San, A. Rompis, B.P. Lee, E. Shaw, G. Oh, M.A. Schillaci, R. Grant, J. Heidrich, S. Schultz-Cherry, and L. Jones-Engel Influenza virus infection in nonhuman primates Emerg. Infect. Dis. 18 2012 1672 1675
117. S.P. Kasturi, I. Skountzou, R.A. Albrecht, D. Koutsonanos, T. Hua, H.I. Nakaya, R. Ravindran, S. Stewart, M. Alam, M. Kwissa, F. Villinger, N. Murthy, J. Steel, J. Jacob, R.J. Hogan, A. García-Sastre, R. Compans, and B. Pulendran Programming the magnitude and persistence of antibody responses with innate immunity Nature 470 2011 543 547
118. A. Kawai, T. Kimoto, I. Oishi, T. Yamada, and N. Kunita Viral infection of cynomolgus macaque (Macaca irus) Primates 9 1968 409 418
119. M. Kitano, Y. Itoh, M. Kodama, H. Ishigaki, M. Nakayama, T. Nagata, H. Ishida, H. Tsuchiya, R. Torii, K. Baba, R. Yoshida, A. Sato, and K. Ogasawara Establishment of a cynomolgus macaque model of influenza B virus infection Virology 407 2010 178 184
120. M. Kitano, Y. Itoh, M. Kodama, H. Ishigaki, M. Nakayama, H. Ishida, K. Baba, T. Noda, K. Sato, Y. Nihashi, T. Kanazu, R. Yoshida, R. Torii, A. Sato, and K. Ogasawara Efficacy of single intravenous injection of peramivir against influenza B virus infection in ferrets and cynomolgus macaques Antimicrob. Agents Chemother. 55 2011 4961 4970
121. M. Kitano, Y. Itoh, H. Ishigaki, M. Nakayama, H. Ishida, V.L. Pham, M. Arikata, S. Shichinohe, H. Tsuchiya, N. Kitagawa, M. Kobayashi, R. Yoshida, A. Sato, Q.M. Le, Y. Kawaoka, and K. Ogasawara Efficacy of repeated intravenous administration of peramivir against highly pathogenic avian influenza A (H5N1) virus in cynomolgus macaques Antimicrob. Agents Chemother. 58 2014 4795 4803
122. D. Kobasa, S.M. Jones, K. Shinya, J.C. Kash, J. Copps, H. Ebihara, Y. Hatta, J.H. Kim, P. Halfmann, M. Hatta, F. Feldmann, J.B. Alimonti, L. Fernando, Y. Li, M.G. Katze, H. Feldmann, and Y. Kawaoka Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus Nature 445 2007 319 323
123. S.D. Kobayashi, R.J. Olsen, R.A. Lacasse, D. Safronetz, M. Ashraf, A.R. Porter, K.R. Braughton, F. Feldmann, D.R. Clifton, J.C. Kash, J.R. Bailey, D.J. Gardner, M. Otto, D.L. Brining, B.N. Kreiswirth, J.K. Taubenberger, M.J. Parnell, H. Feldmann, J.M. Musser, and F.R. Deleo Seasonal H3N2 influenza A virus fails to enhance Staphylococcus aureus co-infection in a non-human primate respiratory tract infection model Virulence 4 2013 707 715
124. J.H. Kreijtz, Y. Suezer, G. De Mutsert, J.M. Van Den Brand, G. Van Amerongen, B.S. Schnierle, T. Kuiken, R.A. Fouchier, J. Lower, A.D. Osterhaus, G. Sutter, and G.F. Rimmelzwaan Preclinical evaluation of a modified vaccinia virus Ankara (MVA)-based vaccine against influenza A/H5N1 viruses Vaccine 27 2009 6296 6299
125. J.H. Kreijtz, Y. Suezer, G. De Mutsert, J.M. Van Den Brand, G. Van Amerongen, B.S. Schnierle, T. Kuiken, R.A. Fouchier, J. Lower, A.D. Osterhaus, G. Sutter, and G.F. Rimmelzwaan Recombinant modified vaccinia virus Ankara expressing the hemagglutinin gene confers protection against homologous and heterologous H5N1 influenza virus infections in macaques J. Infect. Dis. 199 2009 405 413
126. H.F. Krous, G. Altshuler, W.T. London, A.E. Palmer, D.A. Fucillo, and J.L. Sever Congenital hydrocephalus. Animal model: congenital hydrocephalus produced by attenuated influenza A virus vaccine in rhesus monkeys Am. J. Pathol. 92 1978 317 320
127. T. Kuiken, G.F. Rimmelzwaan, G. Van Amerongen, and A.D. Osterhaus Pathology of human influenza A (H5N1) virus infection in cynomolgus macaques (Macaca fascicularis) Vet. Pathol. 40 2003 304 310
128. D.J. Laddy, J. Yan, M. Kutzler, D. Kobasa, G.P. Kobinger, A.S. Khan, J. Greenhouse, N.Y. Sardesai, R. Draghia-Akli, and D.B. Weiner Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens PLoS One 3 2008 e2517
129. D.J. Laddy, J. Yan, A.S. Khan, H. Andersen, A. Cohn, J. Greenhouse, M. Lewis, J. Manischewitz, L.R. King, H. Golding, R. Draghia-Akli, and D.B. Weiner Electroporation of synthetic DNA antigens offers protection in nonhuman primates challenged with highly pathogenic avian influenza virus J. Virol. 83 2009 4624 4630
130. M.Q. Le, P. Horby, A. Fox, H.T. Nguyen, H.K. Le Nguyen, P.M. Hoang, K.C. Nguyen, M.D. de Jong, R.E. Jeeninga, H. Rogier van Doorn, J. Farrar, and H.F. Wertheim Subclinical avian influenza A (H5N1) virus infection in human Vietnam. Emerg. Infect. Dis. 19 2013 1674 1677
131. H.B. Levy, G. Baer, S. Baron, C.E. Buckler, C.J. Gibbs, M.J. Iadarola, W.T. London, and J. Rice A modified polyriboinosinic-polyribocytidylic acid complex that induces interferon in primates J. Infect. Dis. 132 1975 434 439
132. K.S. Li, Y. Guan, J. Wang, G.J. Smith, K.M. Xu, L. Duan, A.P. Rahardjo, P. Puthavathana, C. Buranathai, T.D. Nguyen, A.T. Estoepangestie, A. Chaisingh, P. Auewarakul, H.T. Long, N.T. Hanh, R.J. Webby, L.L. Poon, H. Chen, K.F. Shortridge, K.Y. Yuen, R.G. Webster, and J.S. Peiris Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia Nature 430 6996 2004 209 213
133. Y. Li, J. Li, S. Belisle, C.R. Baskin, T.M. Tumpey, and M.G. Katze Differential microRNA expression and virulence of avian, 1918 reassortant, and reconstructed 1918 influenza A viruses Virology 421 2011 105 113
134. M.A. Liu, W. Mcclements, J.B. Ulmer, J. Shiver, and J. Donnelly Immunization of non-human primates with DNA vaccines Vaccine 15 1997 909 912
135. W.T. London, D.A. Fuccillo, J.L. Sever, and S.G. Kent Influenza virus as a teratogen in rhesus monkeys Nature 255 1975 483 484
136. P.H. Long, E.A. Bliss, and H.M. Carpenter Etiology of influenza: transmission experiments in chimpanzees with filtered material derived from human influenza J. Am. Med. Assoc. 97 1931 1122 1127
137. M. Loomis Great apes M.E. Fowler, R.E. Miller, Zoo and Wild Animal Medicine 2003 Saunders St. Louis, MO
138. P.T. Loudon, E.J. Yager, D.T. Lynch, A. Narendran, C. Stagnar, A.M. Franchini, J.T. Fuller, P.A. White, J. Nyuandi, C.A. Wiley, M. Murphey-Corb, and D.H. Fuller GM-CSF increases mucosal and systemic immunogenicity of an H1N1 influenza DNA vaccine administered into the epidermis of non-human primates PLoS One 5 2010 e11021
139. G. Lussier, A. Boudreault, V. Pavilanis, and E. Difranco Lesions of the central nervous system induced in nonhuman primates by live influenza viruses Can. J. Comp. Med. 38 1974 398 405
140. H. Malherbe, M. Strickland-Cholmey, and G.C. Smith Isolation of myxovirus-like agent from baboons Lancet 306 1975 41 42
141. P. Marois, A. Boudreault, E. Difranco, and V. Pavilanis Response of ferrets and monkeys to intranasal infection with human, equine and avian influenza viruses Can. J. Comp. Med. 35 1971 71 76
142. M.J. Martin, J.C. Rayner, P. Gagneux, J.W. Barnwell, and A. Varki Evolution of human-chimpanzee differences in malaria susceptibility: Relationship to human genetic loss of N-glycolylneuraminic acid PNAS 102 36 2005 12819 12824
143. Y. Matsuoka, A. Suguitan Jr, M. Orandle, M. Paskel, K. Boonnak, D.J. Gardner, F. Feldmann, H. Feldmann, M. Marino, H. Jin, G. Kemble, and K. Subbarao African green monkeys recapitulate the clinical experience with replication of live attenuated pandemic influenza virus vaccine candidates J. Virol. 2014 (May 7, Epub ahead of print)
144. S.R. Matzinger, T.D. Carroll, L. Fritts, M.B. Mcchesney, and C.J. Miller Exogenous IFN-alpha administration reduces influenza A virus replication in the lower respiratory tract of rhesus macaques PLoS One 6 2011 e29255
145. J. Mcintosh, and F.R. Selbie The pathogenicity to animals of viruses isolated from cases of human influenza Brit. J. Exp. Pathol. 18 1937 334 344
146. C. Merino, C.A. Doan, O.C. Woolpert, J.L. Schwab, and S. Saslaw Reactions of monkeys to experimental respiratory infections. III. Response to mixtures of influenza virus and streptococcus Proc. Soc. Exp. Biol. Med. 48 1941 563 565
147. S.M. Michalek, A.A. Lackner, J. Katz, M.W. Russell, J.H. Eldridge, J. Mestecky, R. Lallone, and Z. Moldoveanu Oral immunization studies with Streptococcus mutans and influenza vaccines in rhesus macaque monkeys Adv. Exp. Med. Biol. 371B 1995 1423 1429
148. T. Miyake, K. Soda, Y. Itoh, Y. Sakoda, H. Ishigaki, T. Nagata, H. Ishida, M. Nakayama, H. Ozaki, H. Tsuchiya, R. Torii, H. Kida, and K. Ogasawara Amelioration of pneumonia with Streptococcus pneumoniae infection by inoculation with a vaccine against highly pathogenic avian influenza virus in a non-human primate mixed infection model J. Med. Primatol. 39 2010 58 70
149. K. Miyoshi, E.T. Gamboa, D.H. Harter, A. Wolf, and K.C. Hsu Influenza virus encephalitis in squirrel monkeys receiving immunosuppressive therapy J. Immunol. 106 1971 1119 1121
150. L.H. Moncla, T.M. Ross, J.M. Dinis, J.T. Weinfurter, T.D. Mortimer, N. Schultz-Darken, K. Brunner, S.V. Capuano 3rd, C. Boettcher, J. Post, M. Johnson, C.E. Bloom, A.M. Weiler, and T.C. Friedrich A novel nonhuman primate model for influenza transmission PLoS One 8 2013 e78750
151. A.F. Moreland, J.M. Gaskin, R.D. Schimpff, J.C. Woodard, and G.A. Olson Effects of influenza, mumps, and western equine encephalitis viruses on fetal rhesus monkeys (Macaca mulatta) Teratology 20 1979 53 64
152. D.M. Morens, and J.K. Taubenberger How low is the risk of influenza A(H5N1) infection? J. Infect. Dis. 2014
153. D.M. Morens, J.K. Taubenberger, and A.S. Fauci Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness J. Infect. Dis. 198 2008 962 970
154. M. Mouquet Maladie a allure grippale chez les chimpanzes Bull. Soc. Centr. Med. Vet. 89 1926 46 50
155. Y. Muramoto, J.E. Shoemaker, M.Q. Le, Y. Itoh, D. Tamura, Y. Sakai-Tagawa, H. Imai, R. Uraki, R. Takano, E. Kawakami, M. Ito, K. Okamoto, H. Ishigaki, H. Mimuro, C. Sasakawa, Y. Matsuoka, T. Noda, S. Fukuyama, K. Ogasawara, H. Kitano, and Y. Kawaoka Disease severity is associated with differential gene expression at the early and late phases of infection in nonhuman primates infected with different H5N1 highly pathogenic avian influenza viruses J. Virol. 88 2014 8981 8997
156. B.L. Murphy, J.E. Maynard, D.H. Krushak, and K.R. Berquist Microbial flora of imported marmosets: viruses and enteric bacteria Lab. Anim. Sci. 22 1972 339 343
157. B.R. Murphy, D.L. Sly, N.T. Hosier, W.T. London, and R.M. Chanock Evaluation of three strains of influenza A virus in humans and in owl, cebus, and squirrel monkeys Infect. Immun. 28 1980 688 691
158. B.R. Murphy, V.S. Hinshaw, D.L. Sly, W.T. London, N.T. Hosier, F.T. Wood, R.G. Webster, and R.M. Chanock Virulence of avian influenza A viruses for squirrel monkeys Infect. Immun. 37 1982 1119 1126
159. B.R. Murphy, D.L. Sly, E.L. Tierney, N.T. Hosier, J.G. Massicot, W.T. London, R.M. Chanock, R.G. Webster, and V.S. Hinshaw Reassortant virus derived from avian and human influenza A viruses is attenuated and immunogenic in monkeys Science 218 1982 1330 1332
160. B.R. Murphy, J. Harper, D.L. Sly, W.T. London, N.T. Miller, and R.G. Webster Evaluation of the A/seal/Mass/1/80 virus in squirrel monkeys Infect. Immun. 42 1983 424 426
161. B.R. Murphy, A.J. Buckler-White, W.T. London, J. Harper, E.L. Tierney, N.T. Miller, L.J. Reck, R.M. Chanock, and V.S. Hinshaw Avian-human reassortant influenza A viruses derived by mating avian and human influenza A viruses J. Infect. Dis. 150 1984 841 850
162. B.R. Murphy, A.J. Buckler-White, W.T. London, and M.H. Snyder Characterization of the M protein and nucleoprotein genes of an avian influenza A virus which are involved in host range restriction in monkeys Vaccine 7 1989 557 561
163. L.N. Mutanda, and M.A. Mufson Antibodies to viruses of human origin in monkeys from Uganda Proc. Soc. Exp. Biol. Med. 145 1974 1069 1073
164. S. Neirynck, T. Deroo, X. Saelens, P. Vanlandschoot, W.M. Jou, and W. Fiers A universal influenza A vaccine based on the extracellular domain of the M2 protein Nat. Med. 5 1999 1157 1163
165. C. Nicolle, and C. Lebailly Recherches expérimentales sur la grippe Ann. l'Inst. Pasteur 33 1919 395 402
166. R.M. Nowak, and E.P. Walker Primates. Walker's Mammals of the World sixth ed. 1999 Johns Hopkins University Press Baltimore, MD
167. J.W. Nuzum, I. Pilor, F.H. Strangl, and B.E. Bonar Pandemic influenza and pneumonia in a large civil hospital JAMA 71 1918 1562 1565
168. T.C. O'Brien, and N.M. Tauraso Antibodies to type A influenza viruses in sera from nonhuman primates Arch. Gesamte Virusforsch. 40 1973 359 365
169. Y. Owada, Y. Yamane, T. Nagashima, M. Takada, and T. Asahara Prevalence of antibodies against viruses in Cercopithecus aethiops and Macaca irus Nihon Juigaku Zasshi 32 1970 69 80
170. W. Pan et al. Induction of neutralizing antibodies to influenza A virus H7N9 by inactivated whole virus in mice and nonhuman primates Antiviral Res. 107 2014 1 5
171. C.K. Paniker, and C.M. Nair Experimental infection of animals with influenzavirus types A and B Bull. World Health Organ. 47 1972 461 463
172. J.S. Peiris Avian influenza viruses in humans Rev. Sci. Tech. 28 2009 161 173
173. R. Pfeiffer Die Aetiologie der Influenza Zeitsch. Hyg. Infektionskr 13 1893 357 386
174. V.L. Pham, M. Nakayama, Y. Itoh, H. Ishigaki, M. Kitano, M. Arikata, H. Ishida, N. Kitagawa, S. Shichinohe, M. Okamatsu, Y. Sakoda, H. Tsuchiya, S. Nakamura, H. Kida, and K. Ogasawara Pathogenicity of pandemic H1N1 influenza A virus in immunocompromised cynomolgus macaques PLoS One 8 2013 e75910
175. T.J. Powell, A. Fox, Y. Peng, T. Quynh Mai le, V.T. Lien, N.L. Hang, L. Wang, L.Y. Lee, C.P. Simmons, A.J. McMichael, J.J. Farrar, B.A. Askonas, T.N. Duong, P.Q. Thai, N.T. Thu Yen, S.L. Rowland-Jones, N.T. Hien, P. Horby, and T. Dong Identification of H5N1-specific T-cell responses in a high-risk cohort in vietnam indicates the existence of potential asymptomatic infections J. Infect. Dis. 205 2012 20 27
176. Ratcliffe, H.L., 1942. Deaths and important diseases. Report of the Penrose Research Laboratory. Laboratory and Museum of Comparative Pathology of the Zoological Society of Philadelphia.
177. J.A. Richt, B. Rockx, W. Ma, F. Feldmann, D. Safronetz, A. Marzi, D. Kobasa, J.E. Strong, L. Kercher, D. Long, D. Gardner, D. Brining, and H. Feldmann Recently emerged swine influenza a virus (H2N3) causes severe pneumonia in cynomolgus macaques PLoS One 7 2012 e39990
178. G.F. Rimmelzwaan, M. Baars, R. Van Beek, G. Van Amerongen, K. Lovgren-Bengtsson, E.C. Claas, and A.D. Osterhaus Induction of protective immunity against influenza virus in a macaque model: Comparison of conventional and iscom vaccines J. Gen. Virol. 78 Pt 4 1997 757 765
179. G.F. Rimmelzwaan, M. Baars, R. Van Beek, P. De Lijster, J.C. De Jong, E.C. Claas, and A.D. Osterhaus Influenza virus subtype cross-reactivities of haemagglutination inhibiting and virus neutralising serum antibodies induced by infection or vaccination with an iscom-based vaccine Vaccine 17 1999 2512 2516
180. G.F. Rimmelzwaan, T. Kuiken, G. Van Amerongen, T.M. Bestebroer, R.A. Fouchier, and A.D. Osterhaus Pathogenesis of influenza A (H5N1) virus infection in a primate model J. Virol. 75 2001 6687 6691
181. G.F. Rimmelzwaan, M. Baars, G. Van Amerongen, R. Van Beek, and A.D. Osterhaus A single dose of an iscom influenza vaccine induces long-lasting protective immunity against homologous challenge infection but fails to protect cynomolgus macaques against distant drift variants of influenza A (H3N2) viruses Vaccine 20 2002 158 163
182. G.F. Rimmelzwaan, T. Kuiken, G. Van Amerongen, T.M. Bestebroer, R.A. Fouchier, and A.D. Osterhaus A primate model to study the pathogenesis of influenza A (H5N1) virus infection Avian Dis. 47 2003 931 933
183. J. Romanova, B.M. Krenn, M. Wolschek, B. Ferko, E. Romanovskaja-Romanko, A. Morokutti, A.P. Shurygina, S. Nakowitsch, T. Ruthsatz, B. Kiefmann, U. Konig, M. Bergmann, M. Sachet, S. Balasingam, A. Mann, J. Oxford, M. Slais, O. Kiselev, T. Muster, and A. Egorov Preclinical evaluation of a replication-deficient intranasal deltaNS1 H5N1 influenza vaccine PLoS One 4 2009 e5984
184. C. Ruat, C. Caillet, A. Bidaut, J. Simon, and A.D. Osterhaus Vaccination of macaques with adjuvanted formalin-inactivated influenza A virus (H5N1) vaccines: protection against H5N1 challenge without disease enhancement J. Virol. 82 2008 2565 2569
185. D. Safronetz, B. Rockx, F. Feldmann, S.E. Belisle, R.E. Palermo, D. Brining, D. Gardner, S.C. Proll, A. Marzi, Y. Tsuda, R.A. Lacasse, L. Kercher, A. York, M.J. Korth, D. Long, R. Rosenke, W.L. Shupert, C.A. Aranda, J.S. Mattoon, D. Kobasa, G. Kobinger, Y. Li, J.K. Taubenberger, J.A. Richt, M. Parnell, H. Ebihara, Y. Kawaoka, M.G. Katze, and H. Feldmann Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaques J. Virol. 85 2011 1214 1223
186. J.E. Salk, and A.M. Laurent The use of adjuvants in studies of influenza immunization: I. Measurements in monkeys of the dimensions of antigenicity of virus-mineral oil emulsions J. Exp. Med. 95 1952 429 447
187. J.E. Salk, A.M. Laurent, and M.L. Bailey Direction of research on vaccination against influenza; new studies with immunologic adjuvants Am. J. Public Health Nations Health 41 1951 669 677
188. M.L. Sammons, E.L. Stephen, H.B. Levy, S. Baron, and D.E. Hilmas Interferon induction in cynomolgus and rhesus monkey after repeated doses of a modified polyriboinosinic-polyribocytidylic acid complex Antimicrob. Agents Chemother. 11 1977 80 83
189. S. Saslaw, and H.N. Carlisle Aerosol exposure of monkeys to influenza virus Proc. Soc. Exp. Biol. Med. 119 1965 838 843
190. S. Saslaw, H.E. Wilson, C.A. Doan, O.C. Woolpert, and J.L. Schwab Reactions of monkeys to experimentally induced influenza virus A infection: an analysis of the relative roles of humoral and cellular immunity under conditions of optimal or deficient nutrition J. Exp. Med. 84 1946 113 125
191. R. Scherliess, A. Ajmera, M. Dennis, M.W. Carroll, J. Altrichter, N.J. Silman, M. Scholz, K. Kemter, and A.C. Marriott Induction of protective immunity against H1N1 influenza A(H1N1)pdm09 with spray-dried and electron-beam sterilized vaccines in non-human primates Vaccine 32 2014 2231 2240
192. F.Y. Schulman, A. Farb, R. Virmani, and R.J. Montali Fibrosing cardiomyopathy in captive western lowland gorilla (Gorilla gorilla gorilla) in the United States: a retrospective study J. Zoo Wildl. Med. 26 1995 43 51
193. J.L. Schwab, S. Saslaw, O.C. Woolpert, C. Merino, and C.A. Doan Reactions of monkeys to experimental respiratory infections. II. Response to streptococcus hemolyticus group c Proc. Soc. Exp. Biol. Med. 48 1941 560 563
194. J.A. Schwartz, L. Buonocore, A. Suguitan Jr., M. Hunter, P.A. Marx, K. Subbarao, and J.K. Rose Vesicular stomatitis virus-based H5N1 avian influenza vaccines induce potent cross-clade neutralizing antibodies in rhesus macaques J. Virol. 85 2011 4602 4605
195. G.B.D. Scott The Respiratory System. Comparative Primate Pathology 1992 Oxford University Press Oxford, England
196. G.H. Scott, E.L. Stephen, and R.F. Berendt Activity of amantadine, rimantadine, and ribavirin against swine influenza in mice and squirrel monkeys Antimicrob. Agents Chemother. 13 1978 284 288
197. R.E. Shope Swine influenza: III. Filtration experiments and etiology J. Exp. Med. 54 1931 373 385
198. R.E. Shope Swine influeza: I. Experimental transmission and pathology J. Exp. Med. 54 1931 349 359
199. R.E. Shope The infection of ferrets with swine influenza virus J. Exp. Med. 60 1934 49 61
200. R.E. Shope Influenza: history, epidemiology, and speculation Public Health Rep. 73 1958 165 178
201. S.J. Short, G.R. Lubach, A.I. Karasin, C.W. Olsen, M. Styner, R.C. Knickmeyer, J.H. Gilmore, and C.L. Coe Maternal influenza infection during pregnancy impacts postnatal brain development in the rhesus monkey Biol. Psychiatry 67 2010 965 973
202. J.Y. Siegers, K.R. Short, L.M. Leijten, M. de Graaf, M.I. Spronken, E.J. Schrauwen, N. Marshall, A.C. Lowen, G. Gabriel, A.D. Osterhaus, T. Kuiken, and D. van Riel Novel avian-origin influenza A (H7N9) virus attachment to the respiratory tract of five animal models J. Virol. 88 2014 4595 4599
203. J.A. Skinner, S.M. Zurawski, C. Sugimoto, H. Vinet-Oliphant, P. Vinod, Y. Xue, K. Russel-Lodrigue, R.A. Albrecht, A. García-Sastre, A.M. Salazar, C.J. Roy, M.J. Kuroda, S. Oh, and G. Zurawski Immunologic characterization of a rhesus macaque H1N1 challenge model for candidate influenza vaccine assessment Clin. Vaccine Immunol. 21 2014 1668 1680
204. V.A. Slepushkin, J.M. Katz, R.A. Black, W.C. Gamble, P.A. Rota, and N.J. Cox Protection of mice against influenza a virus challenge by vaccination with baculovirus-expressed M2 protein Vaccine 13 1995 1399 1402
205. W. Smith Cultivation the virus of influenza Brit. J. Exp. Pathol. 16 1935 508 512
206. W. Smith, C.H. Andrewes, and P.P. Laidlaw A virus obtained from influenza patients Lancet 225 1933 66 68
207. A.A. Smorodintseff, M.D. Tushinsky, A.I. Drobyshevskaya, A.A. Korovin, and A.I. Osetroff Investigation on volunteers infected with the influenza virus Am. J. Med. Sci. 194 1937
208. M.H. Snyder, M.L. Clements, D. Herrington, W.T. London, E.L. Tierney, and B.R. Murphy Comparison by studies in squirrel monkeys, chimpanzees, and adult humans of avian-human influenza A virus reassortants derived from different avian influenza virus donors J. Clin. Microbiol. 24 1986 467 469
209. M.H. Snyder, W.T. London, E.L. Tierney, H.F. Maassab, and B.R. Murphy Restricted replication of a cold-adapted reassortant influenza A virus in the lower respiratory tract of chimpanzees J. Infect. Dis. 154 1986 370 371
210. M.H. Snyder, E.H. Stephenson, H. Young, C.G. York, E.L. Tierney, W.T. London, R.M. Chanock, and B.R. Murphy Infectivity and antigenicity of live avian-human influenza A reassortant virus: comparison of intranasal and aerosol routes in squirrel monkeys J. Infect. Dis. 154 1986 709 711
211. M.H. Snyder, A.J. Buckler-White, W.T. London, E.L. Tierney, and B.R. Murphy The avian influenza virus nucleoprotein gene and a specific constellation of avian and human virus polymerase genes each specify attenuation of avian-human influenza A/pintail/79 reassortant viruses for monkeys J. Virol. 61 1987 2857 2863
212. M.H. Snyder, W.T. London, H.F. Maassab, and B.R. Murphy Attenuation and phenotypic stability of influenza B/Texas/1/84 cold-adapted reassortant virus: studies in hamsters and chimpanzees J. Infect. Dis. 160 1989 604 610
213. M.H. Snyder, W.T. London, H.F. Maassab, R.M. Chanock, and B.R. Murphy A 36 nucleotide deletion mutation in the coding region of the NS1 gene of an influenza A virus RNA segment 8 specifies a temperature-dependent host range phenotype Virus Res. 15 1990 69 83
214. A.C. Soloff, S.J. Bissel, B.F. Junecko, B.M. Giles, T.A. Reinhart, T.M. Ross, and S.M. Barratt-Boyes Massive mobilization of dendritic cells during influenza A virus subtype H5N1 infection of nonhuman primates J. Infect. Dis. 2014 (Epub ahead of print)
215. A. Song, K. Myojo, J. Laudenslager, D. Harada, T. Miura, K. Suzuki, R. Kuni-Kamochi, R. Soloff, K. Ohgami, and Y. Kanda Evaluation of a fully human monoclonal antibody against multiple Influenza A viral strains in mice and a pandemic H1N1 strain in nonhuman primates Antiviral Res. 111 2014 60 68
216. E.L. Stephen, D.E. Hilmas, J.A. Mangiafico, and H.B. Levy Swine influenza virus vaccine: potentiation of antibody responses in rhesus monkeys Science 197 1977 1289 1290
217. E.L. Stephen, J.S. Walker, J.W. Dominik, H.W. Young, and R.F. Berendt Aerosol therapy of influenza infections of mice and primates with rimantadine, ribavirin, and related compounds Ann. N. Y. Acad. Sci. 284 1977 264 271
218. K.J. Stittelaar, M. Tisdale, G. Van Amerongen, R.F. Van Lavieren, F. Pistoor, J. Simon, and A.D. Osterhaus Evaluation of intravenous zanamivir against experimental influenza A (H5N1) virus infection in cynomolgus macaques Antiviral Res. 80 2008 225 228
219. D.R. Strayer, W.A. Carter, B.C. Stouch, K.J. Stittelaar, R.J. Thoolen, A.D. Osterhaus, and W.M. Mitchell Protection from pulmonary tissue damage associated with infection of cynomolgus macaques by highly pathogenic avian influenza virus (H5N1) by low dose natural human IFN-α administered to the buccal mucosa Antiviral Res. 110 2014 175 180
220. E.K. Subbarao, W. London, and B.R. Murphy A single amino acid in the PB2 gene of influenza a virus is a determinant of host range J. Virol. 67 1993 1761 1764
221. K. Subbarao, R.G. Webster, Y. Kawaoka, and B.R. Murphy Are there alternative avian influenza viruses for generation of stable attenuated avian-human influenza A reassortant viruses? Virus Res. 39 1995 105 118
222. A.L. Suguitan Jr., Y. Matsuoka, Y.F. Lau, C.P. Santos, L. Vogel, L.I. Cheng, M. Orandle, and K. Subbarao The multibasic cleavage site of the hemagglutinin of highly pathogenic A/Vietnam/1203/2004 (H5N1) avian influenza virus acts as a virulence factor in a host-specific manner in mammals J. Virol. 86 2012 2706 2714
223. J.K. Taubenberger, and D.M. Morens The pathology of influenza virus infections Annu. Rev. Pathol. Mech. Dis. 3 2008 499 522
224. S.F. Tian, A.J. Buckler-White, W.T. London, L.J. Reck, R.M. Chanock, and B.R. Murphy Nucleoprotein and membrane protein genes are associated with restriction of replication of influenza A/mallard/NY/78 virus and its reassortants in squirrel monkey respiratory tract J. Virol. 53 1985 771 775
225. A.E. Tolnay, C.R. Baskin, T.M. Tumpey, P.J. Sabourin, C.L. Sabourin, J.P. Long, J.A. Pyles, R.A. Albrecht, A. García-Sastre, M.G. Katze, and H. Bielefeldt-Ohmann Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus Arch. Virol. 155 2010 905 914
226. F.H. Top Jr., and P.K. Russell Swine influenza A at Fort Dix, New Jersey (January-February 1976). IV. Summary and speculation J. Infect. Dis. 136 Suppl. 1977 S376 S380
227. J.J. Treanor, M.H. Snyder, W.T. London, and B.R. Murphy The B allele of the NS gene of avian influenza viruses, but not the A allele, attenuates a human influenza A virus for squirrel monkeys Virology 171 1989 1 9
228. J.B. Ulmer, R.R. Deck, C.M. Dewitt, A. Friedman, J.J. Donnelly, and M.A. Liu Protective immunity by intramuscular injection of low doses of influenza virus DNA vaccines Vaccine 12 1994 1541 1544
229. T.M. Uyeki, Y.H. Chong, J.M. Katz, W. Lim, Y.Y. Ho, S.S. Wang, T.H. Tsang, W.W. Au, S.C. Chan, T. Rowe, J. Hu-Primmer, J.C. Bell, W.W. Thompson, C.B. Bridges, N.J. Cox, K.H. Mak, and K. Fukuda Lack of evidence for human-to-human transmission of avian influenza A (H9N2) viruses in Hong Kong, China 1999 Emerg. Infect. Dis. 8 2002 154 159
230. D. Van Riel, V.J. Munster, E. De Wit, G.F. Rimmelzwaan, R.A. Fouchier, A.D. Osterhaus, and T. Kuiken Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals Am. J. Pathol. 171 2007 1215 1223
231. D. Van Riel, L.M. Leijten, M. De Graaf, J.Y. Siegers, K.R. Short, M.I. Spronken, E.J. Schrauwen, R.A. Fouchier, A.D. Osterhaus, and T. Kuiken Novel avian-origin influenza A (H7N9) virus attaches to epithelium in both upper and lower respiratory tract of humans Am. J. Pathol. 183 2013 1137 1143
232. D. Van Riel, L.M. Leijten, G. Kochs, A.D. Osterhaus, and T. Kuiken Decrease of virus receptors during highly pathogenic H5N1 virus infection in humans and other mammals Am. J. Pathol. 183 2013 1382 1389
233. N.M. Varki, E. Strobert, E.J. Dick Jr., K. Benirschke, and A. Varki Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology Annu. Rev. Pathol. 6 2011 365 393
234. E.J.L. Veldhuis Kroeze, G. van Amerongen, M.L. Dijkshoorn, J.H. Simon, L. de Waal, I.J. Hartmann, G.P. Krestin, T. Kuiken, A.D. Osterhaus, and K.J. Stittelaar Pulmonary pathology of pandemic influenza A/H1N1 virus (2009)-infected ferrets upon longitudinal evaluation by computed tomography J. Gen. Virol. 92 2011 1854 1858
235. J.D. Verlinde, and O. Makstenieks Experimental respiratory infection in monkeys produced by influenza A virus and Staphylococcus aureus Arch. Gesamte Virusforsch. 5 1954 345 360
236. M.J. Vieuchange Sur la sensibilite de certaines especes simienne Bull. Acad. Med. 121 1939 100 123
237. F. Villinger, R. Miller, K. Mori, A.E. Mayne, P. Bostik, J.B. Sundstrom, C. Sugimoto, and A.A. Ansari Il-15 is superior to il-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus macaques Vaccine 22 2004 3510 3521
238. T. Watanabe, K. Shinya, S. Watanabe, M. Imai, M. Hatta, C. Li, B.F. Wolter, G. Neumann, A. Hanson, M. Ozawa, S. Yamada, H. Imai, S. Sakabe, R. Takano, K. Iwatsuki-Horimoto, M. Kiso, M. Ito, S. Fukuyama, E. Kawakami, T. Gorai, H.A. Simmons, D. Schenkman, K. Brunner, S.V. Capuano 3rd, J.T. Weinfurter, W. Nishio, Y. Maniwa, T. Igarashi, A. Makino, E.A. Travanty, J. Wang, A. Kilander, S.G. Dudman, M. Suresh, R.J. Mason, O. Hungnes, T.C. Friedrich, and Y. Kawaoka Avian-type receptor-binding ability can increase influenza virus pathogenicity in macaques J. Virol. 85 2011 13195 13203
239. T. Watanabe, M. Kiso, S. Fukuyama, N. Nakajima, M. Imai, S. Yamada, S. Murakami, S. Yamayoshi, K. Iwatsuki-Horimoto, Y. Sakoda, E. Takashita, R. Mcbride, T. Noda, M. Hatta, H. Imai, D. Zhao, N. Kishida, M. Shirakura, R.P. De Vries, S. Shichinohe, M. Okamatsu, T. Tamura, Y. Tomita, N. Fujimoto, K. Goto, H. Katsura, E. Kawakami, I. Ishikawa, S. Watanabe, M. Ito, Y. Sakai-Tagawa, Y. Sugita, R. Uraki, R. Yamaji, A.J. Eisfeld, G. Zhong, S. Fan, J. Ping, E.A. Maher, A. Hanson, Y. Uchida, T. Saito, M. Ozawa, G. Neumann, H. Kida, T. Odagiri, J.C. Paulson, H. Hasegawa, M. Tashiro, and Y. Kawaoka Characterization of H7N9 influenza A viruses isolated from humans Nature 501 2013 551 555
240. C.J. Wei, J.C. Boyington, P.M. Mctamney, W.P. Kong, M.B. Pearce, L. Xu, H. Andersen, S. Rao, T.M. Tumpey, Z.Y. Yang, and G.J. Nabel Induction of broadly neutralizing h1n1 influenza antibodies by vaccination Science 329 2010 1060 1064
241. J.T. Weinfurter, K. Brunner, S.V. Capuano 3rd, C. Li, K.W. Broman, Y. Kawaoka, and T.C. Friedrich Cross-reactive T cells are involved in rapid clearance of 2009 pandemic H1N1 influenza virus in nonhuman primates PLoS Pathog. 7 2011 e1002381
242. C. Whittier, F.B. Nutter, and M.R. Cranfield Seroprevalence of infectious agents in free living mountain gorillas (Gorilla beringei ssp.) K. Baerc, Wildlife Disease Association International Conference 2005 Cairns Queensland, Australia
243. H.E. Wilson, M.D. Samuel, S. Saslaw, C.A. Doan, O.C. Woolpert, and J.L. Schwab Reactions of monkeys to experimental mixed influenza and streptococcus infections J. Exp. Med. 85 1947 199 215
244. A.F. Woodhour, A. Friedman, A.A. Tytell, and M.R. Hilleman Hyperpotentiation by synthetic double-stranded RNA of antibody responses to influenza virus vaccine in adjuvant 65 Proc. Soc. Exp. Biol. Med. 131 1969 809 817
245. O.C. Woolpert Reactions of monkeys to experimental respiratory infections, I. Response to influenza A Proc. Soc. Exp. Biol. Med. 48 1941 558 560
246. T. Yamanouchi, K. Sakakami, and S. Iwashima The infecting agent in influenza: an experimental research Lancet 171 1919
247. J. Yin, A. Dai, D.J. Laddy, J. Yan, T. Arango, A.S. Khan, M.G. Lewis, H. Andersen, M.A. Kutzler, R. Draghia-Akli, D.B. Weiner, and J.D. Boyer High dose of plasmid il-15 inhibits immune responses in an influenza non-human primates immunogenicity model Virology 393 2009 49 55
248. K. Zhang, W. Xu, Z. Zhang, T. Wang, X. Sang, K. Cheng, Z. Yu, X. Zheng, H. Wang, Y. Zhao, G. Huang, S. Yang, C. Qin, Y. Gao, and X. Xia Experimental infection of non-human primates with avian influenza virus (H9N2) Arch. Virol. 158 2013 2127 2134
249. G. Zinman, R. Brower-Sinning, C.H. Emeche, J. Ernst, G.T. Huang, S. Mahony, A.J. Myers, D.M. O'dee, J.L. Flynn, G.J. Nau, T.M. Ross, R.D. Salter, P.V. Benos, Z. Bar Joseph, and P.A. Morel Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque PLoS One 6 2011 e22401
250. H. Zinsser The etiology and epidemiology of influenza Medicine 1 1922 213 304