Massive mobilization of dendritic cells during influenza a virus subtype H5N1 infection of nonhuman primates

Journal of Infectious Diseases

Volumn 209, Issue 12, 2014, Pages 2012-2016

  Soloff, Adam C ^a,c   Bissel, Stephanie J ^b   Junecko, Beth Fallert ^a   Giles, Brendan M ^a,d   Reinhart, Todd A ^a   Ross, Ted M ^a,b,e   Barratt Boyes, Simon M ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^e Vaccine and Gene Therapy Institute of Florida   (United States)

Author keywords

cynomolgus macaque; highly pathogenic avian influenza; inflammation; innate immunity; viral pathogenesis

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL ACTIVATION; CELL COUNT; CELL FUNCTION; CELL INFILTRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; DENDRITIC CELL; DISEASE ACTIVITY; DISEASE ASSOCIATION; GRANULOCYTE; INFLUENZA A (H5N1); INFLUENZA VIRUS A H5N1; MACACA FASCICULARIS; MACROPHAGE; MALE; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PNEUMONIA; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; VIRUS IDENTIFICATION; VIRUS STRAIN;

CYNOMOLGUS MACAQUE; HIGHLY PATHOGENIC AVIAN INFLUENZA; INFLAMMATION; INNATE IMMUNITY; VIRAL PATHOGENESIS;

ANIMALS; CELL PROLIFERATION; CHEMOKINE CXCL10; DENDRITIC CELLS; INFLUENZA A VIRUS, H5N1 SUBTYPE; LUNG; LYMPH NODES; MACACA FASCICULARIS; MACROPHAGES; MALE; ORTHOMYXOVIRIDAE INFECTIONS;

EID: 84901757057     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu009     Document Type: Article

References (15)

1. de Jong MD, Simmons CP, Thanh TT, et al. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med 2006; 12:1203-7. (Pubitemid 44527358)
2. Baskin CR, Bielefeldt-Ohmann H, Tumpey TM, et al. Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci U S A 2009; 106:3455-60.
3. Watanabe T, Kiso M, Fukuyama S, et al. Characterization of H7N9 influenza A viruses isolated from humans. Nature 2013; 501:551-5.
4. Shinya K, Gao Y, Cilloniz C, et al. Integrated clinical, pathologic, virologic, and transcriptomic analysis of H5N1 influenza virus-induced viral pneumonia in the rhesus macaque. J Virol 2012; 86:6055-66.
5. Cilloniz C, Shinya K, Peng X, et al. Lethal influenza virus infection in macaques is associated with early dysregulation of inflammatory related genes. PLoS Pathog 2009; 5:e1000604.
6. Coates PT, Barratt-Boyes SM, Zhang L, et al. Dendritic cell subsets in blood and lymphoid tissue of rhesus monkeys and their mobilization with Flt3 ligand. Blood 2003; 102:2513-21. (Pubitemid 37193590)
7. Giles BM, Crevar CJ, Carter DM, et al. A computationally optimized hemagglutinin virus-like particle vaccine elicits broadly reactive antibodies that protect nonhuman primates from H5N1 infection. J Infect Dis 2012; 205:1562-70.
8. Brown KN, Wijewardana V, Liu X, Barratt-Boyes SM. Rapid influx and death of plasmacytoid dendritic cells in lymph nodes mediate depletion in acute simian immunodeficiency virus infection. PLoS Pathog 2009; 5:e1000413.
9. Reinhart TA, Fallert BA, Pfeifer ME, et al. Increased expression of the inflammatory chemokine CXC chemokine ligand 9/monokine induced by interferon-gamma in lymphoid tissues of rhesus macaques during simian immunodeficiency virus infection and acquired immunodeficiency syndrome. Blood 2002; 99:3119-28. (Pubitemid 34525288)
10. Gill MA, Long K, Kwon T, et al. Differential recruitment of dendritic cells and monocytes to respiratory mucosal sites in children with influenza virus or respiratory syncytial virus infection. J Infect Dis 2008; 198:1667-76.
11. Lichtner M, Mastroianni CM, Rossi R, et al. Severe and persistent depletion of circulating plasmacytoid dendritic cells in patients with 2009 pandemic H1N1 infection. PLoS One 2011; 6:e19872.
12. Yoneyama H, Matsuno K, Zhang Y, et al. Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules. Int Immunol 2004; 16:915-28. (Pubitemid 38967174)
13. Aldridge JR Jr., Moseley CE, Boltz DA, et al. TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc Natl Acad Sci U S A 2009; 106:5306-11.
14. Thitithanyanont A, Engering A, Ekchariyawat P, et al. High susceptibility of human dendritic cells to avian influenza H5N1 virus infection and protection by IFN-alpha and TLR ligands. J Immunol 2007; 179:5220-7.
15. Kader M, Smith AP, Guiducci C, et al. Blocking TLR7-and TLR9-mediated IFN-alpha production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection. PLoS Pathog 2013; 9:e1003530.