Preclinical evaluation of a replication-deficient intranasal ΔNS1 H5N1 influenza vaccine

PLoS ONE

Volumn 4, Issue 6, 2009, Pages

  Romanova, Julia ^a   Krenn, Brigitte M ^a   Wolschek, Markus ^a,e   Ferko, Boris ^a   Romanovskaja Romanko, Ekaterina ^b   Morokutti, Alexander ^a   Shurygina, Anna Polina ^b   Nakowitsch, Sabine ^a   Ruthsatz, Tanja ^a   Kiefmann, Bettina ^a   König, Ulrich ^a   Bergmann, Michael ^b   Sachet, Monika ^e   Balasingam, Shobana ^c   Mann, Alexander ^c   Oxford, John ^c   Slais, Martin ^f   Kiselev, Oleg ^b   Muster, Thomas ^a,d   Egorov, Andrej ^a  

^a Avir Green Hills Biotechnology AG   (Austria)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d Universitatsklinik fur Dermatologie   (Austria)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f BioTest Ltd ^*  (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VACCINE; NONSTRUCTURAL PROTEIN 1; INFLUENZA VIRUS HEMAGGLUTININ;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CHICKEN; CONTROLLED STUDY; CROSS REACTION; DRUG SAFETY; FEMALE; FERRET; GENETIC REASSORTMENT; HUMAN; HUMAN CELL; IMMUNOGENICITY; INFLUENZA; INFLUENZA VACCINATION; INFLUENZA VIRUS A H5N1; INNATE IMMUNITY; INTERFERON INDUCTION; MACACA; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; SINGLE DRUG DOSE; VIRUS REPLICATION; VIRUS VIRULENCE; ANIMAL; BRONCHUS; CELL LINE; CERCOPITHECUS; CHEMISTRY; CYTOLOGY; DOG; DRUG SCREENING; EPITHELIUM CELL; GENETICS; INTRANASAL DRUG ADMINISTRATION; MACROPHAGE; METABOLISM; VERO CELL; VIROLOGY;

ANIMALIA; MACACA MULATTA; MUS; MUSTELA; PRIMATES;

ADMINISTRATION, INTRANASAL; ANIMALS; BRONCHI; CELL LINE; CERCOPITHECUS AETHIOPS; CHICKENS; DOGS; DRUG EVALUATION, PRECLINICAL; EPITHELIAL CELLS; FERRETS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA VACCINES; MACROPHAGES; MICE; VERO CELLS; VIRUS REPLICATION;

EID: 67650113035     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005984     Document Type: Article

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