Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Zinman, Guy ^a   Brower Sinning, Rachel ^b   Emeche, Chineye H ^c   Ernst, Jason ^a   Huang, Grace Tzu Wei ^b   Mahony, Shaun ^b   Myers, Amy J ^c   O'Dee, Dawn M ^c   Flynn, JoAnne L ^c   Nau, Gerard J ^c   Ross, Ted M ^c   Salter, Russell D ^c   Benos, Panayiotis V ^b   Bar Joseph, Ziv ^a   Morel, Penelope A ^c  

^a Carnegie Mellon University   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL1 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RANTES; RNA; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FRANCISELLA TULARENSIS; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE GENE; INFLUENZA A (H1N1); INFLUENZA A (H3N2); INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; INNATE IMMUNITY; LUNG ALVEOLUS MACROPHAGE; LUNG TUBERCULOSIS; MACACA FASCICULARIS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SPECIES COMPARISON; SPECIES DIFFERENCE; TULAREMIA; UPREGULATION; ANIMAL; BACTERIUM; COMPARATIVE STUDY; DNA MICROARRAY; GENETICS; IMMUNOLOGY; INFLUENZA VIRUS A; MACACA; METABOLISM; MICROBIOLOGY; ORTHOMYXOVIRUS INFECTION; SIGNAL TRANSDUCTION; TUBERCULOSIS; VIROLOGY; VIRUS;

BACTERIA (MICROORGANISMS); FRANCISELLA TULARENSIS; MACACA; MUS; MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; BACTERIA; FRANCISELLA TULARENSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HOST-PATHOGEN INTERACTIONS; IMMUNITY, INNATE; INFLUENZA A VIRUS; INTERFERON REGULATORY FACTOR-7; MACACA; MACROPHAGES, ALVEOLAR; MICE; MYCOBACTERIUM TUBERCULOSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORTHOMYXOVIRIDAE INFECTIONS; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; TUBERCULOSIS; TULAREMIA; UP-REGULATION; VIRUSES;

EID: 79960567195     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022401     Document Type: Article

References (48)

1. Restrepo MI, Anzueto A, (2009) Severe community-acquired pneumonia. Infect Dis Clin North Am 23: 503-520.
2. Waterer G, Wunderink R, (2009) Respiratory infections: a current and future threat. Respirology 14: 651-655.
3. van Zyl Smit RN, Pai M, Yew WW, Leung CC, Zumla A, et al. (2010) Global lung health: the colliding epidemics of tuberculosis, tobacco smoking, HIV and COPD. Eur Respir J 35: 27-33.
4. Dennis DT, Inglesby TV, Henderson DA, Bartlett JG, Ascher MS, et al. (2001) Tularemia as a Biological Weapon: Medical and Public Health Management. JAMA 285: 2763-2773.
5. McGill J, Heusel JW, Legge KL, (2009) Innate immune control and regulation of influenza virus infections. J Leukoc Biol 86: 803-812.
6. Kuiken T, van den Brand J, van Riel D, Pantin-Jackwood M, Swayne DE, (2010) Comparative Pathology of Select Agent Influenza A Virus Infections. Vet Pathol Online 47: 893-914.
7. Flynn JL, (2006) Lessons from experimental Mycobacterium tuberculosis infections. Microbes and Infection 8: 1179-1188.
8. Cilloniz C, Shinya K, Peng X, Korth MJ, Proll SC, et al. (2009) Lethal Influenza Virus Infection in Macaques Is Associated with Early Dysregulation of Inflammatory Related Genes. PLoS Pathog 5: e1000604.
9. Lin PL, Rodgers M, Smith L, Bigbee M, Myers A, et al. (2009) Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model. Infect Immun 77: 4631-4642.
10. Flynn JL, Capuano SV, Croix D, Pawar S, Myers A, et al. (2003) Non-human primates: a model for tuberculosis research. Tuberculosis (Edinb) 83: 116-118.
11. Wissinger E, Goulding J, Hussell T, (2009) Immune homeostasis in the respiratory tract and its impact on heterologous infection. Semin Immunol 21: 147-155.
12. Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, et al. (2003) Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema. Nature 422: 169-173.
13. Snelgrove RJ, Goulding J, Didierlaurent AM, Lyonga D, Vekaria S, et al. (2008) A critical function for CD200 in lung immune homeostasis and the severity of influenza infection. Nat Immunol 9: 1074-1083.
14. Bosio CM, Dow SW, (2005) Francisella tularensis induces aberrant activation of pulmonary dendritic cells. J Immunol 175: 6792-6801.
15. Kobasa D, Jones SM, Shinya K, Kash JC, Copps J, et al. (2007) Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature 445: 319-323.
16. Elkins KL, Cowley SC, Bosio CM, (2007) Innate and adaptive immunity to Francisella. Ann N Y Acad Sci 1105: 284-324.
17. Sjostedt A, (2006) Intracellular survival mechanisms of Francisella tularensis, a stealth pathogen. Microbes Infect 8: 561-567.
18. Carlson PE Jr, Carroll JA, O'Dee DM, Nau GJ, (2007) Modulation of virulence factors in Francisella tularensis determines human macrophage responses. Microbial Pathogenesis 42: 204-214.
19. Carlson PE Jr, Horzempa J, O'Dee DM, Robinson CM, Neophytou P, et al. (2009) Global Transcriptional Response to Spermine, a Component of the Intramacrophage Environment, Reveals Regulation of Francisella Gene Expression through Insertion Sequence Elements. J Bacteriol 191: 6855-6864.
20. Lin PL, Pawar S, Myers A, Pegu A, Fuhrman C, et al. (2006) Early events in Mycobacterium tuberculosis infection in cynomolgus macaques. Infect Immun 74: 3790-3803.
21. Kawai T, Akira S, (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384.
22. Suzuki K, Suda T, Naito T, Ide K, Chida K, et al. (2005) Impaired toll-like receptor 9 expression in alveolar macrophages with no sensitivity to CpG DNA. Am J Respir Crit Care Med 171: 707-713.
23. Kuo D, Tan K, Zinman G, Ravasi T, Bar-Joseph Z, et al. Evolutionary divergence in the fungal response to fluconazole revealed by soft clustering. Genome Biol 11: R77.
24. Ernst J, Vainas O, Harbison CT, Simon I, Bar-Joseph Z, (2007) Reconstructing dynamic regulatory maps. Mol Syst Biol 3: 74.
25. Garcia-Sastre A, Biron CA, (2006) Type 1 Interferons and the Virus-Host Relationship: A Lesson in Detente. Science 312: 879-882.
26. Hashimoto Y, Moki T, Takizawa T, Shiratsuchi A, Nakanishi Y, (2007) Evidence for phagocytosis of influenza virus-infected, apoptotic cells by neutrophils and macrophages in mice. J Immunol 178: 2448-2457.
27. Tumpey TM, Garcia-Sastre A, Taubenberger JK, Palese P, Swayne DE, et al. (2005) Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice. J Virol 79: 14933-14944.
28. Narasaraju T, Ng HH, Phoon MC, Chow VT, (2010) MCP-1 antibody treatment enhances damage and impedes repair of the alveolar epithelium in influenza pneumonitis. Am J Respir Cell Mol Biol 42: 732-743.
29. Reading PC, Miller JL, Anders EM, (2000) Involvement of the mannose receptor in infection of macrophages by influenza virus. J Virol 74: 5190-5197.
30. Buchweitz JP, Harkema JR, Kaminski NE, (2007) Time-dependent airway epithelial and inflammatory cell responses induced by influenza virus A/PR/8/34 in C57BL/6 mice. Toxicol Pathol 35: 424-435.
31. Toapanta FR, Ross TM, (2009) Impaired immune responses in the lungs of aged mice following influenza infection. Respir Res 10: 112.
32. Herold S, von Wulffen W, Steinmueller M, Pleschka S, Kuziel WA, et al. (2006) Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules. J Immunol 177: 1817-1824.
33. Telepnev M, Golovliov I, Grundstrom T, Tarnvik A, Sjostedt A, (2003) Francisella tularensis inhibits Toll-like receptor-mediated activation of intracellular signalling and secretion of TNF-alpha and IL-1 from murine macrophages. Cell Microbiol 5: 41-51.
34. Clemens DL, Lee BY, Horwitz MA, (2004) Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages. Infect Immun 72: 3204-3217.
35. Matz-Rensing K, Floto A, Schrod A, Becker T, Finke EJ, et al. (2007) Epizootic of tularemia in an outdoor housed group of cynomolgus monkeys (Macaca fascicularis). Vet Pathol 44: 327-334.
36. Hussell T, Cavanagh MM, (2009) The innate immune rheostat: influence on lung inflammatory disease and secondary bacterial pneumonia. Biochem Soc Trans 37: 811-813.
37. Bodnar KA, Serbina NV, Flynn JL, (2001) Fate of Mycobacterium tuberculosis within Murine Dendritic Cells. Infect Immun 69: 800-809.
38. Manca C, Tsenova L, Bergtold A, Freeman S, Tovey M, et al. (2001) Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-α/β. Proc Natl Acad Sci USA 98: 5752-5757.
39. Shi S, Blumenthal A, Hickey CM, Gandotra S, Levy D, et al. (2005) Expression of Many Immunologically Important Genes in Mycobacterium tuberculosis-Infected Macrophages Is Independent of Both TLR2 and TLR4 but Dependent on IFN-αβ Receptor and STAT1. J Immunol 175: 3318-3328.
40. Stanley SA, Johndrow JE, Manzanillo P, Cox JS, (2007) The Type I IFN Response to Infection with Mycobacterium tuberculosis Requires ESX-1-Mediated Secretion and Contributes to Pathogenesis. J Immunol 178: 3143-3152.
41. Antonelli LRV, Gigliotti Rothfuchs A, Gonçalves R, Roffê, Cheever AW, et al. (2010) Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population. J Clin Invest 120: 1674-1682.
42. Berry MP, Graham CM, McNab FW, Xu Z, Bloch SA, et al. (2010) An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466: 973-977.
43. Capuano SV 3rd, Croix DA, Pawar S, Zinovik A, Myers A, et al. (2003) Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection. Infect Immun 71: 5831-5844.
44. Horzempa J, O'Dee DM, Shanks RM, Nau GJ, (2010) Francisella tularensis ΔpyrF mutants show that replication in nonmacrophages is sufficient for pathogenesis in vivo. Infect Immun 78: 2607-2619.
45. Francis T, Magill TP, (1935) Immunological Studies with the Virus of Influenza. J Exp Med 62: 505-516.
46. Troyanskaya O, Cantor M, Sherlock G, Brown P, Hastie T, et al. (2001) Missing value estimation methods for DNA microarrays. Bioinformatics 17: 520-525.
47. Ernst J, Beg QK, Kay KA, Balazsi G, Oltvai ZN, et al. (2008) A semi-supervised method for predicting transcription factor-gene interactions in Escherichia coli. PLoS Comput Biol 4: e1000044.
48. Ernst J, Plasterer HL, Simon I, Bar-Joseph Z, (2010) Integrating multiple evidence sources to predict transcription factor binding in the human genome. Genome Res 20: 526-536.