Protection from pulmonary tissue damage associated with infection of cynomolgus macaques by highly pathogenic avian influenza virus (H5N1) by low dose natural human IFN-α administered to the buccal mucosa

Antiviral Research

Volumn 110, Issue , 2014, Pages 175-180

  Strayer, David R ^a   Carter, William A ^a   Stouch, Bruce C ^b   Stittelaar, Koert J ^c   Thoolen, Robert J M M ^d   Osterhaus, Albert D M E ^c   Mitchell, William M ^e  

^a HEMISPHERX BIOPHARMA INC   (United States)

^b BC Consulting   (United States)

^c ViroClinics Biosciences BV   (Netherlands)

^d Global Pathology Support   (Netherlands)

^e VANDERBILT UNIVERSITY   (United States)

Author keywords

H5N1; Highly pathogenic; Influenza virus; Interferon; Oro mucosal (buccal) administration

Indexed keywords

ALPHAN3 INTERFERON; ALPHA INTERFERON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEEK MUCOSA; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DOSE COMPARISON; DRUG DOSE REGIMEN; IMMUNOTHERAPY; INFLUENZA A (H5N1); INFLUENZA VIRUS A H5N1; LOW DRUG DOSE; LOWER RESPIRATORY TRACT; LUNG EDEMA; LUNG EMPHYSEMA; LUNG HEMORRHAGE; LUNG INJURY; LUNG PARENCHYMA; LUNG PROTECTION; MACACA FASCICULARIS; NONHUMAN; OUTCOME ASSESSMENT; PROPHYLAXIS; PROTECTION; VIRUS LOAD; VIRUS PNEUMONIA; VIRUS TITRATION; ANIMAL; DISEASE MODEL; DRUG EFFECTS; HEMORRHAGE; HUMAN; INFLAMMATION; LUNG ALVEOLUS; MONKEY DISEASES; MOUTH MUCOSA; ORAL DRUG ADMINISTRATION; ORTHOMYXOVIRIDAE INFECTIONS; PATHOGENICITY; PATHOLOGY; VIROLOGY; VIRUS REPLICATION;

AVIAN INFLUENZA VIRUS; MACACA; ORTHOMYXOVIRIDAE;

ADMINISTRATION, ORAL; ANIMALS; DISEASE MODELS, ANIMAL; HEMORRHAGE; HUMANS; INFLAMMATION; INFLUENZA A VIRUS, H5N1 SUBTYPE; INTERFERON-ALPHA; LUNG INJURY; MACACA FASCICULARIS; MONKEY DISEASES; MOUTH MUCOSA; ORTHOMYXOVIRIDAE INFECTIONS; PULMONARY ALVEOLI; VIRUS REPLICATION;

EID: 84907820852     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2014.07.010     Document Type: Article

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