Increased viral loads and exacerbated innate host responses in aged macaques infected with the 2009 pandemic H1N1 influenza a virus

Journal of Virology

Volumn 86, Issue 20, 2012, Pages 11115-11127

  Josset, Laurence ^a   Engelmann, Flora ^b   Haberthur, Kristen ^b,c   Kelly, Sara ^a   Park, Byung ^b   Kawoaka, Yoshi ^d,e,f   García Sastre, Adolfo ^g   Katze, Michael G ^a   Messaoudi, Ilhem ^b,c,h  

^a UNIVERSITY OF WASHINGTON   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e UNIVERSITY OF TOKYO   (Japan)

^f JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^g MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^h OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

2009 H1N1 INFLUENZA; AGE DISTRIBUTION; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; IMMUNE RESPONSE; INFLAMMATION; INFLUENZA VIRUS A H1N1; INNATE IMMUNITY; LOWER RESPIRATORY TRACT; LUNG LAVAGE; LYMPHOCYTE PROLIFERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UPPER RESPIRATORY TRACT; VIRUS LOAD; VIRUS REPLICATION;

ADAPTIVE IMMUNITY; AGING; ANIMALS; ANTIBODIES, VIRAL; BRONCHOALVEOLAR LAVAGE FLUID; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CROSS PROTECTION; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; HOST-PATHOGEN INTERACTIONS; IMMUNITY, INNATE; INFLUENZA A VIRUS, H1N1 SUBTYPE; LYMPHOCYTE ACTIVATION; MACACA MULATTA; NASAL LAVAGE FLUID; ORTHOMYXOVIRIDAE INFECTIONS; PANDEMICS; RESPIRATORY SYSTEM; VIRAL LOAD;

ANIMALIA; INFLUENZA A VIRUS; MACACA; MACACA MULATTA; ORTHOMYXOVIRIDAE;

EID: 84869026338     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01571-12     Document Type: Article

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