Efficacy of influenza vaccination of elderly rhesus macaques is dramatically improved by addition of a cationic lipid/dna adjuvant

Journal of Infectious Diseases

Volumn 209, Issue 1, 2014, Pages 24-33

  Carroll, Timothy D ^a,b   Matzinger, Shannon R ^a,b   Barry, Peter A ^a,b,c   McChesney, Michael B ^b,c   Fairman, Jeffery ^e   Miller, Christopher J ^a,b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Colby Pharmaceutical Company ^*  (United States)

Author keywords

antibody titers; CD8+ T cells; elderly; immunosenescence; inactivated vaccine; macaques; mucosal

Indexed keywords

CATION; CD4 ANTIGEN; CD8 ANTIGEN; DNA; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; INFLUENZA VACCINE; LIPID;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMALE; IMMUNOGLOBULIN BLOOD LEVEL; INFLUENZA; INFLUENZA VACCINATION; INFLUENZA VIRUS; INFLUENZA VIRUS A; INFLUENZA VIRUS A H1N1; JUVENILE ANIMAL; MALE; NONHUMAN; PRIORITY JOURNAL; RECIPIENT; RHESUS MONKEY; VIRUS ISOLATION; VIRUS REPLICATION;

ANTIBODY TITERS; CD8+ T CELLS; ELDERLY; IMMUNOSENESCENCE; INACTIVATED VACCINE; MACAQUES; MUCOSAL;

AGING; ANIMALS; ANTIBODIES, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; INFLUENZA VACCINES; INTEGRIN ALPHA4; INTEGRIN BETA CHAINS; INTERFERON-GAMMA; MACACA MULATTA; MALE; NASAL LAVAGE FLUID; ORTHOMYXOVIRIDAE INFECTIONS; VACCINES, INACTIVATED;

EID: 84891368229     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit540     Document Type: Article

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