Deletion of PDK1 causes cardiac sodium current reduction in mice

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Han, Zhonglin ^a   Jiang, Yu ^a   Yang, Yuqing ^a   Li, Xuehan ^a   Yang, Zhongzhou ^b   Cao, Kejiang ^a   Wang, Dao W ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; SODIUM CHANNEL NAV1.5; TRANSCRIPTION FACTOR FKHR; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, MOUSE; FOXO1 PROTEIN, RAT; NERVE PROTEIN; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE; SCN5A PROTEIN, MOUSE; SCN5A PROTEIN, RAT; SODIUM;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CHANNEL GATING; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE DELETION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION DISTURBANCE; HEART RATE; KINETICS; KNOCKOUT MOUSE; MOUSE; MUSCLE FIBER CULTURE; NEWBORN; NONHUMAN; PATCH CLAMP TECHNIQUE; PDK1 GENE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; QRS COMPLEX; QT PROLONGATION; RAT; SIGNAL TRANSDUCTION; SODIUM CURRENT; WESTERN BLOTTING; ANIMAL; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; GENETICS; ION TRANSPORT; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

MUS; RATTUS;

ANIMALS; FORKHEAD BOX PROTEIN O1; FORKHEAD TRANSCRIPTION FACTORS; GENE DELETION; ION TRANSPORT; MICE; MICE, KNOCKOUT; MYOCARDIUM; MYOCYTES, CARDIAC; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; NERVE TISSUE PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM;

EID: 84925014564     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0122436     Document Type: Article

References (43)

1. Dummler B, Hemmings BA (2007) Physiological roles of PKB/Akt isoforms in development and disease. Biochem Soc Trans 35: 231-235. PMID: 17371246
2. Dann SG, Selvaraj A, Thomas G (2007) mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med 13: 252-259. PMID: 17452018
3. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V (2006) (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev 86: 1151-1178. PMID: 17015487
4. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868. PMID: 10102273
5. Mora A, Komander D, van Aalten DM, Alessi DR (2004) PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol 15: 161-170. PMID: 15209375
6. Ito K, Akazawa H, Tamagawa M, Furukawa K, Ogawa W, Yasuda N, et al. (2009) PDK1 coordinates survival pathways and beta-adrenergic response in the heart. Proc Natl Acad Sci U S A 106: 8689-8694. doi: 10.1073/pnas.0900064106 PMID: 19429709
7. Pretorius L, Du XJ, Woodcock EA, Kiriazis H, Lin RC, Marasco S, et al. (2009) Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation. Am J Pathol 175: 998-1009. doi: 10.2353/ajpath.2009.090126 PMID: 19679877
8. Wu X, Cao Y, Nie J, Liu H, Lu S, Hu X, et al. (2013) Genetic and pharmacological inhibition of Rheb1- mTORC1 signaling exerts cardioprotection against adverse cardiac remodeling in mice. Am J Pathol 182: 2005-2014. doi: 10.1016/j.ajpath.2013.02.012 PMID: 23567640
9. Mora A, Davies AM, Bertrand L, Sharif I, Budas GR, Jovanovic S, et al. (2003) Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J 22: 4666-4676. PMID: 12970179
10. Lu Z, Wu CY, Jiang YP, Ballou LM, Clausen C, Cohen IS, et al. (2012) Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome. Sci Transl Med 4: 131ra150.
11. Mao W, You T, Ye B, Li X, Dong HH, Hill JA, et al. (2012) Reactive oxygen species suppress cardiac NaV1.5 expression through Foxo1. PLoS One 7: e32738. doi: 10.1371/journal.pone.0032738 PMID: 22400069
12. Kaur K, Zarzoso M, Ponce-Balbuena D, Guerrero-Serna G, Hou L, Musa H, et al. (2013) TGF-beta1, released by myofibroblasts, differentially regulates transcription and function of sodium and potassium channels in adult rat ventricular myocytes. PLoS One 8: e55391. doi: 10.1371/journal.pone.0055391 PMID: 23393573
13. Farr MA, Basson CT (2004) Sparking the failing heart. N Engl J Med 351: 185-187. PMID: 15247360
14. Di RM, Feng QT, Chang Z, Luan Q, Zhang YY, Huang J, et al. (2010) PDK1 plays a critical role in regulating cardiac function in mice and human. Chin Med J (Engl) 123: 2358-2363. PMID: 21034549
15. London B, Wang DW, Hill JA, Bennett PB (1998) The transient outward current in mice lacking the potassium channel gene Kv1.4. J Physiol 509 (Pt 1): 171-182. PMID: 9547391
16. Yang T, Atack TC, Stroud DM, Zhang W, Hall L, Roden DM (2012) Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic. Circ Res 111: 322-332. doi: 10.1161/CIRCRESAHA.112.265173 PMID: 22723299
17. Jiang Q, Ni B, Shi J, Han Z, Qi R, Xu W, et al. (2014) Down-regulation of ATBF1 activates STAT3 signaling via PIAS3 in pacing-induced HL-1 atrial myocytes. Biochem Biophys Res Commun 449: 278-283. doi: 10.1016/j.bbrc.2014.05.041 PMID: 24857987
18. Najafov A, Sommer EM, Axten JM, Deyoung MP, Alessi DR (2011) Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1. Biochem J 433: 357-369. doi: 10.1042/BJ20101732 PMID: 21087210
19. Hirai H, Sootome H, Nakatsuru Y, Miyama K, Taguchi S, Tsujioka K, et al. (2010) MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol Cancer Ther 9: 1956-1967. doi: 10.1158/1535-7163.MCT-09-1012 PMID: 20571069
20. Nagashima T, Shigematsu N, Maruki R, Urano Y, Tanaka H, Shimaya A, et al. (2010) Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol Pharmacol 78: 961-970. doi: 10.1124/mol.110.065714 PMID: 20736318
21. Diep CH, Charles NJ, Gilks CB, Kalloger SE, Argenta PA, Lange CA (2013) Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells. Cell Cycle 12: 1433-1449. doi: 10.4161/cc.24550 PMID: 23574718
22. Ruan Y, Liu N, Priori SG (2009) Sodium channel mutations and arrhythmias. Nat Rev Cardiol 6: 337-348. doi: 10.1038/nrcardio.2009.44 PMID: 19377496
23. Lu Z, Jiang YP, Wu CY, Ballou LM, Liu S, Carpenter ES, et al. (2013) Increased persistent sodium current due to decreased PI3K signaling contributes to QT prolongation in the diabetic heart. Diabetes 62: 4257-4265. doi: 10.2337/db13-0420 PMID: 23974924
24. Song W, Xiao Y, Chen H, Ashpole NM, Piekarz AD, Ma P, et al. (2012) The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity. J Physiol 590: 5123-5139. doi: 10.1113/jphysiol.2012.235374 PMID: 22826127
25. Wang DW, Viswanathan PC, Balser JR, George AL Jr, Benson DW (2002) Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction block. Circulation 105: 341-346. PMID: 11804990
26. Remme CA, Verkerk AO, Nuyens D, van Ginneken AC, van Brunschot S, Belterman CN, et al. (2006) Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD. Circulation 114: 2584-2594. PMID: 17145985
27. Korkmaz S, Zitron E, Bangert A, Seyler C, Li S, Hegedus P, et al. (2013) Provocation of an autoimmune response to cardiac voltage-gated sodium channel NaV1.5 induces cardiac conduction defects in rats. J Am Coll Cardiol 62: 340-349. doi: 10.1016/j.jacc.2013.04.041 PMID: 23684688
28. Heath BM, Cui Y, Worton S, Lawton B, Ward G, Ballini E, et al. (2011) Translation of flecainide- and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical. J Pharmacol Toxicol Methods 63: 258-268. doi: 10.1016/j.vascn.2010.12.004 PMID: 21194571
29. Cordes J, Li C, Dugas J, Austin-LaFrance R, Lightbown I, Engwall M, et al. (2009) Translation between in vitro inhibition of the cardiac Nav1.5 channel and pre-clinical and clinical QRS widening. Journal of Pharmacological and Toxicological Methods 60: 221.
30. Schott JJ, Alshinawi C, Kyndt F, Probst V, Hoorntje TM, Hulsbeek M, et al. (1999) Cardiac conduction defects associate with mutations in SCN5A. Nat Genet 23: 20-21. PMID: 10471492
31. Oudit GY, Penninger JM (2009) Cardiac regulation by phosphoinositide 3-kinases and PTEN. Cardiovasc Res 82: 250-260. doi: 10.1093/cvr/cvp014 PMID: 19147653
32. Hashimoto N, Kido Y, Uchida T, Asahara S, Shigeyama Y, Matsuda T, et al. (2006) Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass. Nat Genet 38: 589-593. PMID: 16642023
33. Harris IS, Blaser H, Moreno J, Treloar AE, Gorrini C, Sasaki M, et al. (2014) PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling. Oncogene 33: 1047-1054. doi: 10.1038/onc.2013.24 PMID: 23435421
34. Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, et al. (2007) FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128: 309-323. PMID: 17254969
35. Remme CA, Wilde AA (2008) SCN5A overlap syndromes: no end to disease complexity? Europace 10: 1253-1255. doi: 10.1093/europace/eun267 PMID: 18820249
36. Frigo G, Rampazzo A, Bauce B, Pilichou K, Beffagna G, Danieli GA, et al. (2007) Homozygous SCN5A mutation in Brugada syndrome with monomorphic ventricular tachycardia and structural heart abnormalities. Europace 9: 391-397. PMID: 17442746
37. Nguyen TP, Wang DW, Rhodes TH, George AL Jr (2008) Divergent biophysical defects caused by mutant sodium channels in dilated cardiomyopathy with arrhythmia. Circ Res 102: 364-371. PMID: 18048769
38. Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, et al. (2005) Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 111: 659-670. PMID: 15655131
39. Zicha S, Maltsev VA, Nattel S, Sabbah HN, Undrovinas AI (2004) Post-transcriptional alterations in the expression of cardiac Na+ channel subunits in chronic heart failure. J Mol Cell Cardiol 37: 91-100. PMID: 15242739
40. Boehmer C, Wilhelm V, Palmada M, Wallisch S, Henke G, Brinkmeier H, et al. (2003) Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A. Cardiovasc Res 57: 1079-1084. PMID: 12650886
41. Lang F, Artunc F, Vallon V (2009) The physiological impact of the serum and glucocorticoid-inducible kinase SGK1. Curr Opin Nephrol Hypertens 18: 439-448. doi: 10.1097/MNH.0b013e32832f125e PMID: 19584721
42. Pochynyuk O, Medina J, Gamper N, Genth H, Stockand JD, Staruschenko A (2006) Rapid translocation and insertion of the epithelial Na+ channel in response to RhoA signaling. J Biol Chem 281: 26520-26527. PMID: 16829523
43. Storey NM, O'Bryan JP, Armstrong DL (2002) Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel. Curr Biol 12: 27-33. PMID: 11790300