Provocation of an autoimmune response to cardiac voltage-gated sodium channel NaV1.5 induces cardiac conduction defects in rats

Journal of the American College of Cardiology

Volumn 62, Issue 4, 2013, Pages 340-349

  Korkmaz, Sevil ^a   Zitron, Edgar ^a   Bangert, Anna ^a   Seyler, Claudia ^a   Li, Shiliang ^a   Hegedüs, Peter ^a   Scherer, Daniel ^a   Li, Jin ^a   Fink, Thomas ^a   Schweizer, Patrick A ^a   Giannitsis, Evangelos ^a   Karck, Matthias ^a   Szabó, Gábor ^a   Katus, Hugo A ^a   Kaya, Ziya ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

autoantibodies; autoimmunity; cardiac sodium channel; conduction defect

Indexed keywords

AUTOANTIBODY; MESSENGER RNA; SODIUM CHANNEL NAV1.5; SODIUM CHANNEL NAV1.5 AUTOANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; ATRIOVENTRICULAR BLOCK; AUTOIMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROCARDIOGRAM; GENE EXPRESSION; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION DISTURBANCE; HEART SINOATRIAL BLOCK; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE EXTRASYSTOLE; HISTOPATHOLOGY; HOLTER MONITORING; HUMAN; HUMORAL IMMUNITY; IN VIVO STUDY; MALE; NONHUMAN; PR INTERVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ATRIOVENTRICULAR BLOCK; AUTOANTIBODIES; AUTOIMMUNITY; AVB; CARDIAC SODIUM CHANNEL; CARDIAC TRANSIENT OUTWARD POTASSIUM CURRENT; CARDIAC VOLTAGE-GATED SODIUM CHANNEL Α-SUBUNIT; CARDIAC VOLTAGE-GATED SODIUM CHANNEL Α-SUBUNIT GENE; CARDIAC VOLTAGE-GATED SODIUM-CHANNEL CURRENT; CONDUCTION DEFECT; DP/DT(MAX); DP/DT(MIN); ECG; ELECTROCARDIOGRAPHY; H&E; HEMATOXYLIN AND EOSIN; I(NA); I(TO); LEFT VENTRICULAR; LV; MATRIX METALLOPROTEINASE; MAXIMAL SLOPE OF THE DIASTOLIC PRESSURE DECREMENT; MAXIMAL SLOPE OF THE SYSTOLIC PRESSURE INCREMENT; MMP; NA(V)1.5; SCN5A; TIMP; TISSUE INHIBITOR OF METALLOPROTEINASE;

AMINO ACID SEQUENCE; ANIMALS; ARRHYTHMIAS, CARDIAC; AUTOANTIBODIES; AUTOIMMUNE DISEASES; HEART CONDUCTION SYSTEM; MALE; MOLECULAR SEQUENCE DATA; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; RANDOM ALLOCATION; RATS; RATS, INBRED LEW;

EID: 84880290612     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.04.041     Document Type: Article

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