PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling

Oncogene

Volumn 33, Issue 8, 2014, Pages 1047-1054

  Harris, I S ^a,b   Blaser, H ^a   Moreno, J ^a,b,c   Treloar, A E ^a   Gorrini, C ^a   Sasaki, M ^a   Mason, J M ^a   Knobbe, C B ^a,d   Rufini, A ^e   Halle M ^f   Elia, A J ^a   Wakeham, A ^a   Tremblay, M L ^f   Melino, G ^e   Done, S ^a,b,c   Mak, T W ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e UNIVERSITY OF LEICESTER   (United Kingdom)

^f MCGILL UNIVERSITY   (Canada)

Author keywords

Antioxidant; Breast cancer; Oxidative stress; Protein tyrosine phosphatase; Reactive oxygen species

Indexed keywords

ANIMALS; BREAST NEOPLASMS; CELL DIVISION; CELLS, CULTURED; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MICE; OXIDATIVE STRESS; PROGNOSIS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 12; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84894561151     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.24     Document Type: Article

References (34)

1. Xu D, Rovira II, Finkel T. Oxidants painting the cysteine chapel: Redox regulation of PTPs. Dev Cell 2002; 2: 251-252
2. Karisch R, Fernandez M, Taylor P, Virtanen C, St-Germain JR, Jin LL et al. Global proteomic assessment of the classical protein-Tyrosine phosphatome and redoxome'. Cell 2011; 146: 826-840
3. Wiseman H, Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer. Biochem J 1996; 313: 17-29
4. Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY et al. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 2009; 461: 109-113
5. Storz P. Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal 2011; 14: 593-605
6. Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005; 24: 7410-7425
7. Myatt SS, Brosens JJ, Lam EW. Sense and sensitivity: FOXO and ROS in cancer development and treatment. Antioxid Redox Signal 2011; 14: 675-687
8. Cote JF, Charest A, Wagner J, Tremblay ML. Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model. Biochemistry 1998; 37: 13128-13137
9. Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer 2011; 11: 85-95
10. Vaughn AE, Deshmukh M. Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c. Nat Cell Biol 2008; 10: 1477-1483
11. Meister A. Selective modification of glutathione metabolism. Science 1983; 220: 472-477
12. DeBerardinis RJ, Cheng T. Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 2010; 29: 313-324
13. Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I et al. Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell 2009; 136: 352-363
14. Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I et al. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 2008; 14: 458-470
15. Casamayor A, Morrice NA, Alessi DR. Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identification of five sites of phosphorylation in vivo. Biochem J 1999; 342(Pt 2): 287-292
16. Yang KJ, Shin S, Piao L, Shin E, Li Y, Park KA et al. Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding. J Biol Chem 2008; 283: 1480-1491
17. Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol 2001; 21: 952-965
18. Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 1999; 18: 3024-3033
19. Rogoff D, Black K, McMillan DR, White PC. Contribution of hexose-6-phosphate dehydrogenase to NADPH content and redox environment in the endoplasmic reticulum. Redox Rep 2010; 15: 64-70
20. Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H et al. CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell 2011; 19: 387-400
21. Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT et al. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med 2009; 15: 1307-1311
22. Nemoto S, Finkel T. Redox regulation of forkhead proteins through a p66shcdependent signaling pathway. Science 2002; 295: 2450-2452
23. Essafi A, Fernandez de Mattos S, Hassen YA, Soeiro I, Mufti GJ, Thomas NS et al. Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. Oncogene 2005; 24: 2317-2329
24. Streit S, Ruhe JE, Knyazev P, Knyazeva T, Iacobelli S, Peter S et al. PTP-PEST phosphatase variations in human cancer. Cancer Genet Cytogenet 2006; 170: 48-53
25. Chin K, DeVries S, Fridlyand J, Spellman PT, Roydasgupta R, Kuo WL et al. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell 2006; 10: 529-541
26. Hoadley KA, Weigman VJ, Fan C, Sawyer LR, He X, Troester MA et al. EGFR associated expression profiles vary with breast tumor subtype. BMC Genomics 2007; 8: 258
27. Cheang MC, Voduc D, Bajdik C, Leung S, McKinney S, Chia SK et al. Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype. Clin Cancer Res 2008; 14: 1368-1376
28. Arpaia E, Blaser H, Quintela-Fandino M, Duncan G, Leong HS, Ablack A et al. The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk. Oncogene 2011; 31: 884-896
29. Forteleoni G, Argiolas L, Farris A, Ferraris AM, Gaetani GF, Meloni T. G6PD deficiency and breast cancer. Tumori 1988; 74: 665-667
30. Bailey HH, Ripple G, Tutsch KD, Arzoomanian RZ, Alberti D, Feierabend C et al. Phase I study of continuous-infusion L-S,R-buthionine sulfoximine with intravenous melphalan. J Natl Cancer Inst 1997; 89: 1789-1796
31. Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I et al. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell 2011; 144: 703-718
32. Bakker WJ, Harris IS, Mak TW. FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2. Mol Cell 2007; 28: 941-953
33. Allred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol 1998; 11: 155-168
34. Yerushalmi R, Gelmon KA, Leung S, Gao D, Cheang M, Pollak M et al. Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes. Breast Cancer Res Treat 2011; 132: 131-142.