Association of functional polymorphisms from brain-derived neurotrophic factor and serotonin-related genes with depressive symptoms after a medical stressor in older adults

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Rawson, Kerri S ^a   Dixon, David ^a   Nowotny, Petra ^a   Ricci, William M ^b   Binder, Ellen F ^a   Rodebaugh, Thomas L ^c   Wendleton, Leah ^a   Doré, Peter ^a   Lenze, Eric J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BARNES JEWISH HOSPITAL   (United States)

^c WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; SEROTONIN 1A RECEPTOR; SEROTONIN TRANSPORTER; VALINE; SEROTONIN; SLC6A4 PROTEIN, HUMAN;

5HT1A GENE; 5HTTLPR GENE; AGED; ARTICLE; BDNF GENE; CONTROLLED STUDY; CONVALESCENCE; DEPRESSION; EPISTASIS; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HIP FRACTURE; HUMAN; LIFE STRESS; MAJOR CLINICAL STUDY; MALE; PREDICTION; PROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; SYNAPSE; UNITED STATES; ADULT; CLINICAL TRIAL; GENETICS; MENTAL STRESS; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PSYCHOLOGY;

ADULT; AGED; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSION; FEMALE; GENOTYPE; HIP FRACTURES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS, PSYCHOLOGICAL;

EID: 84925004641     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0120685     Document Type: Article

References (79)

1. Bisschop MI, Kriegsman DMW, Deeg DJH, Beekman ATF, van Tilburg W. The longitudinal relation between chronic diseases and depression in older persons in the community: the Longitudinal Aging Study Amsterdam. J Clin Epidemiol. 2004; 57: 187-194. PMID: 15125629
2. Kennedy GJ, Kelman HR, Thomas C. The emergence of depressive symptoms in late life: the importance of declining health and increasing disability. J Community Health. 1990; 15: 93-104. PMID: 2141337
3. Prince MJ, Harwood RH, Blizard RA, Thomas A, Mann AH. Impairment, disability and handicap as risk factors for depression in old age: the Gospel Oak project V. Psychol Med. 1997; 27: 311-321. PMID: 9089824
4. Marks R, Allegrante JP, MacKenzie C, Lane JM. Hip fractures among the elderly: causes, consequences and control. Ageing Res Rev. 2003; 2: 57-93. PMID: 12437996
5. Kain H. Care of the older adult following hip fracture. Holist Nurs Pract. 2000; 14: 24-39. PMID: 12119649
6. Zuckerman JD. Hip fracture. N Engl J Med. 1996; 334: 1519-1525. PMID: 8618608
7. Williams CS, Tinetti ME, Kasl SV, Peduzzi PN. The role of pain in the recovery of instrumental and social functioning after hip fracture. J Aging Health. 2006; 18: 743-762. PMID: 16980638
8. Parker M, Johansen A. Hip fracture. BMJ. 2006; 333: 27-30. PMID: 16809710
9. Holmes J, House A. Psychiatric illness predicts poor outcome after surgery for hip fracture: a prospective cohort study. Psychol Med. 2000; 30: 921-929. PMID: 11037100
10. Cree M, Soskolne CL, Belseck E, Hornig J, McElhaney JE, Brant R, et al. Mortality and institutionalization following hip fracture. J Am Geriatr Soc. 2000; 48: 283-288. PMID: 10733054
11. Hannan EL, Magaziner J, Wang JJ, Eastwood EA, Silberzweig SB, Gilbert M, et al. Mortality and locomotion 6 months after hospitalization for hip fracture: risk factors and risk-adjusted hospital outcomes. JAMA. 2001; 285: 2736-2742. PMID: 11386929
12. Magaziner J, Lydick E, Hawkes W, Fox KM, Zimmerman SI, Epstein RS, et al. Excess mortality attributable to hip fracture in white women aged 70 years and older. Am J Public Health. 1997; 87: 1630-1636. PMID: 9357344
13. Givens JL, Sanft TB, Marcantonio ER. Functional recovery after hip fracture: the combined effects of depressive symptoms, cognitive impairment, and delirium. J Am Geriatr Soc. 2008; 56: 1075-1079. doi: 10.1111/j.1532-5415.2008.01711.x PMID: 18422945
14. Hershkovitz A, Kalandariov Z, Hermush V, Weiss R, Brill S. Factors affecting short-term rehabilitation outcomes of disabled elderly patients with proximal hip fracture. Arch Phys Med Rehabil. 2007; 88: 916-921. PMID: 17601474
15. Gialanella B, Prometti P, Monguzzi V, Ferlucci C. Neuropsychiatric symptoms and rehabilitation outcomes in patients with hip fracture. Am J Phys Med Rehabil. 2014;
16. Mossey JM, Mutran E, Knott K, Craik R. Determinants of recovery 12 months after hip fracture: the importance of psychosocial factors. Am J Public Health. 1989; 79: 279-286. PMID: 2916712
17. Lenze EJ, Munin MC, Dew MA, Rogers JC, Seligman K, Mulsant BH, et al. Adverse effects of depression and cognitive impairment on rehabilitation participation and recovery from hip fracture. Int J Geriatr Psychiatry. 2004; 19: 472-478. PMID: 15156549
18. Magaziner J, Simonsick EM, Kashner TM, Hebel JR, Kenzora JE. Predictors of functional recovery one year following hospital discharge for hip fracture: a prospective study. J Gerontol. 1990; 45: M101-M107. PMID: 2335719
19. Marottoli R, Berkman L, Cooney L. Decline in physical function following hip fracture. J Am Geriatr Soc. 1992; 40: 861-866. PMID: 1512379
20. Lipsky RH, Marini AM. Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Ann N Y Acad Sci. 2007; 1122: 130-143. PMID: 18077569
21. Krishnan V, Nestler EJ. The molecular neurobiology of depression. Nature. 2008; 455: 894-902. doi: 10.1038/nature07455 PMID: 18923511
22. Campbell S, MacQueen G. The role of the hippocampus in the pathophysiology of major depression. J Psychiatry Neurosci. 2004; 29: 417-426. PMID: 15644983
23. Leibrock J, Lottspeich F, Hohn A, Hofer M, Hengerer B, Masiakowski P, et al. Molecular cloning and expression of brain-derived neurotrophic factor. Nature. 1989; 341: 149-152. PMID: 2779653
24. Tapia-Arancibia L, Aliaga E, Silhol M, Arancibia S. New insights into brain BDNF function in normal aging and Alzheimer disease. Brain Res Rev. 2008; 59: 201-220. doi: 10.1016/j.brainresrev.2008.07.007 PMID: 18708092
25. Hayley S, Anisman H. Neurotrophic paths in the treatment of depression. J Psychiatry Neurosci. 2013; 38: 291-293. doi: 10.1503/jpn.130146 PMID: 23972006
26. Taylor WD, Züchner S, McQuoid DR, Steffens DC, Speer MC, Krishnan KRR. Allelic differences in the brain-derived neurotrophic factor val66met polymorphism in late-life depression. Am J Geriatr Psychiatry. 2007; 15: 850-857. PMID: 17911362
27. Taylor WD, McQuoid DR, Ashley-Koch A, MacFall JR, Bridgers J, Krishnan RR, et al. BDNF val66met genotype and 6-month remission rates in late-life depression. Pharmacogenomics J. 2011; 11: 146-154. doi: 10.1038/tpj.2010.12 PMID: 20195291
28. Kim J, Stewart R, Kim S, Yang S, Shin I, Kim Y, et al. Interactions between life stressors and susceptibility genes (5-httlpr and BDNF) on depression in Korean elders. Biol Psychiatry. 2007; 62: 423-428. PMID: 17482146
29. Pei Y, Smith AK, Wang Y, Pan Y, Yang J, Chen Q, et al. The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated with geriatric depression: a meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2012; 159B: 560-566. doi: 10.1002/ajmg.b.32062 PMID: 22610920
30. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003; 112: 257-269. PMID: 12553913
31. Chen Z, Patel PD, Sant G, Meng C, Teng KK, Hempstead BL, et al. Variant brain-derived neurotrophic factor (BDNF) (met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci. 2004; 24: 4401-4411. PMID: 15128854
32. Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF, et al. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci. 2003; 23: 6690-6694. PMID: 12890761
33. Bueller JA, Aftab M, Sen S, Gomez-Hassan D, Burmeister M, Zubieta J. BDNF val66met allele is associated with reduced hippocampal volume in healthy subjects. Biol Psychiatry. 2006; 59: 812-815. PMID: 16442082
34. MacQueen G, Frodl T. The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research? Mol Psychiatry. 2011; 16: 252-264. doi: 10.1038/mp.2010.80 PMID: 20661246
35. Duman RS. Neuronal damage and protection in the pathophysiology and treatment of psychiatric illness: stress and depression. Dialogues Clin Neurosci. 2009; 11: 239-255. PMID: 19877493
36. Martinowich K, Manji H, Lu B. New insights into BDNF function in depression and anxiety. Nat Neurosci. 2007; 10: 1089-1093. PMID: 17726474
37. Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, et al. Allelic variation of human serotonin transporter gene expression. J Neurochem. 1996; 66: 2621-2624. PMID: 8632190
38. Wendland JR, Martin BJ, Kruse MR, Lesch K, Murphy DL. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry. 2006; 11: 224-226. PMID: 16402131
39. Heils A, Teufel A, Petri S, Seemann M, Bengel D, Balling U, et al. Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene. J Neural Transm. 1995; 102: 247-254. PMID: 8788073
40. Nakatani D, Sato H, Sakata Y, Shiotani I, Kinjo K, Mizuno H, et al. Influence of serotonin transporter gene polymorphism on depressive symptoms and new cardiac events after acute myocardial infarction. Am Heart J. 2005; 150: 652-658. PMID: 16209960
41. Lesch K, Mössner R. Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Biol Psychiatry. 1998; 44: 179-192. PMID: 9693390
42. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003; 301: 386-389. PMID: 12869766
43. Lesch K, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996; 274: 1527-1531. PMID: 8929413
44. Otte C, McCaffery J, Ali S, Whooley MA. Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the Heart and Soul study. Am J Psychiatry. 2007; 164: 1379-1384. PMID: 17728423
45. Kohen R, Cain KC, Mitchell PH, Becker K, Buzaitis A, Millard SP, et al. Association of serotonin transporter gene polymorphisms with poststroke depression. Arch Gen Psychiatry. 2008; 65: 1296-1302. doi: 10.1001/archpsyc.65.11.1296 PMID: 18981341
46. Lenze EJ, Munin MC, Ferrell RE, Pollock BG, Skidmore E, Lotrich F, et al. Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture. Am J Geriatr Psychiatry. 2005; 13: 428-432. PMID: 15879594
47. Albert PR, Franc¸ois BL, Millar AM. Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness. Mol Brain. 2011; 4: 21-34. doi: 10.1186/1756-6606-4-21 PMID: 21619616
48. Kishi T, Yoshimura R, Fukuo Y, Okochi T, Matsunaga S, Umene-Nakano W, et al. The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder. Eur Arch Psychiatry Clin Neurosci. 2013; 263: 105-118. doi: 10.1007/s00406-012-0337-4 PMID: 22752684
49. Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, et al. Impaired repression at a 5-hydroxytryptamine 1a receptor gene polymorphism associated with major depression and suicide. J Neurosci. 2003; 23: 8788-8799. PMID: 14507979
50. Lenze EJ, Shardell M, Ferrell RE, Orwig D, Yu-Yahiro J, Hawkes W, et al. Association of serotonin-1A and 2A receptor promoter polymorphisms with depressive symptoms and functional recovery in elderly persons after hip fracture. J Affect Disord. 2008; 111: 61-66. doi: 10.1016/j.jad.2008.02.005 PMID: 18334271
51. Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979; 134: 382-389. PMID: 444788
52. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Clinician Version, Administration Booklet. American Psychiatric Pub; 2012.
53. Zuckerman J, Koval K, Aharonoff G, Hiebert R, Skovron M. A functional recovery score for elderly hip fracture patients: i. development. J Orthop Trauma January 2000. 2000; 14: 20-25. PMID: 10630798
54. Katzman R, Brown T, Fuld P, Peck A, Schechter R, Schimmel H. Validation of a short Orientation-Memory-Concentration Test of cognitive impairment. Am J Psychiatry. 1983; 140: 734-739. PMID: 6846631
55. Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983; 24: 385-396. PMID: 6668417
56. Hayes AF. Introduction to mediation, moderation, and conditional process analysis: A regression-based approach. New York, NY: Guilford Press; 2013.
57. Hayes AF, Preacher KJ. Statistical mediation analysis with a multicategorical independent variable. Br J Math Stat Psychol. 2013;
58. Hayes AF. Beyond Baron and Kenny: statistical mediation analysis in the new millennium. Commun Monogr. 2009; 76: 408-420.
59. Pritchard JK, Stephens M, Donnelly P. Inference of population structure using multilocus genotype data. Genetics. 2000; 155: 945-959. PMID: 10835412
60. Earl DA, vonHoldt BM. STRUCTURE HARVESTER: a website and program for visualizing STRUCTURE output and implementing the Evanno method. Conserv Genet Resour. 2011;
61. Petryshen TL, Sabeti PC, Aldinger KA, Fry B, Fan JB, Schaffner SF, et al. Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Mol Psychiatry. 2010; 15: 810-815. doi: 10.1038/mp.2009.24 PMID: 19255578
62. Murdoch JD, Speed WC, Pakstis AJ, Heffelfinger CE, Kidd KK. Worldwide population variation and haplotype analysis at the serotonin transporter gene SLC6A4 and implications for association studies. Biol Psychiatry. 2013; 74: 879-889. doi: 10.1016/j.biopsych.2013.02.006 PMID: 23510579
63. Prina AM, Deeg D, Brayne C, Beekman A, Huisman M. The association between depressive symptoms and non-psychiatric hospitalisation in older adults. PLoS ONE. 2012; 7: e34821. doi: 10.1371/journal.pone.0034821 PMID: 22496867
64. Katon WJ. Epidemiology and treatment of depression in patients with chronic medical illness. Dialogues Clin Neurosci. 2011; 13: 7-23. PMID: 21485743
65. Yu H, Chen Z. The role of BDNF in depression on the basis of its location in the neural circuitry. Acta Pharmacol Sin. 2011; 32: 3-11. doi: 10.1038/aps.2010.184 PMID: 21131999
66. Chen Z, Bath K, McEwen B, Hempstead B, Lee F. Impact of genetic variant BDNF (val66met) on brain structure and function. Novartis Found Symp. 2008; 289: 180-195. PMID: 18497103
67. Risch N, Herrell R, Lehner T, Liang KY, Eaves L, Hoh J, et al. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA. 2009; 301: 2462-2471. doi: 10.1001/jama.2009.878 PMID: 19531786
68. Karg K, Burmeister M, Shedden K, Sen S. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry. 2011; 68: 444-454. doi: 10.1001/archgenpsychiatry.2010.189 PMID: 21199959
69. Munafò MR, Durrant C, Lewis G, Flint J. Gene x environment interactions at the serotonin transporter locus. Biol Psychiatry. 2009; 65: 211-219. doi: 10.1016/j.biopsych.2008.06.009 PMID: 18691701
70. Porcelli S, Drago A, Fabbri C, Gibiino S, Calati R, Serretti A. Pharmacogenetics of antidepressant response. J Psychiatry Neurosci. 2011; 36: 87-113. doi: 10.1503/jpn.100059 PMID: 21172166
71. Taylor WD, Steffens DC, Payne ME, MacFall JR, Marchuk DA, Svenson IK, et al. Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression. Arch Gen Psychiatry. 2005; 62: 537-544. PMID: 15867107
72. Martinowich K, Lu B. Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology. 2007; 33: 73-83. PMID: 17882234
73. Mattson MP, Maudsley S, Martin B. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 2004; 27: 589-594. PMID: 15374669
74. Bogdan R, Hyde LW, Hariri AR. A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology. Mol Psychiatry. 2013; 18: 288-299. doi: 10.1038/mp.2012.35 PMID: 22614291
75. Terracciano A, Tanaka T, Sutin AR, Deiana B, Balaci L, Sanna S, et al. BDNF val66met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism. Neuropsychopharmacology. 2010; 35: 1083-1089. doi: 10.1038/npp.2009.213 PMID: 20042999
76. Dougherty LR, Klein DN, Congdon E, Canli T, Hayden EP. Interaction between 5-HTTLPR and BDNF Val66Met polymorphisms on HPA axis reactivity in preschoolers. Biol Psychol. 2010; 83: 93-100. doi: 10.1016/j.biopsycho.2009.10.009 PMID: 19914329
77. Kaufman J, Yang B, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, et al. Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry. 2006; 59: 673-680. PMID: 16458264
78. Shimizu E, Hashimoto K, Iyo M. Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: the possibility to explain ethnic mental traits. Am J Med Genet B Neuropsychiatr Genet. 2004; 126B: 122-123. PMID: 15048661
79. Kendler KS. What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn. Mol Psychiatry. 2013; 18: 1058-1066. doi: 10.1038/mp.2013.50 PMID: 23628988