The serotonin 1A receptor gene confer susceptibility to mood disorders: Results from an extended meta-analysis of patients with major depression and bipolar disorder

European Archives of Psychiatry and Clinical Neuroscience

Volumn 263, Issue 2, 2013, Pages 105-118

  Kishi, Taro ^a   Yoshimura, Reiji ^b   Fukuo, Yasuhisa ^a   Okochi, Tomo ^a   Matsunaga, Shinji ^a   Umene Nakano, Wakako ^b   Nakamura, Jun ^b   Serretti, Alessandro ^c   Correll, Christoph U ^d   Kane, John M ^d   Iwata, Nakao ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d ZUCKER HILLSIDE HOSPITAL   (United States)

Author keywords

Bipolar disorder; Major depressive disorder; Mood disorders; Serotonin 1A receptor gene (HTR1A); SNP

Indexed keywords

SEROTONIN 1A RECEPTOR;

ALLELE; ARTICLE; BIPOLAR DISORDER; DNA FLANKING REGION; EXON; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR DEPRESSION; META ANALYSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMATIC REVIEW;

ADULT; AGED; BIPOLAR DISORDER; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, SEROTONIN, 5-HT1A;

EID: 84879504493     PISSN: 09401334     EISSN: 14338491     Source Type: Journal    
DOI: 10.1007/s00406-012-0337-4     Document Type: Article

References (34)

1. Arias B, Arranz MJ, Gasto C, Catalan R, Pintor L, Gutierrez B, Kerwin RW, Fananas L (2002) Analysis of structural polymorphisms and c-1018 g promoter variant of the 5-ht(1a) receptor gene as putative risk factors in major depression. Mol Psychiatry 7:930-932 (Pubitemid 35333046)
2. Aznar S, Qian Z, Shah R, Rahbek B, Knudsen GM (2003) The 5-ht1a serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain. Brain Res 959:58-67 (Pubitemid 35435406)
3. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of ld and haplotype maps. Bioinformatics 21:263-265 (Pubitemid 40202029)
4. Benjamini Y, Drai D, Elmer G, Kafkafi N, Golani I (2001) Controlling the false discovery rate in behavior genetics research. Behav Brain Res 125:279-284 (Pubitemid 33000466)
5. Calati R, Gaspar-Barba E, Yukler A, Serretti A (2010) T3111c clock single nucleotide polymorphism and mood disorders: a meta-analysis. Chronobiol Int 27:706-721
6. Czesak M, Lemonde S, Peterson EA, Rogaeva A, Albert PR (2006) Cell-specific repressor or enhancer activities of deaf-1 at a serotonin 1a receptor gene polymorphism. J Neurosci 26:1864-1871 (Pubitemid 43236999)
7. David SP, Murthy NV, Rabiner EA, Munafo MR, Johnstone EC, Jacob R, Walton RT, Grasby PM (2005) A functional genetic variation of the serotonin (5-ht) transporter affects 5-ht1a receptor binding in humans. J Neurosci 25:2586-2590 (Pubitemid 40365170)
8. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177-188 (Pubitemid 17189972)
9. Drago A, Crisafulli C, Sidoti A, Serretti A (2011) The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes. Prog Neurobiol 94:418-460
10. Hettema JM, An SS, van den Oord EJ, Neale MC, Kendler KS, Chen X (2008) Association study between the serotonin 1a receptor (htr1a) gene and neuroticism, major depression, and anxiety disorders. Am J Med Genet B Neuropsychiatr Genet 147B:661-666 (Pubitemid 351961672)
11. Huang YY, Battistuzzi C, Oquendo MA, Harkavy-Friedman J, Greenhill L, Zalsman G, Brodsky B, Arango V, Brent DA, Mann JJ (2004) Human 5-ht1a receptor c(-1019)g polymorphism and psychopathology. Int J Neuropsychopharmacol 7:441-451 (Pubitemid 39648074)
12. Illi A, Setala-Soikkeli E, Viikki M, Poutanen O, Huhtala H, Mononen N, Lehtimaki T, Leinonen E, Kampman O (2009) 5-htr1a, 5-htr2a, 5-htr6, tph1 and tph2 polymorphisms and major depression. NeuroReport 20:1125-1128
13. Kato M, Fukuda T, Wakeno M, Okugawa G, Takekita Y, Watanabe S, Yamashita M, Hosoi Y, Azuma J, Kinoshita T, Serretti A (2009) Effect of 5-ht1a gene polymorphisms on antidepressant response in major depressive disorder. Am J Med Genet B Neuropsychiatr Genet 150B:115-123
14. Kato T (2007) Molecular genetics of bipolar disorder and depression. Psychiatry Clin Neurosci 61:3-19 (Pubitemid 46089400)
15. Kishi T, Kitajima T, Tsunoka T, Ikeda M, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Okumura T, Inada T, Ozaki N, Iwata N (2009) Genetic association analysis of serotonin 2a receptor gene (htr2a) with bipolar disorder and major depressive disorder in the Japanese population. Neurosci Res 64:231-234
16. Kishi T, Okochi T, Tsunoka T, Okumura T, Kitajima T, Kawashima K, Yamanouchi Y, Kinoshita Y, Naitoh H, Inada T, Kunugi H, Kato T, Yoshikawa T, Ujike H, Ozaki N, Iwata N (2011) Serotonin 1a receptor gene, schizophrenia and bipolar disorder: an association study and meta-analysis. Psychiatry Res 185:20-26
17. Kishi T, Tsunoka T, Ikeda M, Kawashima K, Okochi T, Kitajima T, Kinoshita Y, Okumura T, Yamanouchi Y, Inada T, Ozaki N, Iwata N (2009) Serotonin 1a receptor gene and major depressive disorder: an association study and meta-analysis. J Hum Genet 54:629-633
18. Koks S, Nikopensius T, Koido K, Maron E, Altmae S, Heinaste E, Vabrit K, Tammekivi V, Hallast P, Kurg A, Shlik J, Vasar V, Metspalu A, Vasar E (2006) Analysis of snp profiles in patients with major depressive disorder. Int J Neuropsychopharmacol 9:167-174 (Pubitemid 43255830)
19. Le Francois B, Czesak M, Steubl D, Albert PR (2008) Transcriptional regulation at a htr1a polymorphism associated with mental illness. Neuropharmacology 55:977-985
20. Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, Sequeira A, Kushwaha N, Morris SJ, Basak A, Ou XM, Albert PR (2003) Impaired repression at a 5-hydroxytryptamine 1a receptor gene polymorphism associated with major depression and suicide. J Neurosci 23:8788-8799 (Pubitemid 37176660)
21. McGuffin P, Cohen S, Knight J (2007) Homing in on depression genes. Am J Psychiatry 164:195-197
22. McGuffin P, Katz R (1989) The genetics of depression: current approaches. Br J Psychiatry Suppl 6:18-26 (Pubitemid 19282134)
23. Molina E, Cervilla J, Rivera M, Torres F, Bellon JA, Moreno B, King M, Nazareth I, Gutierrez B (2011) Polymorphic variation at the serotonin 1-a receptor gene is associated with comorbid depression and generalized anxiety. Psychiatr Genet 21:195-201
24. Neff CD, Abkevich V, Packer JC, Chen Y, Potter J, Riley R, Davenport C, DeGrado Warren J, Jammulapati S, Bhathena A, Choi WS, Kroeger PE, Metzger RE, Gutin A, Skolnick MH, Shattuck D, Katz DA (2009) Evidence for htr1a and lhpp as interacting genetic risk factors in major depression. Mol Psychiatry 14:621-630
25. Parsey RV, Olvet DM, Oquendo MA, Huang YY, Ogden RT, Mann JJ (2006) Higher 5-ht1a receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study. Neuropsychopharmacology 31:1745-1749 (Pubitemid 44106705)
26. Pinto C, Souza RP, Lioult D, Semeralul M, Kennedy JL, Warsh JJ, Wong AH, Luca VD (2011) Parent of origin effect and allelic expression imbalance of the serotonin transporter in bipolar disorder and suicidal behaviour. Eur Arch Psychiatry Clin Neurosci 261:533-538
27. Pompili M, Serafini G, Innamorati M, Moller-Leimkuhler AM, Giupponi G, Girardi P, Tatarelli R, Lester D (2010) The hypothalamic-pituitary-adrenal axis and serotonin abnormalities: a selective overview for the implications of suicide prevention. Eur Arch Psychiatry Clin Neurosci 260:583-600
28. Savitz J, Lucki I, Drevets WC (2009) 5-ht(1a) receptor function in major depressive disorder. Prog Neurobiol 88:17-31
29. Serretti A, Mandelli L, Giegling I, Schneider B, Hartmann AM, Schnabel A, Maurer K, Moller HJ, Rujescu D (2007) Htr2c and htr1a gene variants in german and Italian suicide attempters and completers. Am J Med Genet B Neuropsychiatr Genet 144B:291-299 (Pubitemid 46642017)
30. Soria V, Martinez-Amoros E, Escaramis G, Valero J, Perez-Egea R, Garcia C, Gutierrez-Zotes A, Puigdemont D, Bayes M, Crespo JM, Martorell L, Vilella E, Labad A, Vallejo J, Perez V, Menchon JM, Estivill X, Gratacos M, Urretavizcaya M (2010) Differential association of circadian genes with mood disorders: cry1 and npas2 are associated with unipolar major depression and clock and vip with bipolar disorder. Neuropsychopharmacology 35:1279-1289
31. Sullivan GM, Ogden RT, Oquendo MA, Kumar JS, Simpson N, Huang YY, Mann JJ, Parsey RV (2009) Positron emission tomography quantification of serotonin-1a receptor binding in medication-free bipolar depression. Biol Psychiatry 66:223-230
32. Whitaker-Azmitia PM, Druse M, Walker P, Lauder JM (1996) Serotonin as a developmental signal. Behav Brain Res 73:19-29 (Pubitemid 26008758)
33. Wu Y, Xu Y, Sun Y, Wang YF, Li X, Lang XE, Wang WP, Zhang KR (2008) Association between the serotonin 1a receptor c(-1019)g polymorphism and major depressive disorder in the northern han ethnic group in china. Chin Med J (Engl) 121:874-876
34. Zintzaras E (2010) The generalized odds ratio as a measure of genetic risk effect in the analysis and meta-analysis of association studies. Stat Appl Genet Mol Biol 9(1):Article21