-
2
-
-
33744511935
-
Application of laser-scanning fluorescence microplate cytometry in high content screening
-
Bowen WP, Wylie PG: Application of laser-scanning fluorescence microplate cytometry in high content screening. Assay Drug Dev Technol 2006;4:209-221.
-
(2006)
Assay Drug Dev Technol
, vol.4
, pp. 209-221
-
-
Bowen, W.P.1
Wylie, P.G.2
-
3
-
-
84887877208
-
An HTS-compatible 3D colony formation assay to identify tumor-specific chemotherapeutics
-
Horman SR, To J, Orth AP: An HTS-compatible 3D colony formation assay to identify tumor-specific chemotherapeutics. J Biomol Screen 2013;18:1298-1308.
-
(2013)
J Biomol Screen
, vol.18
, pp. 1298-1308
-
-
Horman, S.R.1
To, J.2
Orth, A.P.3
-
4
-
-
84894574272
-
Knockdown of Slingshot 2 (SSH2) serine phosphatase induces Caspase3 activation in human carcinoma cell lines with the loss of the Birt-Hogg-Dubé tumour suppressor gene (FLCN)
-
Lu X, Boora U, Seabra L, et al.: Knockdown of Slingshot 2 (SSH2) serine phosphatase induces Caspase3 activation in human carcinoma cell lines with the loss of the Birt-Hogg-Dubé tumour suppressor gene (FLCN). Oncogene 2013;33:956-965.
-
(2013)
Oncogene
, vol.33
, pp. 956-965
-
-
Lu, X.1
Boora, U.2
Seabra, L.3
-
5
-
-
84899490766
-
The oncogenic role of PKCiota gene amplification and overexpression in Chinese non-small cell lung cancer
-
Luo Q, Tang L, Lin H, et al.: The oncogenic role of PKCiota gene amplification and overexpression in Chinese non-small cell lung cancer. Lung Cancer 2013;84:190-195.
-
(2013)
Lung Cancer
, vol.84
, pp. 190-195
-
-
Luo, Q.1
Tang, L.2
Lin, H.3
-
6
-
-
84882958621
-
Development and validation of a 96-well cellular assay for the discovery of ALDH1A1 inhibitors
-
Ming W, Ma W, Chen LH, et al.: Development and validation of a 96-well cellular assay for the discovery of ALDH1A1 inhibitors. Assay Drug Dev Technol 2013;11:388-395.
-
(2013)
Assay Drug Dev Technol
, vol.11
, pp. 388-395
-
-
Ming, W.1
Ma, W.2
Chen, L.H.3
-
7
-
-
84885898627
-
Surface proteomic analysis of osteosarcoma identifies EPHA2 as receptor for targeted drug delivery
-
Posthumadeboer J, Piersma SR, Pham TV, et al.: Surface proteomic analysis of osteosarcoma identifies EPHA2 as receptor for targeted drug delivery. Br J Cancer 2013;109:2142-2154.
-
(2013)
Br J Cancer
, vol.109
, pp. 2142-2154
-
-
Posthumadeboer, J.1
Piersma, S.R.2
Pham, T.V.3
-
8
-
-
84877262605
-
Quantitative genetic-interaction mapping in mammalian cells
-
Roguev A, Talbot D, Negri GL, et al.: Quantitative genetic-interaction mapping in mammalian cells. Nat Methods 2013;10:432-437.
-
(2013)
Nat Methods
, vol.10
, pp. 432-437
-
-
Roguev, A.1
Talbot, D.2
Negri, G.L.3
-
9
-
-
84873816898
-
Small molecule screening with laser cytometry can be used to identify pro-survival molecules in human embryonic stem cells
-
Sherman SP, Pyle AD: Small molecule screening with laser cytometry can be used to identify pro-survival molecules in human embryonic stem cells. PLoS One 2013;8:e54948.
-
(2013)
PLoS One
, vol.8
, pp. e54948
-
-
Sherman, S.P.1
Pyle, A.D.2
-
10
-
-
84890822603
-
HIV cell fusion assay: Phenotypic screening tool for the identification of HIV entry inhibitors via CXCR4
-
Smith EB, Ogert RA, Pechter D: HIV cell fusion assay: phenotypic screening tool for the identification of HIV entry inhibitors via CXCR4. J Biomol Screen 2014;19:108-118.
-
(2014)
J Biomol Screen
, vol.19
, pp. 108-118
-
-
Smith, E.B.1
Ogert, R.A.2
Pechter, D.3
-
11
-
-
84878190144
-
Multiparametric cell-based assay for the evaluation of transcription inhibition by high-content imaging
-
Torres-Guzmán R, Chu S, Velasco JA, Lallena MJ: Multiparametric cell-based assay for the evaluation of transcription inhibition by high-content imaging. J Biomol Screen 2013;18:556-566.
-
(2013)
J Biomol Screen
, vol.18
, pp. 556-566
-
-
Torres-Guzmán, R.1
Chu, S.2
Velasco, J.A.3
Lallena, M.J.4
-
12
-
-
84862738897
-
Preclinical pharmacology of AZD5363, an orally bioavailable inhibitor of AKT: Pharmacodynamics, antitumor activity and correlation of monotherapy activity with genetic background
-
Davies BR, Greenwood H, Dudley P, et al.: Preclinical pharmacology of AZD5363, an orally bioavailable inhibitor of AKT: pharmacodynamics, antitumor activity and correlation of monotherapy activity with genetic background. Mol Cancer Ther 2012;11:873-887.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 873-887
-
-
Davies, B.R.1
Greenwood, H.2
Dudley, P.3
-
13
-
-
84860120185
-
AZD4547: An orally bioavailable, potent and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family
-
Gavine PR, Mooney L, Kilgour E, et al.: AZD4547: an orally bioavailable, potent and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res 2012;72:2045-2056.
-
(2012)
Cancer Res
, vol.72
, pp. 2045-2056
-
-
Gavine, P.R.1
Mooney, L.2
Kilgour, E.3
-
14
-
-
84860655854
-
Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target
-
Gerlinger M, Santos CR, Spencer-Dene B, et al.: Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target. J Pathol 2012;227:146-156.
-
(2012)
J Pathol
, vol.227
, pp. 146-156
-
-
Gerlinger, M.1
Santos, C.R.2
Spencer-Dene, B.3
-
15
-
-
84861494447
-
Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions
-
Heald RA, Jackson P, Savy P, et al.: Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions. J Med Chem 2012;55:4594-4604.
-
(2012)
J Med Chem
, vol.55
, pp. 4594-4604
-
-
Heald, R.A.1
Jackson, P.2
Savy, P.3
-
16
-
-
84865534585
-
High-throughput screening for genes that prevent excess DNA replication in human cells and for molecules that inhibit them
-
Lee CY, Johnson RL, Wichterman-Kouznetsova J, et al.: High-throughput screening for genes that prevent excess DNA replication in human cells and for molecules that inhibit them. Methods 2012;57:234-248.
-
(2012)
Methods
, vol.57
, pp. 234-248
-
-
Lee, C.Y.1
Johnson, R.L.2
Wichterman-Kouznetsova, J.3
-
17
-
-
82355175286
-
Surviving cells after treatment with gemcitabine or 5-fluorouracil for the study of de novo resistance of pancreatic cancer
-
Liu QH, Zhang J, Zhao CY, et al.: Surviving cells after treatment with gemcitabine or 5-fluorouracil for the study of de novo resistance of pancreatic cancer. Cancer Lett 2012;314:119-125.
-
(2012)
Cancer Lett
, vol.314
, pp. 119-125
-
-
Liu, Q.H.1
Zhang, J.2
Zhao, C.Y.3
-
18
-
-
84863069956
-
A chemical genomics screen to discover genes that modulate neural stem cell differentiation
-
Kim KJ, Wang J, Xu X, et al.: A chemical genomics screen to discover genes that modulate neural stem cell differentiation. J Biomol Screen 2012;17:129-139.
-
(2012)
J Biomol Screen
, vol.17
, pp. 129-139
-
-
Kim, K.J.1
Wang, J.2
Xu, X.3
-
19
-
-
84871304073
-
A potent anti-HB-EGF monoclonal antibody inhibits cancer cell proliferation and multiple angiogenic activities of HB-EGF
-
Sato S, Drake AW, Tsuji I, Fan J: A potent anti-HB-EGF monoclonal antibody inhibits cancer cell proliferation and multiple angiogenic activities of HB-EGF. PLoS One 2012;7:e51964.
-
(2012)
PLoS One
, vol.7
, pp. e51964
-
-
Sato, S.1
Drake, A.W.2
Tsuji, I.3
Fan, J.4
-
20
-
-
85056067711
-
High-throughput multiplexed quantitation of protein aggregation and cytotoxicity in a Huntington's disease model
-
Titus SA, Southall N, Marugan J, Austin CP, Zheng W: High-throughput multiplexed quantitation of protein aggregation and cytotoxicity in a Huntington's disease model. Curr Chem Genomics 2012;6:79-86.
-
(2012)
Curr Chem Genomics
, vol.6
, pp. 79-86
-
-
Titus, S.A.1
Southall, N.2
Marugan, J.3
Austin, C.P.4
Zheng, W.5
-
21
-
-
84860419274
-
Development and utilization of activated STAT3 detection assays for screening a library of secreted proteins
-
Fursov N, Gates IV, Panavas T, Giles-Komar J, Powers G:. Development and utilization of activated STAT3 detection assays for screening a library of secreted proteins. Assay Drug Devel Technol 2011;9:420-429.
-
(2011)
Assay Drug Devel Technol
, vol.9
, pp. 420-429
-
-
Fursov, N.1
Gates, I.V.2
Panavas, T.3
Giles-Komar, J.4
Powers, G.5
-
22
-
-
79953289737
-
Mapping of signaling networks through synthetic genetic interaction analysis by RNAi
-
Horn T, Sandmann T, Fischer B, Axelsson E, Huber W, Boutros M: Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Nat Methods 2011;8:341-346.
-
(2011)
Nat Methods
, vol.8
, pp. 341-346
-
-
Horn, T.1
Sandmann, T.2
Fischer, B.3
Axelsson, E.4
Huber, W.5
Boutros, M.6
-
23
-
-
79952220937
-
PKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways
-
Kveiborg M, Instrell R, Rowlands C, Howell M, Parker PJ: PKCα and PKCδ regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways. PLoS One 2011;6:e17168.
-
(2011)
PLoS One
, vol.6
, pp. e17168
-
-
Kveiborg, M.1
Instrell, R.2
Rowlands, C.3
Howell, M.4
Parker, P.J.5
-
24
-
-
78751523009
-
Therapeutic targeting the loss of the birt-hoggdube suppressor gene
-
Lu X, Wei W, Fenton J, et al.: Therapeutic targeting the loss of the birt-hoggdube suppressor gene. Mol Cancer Ther 2011;10:80-89.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 80-89
-
-
Lu, X.1
Wei, W.2
Fenton, J.3
-
25
-
-
81055124246
-
A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad-spectrum of anti-tumor activity in several tumor xenograft models
-
Zhao G, Li WY, Chen D, et al.: A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad-spectrum of anti-tumor activity in several tumor xenograft models. Mol Cancer Ther 2011;10:2200-2210.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 2200-2210
-
-
Zhao, G.1
Li, W.Y.2
Chen, D.3
-
26
-
-
79952837088
-
An image based, high-throughput screening assay for molecules that induce excess DNA replication in human cancer cells
-
Zhu W, Lee CY, Johnson RL, Wichterman J, Huang R, DePamphilis ML: An image based, high-throughput screening assay for molecules that induce excess DNA replication in human cancer cells. Mol Cancer Res 2011;9:294-310.
-
(2011)
Mol Cancer Res
, vol.9
, pp. 294-310
-
-
Zhu, W.1
Lee, C.Y.2
Johnson, R.L.3
Wichterman, J.4
Huang, R.5
DePamphilis, M.L.6
-
27
-
-
75149112670
-
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
-
Chresta CM, Davies BR, Hickson I, et al.: AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Res 2010;70:288-298.
-
(2010)
Cancer Res
, vol.70
, pp. 288-298
-
-
Chresta, C.M.1
Davies, B.R.2
Hickson, I.3
-
28
-
-
77956290679
-
FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells
-
Gupta S, Iljin K, Sara H, Mpindi JP, et al.: FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer Res 2010;70:6735-6745.
-
(2010)
Cancer Res
, vol.70
, pp. 6735-6745
-
-
Gupta, S.1
Iljin, K.2
Sara, H.3
Mpindi, J.P.4
-
29
-
-
76749136371
-
AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: A unique agent for simultaneous ERBB receptor blockade in cancer
-
Hickinson DM, Klinowska T, Speake G, et al.: AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer. Clin Cancer Res 2010;16:1159-1169.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1159-1169
-
-
Hickinson, D.M.1
Klinowska, T.2
Speake, G.3
-
30
-
-
77955301625
-
The p38 MAPK promotes cell survival in response to DNA damage but is not required for G2 DNA damage checkpoint in human cancer cells
-
Phong MS, Van Horn RD, Li S, Tucker-Kellogg G, Surana U, Ye XS: The p38 MAPK promotes cell survival in response to DNA damage but is not required for G2 DNA damage checkpoint in human cancer cells. Mol Cell Biol 2010;30:3816-3826.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 3816-3826
-
-
Phong, M.S.1
Van Horn, R.D.2
Li, S.3
Tucker-Kellogg, G.4
Surana, U.5
Ye, X.S.6
-
31
-
-
78650018068
-
Mammary-derived growth inhibitor (MGDI) interacts with integrin alpha-subunits and supresses integrin activity and invasion
-
Nevo J, Mai A, Tuomi S, et al.: Mammary-derived growth inhibitor (MGDI) interacts with integrin alpha-subunits and supresses integrin activity and invasion. Oncogene 2010;29:6452-6463.
-
(2010)
Oncogene
, vol.29
, pp. 6452-6463
-
-
Nevo, J.1
Mai, A.2
Tuomi, S.3
-
32
-
-
77951024743
-
Assessment of the susceptibility of mutant HIV-1 to antiviral agents
-
Wang YJ, McKenna PM, Hrin R, et al.: Assessment of the susceptibility of mutant HIV-1 to antiviral agents. J Virol Methods 2010;165:230-237.
-
(2010)
J Virol Methods
, vol.165
, pp. 230-237
-
-
Wang, Y.J.1
McKenna, P.M.2
Hrin, R.3
-
33
-
-
67649977914
-
Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway
-
Dessole G, Branca D, Ferrigno F, et al.: Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway. Bioorg Med Chem Lett 2009;19:4191-4415.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 4191-4415
-
-
Dessole, G.1
Branca, D.2
Ferrigno, F.3
-
34
-
-
62749155744
-
MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B-cell growth transformation and infected-cell survival
-
Forte E, Luftig MA: MDM2-dependent inhibition of p53 is required for Epstein-Barr virus B-cell growth transformation and infected-cell survival. J Virol 2009;83:2491-2499.
-
(2009)
J Virol
, vol.83
, pp. 2491-2499
-
-
Forte, E.1
Luftig, M.A.2
-
35
-
-
70149107491
-
A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling
-
Klinghoffer RA, Frazier J, Annis J, et al.: A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling. PLoS One 2009;4:e6892.
-
(2009)
PLoS One
, vol.4
, pp. e6892
-
-
Klinghoffer, R.A.1
Frazier, J.2
Annis, J.3
-
36
-
-
70249099911
-
Induction of thrombospondin-1 partially mediates the anti-angiogenic activity of dexrazoxane
-
Maloney SL, Sullivan DC, Suchting S: Induction of thrombospondin-1 partially mediates the anti-angiogenic activity of dexrazoxane. Br J Cancer 2009;101:957-966.
-
(2009)
Br J Cancer
, vol.101
, pp. 957-966
-
-
Maloney, S.L.1
Sullivan, D.C.2
Suchting, S.3
-
37
-
-
70350743119
-
Mammary-derived growth inhibitor alters traffic of EGFR and induces a novel form of cetuximab resistance
-
Nevo J, Mattila E, Pellinen T, et al.: Mammary-derived growth inhibitor alters traffic of EGFR and induces a novel form of cetuximab resistance. Clin Cancer Res 2009;15:6570-6581.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6570-6581
-
-
Nevo, J.1
Mattila, E.2
Pellinen, T.3
-
38
-
-
66749159615
-
Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint
-
Salmela AL, Pouwels J, Varis A, et al.: Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint. Carcinogenesis 2009;30:1032-1040.
-
(2009)
Carcinogenesis
, vol.30
, pp. 1032-1040
-
-
Salmela, A.L.1
Pouwels, J.2
Varis, A.3
-
39
-
-
55049094499
-
Identification of a novel AS160 splice variant that regulates GLUT4 translocation and glucose-uptake in rat muscle cells
-
Baus D, Heermeier K, De Hoop M, et al.: Identification of a novel AS160 splice variant that regulates GLUT4 translocation and glucose-uptake in rat muscle cells. Cell Signal 2008;20:2237-2246.
-
(2008)
Cell Signal
, vol.20
, pp. 2237-2246
-
-
Baus, D.1
Heermeier, K.2
De Hoop, M.3
-
40
-
-
40649104320
-
A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression
-
Johnson RL, Huanga W, Jadhava A, Austin CP, Inglese J, Martinez ED: A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Anal Biochem 2008;375:237-248.
-
(2008)
Anal Biochem
, vol.375
, pp. 237-248
-
-
Johnson, R.L.1
Huanga, W.2
Jadhava, A.3
Austin, C.P.4
Inglese, J.5
Martinez, E.D.6
-
41
-
-
56849110119
-
COPI complex is a regulator of lipid homeostasis
-
Beller M, Sztalryd C, Southall N, et al.: COPI complex is a regulator of lipid homeostasis. PLoS Biol 2008;6:e292.
-
(2008)
PLoS Biol
, vol.6
, pp. e292
-
-
Beller, M.1
Sztalryd, C.2
Southall, N.3
-
42
-
-
42149161113
-
The R-Ras interaction partner ORP3 regulates cell adhesion
-
Lehto M, Mäyränpää MI, Pellinen T, et al.: The R-Ras interaction partner ORP3 regulates cell adhesion. J Cell Sci 2008;121:695-705.
-
(2008)
J Cell Sci
, vol.121
, pp. 695-705
-
-
Lehto, M.1
Mäyränpää, M.I.2
Pellinen, T.3
-
43
-
-
42149196014
-
A novel splicing variant of proprotein convertase subtilisin/kexin type 9
-
Schmidt RJ, Zhang Y, Zhao Y, et al.: A novel splicing variant of proprotein convertase subtilisin/kexin type 9. DNA Cell Biol 2008;27:183-189.
-
(2008)
DNA Cell Biol
, vol.27
, pp. 183-189
-
-
Schmidt, R.J.1
Zhang, Y.2
Zhao, Y.3
-
44
-
-
54149087076
-
Syndecan-1 supports integrin a2b1-mediated adhesion to collagen
-
Vuoriluoto K, Jokinen J, Kallio K, Salmivirta M, Heino J, Ivaska J: Syndecan-1 supports integrin a2b1-mediated adhesion to collagen. Exp Cell Res 2008;314:3369-3381.
-
(2008)
Exp Cell Res
, vol.314
, pp. 3369-3381
-
-
Vuoriluoto, K.1
Jokinen, J.2
Kallio, K.3
Salmivirta, M.4
Heino, J.5
Ivaska, J.6
-
45
-
-
34548175537
-
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis
-
Qian YW, Schmidt RJ, Zhang Y, et al.: Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. J Lipid Res 2007;48:1488-1498.
-
(2007)
J Lipid Res
, vol.48
, pp. 1488-1498
-
-
Qian, Y.W.1
Schmidt, R.J.2
Zhang, Y.3
-
46
-
-
33750843262
-
Fluorescent protein-based cellular assays analysed by laser scanning cytometry in 1536-well format
-
Auld DS, Johnson RL, Zhang YQ, et al.: Fluorescent protein-based cellular assays analysed by laser scanning cytometry in 1536-well format. Methods Enzymol 2006;414:566-589.
-
(2006)
Methods Enzymol
, vol.414
, pp. 566-589
-
-
Auld, D.S.1
Johnson, R.L.2
Zhang, Y.Q.3
-
47
-
-
33747447033
-
Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins
-
Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen JA, Ivaska J: Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins. J Cell Biol 2006;173:767-780.
-
(2006)
J Cell Biol
, vol.173
, pp. 767-780
-
-
Pellinen, T.1
Arjonen, A.2
Vuoriluoto, K.3
Kallio, K.4
Fransen, J.A.5
Ivaska, J.6
-
48
-
-
84887913784
-
The contribution of mechanistic understanding to phenotypic screening for first-in-class medicines
-
Swinney DC: The contribution of mechanistic understanding to phenotypic screening for first-in-class medicines. J Biomol Screen 2013;18:1186-1192.
-
(2013)
J Biomol Screen
, vol.18
, pp. 1186-1192
-
-
Swinney, D.C.1
-
49
-
-
84861490509
-
Modern phenotypic drug discovery is a viable, neoclassic pharma strategy
-
Lee JA, Uhlik MT, Moxham CM, Tomandl D, Sall DJ: Modern phenotypic drug discovery is a viable, neoclassic pharma strategy. J Med Chem 2012;55:4527-4538.
-
(2012)
J Med Chem
, vol.55
, pp. 4527-4538
-
-
Lee, J.A.1
Uhlik, M.T.2
Moxham, C.M.3
Tomandl, D.4
Sall, D.J.5
-
50
-
-
84924998789
-
-
Last accessed on November 3, 2014
-
Acumen Cellista Microplate Cytometer: http://ttplabtech.com/cell-imaging/Acumen (Last accessed on November 3, 2014).
-
Acumen Cellista Microplate Cytometer
-
-
-
52
-
-
84924959172
-
-
Last accessed on November 3, 2014
-
CellProfiler: Cell Image Analysis Software: www.cellprofiler.org/ (Last accessed on November 3, 2014).
-
Cell Image Analysis Software
-
-
-
53
-
-
33747084103
-
High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening
-
O'Brien PJ, Irwin W, Diaz D, et al.: High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening. Arch Toxicol 2006;80:580-604.
-
(2006)
Arch Toxicol
, vol.80
, pp. 580-604
-
-
O'Brien, P.J.1
Irwin, W.2
Diaz, D.3
-
54
-
-
36749016685
-
Genome-scale RNAi profiling of cell division in human tissue culture cells
-
Kittler R, Pelletier R, Heninger A-K, et al.: Genome-scale RNAi profiling of cell division in human tissue culture cells. Nat Cell Biol 2007;9:1401-1412.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1401-1412
-
-
Kittler, R.1
Pelletier, R.2
Heninger, A.-K.3
-
55
-
-
66649137945
-
Chromosomal instability determines taxane response
-
Swanton C, Nicke B, Schuett M, et al.: Chromosomal instability determines taxane response. Proc Natl Acad Sci U S A 2009;106:8671-8676.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 8671-8676
-
-
Swanton, C.1
Nicke, B.2
Schuett, M.3
-
56
-
-
76749090540
-
Genome-wide RNAi screen identified human host factors crucial for influenza virus replication
-
Karlas A, Machuy N, Shin Y, et al.: Genome-wide RNAi screen identified human host factors crucial for influenza virus replication. Nature 2010;463:818-822.
-
(2010)
Nature
, vol.463
, pp. 818-822
-
-
Karlas, A.1
Machuy, N.2
Shin, Y.3
-
57
-
-
77953276042
-
Clustering phenotype populations by genome-wide RNAi and multiparametric imaging
-
Fuchs F, Pau G, Kranz D, et al.: Clustering phenotype populations by genome-wide RNAi and multiparametric imaging. Mol Syst Biol 2010;6:370.
-
(2010)
Mol Syst Biol
, vol.6
, pp. 370
-
-
Fuchs, F.1
Pau, G.2
Kranz, D.3
-
58
-
-
48649086972
-
A novel circular invasion assay mimics in vivo invasive behavior of cancer cell lines and distinguishes single-cell motility in vitro
-
Kam Y, Guess C, Estrada L, Weidow B, Quaranta V: A novel circular invasion assay mimics in vivo invasive behavior of cancer cell lines and distinguishes single-cell motility in vitro. BMC Cancer 2008;8:198-209.
-
(2008)
BMC Cancer
, vol.8
, pp. 198-209
-
-
Kam, Y.1
Guess, C.2
Estrada, L.3
Weidow, B.4
Quaranta, V.5
-
59
-
-
84924998788
-
-
Last accessed on November 3, 2014
-
Oris™ Cell Migration Assays. www.platypustech.com/cellassays.html (Last accessed on November 3, 2014).
-
Oris™ Cell Migration Assays
-
-
-
60
-
-
79951979271
-
A quantitative, facile, and high-throughput image-based cell migration method is a robust alternative to the scratch assay
-
Gough W, Hulkower KI, Lynch R, McGlynn P, Uhlik M, Yan L, Lee JA: A quantitative, facile, and high-throughput image-based cell migration method is a robust alternative to the scratch assay. J. Biomol Screen 2011;16:155-163.
-
(2011)
J. Biomol Screen
, vol.16
, pp. 155-163
-
-
Gough, W.1
Hulkower, K.I.2
Lynch, R.3
McGlynn, P.4
Uhlik, M.5
Yan, L.6
Lee, J.A.7
-
61
-
-
84919691161
-
Bioengineering 3D environments for cancer models
-
Alemany-Ribes M, Semino CE: Bioengineering 3D environments for cancer models. Adv Drug Deliv Rev 2014;79-80C:40-49.
-
(2014)
Adv Drug Deliv Rev
, vol.79-80 C
, pp. 40-49
-
-
Alemany-Ribes, M.1
Semino, C.E.2
-
62
-
-
77953916745
-
Multicellular tumor spheroids: An underestimated tool is catching up again
-
Hirschhaeuser F, Menne H, Dittfeld C, West J, Mueller-Klieser W, Kunz-Schughart LA: Multicellular tumor spheroids: an underestimated tool is catching up again. J Biotechnol 2010;148:3-15.
-
(2010)
J Biotechnol
, vol.148
, pp. 3-15
-
-
Hirschhaeuser, F.1
Menne, H.2
Dittfeld, C.3
West, J.4
Mueller-Klieser, W.5
Kunz-Schughart, L.A.6
-
63
-
-
33645739790
-
Tumor stroma and regulation of cancer development
-
Tlsty TD, Coussens LM: Tumor stroma and regulation of cancer development Annu Rev Pathol 2006;1:119-150.
-
(2006)
Annu Rev Pathol
, vol.1
, pp. 119-150
-
-
Tlsty, T.D.1
Coussens, L.M.2
-
64
-
-
84859949610
-
The extracellular matrix: A dynamic niche in cancer progression
-
Lu P, Weaver VM, Werb Z: The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol 2012;196:395-406.
-
(2012)
J Cell Biol
, vol.196
, pp. 395-406
-
-
Lu, P.1
Weaver, V.M.2
Werb, Z.3
-
65
-
-
34648834682
-
The third dimension bridges the gap between cell culture and live tissue
-
Pampaloni F, Reynaud EG, Stelzer EH: The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol 2007;10:839-845.
-
(2007)
Nat Rev Mol Cell Biol
, vol.10
, pp. 839-845
-
-
Pampaloni, F.1
Reynaud, E.G.2
Stelzer, E.H.3
-
66
-
-
70349439132
-
Generating 'Omic Knowledge': The role of informatics in high content screening
-
Collins MA: Generating 'Omic Knowledge': the role of informatics in high content screening. Comb Chem High Throughput Screen 2009;12:917-925.
-
(2009)
Comb Chem High Throughput Screen
, vol.12
, pp. 917-925
-
-
Collins, M.A.1
-
67
-
-
84887927263
-
High-content analysis to leverage a robust phenotypic profiling approach to vascular modulation
-
Isherwood BJ, Walls RE, Roberts ME, Houslay TM, Brave SR, Barry ST, Carragher NO: High-content analysis to leverage a robust phenotypic profiling approach to vascular modulation. J Biomol Screen 2013;10:1246-1259.
-
(2013)
J Biomol Screen
, vol.10
, pp. 1246-1259
-
-
Isherwood, B.J.1
Walls, R.E.2
Roberts, M.E.3
Houslay, T.M.4
Brave, S.R.5
Barry, S.T.6
Carragher, N.O.7
-
68
-
-
84924998787
-
-
Last accessed on November 3, 2014
-
Michael S, Inglese J, Shukla S, Hasson S, Titus S, Auld DS, Guha J: Connecting high throughput to high content in screening: the Wells to Cells workflow. www.wakoautomation.com/media/documents/ConnectingHT2HCPoster.pdf (Last accessed on November 3, 2014).
-
Connecting High Throughput to High Content in Screening: The Wells to Cells Workflow
-
-
Michael, S.1
Inglese, J.2
Shukla, S.3
Hasson, S.4
Titus, S.5
Auld, D.S.6
Guha, J.7
-
69
-
-
78649630186
-
The future of toxicity testing: A focus on in vitro methods using a quantitative high-throughput screening platform
-
Shukla S, Huang R, Austin C.P, Menghang X: The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform. Drug Discov Today 2010;15:997-1007.
-
(2010)
Drug Discov Today
, vol.15
, pp. 997-1007
-
-
Shukla, S.1
Huang, R.2
Austin, C.P.3
Menghang, X.4
-
70
-
-
77952380155
-
Tracking chondrocytes and assessing their proliferation with carboxyfluorescein diacetate succinimidyl ester: Effects on cell functions
-
Chawla K, Masuda K, Sah RL: Tracking chondrocytes and assessing their proliferation with carboxyfluorescein diacetate succinimidyl ester: effects on cell functions. Tissue Eng Part C Methods 2010;6:301-310.
-
(2010)
Tissue Eng Part C Methods
, vol.6
, pp. 301-310
-
-
Chawla, K.1
Masuda, K.2
Sah, R.L.3
-
71
-
-
84877856607
-
A simple high-content cell cycle assay reveals frequent discrepancies between cell number and ATP and MTS proliferation assays
-
Chan GKY, Kleinheinz TL, Peterson D, Moffat JG: A simple high-content cell cycle assay reveals frequent discrepancies between cell number and ATP and MTS proliferation assays. PLoS One 2013;8:e63583.
-
(2013)
PLoS One
, vol.8
, pp. e63583
-
-
Chan, G.K.Y.1
Kleinheinz, T.L.2
Peterson, D.3
Moffat, J.G.4
-
72
-
-
63849275691
-
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity
-
Gartner ZJ, Bertozzi CR: Programmed assembly of 3-dimensional microtissues with defined cellular connectivity. Proc Natl Acad Sci U S A 2009;106:4606-4610.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 4606-4610
-
-
Gartner, Z.J.1
Bertozzi, C.R.2
-
73
-
-
34147180937
-
Determination of cell colony formation in a high-content screening assay
-
Wylie PG, Bowen WP: Determination of cell colony formation in a high-content screening assay. Clin Lab Med 2007;27:193-199.
-
(2007)
Clin Lab Med
, vol.27
, pp. 193-199
-
-
Wylie, P.G.1
Bowen, W.P.2
-
74
-
-
77954747531
-
High-content cytotoxicity analysis
-
Wylie PG, Janes M: High-content cytotoxicity analysis. GEN 2009;29:11.
-
(2009)
GEN
, vol.29
, pp. 11
-
-
Wylie, P.G.1
Janes, M.2
-
75
-
-
84874104193
-
WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas
-
Caretti V, Hiddingh L, Lagerweij T, et al.: WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas. Mol Cancer Ther 2013;12:141-150.
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 141-150
-
-
Caretti, V.1
Hiddingh, L.2
Lagerweij, T.3
-
76
-
-
84905491101
-
A high-throughput assay for small molecule destabilizers of the KRAS oncoprotein
-
Carver J, Dexheimer TS, Hsu D, et al.: A high-throughput assay for small molecule destabilizers of the KRAS oncoprotein. PLoS One 2014;9:e103836.
-
(2014)
PLoS One
, vol.9
, pp. e103836
-
-
Carver, J.1
Dexheimer, T.S.2
Hsu, D.3
-
77
-
-
84895535497
-
High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers
-
Martin HL, Adams M, Higgins J: High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers. PLoS One 2014;9:e88338.
-
(2014)
PLoS One
, vol.9
, pp. e88338
-
-
Martin, H.L.1
Adams, M.2
Higgins, J.3
-
78
-
-
77950339970
-
High content screening of cortical neurons identifies novel regulators of axon growth
-
Blackmore MG, Moore DL, Smith RP, et al.: High content screening of cortical neurons identifies novel regulators of axon growth. Mol Cell Neurosci 2010;44:43-54.
-
(2010)
Mol Cell Neurosci
, vol.44
, pp. 43-54
-
-
Blackmore, M.G.1
Moore, D.L.2
Smith, R.P.3
-
79
-
-
84924998786
-
-
Last accessed on November 3, 2014
-
Vybrant® DyeCycle™ Green and Orange Stains: http://tools.lifetechnologies.com/content/sfs/manuals/mp35004.pdf (Last accessed on November 3, 2014).
-
Vybrant® DyeCycle™ Green and Orange Stains
-
-
-
80
-
-
0032728297
-
A novel cell permeant and far red-fluorescing DNA probe, DRAQ5, for blood cell discrimination by flow cytometry
-
Smith PJ, Wiltshire M, Davies S, Patterson LH, Hoy T: A novel cell permeant and far red-fluorescing DNA probe, DRAQ5, for blood cell discrimination by flow cytometry. J Immunol Methods 1999;229:131-139.
-
(1999)
J Immunol Methods
, vol.229
, pp. 131-139
-
-
Smith, P.J.1
Wiltshire, M.2
Davies, S.3
Patterson, L.H.4
Hoy, T.5
-
81
-
-
46149124549
-
High-content assay to study protein prenylation
-
Simonen M, Ibig-Rehm Y, Hofmann G, et al.: High-content assay to study protein prenylation. J Biomol Screen 2008;13:456-467.
-
(2008)
J Biomol Screen
, vol.13
, pp. 456-467
-
-
Simonen, M.1
Ibig-Rehm, Y.2
Hofmann, G.3
-
82
-
-
84924998785
-
-
Last accessed on November 3, 2014
-
Lipophilic Tracers-Dil, DiO, DiD, DiA, and DiR: http://tools.lifetechnologies.com/content/sfs/manuals/mp00282.pdf (Last accessed on November 3, 2014).
-
Lipophilic Tracers-Dil, DiO, DiD, DiA, and DiR
-
-
-
83
-
-
84924971674
-
-
Last accessed on November 3, 2014
-
Qtracker® Cell Labeling Kits: http://tools.lifetechnologies.com/content/sfs/manuals/mp10198.pdf (Last accessed on November 3, 2014).
-
Qtracker® Cell Labeling Kits
-
-
-
84
-
-
84925009701
-
-
Last accessed on November 3, 2014
-
Alexa Fluor Dyes: www.mobitec.de/probes/docs/sections/0103.pdf (Last accessed on November 3, 2014).
-
Alexa Fluor Dyes
-
-
-
85
-
-
0025882537
-
Simultaneous use of rhodamine 123, phycoerythrin, Texas red, and allophycocyanin for the isolation of human hematopoietic progenitor cells
-
Srour EF, Leemhuis T, Brandt JE, vanBesien K, Hoffman R: Simultaneous use of rhodamine 123, phycoerythrin, Texas red, and allophycocyanin for the isolation of human hematopoietic progenitor cells. Cytometry 1991;12:179-183.
-
(1991)
Cytometry
, vol.12
, pp. 179-183
-
-
Srour, E.F.1
Leemhuis, T.2
Brandt, J.E.3
VanBesien, K.4
Hoffman, R.5
-
86
-
-
22544448136
-
High content screening-emerging importance of novel reagents/probes and pathway analysis
-
Comley J: High content screening-emerging importance of novel reagents/probes and pathway analysis. Drug Discov World 2005;6:31-53.
-
(2005)
Drug Discov World
, vol.6
, pp. 31-53
-
-
Comley, J.1
-
87
-
-
79960348203
-
Relieving Autophagy and 4EBP1 from Rapamycin Resistance
-
Nyfeler B, Bergman P, Triantafellow E, et al.: Relieving Autophagy and 4EBP1 from Rapamycin Resistance. Mol Cell Biol 2011;31:2867-2876.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 2867-2876
-
-
Nyfeler, B.1
Bergman, P.2
Triantafellow, E.3
-
88
-
-
84924959505
-
-
Last accessed on November 3, 2014
-
LiveBLAzer™ FRET-B/G Loading Kit: http://tools.lifetechnologies.com/content/sfs/manuals/liveblazer-FRETBGLoadingKit-man.pdf (Last accessed on November 3, 2014).
-
LiveBLAzer™ FRET-B/G Loading Kit
-
-
|