Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a bim-dependent fashion

Journal of Biological Chemistry

Volumn 290, Issue 11, 2015, Pages 6868-6877

  Catalán, Elena ^a   Jaime Sánchez, Paula ^a   Aguilo, Nacho ^a   Simon, Markus M ^b   Froelich, Christopher J ^c   Pardo, Julián ^a,d  

^a UNIVERSITY OF ZARAGOZA   (Spain)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^c NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^d Aragon I+D Foundation   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CHEMICAL ACTIVATION; FIBROBLASTS; MITOCHONDRIA; T-CELLS; VIRUSES;

ACTIVE CASPASE-3; CASPASE-3 ACTIVATION; CELL-DEATH PATHWAYS; MITOCHONDRIAL PATHWAYS; MOUSE EMBRYONIC FIBROBLASTS; PHOSPHATIDYLSERINE; RELATIVE RESISTANCE; VIRUS-INFECTED CELLS;

CELL DEATH;

BIM PROTEIN; CASPASE 3; CYTOCHROME C; GRANZYME B; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL XL; PROTEIN MCL 1; APOPTOSIS REGULATORY PROTEIN; BCL-2-LIKE PROTEIN 11; GRANZYME; MCL1 PROTEIN, MOUSE; MEMBRANE PROTEIN; ONCOPROTEIN; PERFORIN, MOUSE; PORE FORMING CYTOTOXIC PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL IMMORTALIZATION; CELL MEMBRANE DEPOLARIZATION; CELL PERMEABILIZATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DOWN REGULATION; EMBRYO; ENDOPLASMIC RETICULUM STRESS; FIBROBLAST; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; TARGET CELL; ANIMAL; CELL LINE; CYTOLOGY; ENZYMOLOGY; GENE DELETION; GENETICS; IMMUNOLOGY; IMMUNOTHERAPY; METABOLISM; NEOPLASMS;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE 3; CELL LINE; FIBROBLASTS; GENE DELETION; GRANZYMES; IMMUNOTHERAPY; MEMBRANE PROTEINS; MICE; MITOCHONDRIA; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NEOPLASMS; PORE FORMING CYTOTOXIC PROTEINS; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84924872592     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.631564     Document Type: Article

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