Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels

Journal of Biological Chemistry

Volumn 290, Issue 10, 2015, Pages 6419-6427

  Kuo, Ivana Y ^a   Hu, Jian ^a,b   Ha, Ya ^a   Ehrlich, Barbara E ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Michigan State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CATALYST ACTIVITY; IONS; LIPID BILAYERS; PROTEINS;

ALZHEIMER DISEASE; ENZYMATIC ACTIVITIES; PROTEASE ACTIVITIES; PROTEOLYTIC ENZYME; PUTATIVE DUAL FUNCTIONS; STRUCTURAL DOMAINS; THREE-DIMENSIONAL STRUCTURE; TRANS-MEMBRANE DOMAINS;

ENZYME ACTIVITY;

ION CHANNEL; PRESENILIN; PROTEASE FLAK; PROTEASE GXGD; PROTEASE PSH; PROTEINASE; UNCLASSIFIED DRUG; CALCIUM CHANNEL; LIPID BILAYER; MEMBRANE PROTEIN; PEPTIDE HYDROLASE; SECRETASE;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; LIPID BILAYER; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; ALZHEIMER DISEASE; ANIMAL; ARCHAEON; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ARCHAEA; CALCIUM CHANNELS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIPID BILAYERS; MEMBRANE PROTEINS; MICE; PEPTIDE HYDROLASES; PRESENILINS; PROTEIN STRUCTURE, TERTIARY;

EID: 84924871544     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.629584     Document Type: Article

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