Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia

Circulation Research

Volumn 111, Issue 6, 2012, Pages 708-717

  Shan, Jian ^a   Xie, Wenjun ^a   Betzenhauser, Matthew ^a   Reiken, Steven ^a   Chen, Bi Xing ^a   Wronska, Anetta ^a   Marks, Andrew R ^b  

^a Clyde and Helen Wu Center for Molecular Cardiology   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

arrhythmia; atrial fibrillation; Ca2sparks; CPVT; ryanodine receptor; SR Ca2leak

Indexed keywords

CALCIUM ION; RYANODINE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE MUTATION; HEART ATRIUM FIBRILLATION; IN VIVO STUDY; MACROMOLECULE; MOUSE; MUSCLE CELL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SARCOPLASMIC RETICULUM; WILD TYPE;

ANIMALS; ATRIAL FIBRILLATION; CAFFEINE; CALCIUM; CARDIAC PACING, ARTIFICIAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; EPINEPHRINE; GENE KNOCK-IN TECHNIQUES; HEART; HUMANS; IMMUNOBLOTTING; MICE; MICE, KNOCKOUT; MUTATION; MYOCYTES, CARDIAC; PHYSICAL CONDITIONING, ANIMAL; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; TACHYCARDIA, VENTRICULAR; TACROLIMUS BINDING PROTEINS; THIAZEPINES;

EID: 84865863426     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.273342     Document Type: Article

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