Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca2+ leak that is impaired by FAD mutations

Journal of Neurochemistry

Volumn 122, Issue 3, 2012, Pages 487-500

  Das, Hriday K ^a   Tchedre, Kissaou ^b   Mueller, Brett ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

Ca2+ signaling; InsP3R1; JNK; p53; Presenilin 1; transcription

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BRADYKININ; CALCIUM ION; CHROMODOMAIN HELICASE DNA BINDING PROTEIN 3; DNA BINDING PROTEIN; GAMMA SECRETASE; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; MUTANT PROTEIN; PRESENILIN 1; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN 237;

ALZHEIMER DISEASE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL DAMAGE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; FAMILIAL ALZHEIMER DISEASE; GENE; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PS1 GENE; TRANSCRIPTION TERMINATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANTHRACENES; CALCIUM; CARRIER PROTEINS; CELL LINE, TUMOR; CYTOSOL; DNA HELICASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; METHIONINE; MUTATION; NEUROBLASTOMA; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PRESENILIN-1; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; THAPSIGARGIN; TRANSFECTION; VALINE;

EID: 84863717709     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07794.x     Document Type: Article

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