TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1

Oncogene

Volumn 30, Issue 35, 2011, Pages 3792-3801

  Jin, H O ^a   Seo, S K ^a   Kim, Y S ^a   Woo, S H ^a   Lee, K H ^a   Yi, J Y ^a   Lee, S J ^b   Choe, T B ^c   Lee, J H ^c   An, S ^c   Hong, S I ^a   Park, I C ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Hanyang University   (South Korea)

^c Konkuk University   (South Korea)

Author keywords

2 deoxyglucose; ATF4; mTOR; Redd1; TXNIP

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CELL PROTEIN; DEOXYGLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN REDD1; SMALL INTERFERING RNA; THIOREDOXIN INTERACTING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ENZYME INHIBITION; ENZYME REPRESSION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

ACTIVATING TRANSCRIPTION FACTOR 4; CARRIER PROTEINS; CELL LINE, TUMOR; DEOXYGLUCOSE; HUMANS; PROTEIN STABILITY; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 80052298175     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.102     Document Type: Article

References (40)

1. Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E et al. (2004). Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 18: 2893-2904. (Pubitemid 39602308)
2. Chung JW, Jeon JH, Yoon SR, Choi I. (2006). Vitamin D3 upregulated protein 1 (VDUP1) is a regulator for redox signaling and stress-mediated diseases. J Dermatol 33: 662-669. (Pubitemid 44536370)
3. Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC, Thomas G. (2001). Mammalian TOR: a homeostatic ATP sensor. Science 294: 1102-1105. (Pubitemid 33041865)
4. DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW. (2008). Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev 22: 239-251.
5. Ellisen LW, Ramsayer KD, Johannessen CM, Yang A, Beppu H, Minda K et al. (2002). REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol Cell 10: 995-1005. (Pubitemid 35453821)
6. Fidler IJ, Radinsky R. (1996). Search for genes that suppress cancer metastasis. J Natl Cancer Inst 88: 1700-1703.
7. Goldberg SF, Miele ME, Hatta N, Takata M, Paquette-Straub C, Freedman LP et al. (2003). Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP. Cancer Res 63: 432-440. (Pubitemid 36152504)
8. Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS et al. (2003). VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. Oncogene 22: 4035-4046. (Pubitemid 36819644)
9. Hardie DG, Hawley SA. (2001). AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays 23: 1112-1119.
10. Hawley SA, Davison M, Woods A, Davies SP, Beri RK, Carling D et al. (1996). Characterization of the AMP-activated protein kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J Biol Chem 271: 27879-27887. (Pubitemid 26367365)
11. Horak P, Crawford AR, Vadysirisack DD, Nash ZM, DeYoung MP, Sgroi D et al. (2010). Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis. Proc Natl Acad Sci USA 107: 4675-4680.
12. Inoki K, Zhu T, Guan KL. (2003). TSC2 mediates cellular energy response to control cell growth and survival. Cell 115: 577-590. (Pubitemid 37506046)
13. Jin HO, Seo SK, Woo SH, Choe TB, Hong SI, Kim JI et al. (2009a). Nuclear protein 1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4. IUBMB Life 61: 1153-1158.
14. Jin HO, Seo SK, Woo SH, Kim ES, Lee HC, Yoo DH et al. (2009b). Activating transcription factor 4 and CCAAT/enhancer-binding protein-beta negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress. Free Radic Biol Med 46: 1158-1167.
15. Junn E, Han SH, Im JY, Yang Y, Cho EW, Um HD et al. (2000). Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. J Immunol 164: 6287-6295. (Pubitemid 30408809)
16. Kang HT, Hwang ES. (2006). 2-Deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic. Life Sci 78: 1392-1399. (Pubitemid 43199960)
17. Katiyar S, Liu E, Knutzen CA, Lang ES, Lombardo CR, Sankar S et al. (2009). REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase. EMBO Rep 10: 866-872.
18. Kim KY, Shin SM, Kim JK, Paik SG, Yang Y, Choi I. (2004). Heat shock factor regulates VDUP1 gene expression. Biochem Biophys Res Commun 315: 369-375. (Pubitemid 38183116)
19. Little E, Ramakrishnan M, Roy B, Gazit G, Lee AS. (1994). The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications. Crit Rev Eukaryot Gene Expr 4: 1-18. (Pubitemid 24238439)
20. Nakamura H, Masutani H, Yodoi J. (2006). Extracellular thioredoxin and thioredoxin-binding protein 2 in control of cancer. Semin Cancer Biol 16: 444-451. (Pubitemid 44780134)
21. Nishinaka Y, Masutani H, Oka S, Matsuo Y, Yamaguchi Y, Nishio K et al. (2004). Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1. J Biol Chem 279: 37559-37565. (Pubitemid 39195469)
22. Oka S, Liu W, Masutani H, Hirata H, Shinkai Y, Yamada S et al. (2006). Impaired fatty acid utilization in thioredoxin binding-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome. FASEB J 20: 121-123. (Pubitemid 43100487)
23. Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM et al. (2009). DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137: 873-886.
24. Saxena G, Chen J, Shalev A. (2010). Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein. J Biol Chem 285: 3997-4005.
25. Schmelzle T, Hall MN. (2000). TOR, a central controller of cell growth. Cell 103: 253-262.
26. Schneider A, Younis RH, Gutkind JS. (2008). Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma. Neoplasia 10: 1295-1302.
27. Schulze PC, De Keulenaer GW, Yoshioka J, Kassik KA, Lee RT. (2002). Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin. Circ Res 91: 689-695. (Pubitemid 35204951)
28. Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT. (2004). Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem 279: 30369-30374. (Pubitemid 38937964)
29. Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA et al. (2005). The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310: 1642-1646. (Pubitemid 41780780)
30. Sheth SS, Bodnar JS, Ghazalpour A, Thipphavong CK, Tsutsumi S, Tward AD et al. (2006). Hepatocellular carcinoma in Txnip-deficient mice. Oncogene 25: 3528-3536. (Pubitemid 43901674)
31. Shor B, Gibbons JJ, Abraham RT, Yu K. (2009). Targeting mTOR globally in cancer: thinking beyond rapamycin. Cell Cycle 8: 3831-3837.
32. Sofer A, Lei K, Johannessen CM, Ellisen LW. (2005). Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol 25: 5834-5845. (Pubitemid 40946541)
33. Stein SC, Woods A, Jones NA, Davison MD, Carling D. (2000). The regulation of AMP-activated protein kinase by phosphorylation. Biochem J 345: 437-443. (Pubitemid 30099070)
34. Stoltzman CA, Peterson CW, Breen KT, Muoio DM, Billin AN, Ayer DE. (2008). Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. Proc Natl AcadSci USA 105: 6912-6917. (Pubitemid 351754504)
35. Sudarsanam S, Johnson DE. (2010). Functional consequences of mTOR inhibition. Curr Opin Drug Discov Devel 13: 31-40.
36. Towler MC, Hardie DG. (2007). AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 100: 328-341.
37. Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH. (2007). Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 9: 316-323. (Pubitemid 46344611)
38. Wang H, Kubica N, Ellisen LW, Jefferson LS, Kimball SR. (2006a). Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1. J Biol Chem 281: 39128-39134. (Pubitemid 46041872)
39. Wang Z, Rong YP, Malone MH, Davis MC, Zhong F, Distelhorst CW. (2006b). Thioredoxin-interacting protein (txnip) is a glucocor-ticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis. Oncogene 25: 1903-1913.
40. Whitney ML, Jefferson LS, Kimball SR. (2009). ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression. Biochem Biophys Res Commun 379: 451-455.