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Volumn 95, Issue 3, 2015, Pages 509-538

Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; BACTERIAL RNA; GLYCEROPHOSPHOLIPID; ISOPRENOID; SIGMA FACTOR RPOS; TRANSCRIPTOME; BACTERIAL PROTEIN; CARRIER PROTEIN; SIGMA FACTOR; SIGMA FACTOR KATF PROTEIN, BACTERIA;

EID: 84924598069     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/mmi.12882     Document Type: Article
Times cited : (106)

References (145)
  • 1
    • 0029597816 scopus 로고
    • Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue
    • Akins, D.R., Porcella, S.F., Popova, T.G., Shevchenko, D., Baker, S.I., Li, M., etal. (1995) Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue. Mol Microbiol 18: 507-520.
    • (1995) Mol Microbiol , vol.18 , pp. 507-520
    • Akins, D.R.1    Porcella, S.F.2    Popova, T.G.3    Shevchenko, D.4    Baker, S.I.5    Li, M.6
  • 2
    • 0032523936 scopus 로고    scopus 로고
    • A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state
    • Akins, D.R., Bourell, K.W., Caimano, M.J., Norgard, M.V., and Radolf, J.D. (1998) A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state. J Clin Invest 101: 2240-2250.
    • (1998) J Clin Invest , vol.101 , pp. 2240-2250
    • Akins, D.R.1    Bourell, K.W.2    Caimano, M.J.3    Norgard, M.V.4    Radolf, J.D.5
  • 3
    • 53149098219 scopus 로고    scopus 로고
    • Surveillance for Lyme disease - United States, 1992-2006
    • Bacon, R.M., Kugeler, K.J., and Mead, P.S. (2008) Surveillance for Lyme disease - United States, 1992-2006. MMWR Surveill Summ 57: 1-9.
    • (2008) MMWR Surveill Summ , vol.57 , pp. 1-9
    • Bacon, R.M.1    Kugeler, K.J.2    Mead, P.S.3
  • 4
    • 29144518548 scopus 로고    scopus 로고
    • Comparative genomic analyses of the bacterial phosphotransferase system
    • Barabote, R.D., and Saier, M.H., Jr. (2005) Comparative genomic analyses of the bacterial phosphotransferase system. Microbiol Mol Biol Rev 69: 608-634.
    • (2005) Microbiol Mol Biol Rev , vol.69 , pp. 608-634
    • Barabote, R.D.1    Saier Jr., M.H.2
  • 5
    • 33645881935 scopus 로고    scopus 로고
    • Regulation of bacterial virulence by two-component systems
    • Beier, D., and Gross, R. (2006) Regulation of bacterial virulence by two-component systems. Curr Opin Microbiol 9: 143-152.
    • (2006) Curr Opin Microbiol , vol.9 , pp. 143-152
    • Beier, D.1    Gross, R.2
  • 6
    • 79958120924 scopus 로고    scopus 로고
    • Structure, function, and biogenesis of the cell envelope
    • Samuels, D.S., and Radolf, J.D. (eds). Norfolk: Caister Academic Press
    • Bergstrom, S., and Zuckert, W.R. (2010) Structure, function, and biogenesis of the cell envelope. In Borrelia: Molecular Biology, Host Interaction, and Pathogenesis. Samuels, D.S., and Radolf, J.D. (eds). Norfolk: Caister Academic Press, pp. 139-166.
    • (2010) Borrelia: Molecular Biology, Host Interaction, and Pathogenesis , pp. 139-166
    • Bergstrom, S.1    Zuckert, W.R.2
  • 7
    • 30844439443 scopus 로고    scopus 로고
    • Analysing the outer membrane subproteome of Methylococcus capsulatus (Bath) using proteomics and novel biocomputing tools
    • Berven, F.S., Karlsen, O.A., Straume, A.H., Flikka, K., Murrell, J.C., Fjellbirkeland, A., etal. (2006) Analysing the outer membrane subproteome of Methylococcus capsulatus (Bath) using proteomics and novel biocomputing tools. Arch Microbiol 184: 362-377.
    • (2006) Arch Microbiol , vol.184 , pp. 362-377
    • Berven, F.S.1    Karlsen, O.A.2    Straume, A.H.3    Flikka, K.4    Murrell, J.C.5    Fjellbirkeland, A.6
  • 8
    • 0031967697 scopus 로고    scopus 로고
    • Oligopeptide permease in Borrelia burgdorferi: putative peptide-binding components encoded by both chromosomal and plasmid loci
    • Bono, J.L., Tilly, K., Stevenson, B., Hogan, D., and Rosa, P. (1998) Oligopeptide permease in Borrelia burgdorferi: putative peptide-binding components encoded by both chromosomal and plasmid loci. Microbiology 144: 1033-1044.
    • (1998) Microbiology , vol.144 , pp. 1033-1044
    • Bono, J.L.1    Tilly, K.2    Stevenson, B.3    Hogan, D.4    Rosa, P.5
  • 9
    • 79959554902 scopus 로고    scopus 로고
    • Nitrosative damage to free and zinc-bound cysteine thiols underlies nitric oxide toxicity in wild-type
    • Bourret, T.J., Boylan, J.A., Lawrence, K.A., and Gherardini, F.C. (2011) Nitrosative damage to free and zinc-bound cysteine thiols underlies nitric oxide toxicity in wild-type. Mol Microbiol 81: 259-273.
    • (2011) Mol Microbiol , vol.81 , pp. 259-273
    • Bourret, T.J.1    Boylan, J.A.2    Lawrence, K.A.3    Gherardini, F.C.4
  • 10
    • 0141482029 scopus 로고    scopus 로고
    • Borrelia oxidative stress response regulator, BosR: a distinctive Zn-dependent transcriptional activator
    • Boylan, J.A., Posey, J.E., and Gherardini, F.C. (2003) Borrelia oxidative stress response regulator, BosR: a distinctive Zn-dependent transcriptional activator. Proc Natl Acad Sci USA 100: 11684-11689.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11684-11689
    • Boylan, J.A.1    Posey, J.E.2    Gherardini, F.C.3
  • 11
    • 33645056190 scopus 로고    scopus 로고
    • Borrelia burgdorferi bb0728 encodes a coenzyme A disulphide reductase whose function suggests a role in intracellular redox and the oxidative stress response
    • Boylan, J.A., Hummel, C.S., Benoit, S., Garcia-Lara, J., Treglown-Downey, J., Crane, E.J., 3rd, and Gherardini, F.C. (2006) Borrelia burgdorferi bb0728 encodes a coenzyme A disulphide reductase whose function suggests a role in intracellular redox and the oxidative stress response. Mol Microbiol 59: 475-486.
    • (2006) Mol Microbiol , vol.59 , pp. 475-486
    • Boylan, J.A.1    Hummel, C.S.2    Benoit, S.3    Garcia-Lara, J.4    Treglown-Downey, J.5    Crane III, E.J.6    Gherardini, F.C.7
  • 12
    • 41749094706 scopus 로고    scopus 로고
    • Borrelia burgdorferi membranes are the primary targets of reactive oxygen species
    • Boylan, J.A., Lawrence, K.A., Downey, J.S., and Gherardini, F.C. (2008) Borrelia burgdorferi membranes are the primary targets of reactive oxygen species. Mol Microbiol 68: 786-799.
    • (2008) Mol Microbiol , vol.68 , pp. 786-799
    • Boylan, J.A.1    Lawrence, K.A.2    Downey, J.S.3    Gherardini, F.C.4
  • 15
    • 34548478386 scopus 로고    scopus 로고
    • Coordinated expression of Borrelia burgdorferi complement regulator-acquiring surface proteins during the Lyme disease spirochete's mammal-tick infection cycle
    • Bykowski, T., Woodman, M.E., Cooley, A.E., Brissette, C.A., Brade, V., Wallich, R., etal. (2007) Coordinated expression of Borrelia burgdorferi complement regulator-acquiring surface proteins during the Lyme disease spirochete's mammal-tick infection cycle. Infect Immun 75: 4227-4236.
    • (2007) Infect Immun , vol.75 , pp. 4227-4236
    • Bykowski, T.1    Woodman, M.E.2    Cooley, A.E.3    Brissette, C.A.4    Brade, V.5    Wallich, R.6
  • 16
    • 7044233312 scopus 로고    scopus 로고
    • RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants
    • Caimano, M.J., Eggers, C.H., Hazlett, K.R., and Radolf, J.D. (2004) RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants. Infect Immun 72: 6433-6445.
    • (2004) Infect Immun , vol.72 , pp. 6433-6445
    • Caimano, M.J.1    Eggers, C.H.2    Hazlett, K.R.3    Radolf, J.D.4
  • 17
    • 34547879640 scopus 로고    scopus 로고
    • Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle
    • Caimano, M.J., Iyer, R., Eggers, C.H., Gonzalez, C., Morton, E.A., Gilbert, M.A., etal. (2007) Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle. Mol Microbiol 65: 1193-1217.
    • (2007) Mol Microbiol , vol.65 , pp. 1193-1217
    • Caimano, M.J.1    Iyer, R.2    Eggers, C.H.3    Gonzalez, C.4    Morton, E.A.5    Gilbert, M.A.6
  • 18
    • 79960955642 scopus 로고    scopus 로고
    • The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks
    • Caimano, M.J., Kenedy, M.R., Kairu, T., Desrosiers, D.C., Harman, M., Dunham-Ems, S., etal. (2011) The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks. Infect Immun 79: 3117-3130.
    • (2011) Infect Immun , vol.79 , pp. 3117-3130
    • Caimano, M.J.1    Kenedy, M.R.2    Kairu, T.3    Desrosiers, D.C.4    Harman, M.5    Dunham-Ems, S.6
  • 19
    • 0033975239 scopus 로고    scopus 로고
    • A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi
    • Casjens, S., Palmer, N., van Vugt, R., Huang, W.M., Stevenson, B., Rosa, P., etal. (2000) A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi. Mol Microbiol 35: 490-516.
    • (2000) Mol Microbiol , vol.35 , pp. 490-516
    • Casjens, S.1    Palmer, N.2    van Vugt, R.3    Huang, W.M.4    Stevenson, B.5    Rosa, P.6
  • 21
    • 0037418252 scopus 로고    scopus 로고
    • Polyamines protect Escherichia coli cells from the toxic effect of oxygen
    • Chattopadhyay, M.K., Tabor, C.W., and Tabor, H. (2003) Polyamines protect Escherichia coli cells from the toxic effect of oxygen. Proc Natl Acad Sci USA 100: 2261-2265.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2261-2265
    • Chattopadhyay, M.K.1    Tabor, C.W.2    Tabor, H.3
  • 22
    • 84884593859 scopus 로고    scopus 로고
    • Structure, dynamics and biophysics of the cytoplasmic protein-protein complexes of the bacterial phosphoenolpyruvate: sugar phosphotransferase system
    • Clore, G.M., and Venditti, V. (2013) Structure, dynamics and biophysics of the cytoplasmic protein-protein complexes of the bacterial phosphoenolpyruvate: sugar phosphotransferase system. Trends Biochem Sci 38: 515-530.
    • (2013) Trends Biochem Sci , vol.38 , pp. 515-530
    • Clore, G.M.1    Venditti, V.2
  • 23
    • 0031587871 scopus 로고    scopus 로고
    • Plasminogen is required for efficient dissemination of B.burgdorferi in ticks and for enhancement of spirochetemia in mice
    • Coleman, J.L., Gebbia, J.A., Piesman, J., Degen, J.L., Bugge, T.H., and Benach, J.L. (1997) Plasminogen is required for efficient dissemination of B.burgdorferi in ticks and for enhancement of spirochetemia in mice. Cell 89: 1111-1119.
    • (1997) Cell , vol.89 , pp. 1111-1119
    • Coleman, J.L.1    Gebbia, J.A.2    Piesman, J.3    Degen, J.L.4    Bugge, T.H.5    Benach, J.L.6
  • 24
    • 0034998230 scopus 로고    scopus 로고
    • Insertion of fluorescent fatty acid probes into the outer membranes of the pathogenic spirochaetes Treponema pallidum and Borrelia burgdorferi
    • Cox, D.L., and Radolf, J.D. (2001) Insertion of fluorescent fatty acid probes into the outer membranes of the pathogenic spirochaetes Treponema pallidum and Borrelia burgdorferi. Microbiology 147: 1161-1169.
    • (2001) Microbiology , vol.147 , pp. 1161-1169
    • Cox, D.L.1    Radolf, J.D.2
  • 25
    • 44949249999 scopus 로고    scopus 로고
    • Structure, function, and evolution of bacterial ATP-binding cassette systems
    • Davidson, A.L., Dassa, E., Orelle, C., and Chen, J. (2008) Structure, function, and evolution of bacterial ATP-binding cassette systems. Microbiol Mol Biol Rev 72: 317-364.
    • (2008) Microbiol Mol Biol Rev , vol.72 , pp. 317-364
    • Davidson, A.L.1    Dassa, E.2    Orelle, C.3    Chen, J.4
  • 26
    • 0028842880 scopus 로고
    • Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding
    • De Silva, A.M., and Fikrig, E. (1995) Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding. Am J Trop Med Hyg 53: 397-404.
    • (1995) Am J Trop Med Hyg , vol.53 , pp. 397-404
    • De Silva, A.M.1    Fikrig, E.2
  • 27
    • 84901013706 scopus 로고    scopus 로고
    • The bacterial phosphoenolpyruvate:carbohydrate phosphotransferase system: regulation by protein phosphorylation and phosphorylation-dependent protein-protein interactions
    • Deutscher, J., Ake, F.M., Derkaoui, M., Zebre, A.C., Cao, T.N., Bouraoui, H., etal. (2014) The bacterial phosphoenolpyruvate:carbohydrate phosphotransferase system: regulation by protein phosphorylation and phosphorylation-dependent protein-protein interactions. Microbiol Mol Biol Rev 78: 231-256.
    • (2014) Microbiol Mol Biol Rev , vol.78 , pp. 231-256
    • Deutscher, J.1    Ake, F.M.2    Derkaoui, M.3    Zebre, A.C.4    Cao, T.N.5    Bouraoui, H.6
  • 29
    • 84860899834 scopus 로고    scopus 로고
    • Borrelia burgdorferi requires the alternative sigma factor RpoS for dissemination within the vector during tick-to-mammal transmission
    • Dunham-Ems, S.M., Caimano, M.J., Eggers, C.H., and Radolf, J.D. (2012) Borrelia burgdorferi requires the alternative sigma factor RpoS for dissemination within the vector during tick-to-mammal transmission. PLoS Pathog 8: e1002532.
    • (2012) PLoS Pathog , vol.8 , pp. e1002532
    • Dunham-Ems, S.M.1    Caimano, M.J.2    Eggers, C.H.3    Radolf, J.D.4
  • 30
    • 80054843740 scopus 로고    scopus 로고
    • The coenzyme A disulfide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host
    • Eggers, C.H., Caimano, M.J., Malizia, R.A., Kariu, T., Cusack, B., Desrosiers, D.C., etal. (2011) The coenzyme A disulfide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host. Mol Microbiol 82: 679-697.
    • (2011) Mol Microbiol , vol.82 , pp. 679-697
    • Eggers, C.H.1    Caimano, M.J.2    Malizia, R.A.3    Kariu, T.4    Cusack, B.5    Desrosiers, D.C.6
  • 31
    • 0030983397 scopus 로고    scopus 로고
    • Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity
    • Fikrig, E., Barthold, S.W., Sun, W., Feng, W., Telford, S.R., 3rd, and Flavell, R.A. (1997) Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity. Immunity 6: 531-539.
    • (1997) Immunity , vol.6 , pp. 531-539
    • Fikrig, E.1    Barthold, S.W.2    Sun, W.3    Feng, W.4    Telford III, S.R.5    Flavell, R.A.6
  • 32
    • 17044399341 scopus 로고    scopus 로고
    • Borrelia burgdorferi σ54 is required for mammalian infection and vector transmission but not for tick colonization
    • Fisher, M.A., Grimm, D., Henion, A.K., Elias, A.F., Stewart, P.E., Rosa, P.A., and Gherardini, F.C. (2005) Borrelia burgdorferi σ54 is required for mammalian infection and vector transmission but not for tick colonization. Proc Natl Acad Sci USA 102: 5162-5167.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5162-5167
    • Fisher, M.A.1    Grimm, D.2    Henion, A.K.3    Elias, A.F.4    Stewart, P.E.5    Rosa, P.A.6    Gherardini, F.C.7
  • 33
    • 80555140065 scopus 로고    scopus 로고
    • Borrelia burgdorferi enolase is a surface-exposed plasminogen binding protein
    • Floden, A.M., Watt, J.A., and Brissette, C.A. (2011) Borrelia burgdorferi enolase is a surface-exposed plasminogen binding protein. PLoS ONE 6: e27502.
    • (2011) PLoS ONE , vol.6 , pp. e27502
    • Floden, A.M.1    Watt, J.A.2    Brissette, C.A.3
  • 34
    • 0031470826 scopus 로고    scopus 로고
    • Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi
    • Fraser, C.M., Casjens, S., Huang, W.M., Sutton, G.G., Clayton, R., Lathigra, R., etal. (1997) Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390: 580-586.
    • (1997) Nature , vol.390 , pp. 580-586
    • Fraser, C.M.1    Casjens, S.2    Huang, W.M.3    Sutton, G.G.4    Clayton, R.5    Lathigra, R.6
  • 37
    • 47549110972 scopus 로고    scopus 로고
    • Carbon catabolite repression in bacteria: many ways to make the most out of nutrients
    • Gorke, B., and Stulke, J. (2008) Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. Nat Rev Microbiol 6: 613-624.
    • (2008) Nat Rev Microbiol , vol.6 , pp. 613-624
    • Gorke, B.1    Stulke, J.2
  • 38
    • 84891115509 scopus 로고    scopus 로고
    • Insights into the biology of Borrelia burgdorferi gained through the application of molecular genetics
    • Groshong, A.M., and Blevins, J.S. (2014) Insights into the biology of Borrelia burgdorferi gained through the application of molecular genetics. Adv Appl Microbiol 86: 41-143.
    • (2014) Adv Appl Microbiol , vol.86 , pp. 41-143
    • Groshong, A.M.1    Blevins, J.S.2
  • 41
    • 79959856937 scopus 로고    scopus 로고
    • Cyclic di-GMP is essential for the survival of Borrelia burgdorferi in ticks
    • He, M., Ouyang, Z., Troxell, B., Xu, H., Moh, A., Fu, X.-Y., etal. (2011) Cyclic di-GMP is essential for the survival of Borrelia burgdorferi in ticks. PLoS Pathog 7: e1002133.
    • (2011) PLoS Pathog , vol.7 , pp. e1002133
    • He, M.1    Ouyang, Z.2    Troxell, B.3    Xu, H.4    Moh, A.5    Fu, X.-Y.6
  • 42
    • 0036084295 scopus 로고    scopus 로고
    • Changes in temporal and spatial patterns of outer surface lipoprotein expression generate population heterogeneity and antigenic diversity in the Lyme disease spirochete, Borrelia burgdorferi
    • Hefty, P.S., Jolliff, S.E., Caimano, M.J., Wikel, S.K., and Akins, D.R. (2002) Changes in temporal and spatial patterns of outer surface lipoprotein expression generate population heterogeneity and antigenic diversity in the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun 70: 3468-3478.
    • (2002) Infect Immun , vol.70 , pp. 3468-3478
    • Hefty, P.S.1    Jolliff, S.E.2    Caimano, M.J.3    Wikel, S.K.4    Akins, D.R.5
  • 43
    • 0026621245 scopus 로고
    • ABC transporters: from microorganisms to man
    • Higgins, C.F. (1992) ABC transporters: from microorganisms to man. Annu Rev Cell Biol 8: 67-113.
    • (1992) Annu Rev Cell Biol , vol.8 , pp. 67-113
    • Higgins, C.F.1
  • 44
    • 0031736727 scopus 로고    scopus 로고
    • Inducer exclusion in Escherichia coli by non-PTS substrates: the role of the PEP to pyruvate ratio in determining the phosphorylation state of enzyme IIAGlc
    • Hogema, B.M., Arents, J.C., Bader, R., Eijkemans, K., Yoshida, H., Takahashi, H., etal. (1998) Inducer exclusion in Escherichia coli by non-PTS substrates: the role of the PEP to pyruvate ratio in determining the phosphorylation state of enzyme IIAGlc. Mol Microbiol 30: 487-498.
    • (1998) Mol Microbiol , vol.30 , pp. 487-498
    • Hogema, B.M.1    Arents, J.C.2    Bader, R.3    Eijkemans, K.4    Yoshida, H.5    Takahashi, H.6
  • 45
    • 77950369259 scopus 로고    scopus 로고
    • Moonlighting proteins: an intriguing mode of multitasking
    • Huberts, D.H., and van der Klei, I.J. (2010) Moonlighting proteins: an intriguing mode of multitasking. Biochim Biophys Acta 1803: 520-525.
    • (2010) Biochim Biophys Acta , vol.1803 , pp. 520-525
    • Huberts, D.H.1    van der Klei, I.J.2
  • 46
    • 0035940482 scopus 로고    scopus 로고
    • Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway
    • Hubner, A., Yang, X., Nolen, D.M., Popova, T.G., Cabello, F.C., and Norgard, M.V. (2001) Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway. Proc Natl Acad Sci USA 98: 12724-12729.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12724-12729
    • Hubner, A.1    Yang, X.2    Nolen, D.M.3    Popova, T.G.4    Cabello, F.C.5    Norgard, M.V.6
  • 47
    • 33846247458 scopus 로고    scopus 로고
    • Borrelia burgdorferi alters its gene expression and antigenic profile in response to CO2 levels
    • Hyde, J.A., Trzeciakowski, J.P., and Skare, J.T. (2007) Borrelia burgdorferi alters its gene expression and antigenic profile in response to CO2 levels. J Bacteriol 189: 437-445.
    • (2007) J Bacteriol , vol.189 , pp. 437-445
    • Hyde, J.A.1    Trzeciakowski, J.P.2    Skare, J.T.3
  • 48
    • 72049101202 scopus 로고    scopus 로고
    • The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete
    • Hyde, J.A., Shaw, D.K., Smith Iii, R., Trzeciakowski, J.P., and Skare, J.T. (2009) The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete. Mol Microbiol 74: 1344-1355.
    • (2009) Mol Microbiol , vol.74 , pp. 1344-1355
    • Hyde, J.A.1    Shaw, D.K.2    Smith Iii, R.3    Trzeciakowski, J.P.4    Skare, J.T.5
  • 49
    • 84874074445 scopus 로고    scopus 로고
    • Detection of Borrelia burgdorferi nucleic acids after antibiotic treatment does not confirm viability
    • Iyer, R., Mukherjee, P., Wang, K., Simons, J., Wormser, G.P., and Schwartz, I. (2013) Detection of Borrelia burgdorferi nucleic acids after antibiotic treatment does not confirm viability. J Clin Microbiol 51: 857-862.
    • (2013) J Clin Microbiol , vol.51 , pp. 857-862
    • Iyer, R.1    Mukherjee, P.2    Wang, K.3    Simons, J.4    Wormser, G.P.5    Schwartz, I.6
  • 51
    • 84855863354 scopus 로고    scopus 로고
    • BpaB and EbfC DNA-binding proteins regulate production of the Lyme disease spirochete's infection-associated Erp surface proteins
    • Jutras, B.L., Verma, A., Adams, C.A., Brissette, C.A., Burns, L.H., Whetstine, C.R., etal. (2012) BpaB and EbfC DNA-binding proteins regulate production of the Lyme disease spirochete's infection-associated Erp surface proteins. J Bacteriol 194: 778-786.
    • (2012) J Bacteriol , vol.194 , pp. 778-786
    • Jutras, B.L.1    Verma, A.2    Adams, C.A.3    Brissette, C.A.4    Burns, L.H.5    Whetstine, C.R.6
  • 52
    • 84883728097 scopus 로고    scopus 로고
    • Bpur, the Lyme disease spirochete's PUR domain protein: identification as a transcriptional modulator and characterization of nucleic acid interactions
    • Jutras, B.L., Chenail, A.M., Carroll, D.W., Miller, M.C., Zhu, H., Bowman, A., and Stevenson, B. (2013a) Bpur, the Lyme disease spirochete's PUR domain protein: identification as a transcriptional modulator and characterization of nucleic acid interactions. J Biol Chem 288: 26220-26234.
    • (2013) J Biol Chem , vol.288 , pp. 26220-26234
    • Jutras, B.L.1    Chenail, A.M.2    Carroll, D.W.3    Miller, M.C.4    Zhu, H.5    Bowman, A.6    Stevenson, B.7
  • 54
    • 84885715722 scopus 로고    scopus 로고
    • A chitin deacetylase-like protein is a predominant constituent of tick peritrophic membrane that influences the persistence of Lyme disease pathogens within the vector
    • Kariu, T., Smith, A., Yang, X., and Pal, U. (2013) A chitin deacetylase-like protein is a predominant constituent of tick peritrophic membrane that influences the persistence of Lyme disease pathogens within the vector. PLoS ONE 8: e78376.
    • (2013) PLoS ONE , vol.8 , pp. e78376
    • Kariu, T.1    Smith, A.2    Yang, X.3    Pal, U.4
  • 56
    • 9244239222 scopus 로고    scopus 로고
    • BBE02 disruption mutants of Borrelia burgdorferi B31 have a highly transformable, infectious phenotype
    • Kawabata, H., Norris, S.J., and Watanabe, H. (2004) BBE02 disruption mutants of Borrelia burgdorferi B31 have a highly transformable, infectious phenotype. Infect Immun 72: 7147-7154.
    • (2004) Infect Immun , vol.72 , pp. 7147-7154
    • Kawabata, H.1    Norris, S.J.2    Watanabe, H.3
  • 57
    • 29144437058 scopus 로고    scopus 로고
    • Alternative sigma factors and their roles in bacterial virulence
    • Kazmierczak, M.J., Wiedmann, M., and Boor, K.J. (2005) Alternative sigma factors and their roles in bacterial virulence. Microbiol Mol Biol Rev 69: 527-543.
    • (2005) Microbiol Mol Biol Rev , vol.69 , pp. 527-543
    • Kazmierczak, M.J.1    Wiedmann, M.2    Boor, K.J.3
  • 59
    • 79959551165 scopus 로고    scopus 로고
    • The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes
    • Kostick, J.L., Szkotnicki, L.T., Rogers, E.A., Bocci, P., Raffaelli, N., and Marconi, R.T. (2011) The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes. Mol Microbiol 81: 219-231.
    • (2011) Mol Microbiol , vol.81 , pp. 219-231
    • Kostick, J.L.1    Szkotnicki, L.T.2    Rogers, E.A.3    Bocci, P.4    Raffaelli, N.5    Marconi, R.T.6
  • 60
    • 84872603749 scopus 로고    scopus 로고
    • Complement regulator-acquiring surface proteins of Borrelia burgdorferi: structure, function and regulation of gene expression
    • Kraiczy, P., and Stevenson, B. (2013) Complement regulator-acquiring surface proteins of Borrelia burgdorferi: structure, function and regulation of gene expression. Ticks Tick Borne Dis 4: 26-34.
    • (2013) Ticks Tick Borne Dis , vol.4 , pp. 26-34
    • Kraiczy, P.1    Stevenson, B.2
  • 61
    • 84884181567 scopus 로고    scopus 로고
    • CDC estimates 300000 US cases of Lyme disease annually
    • Kuehn, B.M. (2013) CDC estimates 300000 US cases of Lyme disease annually. JAMA 310: 1110.
    • (2013) JAMA , vol.310 , pp. 1110
    • Kuehn, B.M.1
  • 62
    • 77749308350 scopus 로고    scopus 로고
    • BBA52 facilitates Borrelia burgdorferi transmission from feeding ticks to murine hosts
    • Kumar, M., Yang, X., Coleman, A.S., and Pal, U. (2010) BBA52 facilitates Borrelia burgdorferi transmission from feeding ticks to murine hosts. J Infect Dis 201: 1084-1095.
    • (2010) J Infect Dis , vol.201 , pp. 1084-1095
    • Kumar, M.1    Yang, X.2    Coleman, A.S.3    Pal, U.4
  • 64
    • 12844252620 scopus 로고    scopus 로고
    • Carbohydrate utilization by the Lyme borreliosis spirochete, Borrelia burgdorferi
    • von Lackum, K., and Stevenson, B. (2005) Carbohydrate utilization by the Lyme borreliosis spirochete, Borrelia burgdorferi. FEMS Microbiol Lett 243: 173-179.
    • (2005) FEMS Microbiol Lett , vol.243 , pp. 173-179
    • von Lackum, K.1    Stevenson, B.2
  • 65
    • 0034700150 scopus 로고    scopus 로고
    • Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes
    • Lange, B.M., Rujan, T., Martin, W., and Croteau, R. (2000) Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes. Proc Natl Acad Sci USA 97: 13172-13177.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13172-13177
    • Lange, B.M.1    Rujan, T.2    Martin, W.3    Croteau, R.4
  • 66
    • 67651205583 scopus 로고    scopus 로고
    • Bacterial PEP-dependent carbohydrate: phosphotransferase systems couple sensing and global control mechanisms
    • Lengeler, J.W., and Jahreis, K. (2009) Bacterial PEP-dependent carbohydrate: phosphotransferase systems couple sensing and global control mechanisms. Contrib Microbiol 16: 65-87.
    • (2009) Contrib Microbiol , vol.16 , pp. 65-87
    • Lengeler, J.W.1    Jahreis, K.2
  • 68
    • 33846217722 scopus 로고    scopus 로고
    • The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks
    • Li, X., Pal, U., Ramamoorthi, N., Liu, X., Desrosiers, D.C., Eggers, C.H., etal. (2007) The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks. Mol Microbiol 63: 694-710.
    • (2007) Mol Microbiol , vol.63 , pp. 694-710
    • Li, X.1    Pal, U.2    Ramamoorthi, N.3    Liu, X.4    Desrosiers, D.C.5    Eggers, C.H.6
  • 69
    • 34147117599 scopus 로고    scopus 로고
    • Regulators of expression of the oligopeptide permease A proteins of Borrelia burgdorferi
    • Medrano, M.S., Ding, Y., Wang, X.G., Lu, P., Coburn, J., and Hu, L.T. (2007) Regulators of expression of the oligopeptide permease A proteins of Borrelia burgdorferi. J Bacteriol 189: 2653-2659.
    • (2007) J Bacteriol , vol.189 , pp. 2653-2659
    • Medrano, M.S.1    Ding, Y.2    Wang, X.G.3    Lu, P.4    Coburn, J.5    Hu, L.T.6
  • 70
    • 84875626787 scopus 로고    scopus 로고
    • Borrelia host adaptation regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi
    • Miller, C.L., Karna, S.L., and Seshu, J. (2013) Borrelia host adaptation regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi. Mol Microbiol 88: 105-124.
    • (2013) Mol Microbiol , vol.88 , pp. 105-124
    • Miller, C.L.1    Karna, S.L.2    Seshu, J.3
  • 72
    • 84904012197 scopus 로고    scopus 로고
    • Coordinating bacterial cell division with nutrient availability: a role for glycolysis
    • Monahan, L.G., Hajduk, I.V., Blaber, S.P., Charles, I.G., and Harry, E.J. (2014) Coordinating bacterial cell division with nutrient availability: a role for glycolysis. mBio 5: e00935.
    • (2014) mBio , vol.5 , pp. e00935
    • Monahan, L.G.1    Hajduk, I.V.2    Blaber, S.P.3    Charles, I.G.4    Harry, E.J.5
  • 73
    • 0030048119 scopus 로고    scopus 로고
    • Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease
    • Montgomery, R.R., Malawista, S.E., Feen, K.J., and Bockenstedt, L.K. (1996) Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. J Exp Med 183: 261-269.
    • (1996) J Exp Med , vol.183 , pp. 261-269
    • Montgomery, R.R.1    Malawista, S.E.2    Feen, K.J.3    Bockenstedt, L.K.4
  • 74
    • 79959326874 scopus 로고    scopus 로고
    • CheY3 of Borrelia burgdorferi is the key response regulator essential for chemotaxis and forms a long-lived phosphorylated Intermediate
    • Motaleb, M.A., Sultan, S.Z., Miller, M.R., Li, C., and Charon, N.W. (2011) CheY3 of Borrelia burgdorferi is the key response regulator essential for chemotaxis and forms a long-lived phosphorylated Intermediate. J Bacteriol 193: 3332-3341.
    • (2011) J Bacteriol , vol.193 , pp. 3332-3341
    • Motaleb, M.A.1    Sultan, S.Z.2    Miller, M.R.3    Li, C.4    Charon, N.W.5
  • 75
    • 65249125095 scopus 로고    scopus 로고
    • Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals
    • Mulay, V.B., Caimano, M.J., Iyer, R., Dunham-Ems, S., Liveris, D., Petzke, M.M., etal. (2009) Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals. J Bacteriol 191: 2783-2794.
    • (2009) J Bacteriol , vol.191 , pp. 2783-2794
    • Mulay, V.B.1    Caimano, M.J.2    Iyer, R.3    Dunham-Ems, S.4    Liveris, D.5    Petzke, M.M.6
  • 76
    • 0035895241 scopus 로고    scopus 로고
    • Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks
    • Ohnishi, J., Piesman, J., and de Silva, A.M. (2001) Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks. Proc Natl Acad Sci USA 98: 670-675.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 670-675
    • Ohnishi, J.1    Piesman, J.2    de Silva, A.M.3
  • 77
    • 0345535124 scopus 로고    scopus 로고
    • Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays
    • Ojaimi, C., Brooks, C., Casjens, S., Rosa, P., Elias, A., Barbour, A., etal. (2003) Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays. Infect Immun 71: 1689-1705.
    • (2003) Infect Immun , vol.71 , pp. 1689-1705
    • Ojaimi, C.1    Brooks, C.2    Casjens, S.3    Rosa, P.4    Elias, A.5    Barbour, A.6
  • 79
    • 79952237303 scopus 로고    scopus 로고
    • BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism
    • Ouyang, Z., Deka, R.K., and Norgard, M.V. (2011) BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism. PLoS Pathog 7: e1001272.
    • (2011) PLoS Pathog , vol.7 , pp. e1001272
    • Ouyang, Z.1    Deka, R.K.2    Norgard, M.V.3
  • 80
    • 84896441029 scopus 로고    scopus 로고
    • CsrA (BB0184) is not involved in activation of the RpoN-RpoS regulatory pathway in Borrelia burgdorferi
    • Ouyang, Z., Zhou, J., and Norgard, M.V. (2014) CsrA (BB0184) is not involved in activation of the RpoN-RpoS regulatory pathway in Borrelia burgdorferi. Infect Immun 82: 1511-1522.
    • (2014) Infect Immun , vol.82 , pp. 1511-1522
    • Ouyang, Z.1    Zhou, J.2    Norgard, M.V.3
  • 81
  • 82
    • 39349089426 scopus 로고    scopus 로고
    • A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks
    • Pal, U., Dai, J., Li, X., Neelakanta, G., Luo, P., Kumar, M., etal. (2008) A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks. J Infect Dis 197: 148-155.
    • (2008) J Infect Dis , vol.197 , pp. 148-155
    • Pal, U.1    Dai, J.2    Li, X.3    Neelakanta, G.4    Luo, P.5    Kumar, M.6
  • 83
    • 79960963391 scopus 로고    scopus 로고
    • Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle
    • Pappas, C.J., Iyer, R., Petze, M.M., Caimano, M.J., Radolf, J.D., and Schwartz, I. (2011) Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle. PLoS Pathog 7: e1002102.
    • (2011) PLoS Pathog , vol.7 , pp. e1002102
    • Pappas, C.J.1    Iyer, R.2    Petze, M.M.3    Caimano, M.J.4    Radolf, J.D.5    Schwartz, I.6
  • 84
    • 77950870461 scopus 로고    scopus 로고
    • Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum
    • Parsonage, D., Desrosiers, D.C., Hazlett, K.R., Sun, Y., Nelson, K.J., Cox, D.L., etal. (2010) Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum. Proc Natl Acad Sci USA 107: 6240-6245.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 6240-6245
    • Parsonage, D.1    Desrosiers, D.C.2    Hazlett, K.R.3    Sun, Y.4    Nelson, K.J.5    Cox, D.L.6
  • 85
    • 0025264399 scopus 로고
    • Growth kinetics of the Lyme disease spirochete (Borrelia burgdorferi) in vector ticks (Ixodes dammini)
    • Piesman, J., Oliver, J.R., and Sinsky, R.J. (1990) Growth kinetics of the Lyme disease spirochete (Borrelia burgdorferi) in vector ticks (Ixodes dammini). Am J Trop Med Hyg 42: 352-357.
    • (1990) Am J Trop Med Hyg , vol.42 , pp. 352-357
    • Piesman, J.1    Oliver, J.R.2    Sinsky, R.J.3
  • 86
    • 0034764243 scopus 로고    scopus 로고
    • Use of quantitative PCR to measure density of Borrelia burgdorferi in the midgut and salivary glands of feeding tick vectors
    • Piesman, J., Schneider, B.S., and Zeidner, N.S. (2001) Use of quantitative PCR to measure density of Borrelia burgdorferi in the midgut and salivary glands of feeding tick vectors. J Clin Microbiol 39: 4145-4148.
    • (2001) J Clin Microbiol , vol.39 , pp. 4145-4148
    • Piesman, J.1    Schneider, B.S.2    Zeidner, N.S.3
  • 87
    • 79951852204 scopus 로고    scopus 로고
    • Signal processing in complex chemotaxis pathways
    • Porter, S.L., Wadhams, G.H., and Armitage, J.P. (2011) Signal processing in complex chemotaxis pathways. Nat Rev Microbiol 9: 153-165.
    • (2011) Nat Rev Microbiol , vol.9 , pp. 153-165
    • Porter, S.L.1    Wadhams, G.H.2    Armitage, J.P.3
  • 88
    • 0038687785 scopus 로고    scopus 로고
    • A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host
    • Purser, J.E., Lawrenz, M.B., Caimano, M.J., Howell, J.K., Radolf, J.D., and Norris, S.J. (2003) A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host. Mol Microbiol 48: 753-764.
    • (2003) Mol Microbiol , vol.48 , pp. 753-764
    • Purser, J.E.1    Lawrenz, M.B.2    Caimano, M.J.3    Howell, J.K.4    Radolf, J.D.5    Norris, S.J.6
  • 89
    • 84855900042 scopus 로고    scopus 로고
    • Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes
    • Radolf, J.D., Caimano, M.J., Stevenson, B., and Hu, L.T. (2012) Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes. Nat Rev Microbiol 10: 87-99.
    • (2012) Nat Rev Microbiol , vol.10 , pp. 87-99
    • Radolf, J.D.1    Caimano, M.J.2    Stevenson, B.3    Hu, L.T.4
  • 90
    • 79961103202 scopus 로고    scopus 로고
    • Oligopeptide permease A5 modulates vertebrate host-specific adaptation of Borrelia burgdorferi
    • Raju, B.V., Esteve-Gassent, M.D., Karna, S.L., Miller, C.L., Van Laar, T.A., and Seshu, J. (2011) Oligopeptide permease A5 modulates vertebrate host-specific adaptation of Borrelia burgdorferi. Infect Immun 79: 3407-3420.
    • (2011) Infect Immun , vol.79 , pp. 3407-3420
    • Raju, B.V.1    Esteve-Gassent, M.D.2    Karna, S.L.3    Miller, C.L.4    Van Laar, T.A.5    Seshu, J.6
  • 91
    • 0037022354 scopus 로고    scopus 로고
    • DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete
    • Revel, A.T., Talaat, A.M., and Norgard, M.V. (2002) DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete. Proc Natl Acad Sci USA 99: 1562-1567.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 1562-1567
    • Revel, A.T.1    Talaat, A.M.2    Norgard, M.V.3
  • 92
    • 77649306815 scopus 로고    scopus 로고
    • The chitobiose transporter, chbC, is required for chitin utilization in Borrelia burgdorferi
    • Rhodes, R.G., Atoyan, J.A., and Nelson, D.R. (2010) The chitobiose transporter, chbC, is required for chitin utilization in Borrelia burgdorferi. BMC Microbiol 10: 21.
    • (2010) BMC Microbiol , vol.10 , pp. 21
    • Rhodes, R.G.1    Atoyan, J.A.2    Nelson, D.R.3
  • 93
    • 0023100179 scopus 로고
    • Dissemination and salivary delivery of Lyme disease spirochetes in vector ticks (Acari: Ixodidae)
    • Ribeiro, J.M., Mather, T.N., Piesman, J., and Spielman, A. (1987) Dissemination and salivary delivery of Lyme disease spirochetes in vector ticks (Acari: Ixodidae). J Med Entomol 24: 201-205.
    • (1987) J Med Entomol , vol.24 , pp. 201-205
    • Ribeiro, J.M.1    Mather, T.N.2    Piesman, J.3    Spielman, A.4
  • 95
    • 62449269945 scopus 로고    scopus 로고
    • Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions
    • Rogers, E.A., Terekhova, D., Zhang, H.M., Hovis, K.M., Schwartz, I., and Marconi, R.T. (2009) Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions. Mol Microbiol 71: 1551-1573.
    • (2009) Mol Microbiol , vol.71 , pp. 1551-1573
    • Rogers, E.A.1    Terekhova, D.2    Zhang, H.M.3    Hovis, K.M.4    Schwartz, I.5    Marconi, R.T.6
  • 96
    • 0344286495 scopus 로고    scopus 로고
    • Phylogenetic characterization of novel transport protein families revealed by genome analyses
    • Saier, M.H., Jr, Eng, B.H., Fard, S., Garg, J., Haggerty, D.A., Hutchinson, W.J., etal. (1999) Phylogenetic characterization of novel transport protein families revealed by genome analyses. Biochim Biophys Acta 1422: 1-56.
    • (1999) Biochim Biophys Acta , vol.1422 , pp. 1-56
    • Saier Jr., M.H.1    Eng, B.H.2    Fard, S.3    Garg, J.4    Haggerty, D.A.5    Hutchinson, W.J.6
  • 97
    • 0029200874 scopus 로고
    • Electrotransformation of the spirochete Borrelia burgdorferi
    • Samuels, D.S. (1995) Electrotransformation of the spirochete Borrelia burgdorferi. Methods Mol Biol 47: 253-259.
    • (1995) Methods Mol Biol , vol.47 , pp. 253-259
    • Samuels, D.S.1
  • 98
    • 80053278392 scopus 로고    scopus 로고
    • Gene regulation in Borrelia burgdorferi
    • Samuels, D.S. (2011) Gene regulation in Borrelia burgdorferi. Annu Rev Microbiol 65: 479-499.
    • (2011) Annu Rev Microbiol , vol.65 , pp. 479-499
    • Samuels, D.S.1
  • 100
    • 0033984294 scopus 로고    scopus 로고
    • Temporal changes in outer surface proteins A and C of the Lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice
    • Schwan, T.G., and Piesman, J. (2000) Temporal changes in outer surface proteins A and C of the Lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice. J Clin Microbiol 38: 382-388.
    • (2000) J Clin Microbiol , vol.38 , pp. 382-388
    • Schwan, T.G.1    Piesman, J.2
  • 101
    • 0036199104 scopus 로고    scopus 로고
    • Vector interactions and molecular adaptations of lyme disease and relapsing fever spirochetes associated with transmission by ticks
    • Schwan, T.G., and Piesman, J. (2002) Vector interactions and molecular adaptations of lyme disease and relapsing fever spirochetes associated with transmission by ticks. Emerg Infect Dis 8: 115-121.
    • (2002) Emerg Infect Dis , vol.8 , pp. 115-121
    • Schwan, T.G.1    Piesman, J.2
  • 102
    • 0028926240 scopus 로고
    • Induction of an outer surface protein on Borrelia burgdorferi during tick feeding
    • Schwan, T.G., Piesman, J., Golde, W.T., Dolan, M.C., and Rosa, P.A. (1995) Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc Natl Acad Sci USA 92: 2909-2913.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 2909-2913
    • Schwan, T.G.1    Piesman, J.2    Golde, W.T.3    Dolan, M.C.4    Rosa, P.A.5
  • 103
    • 0026469028 scopus 로고
    • Diagnosis of early Lyme disease by polymerase chain reaction amplification and culture of skin biopsies from erythema migrans lesions
    • Schwartz, I., Wormser, G.P., Schwartz, J.J., Cooper, D., Weissensee, P., Gazumyan, A., etal. (1992) Diagnosis of early Lyme disease by polymerase chain reaction amplification and culture of skin biopsies from erythema migrans lesions. J Clin Microbiol 30: 3082-3088.
    • (1992) J Clin Microbiol , vol.30 , pp. 3082-3088
    • Schwartz, I.1    Wormser, G.P.2    Schwartz, J.J.3    Cooper, D.4    Weissensee, P.5    Gazumyan, A.6
  • 104
    • 30744477217 scopus 로고    scopus 로고
    • Lipoprotein computational prediction in spirochaetal genomes
    • Setubal, J.C., Reis, M., Matsunaga, J., and Haake, D.A. (2006) Lipoprotein computational prediction in spirochaetal genomes. Microbiology 152: 113-121.
    • (2006) Microbiology , vol.152 , pp. 113-121
    • Setubal, J.C.1    Reis, M.2    Matsunaga, J.3    Haake, D.A.4
  • 105
    • 40549096043 scopus 로고    scopus 로고
    • A multifaceted role for polyamines in bacterial pathogens
    • Shah, P., and Swiatlo, E. (2008) A multifaceted role for polyamines in bacterial pathogens. Mol Microbiol 68: 4-16.
    • (2008) Mol Microbiol , vol.68 , pp. 4-16
    • Shah, P.1    Swiatlo, E.2
  • 107
    • 0030025949 scopus 로고    scopus 로고
    • Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine
    • de Silva, A.M., Telford, S.R., 3rd, Brunet, L.R., Barthold, S.W., and Fikrig, E. (1996) Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. J Exp Med 183: 271-275.
    • (1996) J Exp Med , vol.183 , pp. 271-275
    • de Silva, A.M.1    Telford III, S.R.2    Brunet, L.R.3    Barthold, S.W.4    Fikrig, E.5
  • 110
    • 31544467534 scopus 로고    scopus 로고
    • Kinetics of Borrelia burgdorferi infection in larvae of refractory and competent tick vectors
    • Soares, C.A., Zeidner, N.S., Beard, C.B., Dolan, M.C., Dietrich, G., and Piesman, J. (2006) Kinetics of Borrelia burgdorferi infection in larvae of refractory and competent tick vectors. J Med Entomol 43: 61-67.
    • (2006) J Med Entomol , vol.43 , pp. 61-67
    • Soares, C.A.1    Zeidner, N.S.2    Beard, C.B.3    Dolan, M.C.4    Dietrich, G.5    Piesman, J.6
  • 112
    • 0035849985 scopus 로고    scopus 로고
    • Lyme disease
    • Steere, A.C. (2001) Lyme disease. N Engl J Med 345: 115-125.
    • (2001) N Engl J Med , vol.345 , pp. 115-125
    • Steere, A.C.1
  • 114
    • 0028828202 scopus 로고
    • Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi
    • Stevenson, B., Schwan, T.G., and Rosa, P.A. (1995) Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun 63: 4535-4539.
    • (1995) Infect Immun , vol.63 , pp. 4535-4539
    • Stevenson, B.1    Schwan, T.G.2    Rosa, P.A.3
  • 116
    • 0036066456 scopus 로고    scopus 로고
    • Pattern searches for the identification of putative lipoprotein genes in Gram-positive bacterial genomes
    • Sutcliffe, I.C., and Harrington, D.J. (2002) Pattern searches for the identification of putative lipoprotein genes in Gram-positive bacterial genomes. Microbiology 148: 2065-2077.
    • (2002) Microbiology , vol.148 , pp. 2065-2077
    • Sutcliffe, I.C.1    Harrington, D.J.2
  • 117
    • 79952286835 scopus 로고    scopus 로고
    • Inactivation of bb0184, which encodes carbon storage regulator A, represses the infectivity of Borrelia burgdorferi
    • Sze, C.W., and Li, C. (2011) Inactivation of bb0184, which encodes carbon storage regulator A, represses the infectivity of Borrelia burgdorferi. Infect Immun 79: 1270-1279.
    • (2011) Infect Immun , vol.79 , pp. 1270-1279
    • Sze, C.W.1    Li, C.2
  • 118
    • 84864821396 scopus 로고    scopus 로고
    • Borrelia burgdorferi needs chemotaxis to establish infection in mammals and to accomplish its enzootic cycle
    • Sze, C.W., Zhang, K., Kariu, T., Pal, U., and Li, C. (2012) Borrelia burgdorferi needs chemotaxis to establish infection in mammals and to accomplish its enzootic cycle. Infect Immun 80: 2485-2492.
    • (2012) Infect Immun , vol.80 , pp. 2485-2492
    • Sze, C.W.1    Zhang, K.2    Kariu, T.3    Pal, U.4    Li, C.5
  • 119
    • 84877796869 scopus 로고    scopus 로고
    • Study of the response regulator Rrp1 reveals its regulatory role in chitobiose utilization and virulence of Borrelia burgdorferi
    • Sze, C.W., Smith, A., Choi, Y.H., Yang, X., Pal, U., Yu, A., and Li, C. (2013) Study of the response regulator Rrp1 reveals its regulatory role in chitobiose utilization and virulence of Borrelia burgdorferi. Infect Immun 81: 1775-1787.
    • (2013) Infect Immun , vol.81 , pp. 1775-1787
    • Sze, C.W.1    Smith, A.2    Choi, Y.H.3    Yang, X.4    Pal, U.5    Yu, A.6    Li, C.7
  • 120
    • 0022001625 scopus 로고
    • Polyamines in microorganisms
    • Tabor, C.W., and Tabor, H. (1985) Polyamines in microorganisms. Microbiol Rev 49: 81-99.
    • (1985) Microbiol Rev , vol.49 , pp. 81-99
    • Tabor, C.W.1    Tabor, H.2
  • 121
    • 0034823641 scopus 로고    scopus 로고
    • Genetics and regulation of chitobiose utilization in Borrelia burgdorferi
    • Tilly, K., Elias, A.F., Errett, J., Fischer, E., Iyer, R., Schwartz, I., etal. (2001) Genetics and regulation of chitobiose utilization in Borrelia burgdorferi. J Bacteriol 183: 5544-5553.
    • (2001) J Bacteriol , vol.183 , pp. 5544-5553
    • Tilly, K.1    Elias, A.F.2    Errett, J.3    Fischer, E.4    Iyer, R.5    Schwartz, I.6
  • 122
    • 3543070597 scopus 로고    scopus 로고
    • Infectious cycle analysis of a Borrelia burgdorferi mutant defective in transport of chitobiose, a tick cuticle component
    • Tilly, K., Grimm, D., Bueschel, D.M., Krum, J.G., and Rosa, P. (2004) Infectious cycle analysis of a Borrelia burgdorferi mutant defective in transport of chitobiose, a tick cuticle component. Vector Borne Zoonotic Dis 4: 159-168.
    • (2004) Vector Borne Zoonotic Dis , vol.4 , pp. 159-168
    • Tilly, K.1    Grimm, D.2    Bueschel, D.M.3    Krum, J.G.4    Rosa, P.5
  • 123
  • 124
    • 84857066761 scopus 로고    scopus 로고
    • The enolase of Borrelia burgdorferi is a plasminogen receptor released in outer membrane vesicles
    • Toledo, A., Coleman, J.L., Kuhlow, C.J., Crowley, J.T., and Benach, J.L. (2012) The enolase of Borrelia burgdorferi is a plasminogen receptor released in outer membrane vesicles. Infect Immun 80: 359-368.
    • (2012) Infect Immun , vol.80 , pp. 359-368
    • Toledo, A.1    Coleman, J.L.2    Kuhlow, C.J.3    Crowley, J.T.4    Benach, J.L.5
  • 125
    • 84861675491 scopus 로고    scopus 로고
    • Effect of levels of acetate on the mevalonate pathway of Borrelia burgdorferi
    • Van Laar, T.A., Lin, Y.H., Miller, C.L., Karna, S.L., Chambers, J.P., and Seshu, J. (2012) Effect of levels of acetate on the mevalonate pathway of Borrelia burgdorferi. PLoS ONE 7: e38171.
    • (2012) PLoS ONE , vol.7 , pp. e38171
    • Van Laar, T.A.1    Lin, Y.H.2    Miller, C.L.3    Karna, S.L.4    Chambers, J.P.5    Seshu, J.6
  • 126
    • 0029122852 scopus 로고
    • Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo
    • Wallich, R., Brenner, C., Kramer, M.D., and Simon, M.M. (1995) Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo. Infect Immun 63: 3327-3335.
    • (1995) Infect Immun , vol.63 , pp. 3327-3335
    • Wallich, R.1    Brenner, C.2    Kramer, M.D.3    Simon, M.M.4
  • 127
    • 0034967970 scopus 로고    scopus 로고
    • Impact of genotypic variation of Borrelia burgdorferi sensu stricto on kinetics of dissemination and severity of disease in C3H/HeJ mice
    • Wang, G., Ojaimi, C., Iyer, R., Saksenberg, V., McClain, S.A., Wormser, G.P., and Schwartz, I. (2001) Impact of genotypic variation of Borrelia burgdorferi sensu stricto on kinetics of dissemination and severity of disease in C3H/HeJ mice. Infect Immun 69: 4303-4312.
    • (2001) Infect Immun , vol.69 , pp. 4303-4312
    • Wang, G.1    Ojaimi, C.2    Iyer, R.3    Saksenberg, V.4    McClain, S.A.5    Wormser, G.P.6    Schwartz, I.7
  • 128
    • 7044226563 scopus 로고    scopus 로고
    • Variations in Barbour-Stoenner-Kelly culture medium modulate infectivity and pathogenicity of Borrelia burgdorferi clinical isolates
    • Wang, G., Iyer, R., Bittker, S., Cooper, D., Small, J., Wormser, G.P., and Schwartz, I. (2004a) Variations in Barbour-Stoenner-Kelly culture medium modulate infectivity and pathogenicity of Borrelia burgdorferi clinical isolates. Infect Immun 72: 6702-6706.
    • (2004) Infect Immun , vol.72 , pp. 6702-6706
    • Wang, G.1    Iyer, R.2    Bittker, S.3    Cooper, D.4    Small, J.5    Wormser, G.P.6    Schwartz, I.7
  • 129
    • 84884287311 scopus 로고    scopus 로고
    • Borrelia burgdorferi oxidative stress regulator BosR directly represses lipoproteins primarily expressed in the tick during mammalian infection
    • Wang, P., Dadhwal, P., Cheng, Z., Zianni, M.R., Rikihisa, Y., Liang, F.T., and Li, X. (2013) Borrelia burgdorferi oxidative stress regulator BosR directly represses lipoproteins primarily expressed in the tick during mammalian infection. Mol Microbiol 89: 1140-1153.
    • (2013) Mol Microbiol , vol.89 , pp. 1140-1153
    • Wang, P.1    Dadhwal, P.2    Cheng, Z.3    Zianni, M.R.4    Rikihisa, Y.5    Liang, F.T.6    Li, X.7
  • 130
    • 0036842061 scopus 로고    scopus 로고
    • Effects of environmental changes on expression of the oligopeptide permease (opp) genes of Borrelia burgdorferi
    • Wang, X.G., Lin, B., Kidder, J.M., Telford, S., and Hu, L.T. (2002) Effects of environmental changes on expression of the oligopeptide permease (opp) genes of Borrelia burgdorferi. J Bacteriol 184: 6198-6206.
    • (2002) J Bacteriol , vol.184 , pp. 6198-6206
    • Wang, X.G.1    Lin, B.2    Kidder, J.M.3    Telford, S.4    Hu, L.T.5
  • 131
    • 0345730812 scopus 로고    scopus 로고
    • Analysis of differences in the functional properties of the substrate binding proteins of the Borrelia burgdorferi oligopeptide permease (Opp) operon
    • Wang, X.G., Kidder, J.M., Scagliotti, J.P., Klempner, M.S., Noring, R., and Hu, L.T. (2004b) Analysis of differences in the functional properties of the substrate binding proteins of the Borrelia burgdorferi oligopeptide permease (Opp) operon. J Bacteriol 186: 51-60.
    • (2004) J Bacteriol , vol.186 , pp. 51-60
    • Wang, X.G.1    Kidder, J.M.2    Scagliotti, J.P.3    Klempner, M.S.4    Noring, R.5    Hu, L.T.6
  • 132
    • 0007933664 scopus 로고    scopus 로고
    • Biosynthesis of isoprenoids in bacteria
    • In . Neidhardt, F.C. (ed.). Washington, DC: ASM Press
    • White, R.W. (1996) Biosynthesis of isoprenoids in bacteria. In Escherichia coli and Salmonella. Neidhardt, F.C. (ed.). Washington, DC: ASM Press, pp. 637-641.
    • (1996) Escherichia coli and Salmonella , pp. 637-641
    • White, R.W.1
  • 133
    • 0033810917 scopus 로고    scopus 로고
    • Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus
    • Wilding, E.I., Kim, D.Y., Bryant, A.P., Gwynn, M.N., Lunsford, R.D., McDevitt, D., etal. (2000) Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus. J Bacteriol 182: 5147-5152.
    • (2000) J Bacteriol , vol.182 , pp. 5147-5152
    • Wilding, E.I.1    Kim, D.Y.2    Bryant, A.P.3    Gwynn, M.N.4    Lunsford, R.D.5    McDevitt, D.6
  • 135
    • 77949914858 scopus 로고    scopus 로고
    • Physiologically relevant small phosphodonors link metabolism to signal transduction
    • Wolfe, A.J. (2010) Physiologically relevant small phosphodonors link metabolism to signal transduction. Curr Opin Microbiol 13: 204-209.
    • (2010) Curr Opin Microbiol , vol.13 , pp. 204-209
    • Wolfe, A.J.1
  • 136
    • 0029911312 scopus 로고    scopus 로고
    • Borrelia burgdorferi is an adenine and spermidine auxotroph
    • Wyss, C., and Emert, P. (1996) Borrelia burgdorferi is an adenine and spermidine auxotroph. Microb Ecol Health Dis 9: 181-185.
    • (1996) Microb Ecol Health Dis , vol.9 , pp. 181-185
    • Wyss, C.1    Emert, P.2
  • 137
    • 78149342510 scopus 로고    scopus 로고
    • Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi
    • Xu, H., Caimano, M.J., Lin, T., He, M., Radolf, J.D., Norris, S.J., etal. (2010) Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi. PLoS Pathog 6: e1001104.
    • (2010) PLoS Pathog , vol.6 , pp. e1001104
    • Xu, H.1    Caimano, M.J.2    Lin, T.3    He, M.4    Radolf, J.D.5    Norris, S.J.6
  • 138
    • 79956117013 scopus 로고    scopus 로고
    • Chemoreceptors and flagellar motors are subterminally located in close proximity at the two cell poles in spirochetes
    • Xu, H., Raddi, G., Liu, J., Charon, N.W., and Li, C. (2011) Chemoreceptors and flagellar motors are subterminally located in close proximity at the two cell poles in spirochetes. J Bacteriol 193: 2652-2656.
    • (2011) J Bacteriol , vol.193 , pp. 2652-2656
    • Xu, H.1    Raddi, G.2    Liu, J.3    Charon, N.W.4    Li, C.5
  • 139
    • 0033778628 scopus 로고    scopus 로고
    • Interdependence of environmental factors influencing reciprocal patterns of gene expression in virulent Borrelia burgdorferi
    • Yang, X., Goldberg, M.S., Popova, T.G., Schoeler, G.B., Wikel, S.K., Hagman, K.E., and Norgard, M.V. (2000) Interdependence of environmental factors influencing reciprocal patterns of gene expression in virulent Borrelia burgdorferi. Mol Microbiol 37: 1470-1479.
    • (2000) Mol Microbiol , vol.37 , pp. 1470-1479
    • Yang, X.1    Goldberg, M.S.2    Popova, T.G.3    Schoeler, G.B.4    Wikel, S.K.5    Hagman, K.E.6    Norgard, M.V.7
  • 140
    • 84899743143 scopus 로고    scopus 로고
    • A dityrosine network mediated by dual oxidase and peroxidase influences the persistence of Lyme disease pathogens within the vector
    • Yang, X., Smith, A.A., Williams, M.S., and Pal, U. (2014) A dityrosine network mediated by dual oxidase and peroxidase influences the persistence of Lyme disease pathogens within the vector. J Biol Chem 289: 12813-12822.
    • (2014) J Biol Chem , vol.289 , pp. 12813-12822
    • Yang, X.1    Smith, A.A.2    Williams, M.S.3    Pal, U.4
  • 141
    • 0141814623 scopus 로고    scopus 로고
    • The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi
    • Yang, X.F., Alani, S.M., and Norgard, M.V. (2003) The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi. Proc Natl Acad Sci USA 100: 11001-11006.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11001-11006
    • Yang, X.F.1    Alani, S.M.2    Norgard, M.V.3
  • 142
    • 1542283705 scopus 로고    scopus 로고
    • Essential role for OspA/B in the life cycle of the Lyme disease spirochete
    • Yang, X.F., Pal, U., Alani, S.M., Fikrig, E., and Norgard, M.V. (2004) Essential role for OspA/B in the life cycle of the Lyme disease spirochete. J Exp Med 199: 641-648.
    • (2004) J Exp Med , vol.199 , pp. 641-648
    • Yang, X.F.1    Pal, U.2    Alani, S.M.3    Fikrig, E.4    Norgard, M.V.5
  • 143
    • 84864794741 scopus 로고    scopus 로고
    • Two CheW coupling proteins are essential in a chemosensory pathway of Borrelia burgdorferi
    • Zhang, K., Liu, J., Tu, Y., Xu, H., Charon, N.W., and Li, C. (2012) Two CheW coupling proteins are essential in a chemosensory pathway of Borrelia burgdorferi. Mol Microbiol 85: 782-794.
    • (2012) Mol Microbiol , vol.85 , pp. 782-794
    • Zhang, K.1    Liu, J.2    Tu, Y.3    Xu, H.4    Charon, N.W.5    Li, C.6
  • 145
    • 0000244555 scopus 로고
    • Fine structural evidence for the penetration of the Lyme disease spirochete Borrelia burgdorferi through the gut and salivary tissues of Ixodes dammini
    • Zung, J.L., Lewengrub, S., Rudzinska, M.A., Spielman, A., Telford, S.R., and Piesman, J. (1989) Fine structural evidence for the penetration of the Lyme disease spirochete Borrelia burgdorferi through the gut and salivary tissues of Ixodes dammini. Can J Zool 67: 1737-1748.
    • (1989) Can J Zool , vol.67 , pp. 1737-1748
    • Zung, J.L.1    Lewengrub, S.2    Rudzinska, M.A.3    Spielman, A.4    Telford, S.R.5    Piesman, J.6


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