Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity

Immunity

Volumn 6, Issue 5, 1997, Pages 531-539

  Fikrig, Erol ^a   Barthold, Stephen W ^a   Sun, Wei ^a   Feng, Wen ^a   Telford III, Sam R ^b   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PARASITE ANTIGEN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; BORRELIA BURGDORFERI; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNE RESPONSE; LYME DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERODIAGNOSIS;

EID: 0030983397     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80341-6     Document Type: Article

References (31)

1. Akins, D., Porcella, S.R., Popova, T.G., Shevchenko, D., Baker, S.I., Li, M., Norgard, M.V., and Radolf, J.D. (1996). Evidence for in vivo but not in vitro expression of a Borrelia burgdorferi outer surface protein F (OspF) homologue. Mol. Microbiol. 18, 507-520.
2. Barbour, A.G. (1984). Isolation and cultivation of Lyme disease spirochetes. Yale J. Biol. Med. 57, 521-525.
3. Barthold, S.W., Persing, D.H., Armstrong, A.L., and Peeples, R.A. (1991). Kinetics of Borrelia burgdorferi: dissemination and evolution of disease following intradermal innoculation of mice. Am. J. Pathol. 163, 263-273.
4. Barthold, S.W., and Bockenstedt, L.K. (1993). Passive immunizing activity of sera from mice infected with Borrelia burgdorferi. Infect. Immun. 61, 4696-4702.
5. Barthold, S.W., Fikrig, E., Bockenstedt, L.K., and Persing, D.H. (1995). Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi. Infect. Immun. 63, 2255-2261.
6. Barthold, S., Feng, S., Bockenstedt, L., Fikrig, E., and Feen, K. (1997). Protective and arthritis-resolving activity in mice infected with Borrelia burgdorferi. Clin. Infect. Dis., in press.
7. Barthold, S., Souza, M.D., and Feng, S. (1996). Serum-mediated resolution of Lyme arthritis in mice. Lab. Invest. 74, 57-67.
8. Champion, C.I., Blanco, D.R., Skare, J.T., Haake, D.A., Giladi, M., Foley, D., Miller, J.N., and Lovett, M.A. (1994). A 9.0-kilobase-pair circular plasmid of Borrelia burgdorferi encodes an exported protein: evidence for expression only during infection. Infect. Immun. 62, 2653-2661.
9. de Silva, A.M., Telford, S.R., Brunet, L.R., Barthold, S.W., and Fikrig, E. (1996). Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. J. Exp. Med. 183, 271-275.
10. Dressler, F., Whalen, J.A., Reinhardt, B.A., and Steere, A.C. (1993). Western blotting in the serologic diagnosis of Lyme disease. J. Infect. Dis. 167, 392-400.
11. Fikrig, E., Barthold, S.W., Kantor, F.S., and Flavell, R.S. (1990). Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science 250, 553-556.
12. Fikrig, E., Huguenel, E.D., Berland, R., Rahn, D.W., Hardin, J.A., and Flavell, R.A. (1992). Serologic diagnosis of Lyme disease using recombinant outer surface proteins A and B and flagellin. J. Infect. Dis. 165, 1127-1132.
13. Fikrig, E., Barthold, S.W., and Flavell, R.A. (1993). OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection. Infect. Immun. 61, 2553-2557.
14. Fikrig, E., Tao, H., Chen, M., Barthold, S.W., and Flavell, R.A. (1995). Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B. J. Clin. Invest. 96, 1706-1714.
15. Fingerle, V., Hauser, U., Liegl, G., Petko, B., Preac-Mursic, V., and Wilske, B. (1995). Expression of outer surface proteins A and C of Borrelia burgdorferi in Ixodes ricinus. J. Clin. Microbiol. 33, 1867-1869.
16. Johnson, B.J., Robbins, K.E., Bailey, R.E., Cao, B.L., Sviat, S.L., Craven, R.B., Mayer, L.W., and Dennis, D.T. (1996). Serodiagnosis of Lyme disease: accuracy of a two-step approach using a flagella-based ELISA and immunoblotting. J. Infect. Dis. 174, 346-353.
17. Kalish, R., Leong, J.M., and Steere, A.C. (1993). Association of treatment-resistant chronic Lyme arthritis with antibody reactivity to OspA and OspB of Borrelia burgdorferi. Infect. Immun. 61, 2774-2779.
18. Kalish, R.A., Leong, J.M., and Steere, A.C. (1995). Early and late antibody responses to full-length and truncated constructs of outer surface protein A of Borrelia burgdorferi in Lyme disease. Infect. Immun. 63, 2228-2235.
19. Lam, T.T., Nguyen, T.P., Montgomery, R.R., Kantor, F.S., Fikrig, E., and Flavell, R.A. (1994). Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease. Infect. Immun. 62, 290-298.
20. Magnarelli, L.A. (1989). Laboratory diagnosis of Lyme disease. Rheum. Dis. Clin. North. Am. 15, 735-745.
21. Magnarelli, L., Fikrig, E., Padula, S.J., Anderson, J.F., and Flavell, R.A. (1996). Use of recombinant antigens of Borrelia burgdorferi in serologic tests for diagnosis of Lyme borreliosis. J. Clin. Microbiol. 34, 237-243.
22. Marconi, R., Sung, S.Y., Hughes, C., and Carlyon, J.A. (1996). Molecular and evolutionary analyses of a variable series of genes in Borrelia burgdorferi that are related to ospE and ospF, constitute a gene family and share a common upstream homology box. J. Bacteriol. 178, 5615-5626.
23. Montgomery, R.R., Malawista, S.E., Feen, K.J., and Bockenstedt, L.K. (1996). Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. J. Exp. Med. 183, 261-269.
24. Schutzer, S.E., Coyle, P.K., Dunn, J.J., Luft, B.J., and Brunner, M. (1994). Early and specific antibody responses to OspA in Lyme disease. J. Clin. Invest. 94, 454-457.
25. Schwan, T.G., Piesman, J., Golde, W.T., Dolan, M.C., and Rosa, P.A. (1995). Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc. Natl. Acad. Sci. USA 92, 2909-2913.
26. Sears, J., Fikrig, E., Nakagawa, T., Deponte, K., Marcantonio, N., Kantor, F., and Flavell, R.A. (1991). Molecular mapping of OspA-mediated protection against Borrelia burgdorferi, the Lyme disease agent. J. Immunol. 147, 1995-2001.
27. Stanek, G., Flamm, H., Barbour, A.G., and Burgdorfer, W. (1987). Lyme Borreliosis (New York: Gustav Fischer Verlag).
28. Stevenson, B., Tilly, K., and Rosa, P.A. (1996). A family of genes located on four separate 32-kilobase circular plasmids in Borrelia burgdorferi B31. J. Bacteriol. 178, 3508-3516.
29. Suk, K., Das, S., Sun, W., Jwang, B., Barthold, S.W., Flavell, R.A., and Fikrig, E. (1995). Borrelia burgdorferi genes selectively expressed in the infected host. Proc. Natl. Acad. Sci. USA 92, 4269-4273.
30. Wallich, R., Brenner, C., Kramer, M.D., and Simon, M.M. (1995). Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo. Infect. Immun. 63, 3327-3335.
31. Yssel, H., Shanafelt, M.C., Soderberg, C., Schneider, P.V., Anzola, J., and Peltz, G. (1991). Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis. J. Exp. Med. 174, 593-601.