메뉴 건너뛰기




Volumn 66, Issue 1, 2012, Pages 1-19

The role of Borrelia burgdorferi outer surface proteins

Author keywords

Borrelia; Lipoprotein; Lyme disease; Outer membrane protein; Spirochete

Indexed keywords

BACTERIAL PROTEIN; BINDING PROTEIN; BORRELIA EFFLUX SYSTEM PROTEIN C; COMPLEMENT REGULATOR ACQUIRING SURFACE PROTEIN; DECORIN; DECORIN BINDING PROTEIN A; DECORIN BINDING PROTEIN B; GLYCOSAMINOGLYCAN; LIPOPROTEIN; LYME DISEASE VACCINE; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN C; OUTER MEMBRANE PROTEIN F; OUTER SURFACE PROTEIN A; OUTER SURFACE PROTEIN B; OUTER SURFACE PROTEIN D; OUTER SURFACE PROTEIN E; PORIN; PROTEIN BAMA; PROTEIN BGP; PROTEIN P66; SURFACE LOCATED MEMBRANE PROTEIN 1; UNCLASSIFIED DRUG;

EID: 84866177740     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2012.00980.x     Document Type: Article
Times cited : (110)

References (194)
  • 2
    • 0036784619 scopus 로고    scopus 로고
    • Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs
    • Alitalo A, Meri T, Lankinen H, Seppala I, Lahdenne P, Hefty PS, Akins DR & Meri S (2002) Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs. J Immunol 169: 3847-3853.
    • (2002) J Immunol , vol.169 , pp. 3847-3853
    • Alitalo, A.1    Meri, T.2    Lankinen, H.3    Seppala, I.4    Lahdenne, P.5    Hefty, P.S.6    Akins, D.R.7    Meri, S.8
  • 3
    • 2442458752 scopus 로고    scopus 로고
    • Lysine-dependent multipoint binding of the Borrelia burgdorferi virulence factor outer surface protein E to the C terminus of factor H
    • Alitalo A, Meri T, Chen T et al. (2004) Lysine-dependent multipoint binding of the Borrelia burgdorferi virulence factor outer surface protein E to the C terminus of factor H. J Immunol 172: 6195-6201.
    • (2004) J Immunol , vol.172 , pp. 6195-6201
    • Alitalo, A.1    Meri, T.2    Chen, T.3
  • 4
    • 0038575105 scopus 로고    scopus 로고
    • Transcriptional regulation of the ospAB and ospC promoters from Borrelia burgdorferi
    • Alverson J, Bundle SF, Sohaskey CD, Lybecker MC & Samuels DS (2003) Transcriptional regulation of the ospAB and ospC promoters from Borrelia burgdorferi. Mol Microbiol 48: 1665-1677.
    • (2003) Mol Microbiol , vol.48 , pp. 1665-1677
    • Alverson, J.1    Bundle, S.F.2    Sohaskey, C.D.3    Lybecker, M.C.4    Samuels, D.S.5
  • 5
    • 34548694325 scopus 로고    scopus 로고
    • Borrelia burgdorferi adhesins identified using in vivo phage display
    • Antonara S, Chafel RM, LaFrance M & Coburn J (2007) Borrelia burgdorferi adhesins identified using in vivo phage display. Mol Microbiol 66: 262-276.
    • (2007) Mol Microbiol , vol.66 , pp. 262-276
    • Antonara, S.1    Chafel, R.M.2    LaFrance, M.3    Coburn, J.4
  • 6
    • 0030589698 scopus 로고    scopus 로고
    • Identification and mapping of a chromosomal gene cluster of Borrelia burgdorferi containing genes expressed in vivo
    • Aron L, Toth C, Godfrey HP & Cabello FC (1996) Identification and mapping of a chromosomal gene cluster of Borrelia burgdorferi containing genes expressed in vivo. FEMS Microbiol Lett 145: 309-314.
    • (1996) FEMS Microbiol Lett , vol.145 , pp. 309-314
    • Aron, L.1    Toth, C.2    Godfrey, H.P.3    Cabello, F.C.4
  • 7
    • 34548309048 scopus 로고    scopus 로고
    • The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens
    • Bankhead T & Chaconas G (2007) The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens. Mol Microbiol 65: 1547-1558.
    • (2007) Mol Microbiol , vol.65 , pp. 1547-1558
    • Bankhead, T.1    Chaconas, G.2
  • 8
    • 0027292427 scopus 로고
    • Linear DNA of Borrelia species and antigenic variation
    • Barbour AG (1993) Linear DNA of Borrelia species and antigenic variation. Trends Microbiol 1: 236-239.
    • (1993) Trends Microbiol , vol.1 , pp. 236-239
    • Barbour, A.G.1
  • 9
    • 0027170272 scopus 로고
    • The biological and social phenomenon of Lyme disease
    • Barbour AG & Fish D (1993) The biological and social phenomenon of Lyme disease. Science 260: 1610-1616.
    • (1993) Science , vol.260 , pp. 1610-1616
    • Barbour, A.G.1    Fish, D.2
  • 10
    • 0023663587 scopus 로고
    • Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends
    • Barbour AG & Garon CF (1987) Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends. Science 237: 409-411.
    • (1987) Science , vol.237 , pp. 409-411
    • Barbour, A.G.1    Garon, C.F.2
  • 11
    • 0020598076 scopus 로고
    • Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody
    • Barbour AG, Tessier SL & Todd WJ (1983) Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody. Infect Immun 41: 795-804.
    • (1983) Infect Immun , vol.41 , pp. 795-804
    • Barbour, A.G.1    Tessier, S.L.2    Todd, W.J.3
  • 12
    • 0021186157 scopus 로고
    • Variation in a major surface protein of Lyme disease spirochetes
    • Barbour AG, Tessier SL & Hayes SF (1984) Variation in a major surface protein of Lyme disease spirochetes. Infect Immun 45: 94-100.
    • (1984) Infect Immun , vol.45 , pp. 94-100
    • Barbour, A.G.1    Tessier, S.L.2    Hayes, S.F.3
  • 13
    • 0030034399 scopus 로고    scopus 로고
    • Identification of an uncultivable Borrelia species in the hard tick Amblymomma americanum: possible agent of a Lyme-like illness
    • Barbour AG, Maupin GO, Teltow GJ, Carter CJ & Piesman J (1996) Identification of an uncultivable Borrelia species in the hard tick Amblymomma americanum: possible agent of a Lyme-like illness. J Infect Dis 173: 403-409.
    • (1996) J Infect Dis , vol.173 , pp. 403-409
    • Barbour, A.G.1    Maupin, G.O.2    Teltow, G.J.3    Carter, C.J.4    Piesman, J.5
  • 14
    • 77952545940 scopus 로고    scopus 로고
    • P66 porins are present in both Lyme disease and relapsing fever spirochetes: a comparison of the biophysical properties of P66 porins from six Borrelia species
    • Barcena-Uribarri I, Thein M, Sacher A, Bunikis I, Bonde M, Bergstrom S & Benz R (2010) P66 porins are present in both Lyme disease and relapsing fever spirochetes: a comparison of the biophysical properties of P66 porins from six Borrelia species. Biochim Biophys Acta 1798: 1197-1203.
    • (2010) Biochim Biophys Acta , vol.1798 , pp. 1197-1203
    • Barcena-Uribarri, I.1    Thein, M.2    Sacher, A.3    Bunikis, I.4    Bonde, M.5    Bergstrom, S.6    Benz, R.7
  • 15
    • 20444438758 scopus 로고    scopus 로고
    • Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab target
    • Becker M, Bunikis J, Lade BD, Dunn JJ, Barbour AG & Lawson CL (2005) Structural investigation of Borrelia burgdorferi OspB, a bactericidal Fab target. J Biol Chem 280: 17363-17370.
    • (2005) J Biol Chem , vol.280 , pp. 17363-17370
    • Becker, M.1    Bunikis, J.2    Lade, B.D.3    Dunn, J.J.4    Barbour, A.G.5    Lawson, C.L.6
  • 16
    • 0020662118 scopus 로고
    • Spirochetes isolated from the blood of two patients with Lyme disease
    • Benach JL, Bosler EM, Hanrahan JP et al. (1983) Spirochetes isolated from the blood of two patients with Lyme disease. N Engl J Med 308: 740-742.
    • (1983) N Engl J Med , vol.308 , pp. 740-742
    • Benach, J.L.1    Bosler, E.M.2    Hanrahan, J.P.3
  • 17
    • 0024421344 scopus 로고
    • Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi
    • Bergstrom S, Bundoc VG & Barbour AG (1989) Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi. Mol Microbiol 3: 479-486.
    • (1989) Mol Microbiol , vol.3 , pp. 479-486
    • Bergstrom, S.1    Bundoc, V.G.2    Barbour, A.G.3
  • 18
    • 46249092176 scopus 로고    scopus 로고
    • Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection
    • Blevins JS, Hagman KE & Norgard MV (2008) Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection. BMC Microbiol 8: 82.
    • (2008) BMC Microbiol , vol.8 , pp. 82
    • Blevins, J.S.1    Hagman, K.E.2    Norgard, M.V.3
  • 20
    • 35348906348 scopus 로고    scopus 로고
    • Biogenesis of the Gram-negative bacterial outer membrane
    • Bos MP, Robert V & Tommassen J (2007) Biogenesis of the Gram-negative bacterial outer membrane. Annu Rev Microbiol 61: 191-214.
    • (2007) Annu Rev Microbiol , vol.61 , pp. 191-214
    • Bos, M.P.1    Robert, V.2    Tommassen, J.3
  • 22
    • 0038104769 scopus 로고    scopus 로고
    • Global analysis of Borrelia burgdorferi genes regulated by mammalian host-specific signals
    • Brooks CS, Hefty PS, Jolliff SE & Akins DR (2003) Global analysis of Borrelia burgdorferi genes regulated by mammalian host-specific signals. Infect Immun 71: 3371-3383.
    • (2003) Infect Immun , vol.71 , pp. 3371-3383
    • Brooks, C.S.1    Hefty, P.S.2    Jolliff, S.E.3    Akins, D.R.4
  • 23
    • 23844518311 scopus 로고    scopus 로고
    • Complement regulator-acquiring surface protein 1 imparts resistance to human serum in Borrelia burgdorferi
    • Brooks CS, Vuppala SR, Jett AM, Alitalo A, Meri S & Akins DR (2005) Complement regulator-acquiring surface protein 1 imparts resistance to human serum in Borrelia burgdorferi. J Immunol 175: 3299-3308.
    • (2005) J Immunol , vol.175 , pp. 3299-3308
    • Brooks, C.S.1    Vuppala, S.R.2    Jett, A.M.3    Alitalo, A.4    Meri, S.5    Akins, D.R.6
  • 24
    • 29644440332 scopus 로고    scopus 로고
    • Identification of Borrelia burgdorferi outer surface proteins
    • Brooks CS, Vuppala SR, Jett AM & Akins DR (2006) Identification of Borrelia burgdorferi outer surface proteins. Infect Immun 74: 296-304.
    • (2006) Infect Immun , vol.74 , pp. 296-304
    • Brooks, C.S.1    Vuppala, S.R.2    Jett, A.M.3    Akins, D.R.4
  • 26
    • 18844363955 scopus 로고    scopus 로고
    • Multicomponent Lyme vaccine: three is not a crowd
    • Brown EL, Kim JH, Reisenbichler ES & Hook M (2005) Multicomponent Lyme vaccine: three is not a crowd. Vaccine 23: 3687-3696.
    • (2005) Vaccine , vol.23 , pp. 3687-3696
    • Brown, E.L.1    Kim, J.H.2    Reisenbichler, E.S.3    Hook, M.4
  • 27
    • 0029124716 scopus 로고
    • Molecular analysis of a 66-kDa protein associated with the outer membrane of Lyme disease Borrelia
    • Bunikis J, Noppa L & Bergstrom S (1995) Molecular analysis of a 66-kDa protein associated with the outer membrane of Lyme disease Borrelia. FEMS Microbiol Lett 131: 139-145.
    • (1995) FEMS Microbiol Lett , vol.131 , pp. 139-145
    • Bunikis, J.1    Noppa, L.2    Bergstrom, S.3
  • 28
    • 0029830332 scopus 로고    scopus 로고
    • Surface exposure and species specificity of an immunoreactive domain of a 66-kilodalton outer membrane protein (P66) of the Borrelia species that cause Lyme disease
    • Bunikis J, Noppa L, Ostberg Y, Barbour AG & Bergstrom S (1996) Surface exposure and species specificity of an immunoreactive domain of a 66-kilodalton outer membrane protein (P66) of the Borrelia species that cause Lyme disease. Infect Immun 64: 5111-5116.
    • (1996) Infect Immun , vol.64 , pp. 5111-5116
    • Bunikis, J.1    Noppa, L.2    Ostberg, Y.3    Barbour, A.G.4    Bergstrom, S.5
  • 29
    • 40349106166 scopus 로고    scopus 로고
    • An RND-type efflux system in Borrelia burgdorferi is involved in virulence and resistance to antimicrobial compounds
    • Bunikis I, Denker K, Ostberg Y, Andersen C, Benz R & Bergstrom S (2008) An RND-type efflux system in Borrelia burgdorferi is involved in virulence and resistance to antimicrobial compounds. PLoS Pathog 4: e1000009.
    • (2008) PLoS Pathog , vol.4
    • Bunikis, I.1    Denker, K.2    Ostberg, Y.3    Andersen, C.4    Benz, R.5    Bergstrom, S.6
  • 31
    • 34548478386 scopus 로고    scopus 로고
    • Coordinated expression of Borrelia burgdorferi complement regulator-acquiring surface proteins during the Lyme disease spirochete's mammal-tick infection cycle
    • Bykowski T, Woodman ME, Cooley AE, Brissette CA, Brade V, Wallich R, Kraiczy P & Stevenson B (2007) Coordinated expression of Borrelia burgdorferi complement regulator-acquiring surface proteins during the Lyme disease spirochete's mammal-tick infection cycle. Infect Immun 75: 4227-4236.
    • (2007) Infect Immun , vol.75 , pp. 4227-4236
    • Bykowski, T.1    Woodman, M.E.2    Cooley, A.E.3    Brissette, C.A.4    Brade, V.5    Wallich, R.6    Kraiczy, P.7    Stevenson, B.8
  • 32
    • 7044233312 scopus 로고    scopus 로고
    • RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants
    • Caimano MJ, Eggers CH, Hazlett KR & Radolf JD (2004) RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants. Infect Immun 72: 6433-6445.
    • (2004) Infect Immun , vol.72 , pp. 6433-6445
    • Caimano, M.J.1    Eggers, C.H.2    Hazlett, K.R.3    Radolf, J.D.4
  • 33
    • 34547879640 scopus 로고    scopus 로고
    • Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle
    • Caimano MJ, Iyer R, Eggers CH, Gonzalez C, Morton EA, Gilbert MA, Schwartz I & Radolf JD (2007) Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle. Mol Microbiol 65: 1193-1217.
    • (2007) Mol Microbiol , vol.65 , pp. 1193-1217
    • Caimano, M.J.1    Iyer, R.2    Eggers, C.H.3    Gonzalez, C.4    Morton, E.A.5    Gilbert, M.A.6    Schwartz, I.7    Radolf, J.D.8
  • 34
    • 0032967572 scopus 로고    scopus 로고
    • Effects of environmental pH on membrane proteins in Borrelia burgdorferi
    • Carroll JA, Garon CF & Schwan TG (1999) Effects of environmental pH on membrane proteins in Borrelia burgdorferi. Infect Immun 67: 3181-3187.
    • (1999) Infect Immun , vol.67 , pp. 3181-3187
    • Carroll, J.A.1    Garon, C.F.2    Schwan, T.G.3
  • 35
    • 0034441169 scopus 로고    scopus 로고
    • Identification of 11 pH-regulated genes in Borrelia burgdorferi localizing to linear plasmids
    • Carroll JA, Cordova RM & Garon CF (2000) Identification of 11 pH-regulated genes in Borrelia burgdorferi localizing to linear plasmids. Infect Immun 68: 6677-6684.
    • (2000) Infect Immun , vol.68 , pp. 6677-6684
    • Carroll, J.A.1    Cordova, R.M.2    Garon, C.F.3
  • 36
    • 0033975239 scopus 로고    scopus 로고
    • A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi
    • Casjens S, Palmer N, van Vugt R et al. (2000) A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi. Mol Microbiol 35: 490-516.
    • (2000) Mol Microbiol , vol.35 , pp. 490-516
    • Casjens, S.1    Palmer, N.2    van Vugt, R.3
  • 37
    • 0030583043 scopus 로고    scopus 로고
    • Lyme disease - United States, 1995
    • Centers for Disease Control
    • Centers for Disease Control (1996) Lyme disease - United States, 1995. MMWR Morb Mortal Wkly Rep 45: 481-487.
    • (1996) MMWR Morb Mortal Wkly Rep , vol.45 , pp. 481-487
  • 38
    • 0028335843 scopus 로고
    • A 9.0 kilobase-pair circular plasmid of Borrelia burgdorferi encodes an exported protein: evidence for expression only during infection
    • Champion CI, Blanco DR, Skare JT, Haake DA, Giladi M, Foley D, Miller JN & Lovett MA (1994) A 9.0 kilobase-pair circular plasmid of Borrelia burgdorferi encodes an exported protein: evidence for expression only during infection. Infect Immun 62: 2653-2661.
    • (1994) Infect Immun , vol.62 , pp. 2653-2661
    • Champion, C.I.1    Blanco, D.R.2    Skare, J.T.3    Haake, D.A.4    Giladi, M.5    Foley, D.6    Miller, J.N.7    Lovett, M.A.8
  • 39
    • 7044253307 scopus 로고    scopus 로고
    • Extracellular secretion of the Borrelia burgdorferi Oms28 porin and Bgp, a glycosaminoglycan binding protein
    • Cluss RG, Silverman DA & Stafford TR (2004) Extracellular secretion of the Borrelia burgdorferi Oms28 porin and Bgp, a glycosaminoglycan binding protein. Infect Immun 72: 6279-6286.
    • (2004) Infect Immun , vol.72 , pp. 6279-6286
    • Cluss, R.G.1    Silverman, D.A.2    Stafford, T.R.3
  • 40
    • 0038809086 scopus 로고    scopus 로고
    • Targeted mutation of the outer membrane protein P66 disrupts attachment of the Lyme disease agent, Borrelia burgdorferi, to integrin alphavbeta3
    • Coburn J & Cugini C (2003) Targeted mutation of the outer membrane protein P66 disrupts attachment of the Lyme disease agent, Borrelia burgdorferi, to integrin alphavbeta3. P Natl Acad Sci USA 100: 7301-7306.
    • (2003) P Natl Acad Sci USA , vol.100 , pp. 7301-7306
    • Coburn, J.1    Cugini, C.2
  • 41
    • 0033233457 scopus 로고    scopus 로고
    • Characterization of a candidate Borrelia burgdorferi beta(3)-chain integrin ligand identified using a phage display library
    • Coburn J, Chege W, Magoun L, Bodary SC & Leong JM (1999) Characterization of a candidate Borrelia burgdorferi beta(3)-chain integrin ligand identified using a phage display library. Mol Microbiol 34: 926-940.
    • (1999) Mol Microbiol , vol.34 , pp. 926-940
    • Coburn, J.1    Chege, W.2    Magoun, L.3    Bodary, S.C.4    Leong, J.M.5
  • 42
    • 0023146944 scopus 로고
    • Isolation of antigenic components from the Lyme disease spirochete: their role in early diagnosis
    • Coleman JL & Benach JL (1987) Isolation of antigenic components from the Lyme disease spirochete: their role in early diagnosis. J Infect Dis 155: 756-765.
    • (1987) J Infect Dis , vol.155 , pp. 756-765
    • Coleman, J.L.1    Benach, J.L.2
  • 44
    • 20244363221 scopus 로고    scopus 로고
    • A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi
    • Cordes FS, Roversi P, Kraiczy P et al. (2005) A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi. Nat Struct Mol Biol 12: 276-277.
    • (2005) Nat Struct Mol Biol , vol.12 , pp. 276-277
    • Cordes, F.S.1    Roversi, P.2    Kraiczy, P.3
  • 46
    • 0037306601 scopus 로고    scopus 로고
    • Regulation of expression of the Borrelia burgdorferi beta(3)-chain integrin ligand, P66, in ticks and in culture
    • Cugini C, Medrano M, Schwan TG & Coburn J (2003) Regulation of expression of the Borrelia burgdorferi beta(3)-chain integrin ligand, P66, in ticks and in culture. Infect Immun 71: 1001-1007.
    • (2003) Infect Immun , vol.71 , pp. 1001-1007
    • Cugini, C.1    Medrano, M.2    Schwan, T.G.3    Coburn, J.4
  • 47
    • 0344628648 scopus 로고    scopus 로고
    • TPR proteins: the versatile helix
    • D'Andrea LD & Regan L (2003) TPR proteins: the versatile helix. Trends Biochem Sci 28: 655-662.
    • (2003) Trends Biochem Sci , vol.28 , pp. 655-662
    • D'Andrea, L.D.1    Regan, L.2
  • 48
    • 0030025949 scopus 로고    scopus 로고
    • Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine
    • de Silva AM, Telford SR, Brunet LR, Barthold SW & Fikrig E (1996) Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. J Exp Med 183: 271-275.
    • (1996) J Exp Med , vol.183 , pp. 271-275
    • de Silva, A.M.1    Telford, S.R.2    Brunet, L.R.3    Barthold, S.W.4    Fikrig, E.5
  • 49
    • 0035055365 scopus 로고    scopus 로고
    • Delineation of Borrelia burgdorferi p66 sequences required for integrin alpha(IIb)beta(3) recognition
    • Defoe G & Coburn J (2001) Delineation of Borrelia burgdorferi p66 sequences required for integrin alpha(IIb)beta(3) recognition. Infect Immun 69: 3455-3459.
    • (2001) Infect Immun , vol.69 , pp. 3455-3459
    • Defoe, G.1    Coburn, J.2
  • 50
    • 37649013925 scopus 로고    scopus 로고
    • An octavalent lyme disease vaccine induces antibodies that recognize all incorporated OspC type-specific sequences
    • Earnhart CG & Marconi RT (2007) An octavalent lyme disease vaccine induces antibodies that recognize all incorporated OspC type-specific sequences. Hum Vaccin 3: 281-289.
    • (2007) Hum Vaccin , vol.3 , pp. 281-289
    • Earnhart, C.G.1    Marconi, R.T.2
  • 51
    • 28044444737 scopus 로고    scopus 로고
    • Demonstration of OspC type diversity in invasive human lyme disease isolates and identification of previously uncharacterized epitopes that define the specificity of the OspC murine antibody response
    • Earnhart CG, Buckles EL, Dumler JS & Marconi RT (2005) Demonstration of OspC type diversity in invasive human lyme disease isolates and identification of previously uncharacterized epitopes that define the specificity of the OspC murine antibody response. Infect Immun 73: 7869-7877.
    • (2005) Infect Immun , vol.73 , pp. 7869-7877
    • Earnhart, C.G.1    Buckles, E.L.2    Dumler, J.S.3    Marconi, R.T.4
  • 52
    • 33845212331 scopus 로고    scopus 로고
    • Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains
    • Earnhart CG, Buckles EL & Marconi RT (2007) Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains. Vaccine 25: 466-480.
    • (2007) Vaccine , vol.25 , pp. 466-480
    • Earnhart, C.G.1    Buckles, E.L.2    Marconi, R.T.3
  • 53
    • 77951151121 scopus 로고    scopus 로고
    • Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment
    • Earnhart CG, Leblanc DV, Alix KE, Desrosiers DC, Radolf JD & Marconi RT (2010) Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment. Mol Microbiol 76: 393-408.
    • (2010) Mol Microbiol , vol.76 , pp. 393-408
    • Earnhart, C.G.1    Leblanc, D.V.2    Alix, K.E.3    Desrosiers, D.C.4    Radolf, J.D.5    Marconi, R.T.6
  • 54
    • 6044267456 scopus 로고    scopus 로고
    • Analysis of promoter elements involved in the transcriptional initiation of RpoS-dependent Borrelia burgdorferi genes
    • Eggers CH, Caimano MJ & Radolf JD (2004) Analysis of promoter elements involved in the transcriptional initiation of RpoS-dependent Borrelia burgdorferi genes. J Bacteriol 186: 7390-7402.
    • (2004) J Bacteriol , vol.186 , pp. 7390-7402
    • Eggers, C.H.1    Caimano, M.J.2    Radolf, J.D.3
  • 57
    • 0025723521 scopus 로고
    • Protection of mice from Lyme borreliosis by oral vaccination with Escherichia coli expressing OspA
    • Fikrig E, Barthold SW, Kantor FS & Flavell RA (1991) Protection of mice from Lyme borreliosis by oral vaccination with Escherichia coli expressing OspA. J Infect Dis 164: 1224-1227.
    • (1991) J Infect Dis , vol.164 , pp. 1224-1227
    • Fikrig, E.1    Barthold, S.W.2    Kantor, F.S.3    Flavell, R.A.4
  • 59
    • 0034657179 scopus 로고    scopus 로고
    • Arthropod- and host-specific Borrelia burgdorferi bbk32 expression and the inhibition of spirochete transmission
    • Fikrig E, Feng W, Barthold SW, Telford SR III & Flavell RA (2000) Arthropod- and host-specific Borrelia burgdorferi bbk32 expression and the inhibition of spirochete transmission. J Immunol 164: 5344-5351.
    • (2000) J Immunol , vol.164 , pp. 5344-5351
    • Fikrig, E.1    Feng, W.2    Barthold, S.W.3    Telford, S.I.4    Flavell, R.A.5
  • 60
    • 1342302473 scopus 로고    scopus 로고
    • OspB antibody prevents Borrelia burgdorferi colonization of Ixodes scapularis
    • Fikrig E, Pal U, Chen M, Anderson JF & Flavell RA (2004) OspB antibody prevents Borrelia burgdorferi colonization of Ixodes scapularis. Infect Immun 72: 1755-1759.
    • (2004) Infect Immun , vol.72 , pp. 1755-1759
    • Fikrig, E.1    Pal, U.2    Chen, M.3    Anderson, J.F.4    Flavell, R.A.5
  • 61
    • 0038132181 scopus 로고    scopus 로고
    • Decorin-binding proteins A and B confer distinct mammalian cell type-specific attachment by Borrelia burgdorferi, the Lyme disease spirochete
    • Fischer JR, Parveen N, Magoun L & Leong JM (2003) Decorin-binding proteins A and B confer distinct mammalian cell type-specific attachment by Borrelia burgdorferi, the Lyme disease spirochete. P Natl Acad Sci USA 100: 7307-7312.
    • (2003) P Natl Acad Sci USA , vol.100 , pp. 7307-7312
    • Fischer, J.R.1    Parveen, N.2    Magoun, L.3    Leong, J.M.4
  • 62
    • 29644446929 scopus 로고    scopus 로고
    • Fibronectin binding protein BBK32 of the Lyme disease spirochete promotes bacterial attachment to glycosaminoglycans
    • Fischer JR, LeBlanc KT & Leong JM (2006) Fibronectin binding protein BBK32 of the Lyme disease spirochete promotes bacterial attachment to glycosaminoglycans. Infect Immun 74: 435-441.
    • (2006) Infect Immun , vol.74 , pp. 435-441
    • Fischer, J.R.1    LeBlanc, K.T.2    Leong, J.M.3
  • 63
    • 0031470826 scopus 로고    scopus 로고
    • Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi
    • Fraser CM, Casjens S, Huang WM et al. (1997) Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390: 580-586.
    • (1997) Nature , vol.390 , pp. 580-586
    • Fraser, C.M.1    Casjens, S.2    Huang, W.M.3
  • 64
    • 0026529325 scopus 로고
    • Molecular analysis and expression of a Borrelia burgdorferi gene encoding a 22kDa protein (pC) in Escherichia coli
    • Fuchs R, Jauris S, Lottspeich F, Preac-Mursic V, Wilske B & Soutschek E (1992) Molecular analysis and expression of a Borrelia burgdorferi gene encoding a 22kDa protein (pC) in Escherichia coli. Mol Microbiol 6: 503-509.
    • (1992) Mol Microbiol , vol.6 , pp. 503-509
    • Fuchs, R.1    Jauris, S.2    Lottspeich, F.3    Preac-Mursic, V.4    Wilske, B.5    Soutschek, E.6
  • 65
    • 0345861754 scopus 로고    scopus 로고
    • The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria
    • Gentle I, Gabriel K, Beech P, Waller R & Lithgow T (2004) The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria. J Cell Biol 164: 19-24.
    • (2004) J Cell Biol , vol.164 , pp. 19-24
    • Gentle, I.1    Gabriel, K.2    Beech, P.3    Waller, R.4    Lithgow, T.5
  • 66
    • 28244436432 scopus 로고    scopus 로고
    • Molecular architecture and function of the Omp85 family of proteins
    • Gentle I, Burri L & Lithgow T (2005) Molecular architecture and function of the Omp85 family of proteins. Mol Microbiol 58: 1216-1225.
    • (2005) Mol Microbiol , vol.58 , pp. 1216-1225
    • Gentle, I.1    Burri, L.2    Lithgow, T.3
  • 67
    • 0029948977 scopus 로고    scopus 로고
    • Outer surface protein C (OspC), but not P39, is a protective immunogen against tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC
    • Gilmore RD Jr, Kappel KJ, Dolan MC, Burkot TR & Johnson BJB (1996) Outer surface protein C (OspC), but not P39, is a protective immunogen against tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC. Infect Immun 64: 2234-2239.
    • (1996) Infect Immun , vol.64 , pp. 2234-2239
    • Gilmore, R.J.1    Kappel, K.J.2    Dolan, M.C.3    Burkot, T.R.4    Johnson, B.J.B.5
  • 68
    • 1642528894 scopus 로고    scopus 로고
    • Molecular characterization of a 35-kilodalton protein of Borrelia burgdorferi, an antigen of diagnostic importance in early Lyme disease
    • Gilmore RD Jr, Kappel KJ & Johnson BJ (1997) Molecular characterization of a 35-kilodalton protein of Borrelia burgdorferi, an antigen of diagnostic importance in early Lyme disease. J Clin Microbiol 35: 86-91.
    • (1997) J Clin Microbiol , vol.35 , pp. 86-91
    • Gilmore, R.J.1    Kappel, K.J.2    Johnson, B.J.3
  • 69
    • 0034802110 scopus 로고    scopus 로고
    • Analysis of Borrelia burgdorferi gene expression during life cycle phases of the tick vector Ixodes scapularis
    • Gilmore RD, Mbow ML & Stevenson B (2001) Analysis of Borrelia burgdorferi gene expression during life cycle phases of the tick vector Ixodes scapularis. Microbes Infect 3: 799-808.
    • (2001) Microbes Infect , vol.3 , pp. 799-808
    • Gilmore, R.D.1    Mbow, M.L.2    Stevenson, B.3
  • 70
    • 34249868443 scopus 로고    scopus 로고
    • Temporal expression analysis of the Borrelia burgdorferi paralogous gene family 54 genes BBA64, BBA65, and BBA66 during persistent infection in mice
    • Gilmore RD Jr, Howison RR, Schmit VL, Nowalk AJ, Clifton DR, Nolder C, Hughes JL & Carroll JA (2007) Temporal expression analysis of the Borrelia burgdorferi paralogous gene family 54 genes BBA64, BBA65, and BBA66 during persistent infection in mice. Infect Immun 75: 2753-2764.
    • (2007) Infect Immun , vol.75 , pp. 2753-2764
    • Gilmore, R.J.1    Howison, R.R.2    Schmit, V.L.3    Nowalk, A.J.4    Clifton, D.R.5    Nolder, C.6    Hughes, J.L.7    Carroll, J.A.8
  • 71
    • 77952166427 scopus 로고    scopus 로고
    • The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission
    • Gilmore RD JrJr, Howison RR, Dietrich G, Patton TG, Clifton DR & Carroll JA (2010) The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission. P Natl Acad Sci USA 107: 7515-7520.
    • (2010) P Natl Acad Sci USA , vol.107 , pp. 7515-7520
    • Gilmore, R.J.1    Howison, R.R.2    Dietrich, G.3    Patton, T.G.4    Clifton, D.R.5    Carroll, J.A.6
  • 73
    • 0029117215 scopus 로고
    • Adherence of Borrelia burgdorferi to the proteoglycan decorin
    • Guo B, Norris SJ, Rosenberg LC & Hook M (1995) Adherence of Borrelia burgdorferi to the proteoglycan decorin. Infect Immun 63: 3467-3472.
    • (1995) Infect Immun , vol.63 , pp. 3467-3472
    • Guo, B.1    Norris, S.J.2    Rosenberg, L.C.3    Hook, M.4
  • 75
    • 0031812736 scopus 로고    scopus 로고
    • Decorin-binding protein of Borrelia burgdorferi is encoded within a two-gene operon and is protective in the murine model of Lyme borreliosis
    • Hagman KE, Lahdenne P, Popova TG, Porcella SF, Akins DR, Radolf JD & Norgard MV (1998) Decorin-binding protein of Borrelia burgdorferi is encoded within a two-gene operon and is protective in the murine model of Lyme borreliosis. Infect Immun 66: 2674-2683.
    • (1998) Infect Immun , vol.66 , pp. 2674-2683
    • Hagman, K.E.1    Lahdenne, P.2    Popova, T.G.3    Porcella, S.F.4    Akins, D.R.5    Radolf, J.D.6    Norgard, M.V.7
  • 76
    • 0031925530 scopus 로고    scopus 로고
    • Active and passive immunity against Borrelia burgdorferi decorin binding protein A (DbpA) protects against infection
    • Hanson MS, Cassatt DR, Guo BP, Patel NK, McCarthy MP, Dorward DW & Hook M (1998) Active and passive immunity against Borrelia burgdorferi decorin binding protein A (DbpA) protects against infection. Infect Immun 66: 2143-2153.
    • (1998) Infect Immun , vol.66 , pp. 2143-2153
    • Hanson, M.S.1    Cassatt, D.R.2    Guo, B.P.3    Patel, N.K.4    McCarthy, M.P.5    Dorward, D.W.6    Hook, M.7
  • 77
    • 33747057122 scopus 로고    scopus 로고
    • Functional characterization of BbCRASP-2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL-1
    • Hartmann K, Corvey C, Skerka C et al. (2006) Functional characterization of BbCRASP-2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL-1. Mol Microbiol 61: 1220-1236.
    • (2006) Mol Microbiol , vol.61 , pp. 1220-1236
    • Hartmann, K.1    Corvey, C.2    Skerka, C.3
  • 78
    • 36549049885 scopus 로고    scopus 로고
    • Regulation of expression of the fibronectin-binding protein BBK32 in Borrelia burgdorferi
    • He M, Boardman BK, Yan D & Yang XF (2007) Regulation of expression of the fibronectin-binding protein BBK32 in Borrelia burgdorferi. J Bacteriol 189: 8377-8380.
    • (2007) J Bacteriol , vol.189 , pp. 8377-8380
    • He, M.1    Boardman, B.K.2    Yan, D.3    Yang, X.F.4
  • 79
    • 0035019732 scopus 로고    scopus 로고
    • Regulation of OspE-related, OspF-related, and Elp lipoproteins of Borrelia burgdorferi strain 297 by mammalian host-specific signals
    • Hefty PS, Jolliff SE, Caimano MJ, Wikel SK, Radolf JD & Akins DR (2001) Regulation of OspE-related, OspF-related, and Elp lipoproteins of Borrelia burgdorferi strain 297 by mammalian host-specific signals. Infect Immun 69: 3618-3627.
    • (2001) Infect Immun , vol.69 , pp. 3618-3627
    • Hefty, P.S.1    Jolliff, S.E.2    Caimano, M.J.3    Wikel, S.K.4    Radolf, J.D.5    Akins, D.R.6
  • 80
    • 0036840122 scopus 로고    scopus 로고
    • OspE-related, OspF-related, and Elp lipoproteins are immunogenic in baboons experimentally infected with Borrelia burgdorferi and in human Lyme disease patients
    • Hefty PS, Brooks CS, Jett AM, White GL, Wikel SK, Kennedy RC & Akins DR (2002a) OspE-related, OspF-related, and Elp lipoproteins are immunogenic in baboons experimentally infected with Borrelia burgdorferi and in human Lyme disease patients. J Clin Microbiol 40: 4256-4265.
    • (2002) J Clin Microbiol , vol.40 , pp. 4256-4265
    • Hefty, P.S.1    Brooks, C.S.2    Jett, A.M.3    White, G.L.4    Wikel, S.K.5    Kennedy, R.C.6    Akins, D.R.7
  • 81
    • 0036084295 scopus 로고    scopus 로고
    • Changes in temporal and spatial patterns of outer surface lipoprotein expression generate population heterogeneity and antigenic diversity in the Lyme disease spirochete, Borrelia burgdorferi
    • Hefty PS, Jolliff SE, Caimano MJ, Wikel SK & Akins DR (2002b) Changes in temporal and spatial patterns of outer surface lipoprotein expression generate population heterogeneity and antigenic diversity in the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun 70: 3468-3478.
    • (2002) Infect Immun , vol.70 , pp. 3468-3478
    • Hefty, P.S.1    Jolliff, S.E.2    Caimano, M.J.3    Wikel, S.K.4    Akins, D.R.5
  • 83
    • 0021956998 scopus 로고
    • A single recombinant plasmid expressing two major outer surface proteins of the Lyme disease spirochete
    • Howe TR, Mayer LW & Barbour AG (1985) A single recombinant plasmid expressing two major outer surface proteins of the Lyme disease spirochete. Science 227: 645-646.
    • (1985) Science , vol.227 , pp. 645-646
    • Howe, T.R.1    Mayer, L.W.2    Barbour, A.G.3
  • 84
    • 0022529650 scopus 로고
    • Organization of genes encoding two outer membrane proteins of the Lyme disease agent Borrelia burgdorferi within a single transcriptional unit
    • Howe TR, LaQuier FW & Barbour AG (1986) Organization of genes encoding two outer membrane proteins of the Lyme disease agent Borrelia burgdorferi within a single transcriptional unit. Infect Immun 54: 207-212.
    • (1986) Infect Immun , vol.54 , pp. 207-212
    • Howe, T.R.1    LaQuier, F.W.2    Barbour, A.G.3
  • 85
    • 0035940482 scopus 로고    scopus 로고
    • Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway
    • Hübner A, Yang X, Nolen DM, Popova TG, Cabello FC & Norgard MV (2001) Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway. P Natl Acad Sci USA 98: 12724-12729.
    • (2001) P Natl Acad Sci USA , vol.98 , pp. 12724-12729
    • Hübner, A.1    Yang, X.2    Nolen, D.M.3    Popova, T.G.4    Cabello, F.C.5    Norgard, M.V.6
  • 86
    • 46249094238 scopus 로고    scopus 로고
    • Borrelia burgdorferi surface-localized proteins expressed during persistent murine infection are conserved among diverse Borrelia spp
    • Hughes JL, Nolder CL, Nowalk AJ, Clifton DR, Howison RR, Schmit VL, Gilmore RD Jr & Carroll JA (2008) Borrelia burgdorferi surface-localized proteins expressed during persistent murine infection are conserved among diverse Borrelia spp. Infect Immun 76: 2498-2511.
    • (2008) Infect Immun , vol.76 , pp. 2498-2511
    • Hughes, J.L.1    Nolder, C.L.2    Nowalk, A.J.3    Clifton, D.R.4    Howison, R.R.5    Schmit, V.L.6    Gilmore, R.J.7    Carroll, J.A.8
  • 88
    • 67651155750 scopus 로고    scopus 로고
    • Comprehensive seroprofiling of sixteen B. burgdorferi OspC: implications for Lyme disease diagnostics design
    • Ivanova L, Christova I, Neves V, Aroso M, Meirelles L, Brisson D & Gomes-Solecki M (2009) Comprehensive seroprofiling of sixteen B. burgdorferi OspC: implications for Lyme disease diagnostics design. Clin Immunol 132: 393-400.
    • (2009) Clin Immunol , vol.132 , pp. 393-400
    • Ivanova, L.1    Christova, I.2    Neves, V.3    Aroso, M.4    Meirelles, L.5    Brisson, D.6    Gomes-Solecki, M.7
  • 90
    • 67650070597 scopus 로고    scopus 로고
    • CspA-mediated binding of human factor H inhibits complement deposition and confers serum resistance in Borrelia burgdorferi
    • Kenedy MR, Vuppala SR, Siegel C, Kraiczy P & Akins DR (2009) CspA-mediated binding of human factor H inhibits complement deposition and confers serum resistance in Borrelia burgdorferi. Infect Immun 77: 2773-2782.
    • (2009) Infect Immun , vol.77 , pp. 2773-2782
    • Kenedy, M.R.1    Vuppala, S.R.2    Siegel, C.3    Kraiczy, P.4    Akins, D.R.5
  • 91
    • 60749102331 scopus 로고    scopus 로고
    • Membrane protein architects: the role of the BAM complex in outer membrane protein assembly
    • Knowles TJ, Scott-Tucker A, Overduin M & Henderson IR (2009) Membrane protein architects: the role of the BAM complex in outer membrane protein assembly. Nat Rev Microbiol 7: 206-214.
    • (2009) Nat Rev Microbiol , vol.7 , pp. 206-214
    • Knowles, T.J.1    Scott-Tucker, A.2    Overduin, M.3    Henderson, I.R.4
  • 92
    • 0033942874 scopus 로고    scopus 로고
    • Structure and function of bacterial outer membrane proteins: barrels in a nutshell
    • Koebnik R, Locher KP & Van Gelder P (2000) Structure and function of bacterial outer membrane proteins: barrels in a nutshell. Mol Microbiol 37: 239-253.
    • (2000) Mol Microbiol , vol.37 , pp. 239-253
    • Koebnik, R.1    Locher, K.P.2    Van Gelder, P.3
  • 93
    • 0035185119 scopus 로고    scopus 로고
    • Further characterization of complement regulator-acquiring surface proteins of Borrelia burgdorferi
    • Kraiczy P, Skerka C, Brade V & Zipfel PF (2001) Further characterization of complement regulator-acquiring surface proteins of Borrelia burgdorferi. Infect Immun 69: 7800-7809.
    • (2001) Infect Immun , vol.69 , pp. 7800-7809
    • Kraiczy, P.1    Skerka, C.2    Brade, V.3    Zipfel, P.F.4
  • 94
    • 1642535449 scopus 로고    scopus 로고
    • Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins
    • Kraiczy P, Hellwage J, Skerka C, Becker H, Kirschfink M, Simon MM, Brade V, Zipfel PF & Wallich R (2004) Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins. J Biol Chem 279: 2421-2429.
    • (2004) J Biol Chem , vol.279 , pp. 2421-2429
    • Kraiczy, P.1    Hellwage, J.2    Skerka, C.3    Becker, H.4    Kirschfink, M.5    Simon, M.M.6    Brade, V.7    Zipfel, P.F.8    Wallich, R.9
  • 95
    • 0035168567 scopus 로고    scopus 로고
    • Decreased infectivity in Borrelia burgdorferi strain B31 is associated with loss of linear plasmid 25 or 28-1
    • Labandeira-Rey M & Skare JT (2001) Decreased infectivity in Borrelia burgdorferi strain B31 is associated with loss of linear plasmid 25 or 28-1. Infect Immun 69: 446-455.
    • (2001) Infect Immun , vol.69 , pp. 446-455
    • Labandeira-Rey, M.1    Skare, J.T.2
  • 96
    • 0042766235 scopus 로고    scopus 로고
    • The absence of linear plasmid 25 or 28-1 of Borrelia burgdorferi dramatically alters the kinetics of experimental infection via distinct mechanisms
    • Labandeira-Rey M, Seshu J & Skare JT (2003) The absence of linear plasmid 25 or 28-1 of Borrelia burgdorferi dramatically alters the kinetics of experimental infection via distinct mechanisms. Infect Immun 71: 4608-4613.
    • (2003) Infect Immun , vol.71 , pp. 4608-4613
    • Labandeira-Rey, M.1    Seshu, J.2    Skare, J.T.3
  • 98
    • 0026039295 scopus 로고
    • Lyme borreliosis: relation of its causative agent to its vectors and hosts in North America and Europe
    • Lane RS, Piesman J & Burgdorfer W (1991) Lyme borreliosis: relation of its causative agent to its vectors and hosts in North America and Europe. Annu Rev Entomol 36: 587-609.
    • (1991) Annu Rev Entomol , vol.36 , pp. 587-609
    • Lane, R.S.1    Piesman, J.2    Burgdorfer, W.3
  • 99
    • 75149192610 scopus 로고    scopus 로고
    • Borrelia burgdorferi locus BB0795 encodes a BamA orthologue required for growth and efficient localization of outer membrane proteins
    • Lenhart TR & Akins DR (2010) Borrelia burgdorferi locus BB0795 encodes a BamA orthologue required for growth and efficient localization of outer membrane proteins. Mol Microbiol 75: 692-795.
    • (2010) Mol Microbiol , vol.75 , pp. 692-795
    • Lenhart, T.R.1    Akins, D.R.2
  • 100
    • 0030932886 scopus 로고    scopus 로고
    • Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab
    • Li H, Dunn JJ, Luft BJ & Lawson CL (1997) Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab. P Natl Acad Sci USA 94: 3584-3589.
    • (1997) P Natl Acad Sci USA , vol.94 , pp. 3584-3589
    • Li, H.1    Dunn, J.J.2    Luft, B.J.3    Lawson, C.L.4
  • 101
    • 33646950247 scopus 로고    scopus 로고
    • Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity
    • Li X, Liu X, Beck DS, Kantor FS & Fikrig E (2006) Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity. Infect Immun 74: 3305-3313.
    • (2006) Infect Immun , vol.74 , pp. 3305-3313
    • Li, X.1    Liu, X.2    Beck, D.S.3    Kantor, F.S.4    Fikrig, E.5
  • 103
    • 0037128163 scopus 로고    scopus 로고
    • An immune evasion mechanism for spirochetal persistence in Lyme borreliosis
    • Liang FT, Jacobs MB, Bowers LC & Philipp MT (2002a) An immune evasion mechanism for spirochetal persistence in Lyme borreliosis. J Exp Med 195: 415-422.
    • (2002) J Exp Med , vol.195 , pp. 415-422
    • Liang, F.T.1    Jacobs, M.B.2    Bowers, L.C.3    Philipp, M.T.4
  • 104
    • 0037099692 scopus 로고    scopus 로고
    • Molecular adaptation of Borrelia burgdorferi in the murine host
    • Liang FT, Nelson FK & Fikrig E (2002b) Molecular adaptation of Borrelia burgdorferi in the murine host. J Exp Med 196: 275-280.
    • (2002) J Exp Med , vol.196 , pp. 275-280
    • Liang, F.T.1    Nelson, F.K.2    Fikrig, E.3
  • 105
    • 4344587743 scopus 로고    scopus 로고
    • Protective niche for Borrelia burgdorferi to evade humoral immunity
    • Liang FT, Brown EL, Wang T, Iozzo RV & Fikrig E (2004) Protective niche for Borrelia burgdorferi to evade humoral immunity. Am J Pathol 165: 977-985.
    • (2004) Am J Pathol , vol.165 , pp. 977-985
    • Liang, F.T.1    Brown, E.L.2    Wang, T.3    Iozzo, R.V.4    Fikrig, E.5
  • 106
    • 0028305736 scopus 로고
    • Seroprotective groups of Lyme borreliosis spirochetes from North America and Europe
    • Lovrich SD, Callister SM, Lim LC, DuChateau BK & Schell RF (1994) Seroprotective groups of Lyme borreliosis spirochetes from North America and Europe. J Infect Dis 170: 115-121.
    • (1994) J Infect Dis , vol.170 , pp. 115-121
    • Lovrich, S.D.1    Callister, S.M.2    Lim, L.C.3    DuChateau, B.K.4    Schell, R.F.5
  • 107
    • 0020636951 scopus 로고
    • Molecular architecture and functioning of the outer membrane of Escherichia coli and other Gram-negative bacteria
    • Lugtenberg B & van Alphen L (1983) Molecular architecture and functioning of the outer membrane of Escherichia coli and other Gram-negative bacteria. Biochim Biophys Acta 737: 51-115.
    • (1983) Biochim Biophys Acta , vol.737 , pp. 51-115
    • Lugtenberg, B.1    van Alphen, L.2
  • 108
    • 34248398787 scopus 로고    scopus 로고
    • Temperature-induced regulation of RpoS by a small RNA in Borrelia burgdorferi
    • Lybecker MC & Samuels DS (2007) Temperature-induced regulation of RpoS by a small RNA in Borrelia burgdorferi. Mol Microbiol 64: 1075-1089.
    • (2007) Mol Microbiol , vol.64 , pp. 1075-1089
    • Lybecker, M.C.1    Samuels, D.S.2
  • 109
    • 0027537039 scopus 로고
    • Transcriptional analyses and mapping of the ospC gene in Lyme disease spirochetes
    • Marconi RT, Samuels DS & Garon CF (1993) Transcriptional analyses and mapping of the ospC gene in Lyme disease spirochetes. J Bacteriol 175: 926-932.
    • (1993) J Bacteriol , vol.175 , pp. 926-932
    • Marconi, R.T.1    Samuels, D.S.2    Garon, C.F.3
  • 110
    • 0027968978 scopus 로고
    • Analysis of the distribution and molecular heterogeneity of the ospD gene among the Lyme disease spirochetes: evidence for lateral gene exchange
    • Marconi RT, Samuels DS, Landry RK & Garon CF (1994) Analysis of the distribution and molecular heterogeneity of the ospD gene among the Lyme disease spirochetes: evidence for lateral gene exchange. J Bacteriol 176: 4572-4582.
    • (1994) J Bacteriol , vol.176 , pp. 4572-4582
    • Marconi, R.T.1    Samuels, D.S.2    Landry, R.K.3    Garon, C.F.4
  • 111
    • 55849145829 scopus 로고    scopus 로고
    • Deletion of BBA64, BBA65, and BBA66 loci does not alter the infectivity of Borrelia burgdorferi in the murine model of Lyme disease
    • Maruskova M & Seshu J (2008) Deletion of BBA64, BBA65, and BBA66 loci does not alter the infectivity of Borrelia burgdorferi in the murine model of Lyme disease. Infect Immun 76: 5274-5284.
    • (2008) Infect Immun , vol.76 , pp. 5274-5284
    • Maruskova, M.1    Seshu, J.2
  • 112
    • 0035010058 scopus 로고    scopus 로고
    • Analysis of mechanisms associated with loss of infectivity of clonal populations of Borrelia burgdorferi B31MI
    • McDowell JV, Sung SY, Labandeira-Rey M, Skare JT & Marconi RT (2001) Analysis of mechanisms associated with loss of infectivity of clonal populations of Borrelia burgdorferi B31MI. Infect Immun 69: 3670-3677.
    • (2001) Infect Immun , vol.69 , pp. 3670-3677
    • McDowell, J.V.1    Sung, S.Y.2    Labandeira-Rey, M.3    Skare, J.T.4    Marconi, R.T.5
  • 113
    • 10344228235 scopus 로고    scopus 로고
    • Demonstration of the involvement of outer surface protein E coiled coil structural domains and higher order structural elements in the binding of infection-induced antibody and the complement-regulatory protein, factor H
    • McDowell JV, Wolfgang J, Senty L, Sundy CM, Noto MJ & Marconi RT (2004) Demonstration of the involvement of outer surface protein E coiled coil structural domains and higher order structural elements in the binding of infection-induced antibody and the complement-regulatory protein, factor H. J Immunol 173: 7471-7480.
    • (2004) J Immunol , vol.173 , pp. 7471-7480
    • McDowell, J.V.1    Wolfgang, J.2    Senty, L.3    Sundy, C.M.4    Noto, M.J.5    Marconi, R.T.6
  • 114
    • 14544300067 scopus 로고    scopus 로고
    • Putative coiled-coil structural elements of the BbA68 protein of Lyme disease spirochetes are required for formation of its factor H binding site
    • McDowell JV, Harlin ME, Rogers EA & Marconi RT (2005) Putative coiled-coil structural elements of the BbA68 protein of Lyme disease spirochetes are required for formation of its factor H binding site. J Bacteriol 187: 1317-1323.
    • (2005) J Bacteriol , vol.187 , pp. 1317-1323
    • McDowell, J.V.1    Harlin, M.E.2    Rogers, E.A.3    Marconi, R.T.4
  • 115
    • 33646370724 scopus 로고    scopus 로고
    • Evidence that the BBA68 protein (BbCRASP-1) of the Lyme disease spirochetes does not contribute to factor H-mediated immune evasion in humans and other animals
    • McDowell JV, Hovis KM, Zhang H, Tran E, Lankford J & Marconi RT (2006) Evidence that the BBA68 protein (BbCRASP-1) of the Lyme disease spirochetes does not contribute to factor H-mediated immune evasion in humans and other animals. Infect Immun 74: 3030-3034.
    • (2006) Infect Immun , vol.74 , pp. 3030-3034
    • McDowell, J.V.1    Hovis, K.M.2    Zhang, H.3    Tran, E.4    Lankford, J.5    Marconi, R.T.6
  • 116
    • 0037512362 scopus 로고    scopus 로고
    • Analysis of the OspE determinants involved in binding of factor H and OspE-targeting antibodies elicited during Borrelia burgdorferi infection in mice
    • Metts MS, McDowell JV, Theisen M, Hansen PR & Marconi RT (2003) Analysis of the OspE determinants involved in binding of factor H and OspE-targeting antibodies elicited during Borrelia burgdorferi infection in mice. Infect Immun 71: 3587-3596.
    • (2003) Infect Immun , vol.71 , pp. 3587-3596
    • Metts, M.S.1    McDowell, J.V.2    Theisen, M.3    Hansen, P.R.4    Marconi, R.T.5
  • 117
    • 0033996151 scopus 로고    scopus 로고
    • Borrelia burgdorferi B31 Erp proteins that are dominant immunoblot antigens of animals infected with isolate B31 are recognized by only a subset of human lyme disease patient sera
    • Miller JC, El Hage N, Babb K & Stevenson B (2000) Borrelia burgdorferi B31 Erp proteins that are dominant immunoblot antigens of animals infected with isolate B31 are recognized by only a subset of human lyme disease patient sera. J Clin Microbiol 38: 1569-1574.
    • (2000) J Clin Microbiol , vol.38 , pp. 1569-1574
    • Miller, J.C.1    El Hage, N.2    Babb, K.3    Stevenson, B.4
  • 118
    • 0345714742 scopus 로고    scopus 로고
    • Temporal analysis of Borrelia burgdorferi Erp protein expression throughout the mammal-tick infectious cycle
    • Miller JC, von Lackum K, Babb K, McAlister JD & Stevenson B (2003) Temporal analysis of Borrelia burgdorferi Erp protein expression throughout the mammal-tick infectious cycle. Infect Immun 71: 6943-6952.
    • (2003) Infect Immun , vol.71 , pp. 6943-6952
    • Miller, J.C.1    von Lackum, K.2    Babb, K.3    McAlister, J.D.4    Stevenson, B.5
  • 120
    • 33947374770 scopus 로고    scopus 로고
    • Borrelia burgdorferi BBA74, a periplasmic protein associated with the outer membrane, lacks porin-like properties
    • Mulay V, Caimano M, Liveris D, Desrosiers DC, Radolf JD & Schwartz I (2007) Borrelia burgdorferi BBA74, a periplasmic protein associated with the outer membrane, lacks porin-like properties. J Bacteriol 189: 2063-2068.
    • (2007) J Bacteriol , vol.189 , pp. 2063-2068
    • Mulay, V.1    Caimano, M.2    Liveris, D.3    Desrosiers, D.C.4    Radolf, J.D.5    Schwartz, I.6
  • 122
    • 0347479229 scopus 로고    scopus 로고
    • Molecular basis of bacterial outer membrane permeability revisited
    • Nikaido H (2003) Molecular basis of bacterial outer membrane permeability revisited. Microbiol Mol Biol Rev 67: 593-656.
    • (2003) Microbiol Mol Biol Rev , vol.67 , pp. 593-656
    • Nikaido, H.1
  • 123
    • 64649096369 scopus 로고    scopus 로고
    • Mechanisms of RND multidrug efflux pumps
    • Nikaido H & Takatsuka Y (2009) Mechanisms of RND multidrug efflux pumps. Biochim Biophys Acta 1794: 769-781.
    • (2009) Biochim Biophys Acta , vol.1794 , pp. 769-781
    • Nikaido, H.1    Takatsuka, Y.2
  • 125
    • 0035063204 scopus 로고    scopus 로고
    • P13, an integral membrane protein of Borrelia burgdorferi, is C-terminally processed and contains surface-exposed domains
    • Noppa L, Ostberg Y, Lavrinovicha M & Bergstrom S (2001) P13, an integral membrane protein of Borrelia burgdorferi, is C-terminally processed and contains surface-exposed domains. Infect Immun 69: 3323-3334.
    • (2001) Infect Immun , vol.69 , pp. 3323-3334
    • Noppa, L.1    Ostberg, Y.2    Lavrinovicha, M.3    Bergstrom, S.4
  • 126
    • 55449126064 scopus 로고    scopus 로고
    • Molecular mechanisms involved in vascular interactions of the Lyme disease pathogen in a living host
    • Norman MU, Moriarty TJ, Dresser AR, Millen B, Kubes P & Chaconas G (2008) Molecular mechanisms involved in vascular interactions of the Lyme disease pathogen in a living host. PLoS Pathog 4: e1000169.
    • (2008) PLoS Pathog , vol.4
    • Norman, M.U.1    Moriarty, T.J.2    Dresser, A.R.3    Millen, B.4    Kubes, P.5    Chaconas, G.6
  • 127
    • 0026488056 scopus 로고
    • Low-passage-associated proteins of Borrelia burgdorferi B31: characterization and molecular cloning of OspD, a surface-exposed, plasmid-encoded lipoprotein
    • Norris SJ, Carter CJ, Howell JK & Barbour AG (1992) Low-passage-associated proteins of Borrelia burgdorferi B31: characterization and molecular cloning of OspD, a surface-exposed, plasmid-encoded lipoprotein. Infect Immun 60: 4662-4672.
    • (1992) Infect Immun , vol.60 , pp. 4662-4672
    • Norris, S.J.1    Carter, C.J.2    Howell, J.K.3    Barbour, A.G.4
  • 128
    • 0035895241 scopus 로고    scopus 로고
    • Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks
    • Ohnishi J, Piesman J & de Silva A (2001) Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks. P Natl Acad Sci USA 98: 670-675.
    • (2001) P Natl Acad Sci USA , vol.98 , pp. 670-675
    • Ohnishi, J.1    Piesman, J.2    de Silva, A.3
  • 129
    • 0345535124 scopus 로고    scopus 로고
    • Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays
    • Ojaimi C, Brooks C, Casjens S et al. (2003) Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays. Infect Immun 71: 1689-1705.
    • (2003) Infect Immun , vol.71 , pp. 1689-1705
    • Ojaimi, C.1    Brooks, C.2    Casjens, S.3
  • 130
    • 0036947229 scopus 로고    scopus 로고
    • Elimination of channel-forming activity by insertional inactivation of the p13 gene in Borrelia burgdorferi
    • Ostberg Y, Pinne M, Benz R, Rosa P & Bergstrom S (2002) Elimination of channel-forming activity by insertional inactivation of the p13 gene in Borrelia burgdorferi. J Bacteriol 184: 6811-6819.
    • (2002) J Bacteriol , vol.184 , pp. 6811-6819
    • Ostberg, Y.1    Pinne, M.2    Benz, R.3    Rosa, P.4    Bergstrom, S.5
  • 131
    • 1642336137 scopus 로고    scopus 로고
    • Pleiotropic effects of inactivating a carboxyl-terminal protease, CtpA, in Borrelia burgdorferi
    • Ostberg Y, Carroll JA, Pinne M, Krum JG, Rosa P & Bergstrom S (2004) Pleiotropic effects of inactivating a carboxyl-terminal protease, CtpA, in Borrelia burgdorferi. J Bacteriol 186: 2074-2084.
    • (2004) J Bacteriol , vol.186 , pp. 2074-2084
    • Ostberg, Y.1    Carroll, J.A.2    Pinne, M.3    Krum, J.G.4    Rosa, P.5    Bergstrom, S.6
  • 132
    • 53449090658 scopus 로고    scopus 로고
    • Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi
    • Ouyang Z, Blevins JS & Norgard MV (2008) Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi. Microbiology 154: 2641-2658.
    • (2008) Microbiology , vol.154 , pp. 2641-2658
    • Ouyang, Z.1    Blevins, J.S.2    Norgard, M.V.3
  • 134
    • 8344262276 scopus 로고    scopus 로고
    • TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi
    • Pal U, Li X, Wang T et al. (2004a) TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi. Cell 119: 457-468.
    • (2004) Cell , vol.119 , pp. 457-468
    • Pal, U.1    Li, X.2    Wang, T.3
  • 136
    • 0034096379 scopus 로고    scopus 로고
    • Identification of a candidate glycosaminoglycan-binding adhesin of the Lyme disease spirochete Borrelia burgdorferi
    • Parveen N & Leong J (2000) Identification of a candidate glycosaminoglycan-binding adhesin of the Lyme disease spirochete Borrelia burgdorferi. Mol Microbiol 35: 1220-1234.
    • (2000) Mol Microbiol , vol.35 , pp. 1220-1234
    • Parveen, N.1    Leong, J.2
  • 137
    • 33646344197 scopus 로고    scopus 로고
    • Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice
    • Parveen N, Cornell KA, Bono JL, Chamberland C, Rosa P & Leong JM (2006) Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice. Infect Immun 74: 3016-3020.
    • (2006) Infect Immun , vol.74 , pp. 3016-3020
    • Parveen, N.1    Cornell, K.A.2    Bono, J.L.3    Chamberland, C.4    Rosa, P.5    Leong, J.M.6
  • 138
    • 1642268055 scopus 로고    scopus 로고
    • Molecular analysis of the channel-forming protein P13 and its paralogue family 48 from different Lyme disease Borrelia species
    • Pinne M, Ostberg Y, Comstedt P & Bergstrom S (2004) Molecular analysis of the channel-forming protein P13 and its paralogue family 48 from different Lyme disease Borrelia species. Microbiology 150: 549-559.
    • (2004) Microbiology , vol.150 , pp. 549-559
    • Pinne, M.1    Ostberg, Y.2    Comstedt, P.3    Bergstrom, S.4
  • 139
    • 33744990631 scopus 로고    scopus 로고
    • The BBA01 protein, a member of paralog family 48 from Borrelia burgdorferi, is potentially interchangeable with the channel-forming protein P13
    • Pinne M, Denker K, Nilsson E, Benz R & Bergstrom S (2006) The BBA01 protein, a member of paralog family 48 from Borrelia burgdorferi, is potentially interchangeable with the channel-forming protein P13. J Bacteriol 188: 4207-4217.
    • (2006) J Bacteriol , vol.188 , pp. 4207-4217
    • Pinne, M.1    Denker, K.2    Nilsson, E.3    Benz, R.4    Bergstrom, S.5
  • 140
    • 0031769859 scopus 로고    scopus 로고
    • Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31
    • Probert WS & Johnson BJB (1998) Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31. Mol Microbiol 30: 1003-1015.
    • (1998) Mol Microbiol , vol.30 , pp. 1003-1015
    • Probert, W.S.1    Johnson, B.J.B.2
  • 141
    • 0028900999 scopus 로고
    • Identification and characterization of a surface-exposed 66-kilodalton protein from Borrelia burgdorferi
    • Probert WS, Allsup KM & LeFebvre RB (1995) Identification and characterization of a surface-exposed 66-kilodalton protein from Borrelia burgdorferi. Infect Immun 63: 1933-1939.
    • (1995) Infect Immun , vol.63 , pp. 1933-1939
    • Probert, W.S.1    Allsup, K.M.2    LeFebvre, R.B.3
  • 142
    • 0035007253 scopus 로고    scopus 로고
    • Mapping the ligand-binding region of Borrelia burgdorferi fibronectin-binding protein BBK32
    • Probert WS, Kim JH, Hook M & Johnson BJ (2001) Mapping the ligand-binding region of Borrelia burgdorferi fibronectin-binding protein BBK32. Infect Immun 69: 4129-4133.
    • (2001) Infect Immun , vol.69 , pp. 4129-4133
    • Probert, W.S.1    Kim, J.H.2    Hook, M.3    Johnson, B.J.4
  • 143
    • 0034610332 scopus 로고    scopus 로고
    • Correlation between plasmid content and infectivity in Borrelia burgdorferi
    • Purser JE & Norris SJ (2000) Correlation between plasmid content and infectivity in Borrelia burgdorferi. P Natl Acad Sci USA 97: 13865-13870.
    • (2000) P Natl Acad Sci USA , vol.97 , pp. 13865-13870
    • Purser, J.E.1    Norris, S.J.2
  • 144
    • 0038687785 scopus 로고    scopus 로고
    • A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host
    • Purser JE, Lawrenz MB, Caimano MJ, Howell JK, Radolf JD & Norris SJ (2003) A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host. Mol Microbiol 48: 753-764.
    • (2003) Mol Microbiol , vol.48 , pp. 753-764
    • Purser, J.E.1    Lawrenz, M.B.2    Caimano, M.J.3    Howell, J.K.4    Radolf, J.D.5    Norris, S.J.6
  • 145
    • 45149117244 scopus 로고    scopus 로고
    • The long strange trip of Borrelia burgdorferi outer-surface protein C
    • Radolf JD & Caimano MJ (2008) The long strange trip of Borrelia burgdorferi outer-surface protein C. Mol Microbiol 69: 1-4.
    • (2008) Mol Microbiol , vol.69 , pp. 1-4
    • Radolf, J.D.1    Caimano, M.J.2
  • 146
    • 0028057599 scopus 로고
    • Analysis of Borrelia burgdorferi membrane architecture by freeze-fracture electron microscopy
    • Radolf JD, Bourell KW, Akins DR, Brusca JS & Norgard MV (1994) Analysis of Borrelia burgdorferi membrane architecture by freeze-fracture electron microscopy. J Bacteriol 176: 21-31.
    • (1994) J Bacteriol , vol.176 , pp. 21-31
    • Radolf, J.D.1    Bourell, K.W.2    Akins, D.R.3    Brusca, J.S.4    Norgard, M.V.5
  • 147
    • 23144451856 scopus 로고    scopus 로고
    • The Lyme disease agent exploits a tick protein to infect the mammalian host
    • Ramamoorthi N, Narasimhan S, Pal U et al. (2005) The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature 436: 573-577.
    • (2005) Nature , vol.436 , pp. 573-577
    • Ramamoorthi, N.1    Narasimhan, S.2    Pal, U.3
  • 148
    • 0037022354 scopus 로고    scopus 로고
    • DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete
    • Revel AT, Talaat AM & Norgard MV (2002) DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete. P Natl Acad Sci USA 99: 1562-1567.
    • (2002) P Natl Acad Sci USA , vol.99 , pp. 1562-1567
    • Revel, A.T.1    Talaat, A.M.2    Norgard, M.V.3
  • 150
    • 0027158861 scopus 로고
    • The cryptic ospC gene of Borrelia burgdorferi B31 is located on a circular plasmid
    • Sadziene A, Wilske B, Ferdows MS & Barbour AG (1993) The cryptic ospC gene of Borrelia burgdorferi B31 is located on a circular plasmid. Infect Immun 61: 2192-2195.
    • (1993) Infect Immun , vol.61 , pp. 2192-2195
    • Sadziene, A.1    Wilske, B.2    Ferdows, M.S.3    Barbour, A.G.4
  • 151
    • 0028953918 scopus 로고
    • Borrelia burgdorferi mutant lacking Osp: biological and immunological characterization
    • Sadziene A, Thomas DD & Barbour AG (1995) Borrelia burgdorferi mutant lacking Osp: biological and immunological characterization. Infect Immun 63: 1573-1580.
    • (1995) Infect Immun , vol.63 , pp. 1573-1580
    • Sadziene, A.1    Thomas, D.D.2    Barbour, A.G.3
  • 152
    • 0043198261 scopus 로고    scopus 로고
    • A DNA vaccine encoding the outer surface protein C from Borrelia burgdorferi is able to induce protective immune responses
    • Scheiblhofer S, Weiss R, Durnberger H, Mostbock S, Breitenbach M, Livey I & Thalhamer J (2003) A DNA vaccine encoding the outer surface protein C from Borrelia burgdorferi is able to induce protective immune responses. Microbes Infect 5: 939-946.
    • (2003) Microbes Infect , vol.5 , pp. 939-946
    • Scheiblhofer, S.1    Weiss, R.2    Durnberger, H.3    Mostbock, S.4    Breitenbach, M.5    Livey, I.6    Thalhamer, J.7
  • 153
    • 0037064291 scopus 로고    scopus 로고
    • The structure of bacterial outer membrane proteins
    • Schulz GE (2002) The structure of bacterial outer membrane proteins. Biochim Biophys Acta 1565: 308-317.
    • (2002) Biochim Biophys Acta , vol.1565 , pp. 308-317
    • Schulz, G.E.1
  • 154
    • 33645077876 scopus 로고    scopus 로고
    • Borrelia burgdorferi lipoproteins are secreted to the outer surface by default
    • Schulze RJ & Zuckert WR (2006) Borrelia burgdorferi lipoproteins are secreted to the outer surface by default. Mol Microbiol 59: 1473-1484.
    • (2006) Mol Microbiol , vol.59 , pp. 1473-1484
    • Schulze, R.J.1    Zuckert, W.R.2
  • 155
    • 0037326941 scopus 로고    scopus 로고
    • Temporal regulation of outer surface proteins of the Lyme-disease spirochaete Borrelia burgdorferi
    • Schwan TG (2003) Temporal regulation of outer surface proteins of the Lyme-disease spirochaete Borrelia burgdorferi. Biochem Soc Trans 31: 108-112.
    • (2003) Biochem Soc Trans , vol.31 , pp. 108-112
    • Schwan, T.G.1
  • 156
    • 0033984294 scopus 로고    scopus 로고
    • Temporal changes in outer surface proteins A and C of the Lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice
    • Schwan TG & Piesman J (2000) Temporal changes in outer surface proteins A and C of the Lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice. J Clin Microbiol 38: 382-388.
    • (2000) J Clin Microbiol , vol.38 , pp. 382-388
    • Schwan, T.G.1    Piesman, J.2
  • 157
    • 0028926240 scopus 로고
    • Induction of an outer surface protein on Borrelia burgdorferi during tick feeding
    • Schwan TG, Piesman J, Golde WT, Dolan MC & Rosa PA (1995) Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. P Natl Acad Sci USA 92: 2909-2913.
    • (1995) P Natl Acad Sci USA , vol.92 , pp. 2909-2913
    • Schwan, T.G.1    Piesman, J.2    Golde, W.T.3    Dolan, M.C.4    Rosa, P.A.5
  • 158
    • 33645092915 scopus 로고    scopus 로고
    • Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi
    • Seshu J, Esteve-Gassent MD, Labandeira-Rey M, Kim JH, Trzeciakowski JP, Hook M & Skare JT (2006) Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi. Mol Microbiol 59: 1591-1601.
    • (2006) Mol Microbiol , vol.59 , pp. 1591-1601
    • Seshu, J.1    Esteve-Gassent, M.D.2    Labandeira-Rey, M.3    Kim, J.H.4    Trzeciakowski, J.P.5    Hook, M.6    Skare, J.T.7
  • 159
    • 33750475236 scopus 로고    scopus 로고
    • The dbpBA locus of Borrelia burgdorferi is not essential for infection of mice
    • Shi Y, Xu Q, Seemanapalli SV, McShan K & Liang FT (2006) The dbpBA locus of Borrelia burgdorferi is not essential for infection of mice. Infect Immun 74: 6509-6512.
    • (2006) Infect Immun , vol.74 , pp. 6509-6512
    • Shi, Y.1    Xu, Q.2    Seemanapalli, S.V.3    McShan, K.4    Liang, F.T.5
  • 160
    • 40749130867 scopus 로고    scopus 로고
    • Both decorin-binding proteins A and B are critical for the overall virulence of Borrelia burgdorferi
    • Shi Y, Xu Q, McShan K & Liang FT (2008) Both decorin-binding proteins A and B are critical for the overall virulence of Borrelia burgdorferi. Infect Immun 76: 1239-1246.
    • (2008) Infect Immun , vol.76 , pp. 1239-1246
    • Shi, Y.1    Xu, Q.2    McShan, K.3    Liang, F.T.4
  • 161
    • 0025159176 scopus 로고
    • A repeating amino acid motif in CDC23 defines a family of proteins and a new relationship among genes required for mitosis and RNA synthesis
    • Sikorski RS, Boguski MS, Goebl M & Hieter P (1990) A repeating amino acid motif in CDC23 defines a family of proteins and a new relationship among genes required for mitosis and RNA synthesis. Cell 60: 307-317.
    • (1990) Cell , vol.60 , pp. 307-317
    • Sikorski, R.S.1    Boguski, M.S.2    Goebl, M.3    Hieter, P.4
  • 164
    • 0030930266 scopus 로고    scopus 로고
    • The Oms66 (p66) protein is a Borrelia burgdorferi porin
    • Skare JT, Mirzabekov TA, Shang ES et al. (1997) The Oms66 (p66) protein is a Borrelia burgdorferi porin. Infect Immun 65: 3654-3661.
    • (1997) Infect Immun , vol.65 , pp. 3654-3661
    • Skare, J.T.1    Mirzabekov, T.A.2    Shang, E.S.3
  • 165
    • 34547512065 scopus 로고    scopus 로고
    • Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli
    • Sklar JG, Wu T, Gronenberg LS, Malinverni JC, Kahne D & Silhavy TJ (2007) Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli. P Natl Acad Sci USA 104: 6400-6405.
    • (2007) P Natl Acad Sci USA , vol.104 , pp. 6400-6405
    • Sklar, J.G.1    Wu, T.2    Gronenberg, L.S.3    Malinverni, J.C.4    Kahne, D.5    Silhavy, T.J.6
  • 167
    • 0017714446 scopus 로고
    • Erythema chronicum migrans and Lyme arthritis:the enlarging clinical spectrum
    • Steere AC, Malawista SE, Hardin JA et al. (1977a) Erythema chronicum migrans and Lyme arthritis:the enlarging clinical spectrum. Ann Intern Med 86: 685-698.
    • (1977) Ann Intern Med , vol.86 , pp. 685-698
    • Steere, A.C.1    Malawista, S.E.2    Hardin, J.A.3
  • 170
    • 0028828202 scopus 로고
    • Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi
    • Stevenson B, Schwan TG & Rosa PA (1995) Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi. Infect Immun 63: 4535-4539.
    • (1995) Infect Immun , vol.63 , pp. 4535-4539
    • Stevenson, B.1    Schwan, T.G.2    Rosa, P.A.3
  • 171
    • 0029892683 scopus 로고    scopus 로고
    • A family of genes located on four separate 32-kilobase circular plasmids in Borrelia burgdorferi
    • Stevenson B, Tilly K & Rosa PA (1996) A family of genes located on four separate 32-kilobase circular plasmids in Borrelia burgdorferi. J Bacteriol 178: 3508-3516.
    • (1996) J Bacteriol , vol.178 , pp. 3508-3516
    • Stevenson, B.1    Tilly, K.2    Rosa, P.A.3
  • 172
    • 0031812086 scopus 로고    scopus 로고
    • Borrelia burgdorferi Erp proteins are immunogenic in mammals infected by tick bite, and their synthesis is inducible in cultured bacteria
    • Stevenson B, Bono JL, Schwan TG & Rosa PA (1998) Borrelia burgdorferi Erp proteins are immunogenic in mammals infected by tick bite, and their synthesis is inducible in cultured bacteria. Infect Immun 66: 2648-2654.
    • (1998) Infect Immun , vol.66 , pp. 2648-2654
    • Stevenson, B.1    Bono, J.L.2    Schwan, T.G.3    Rosa, P.A.4
  • 173
    • 0036156137 scopus 로고    scopus 로고
    • Differential binding of host complement inhibitor factor H by Borrelia burgdorferi Erp surface proteins: a possible mechanism underlying the expansive host range of Lyme disease spirochetes
    • Stevenson B, El Hage N, Hines MA, Miller JC & Babb K (2002) Differential binding of host complement inhibitor factor H by Borrelia burgdorferi Erp surface proteins: a possible mechanism underlying the expansive host range of Lyme disease spirochetes. Infect Immun 70: 491-497.
    • (2002) Infect Immun , vol.70 , pp. 491-497
    • Stevenson, B.1    El Hage, N.2    Hines, M.A.3    Miller, J.C.4    Babb, K.5
  • 175
    • 42949083309 scopus 로고    scopus 로고
    • A tightly regulated surface protein of Borrelia burgdorferi is not essential to the mouse-tick infectious cycle
    • Stewart PE, Bestor A, Cullen JN & Rosa PA (2008) A tightly regulated surface protein of Borrelia burgdorferi is not essential to the mouse-tick infectious cycle. Infect Immun 76: 1970-1978.
    • (2008) Infect Immun , vol.76 , pp. 1970-1978
    • Stewart, P.E.1    Bestor, A.2    Cullen, J.N.3    Rosa, P.A.4
  • 178
    • 33646930883 scopus 로고    scopus 로고
    • Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection
    • Tilly K, Krum JG, Bestor A et al. (2006) Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection. Infect Immun 74: 3554-3564.
    • (2006) Infect Immun , vol.74 , pp. 3554-3564
    • Tilly, K.1    Krum, J.G.2    Bestor, A.3
  • 179
    • 4544350205 scopus 로고    scopus 로고
    • Combined effects of blood and temperature shift on Borrelia burgdorferi gene expression as determined by whole genome DNA array
    • Tokarz R, Anderton JM, Katona LI & Benach JL (2004) Combined effects of blood and temperature shift on Borrelia burgdorferi gene expression as determined by whole genome DNA array. Infect Immun 72: 5419-5432.
    • (2004) Infect Immun , vol.72 , pp. 5419-5432
    • Tokarz, R.1    Anderton, J.M.2    Katona, L.I.3    Benach, J.L.4
  • 180
    • 1842471109 scopus 로고    scopus 로고
    • Omp85, an evolutionarily conserved bacterial protein involved in outer-membrane-protein assembly
    • Voulhoux R & Tommassen J (2004) Omp85, an evolutionarily conserved bacterial protein involved in outer-membrane-protein assembly. Res Microbiol 155: 129-135.
    • (2004) Res Microbiol , vol.155 , pp. 129-135
    • Voulhoux, R.1    Tommassen, J.2
  • 181
    • 0029122852 scopus 로고
    • Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo
    • Wallich R, Brenner C, Kramer MD & Simon MM (1995) Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo. Infect Immun 63: 3327-3335.
    • (1995) Infect Immun , vol.63 , pp. 3327-3335
    • Wallich, R.1    Brenner, C.2    Kramer, M.D.3    Simon, M.M.4
  • 182
    • 0035084743 scopus 로고    scopus 로고
    • DNA vaccines expressing a fusion product of outer surface proteins A and C from Borrelia burgdorferi induce protective antibodies suitable for prophylaxis but not for resolution of Lyme disease
    • Wallich R, Siebers A, Jahraus O, Brenner C, Stehle T & Simon MM (2001) DNA vaccines expressing a fusion product of outer surface proteins A and C from Borrelia burgdorferi induce protective antibodies suitable for prophylaxis but not for resolution of Lyme disease. Infect Immun 69: 2130-2136.
    • (2001) Infect Immun , vol.69 , pp. 2130-2136
    • Wallich, R.1    Siebers, A.2    Jahraus, O.3    Brenner, C.4    Stehle, T.5    Simon, M.M.6
  • 183
    • 0032894835 scopus 로고    scopus 로고
    • Genetic diversity of ospC in a local population of Borrelia burgdorferi sensu stricto
    • Wang IN, Dykhuizen DE, Qiu W, Dunn JJ, Bosler EM & Luft BJ (1999) Genetic diversity of ospC in a local population of Borrelia burgdorferi sensu stricto. Genetics 151: 15-30.
    • (1999) Genetics , vol.151 , pp. 15-30
    • Wang, I.N.1    Dykhuizen, D.E.2    Qiu, W.3    Dunn, J.J.4    Bosler, E.M.5    Luft, B.J.6
  • 184
    • 57349121039 scopus 로고    scopus 로고
    • Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection
    • Weening EH, Parveen N, Trzeciakowski JP, Leong JM, Hook M & Skare JT (2008) Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection. Infect Immun 76: 5694-5705.
    • (2008) Infect Immun , vol.76 , pp. 5694-5705
    • Weening, E.H.1    Parveen, N.2    Trzeciakowski, J.P.3    Leong, J.M.4    Hook, M.5    Skare, J.T.6
  • 185
    • 0030102694 scopus 로고    scopus 로고
    • Immunological and molecular variability of OspA and OspC. Implications for Borrelia vaccine development
    • Wilske B, Busch U, Fingerle V, Jauris-Heipke S, Preac Mursic V & Will G (1996) Immunological and molecular variability of OspA and OspC. Implications for Borrelia vaccine development. Infection 24: 208-212.
    • (1996) Infection , vol.24 , pp. 208-212
    • Wilske, B.1    Busch, U.2    Fingerle, V.3    Jauris-Heipke, S.4    Preac Mursic, V.5    Will, G.6
  • 186
    • 17444381980 scopus 로고    scopus 로고
    • Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli
    • Wu T, Malinverni J, Ruiz N, Kim S, Silhavy TJ & Kahne D (2005) Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli. Cell 121: 235-245.
    • (2005) Cell , vol.121 , pp. 235-245
    • Wu, T.1    Malinverni, J.2    Ruiz, N.3    Kim, S.4    Silhavy, T.J.5    Kahne, D.6
  • 187
    • 1542283705 scopus 로고    scopus 로고
    • Essential role for OspA/B in the life cycle of the Lyme disease Spirochete
    • Yang XF, Pal U, Alani SM, Fikrig E & Norgard MV (2004) Essential role for OspA/B in the life cycle of the Lyme disease Spirochete. J Exp Med 199: 641-648.
    • (2004) J Exp Med , vol.199 , pp. 641-648
    • Yang, X.F.1    Pal, U.2    Alani, S.M.3    Fikrig, E.4    Norgard, M.V.5
  • 189
    • 63449100910 scopus 로고    scopus 로고
    • A chromosomally encoded virulence factor protects the Lyme disease pathogen against host-adaptive immunity
    • Yang X, Coleman AS, Anguita J & Pal U (2009) A chromosomally encoded virulence factor protects the Lyme disease pathogen against host-adaptive immunity. PLoS Pathog 5: e1000326.
    • (2009) PLoS Pathog , vol.5
    • Yang, X.1    Coleman, A.S.2    Anguita, J.3    Pal, U.4
  • 190
    • 78049419952 scopus 로고    scopus 로고
    • Characterization of unique regions of Borrelia burgdorferi surface-located membrane protein 1
    • Yang X, Lenhart TR, Kariu T, Anguita J, Akins DR & Pal U (2010) Characterization of unique regions of Borrelia burgdorferi surface-located membrane protein 1. Infect Immun 78: 4477-4487.
    • (2010) Infect Immun , vol.78 , pp. 4477-4487
    • Yang, X.1    Lenhart, T.R.2    Kariu, T.3    Anguita, J.4    Akins, D.R.5    Pal, U.6
  • 192
    • 0031824610 scopus 로고    scopus 로고
    • Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion
    • Zhang JR & Norris SJ (1998a) Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion. Infect Immun 66: 3698-3704.
    • (1998) Infect Immun , vol.66 , pp. 3698-3704
    • Zhang, J.R.1    Norris, S.J.2
  • 193
    • 0031850030 scopus 로고    scopus 로고
    • Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi
    • Zhang JR & Norris SJ (1998b) Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi. Infect Immun 66: 3689-3697.
    • (1998) Infect Immun , vol.66 , pp. 3689-3697
    • Zhang, J.R.1    Norris, S.J.2
  • 194
    • 0030904280 scopus 로고    scopus 로고
    • Antigenic variation in Lyme disease Borreliae by promiscuous recombination of Vmp-like sequence cassettes
    • Zhang JR, Hardham JM, Barbour AG & Norris SJ (1997) Antigenic variation in Lyme disease Borreliae by promiscuous recombination of Vmp-like sequence cassettes. Cell 89: 275-285.
    • (1997) Cell , vol.89 , pp. 275-285
    • Zhang, J.R.1    Hardham, J.M.2    Barbour, A.G.3    Norris, S.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.