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Volumn 101, Issue 10, 1998, Pages 2240-2250

A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state

Author keywords

Borrelia burgdorferi; Chamber implants; Host adapted; Outer surface protein; Ticks

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL DNA; BACTERIAL PROTEIN; EPITOPE; LIPOPROTEIN; MEMBRANE PROTEIN; OUTER SURFACE PROTEIN A; PROTEIN OSPC; PROTEIN OSPE; PROTEIN P21; UNCLASSIFIED DRUG;

EID: 0032523936     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI2325     Document Type: Article
Times cited : (200)

References (67)
  • 3
    • 0026039295 scopus 로고
    • Lyme borreliosis: Relation of its causative agent to its vectors and hosts in North America and Europe
    • Lane, R.S., J. Piesman, and W. Burgdorfer. 1991. Lyme borreliosis: relation of its causative agent to its vectors and hosts in North America and Europe. Ann. Rev. Entomol. 36:587-609.
    • (1991) Ann. Rev. Entomol. , vol.36 , pp. 587-609
    • Lane, R.S.1    Piesman, J.2    Burgdorfer, W.3
  • 5
  • 6
    • 0030048119 scopus 로고    scopus 로고
    • Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: Exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease
    • Montgomery, R.K., S.E. Malawista, K.J.M. Feen, and L.K. Bockenstedt. 1996. Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. J. Exp. Med. 183:261-269.
    • (1996) J. Exp. Med. , vol.183 , pp. 261-269
    • Montgomery, R.K.1    Malawista, S.E.2    Feen, K.J.M.3    Bockenstedt, L.K.4
  • 7
    • 0030025949 scopus 로고    scopus 로고
    • Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine
    • de Silva, A.M., S.R. Telford, L.R. Brunet, S.W. Barthold, and E. Fikrig. 1996. Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. J. Exp. Med. 183:271-275.
    • (1996) J. Exp. Med. , vol.183 , pp. 271-275
    • De Silva, A.M.1    Telford, S.R.2    Brunet, L.R.3    Barthold, S.W.4    Fikrig, E.5
  • 8
    • 0030777290 scopus 로고    scopus 로고
    • Arthropod- and host-specific gene expression by Borrelia burgdorferi
    • de Silva, A.M., and E. Fikrig. 1997. Arthropod-and host-specific gene expression by Borrelia burgdorferi. J. Clin. Invest. 99:377-379.
    • (1997) J. Clin. Invest. , vol.99 , pp. 377-379
    • De Silva, A.M.1    Fikrig, E.2
  • 9
    • 0028335843 scopus 로고
    • A 9.0 kilobase-pair circular plasmid of Borrelia burgdorferi encodes an exported protein: Evidence for expression only during infection
    • Champion, C.I., D.R. Blanco, J.T. Skare, D.A. Haake, M. Giladi, D. Foley, J.N. Miller, and M.A. Lovett. 1994. A 9.0 kilobase-pair circular plasmid of Borrelia burgdorferi encodes an exported protein: evidence for expression only during infection. Infect. Immun. 62:2653-2661.
    • (1994) Infect. Immun. , vol.62 , pp. 2653-2661
    • Champion, C.I.1    Blanco, D.R.2    Skare, J.T.3    Haake, D.A.4    Giladi, M.5    Foley, D.6    Miller, J.N.7    Lovett, M.A.8
  • 10
    • 0030983397 scopus 로고    scopus 로고
    • Borrelia burgdorferi p35 and p37 proteins, expressed in vivo, elicit protective immunity
    • Fikrig, E., S.W. Barthold, W. Sun, W. Feng, S.R. Telford, and R.A. Flavell. 1997. Borrelia burgdorferi p35 and p37 proteins, expressed in vivo, elicit protective immunity. Immunity. 6:531-539.
    • (1997) Immunity , vol.6 , pp. 531-539
    • Fikrig, E.1    Barthold, S.W.2    Sun, W.3    Feng, W.4    Telford, S.R.5    Flavell, R.A.6
  • 13
    • 0029122852 scopus 로고
    • Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo
    • Wallich, R., C. Brenner, M.D. Kramer, and M.M. Simon. 1995. Molecular cloning and immunological characterization of a novel linear-plasmid-encoded gene, pG, of Borrelia burgdorferi expressed only in vivo. Infect. Immun. 63:3327-3335.
    • (1995) Infect. Immun. , vol.63 , pp. 3327-3335
    • Wallich, R.1    Brenner, C.2    Kramer, M.D.3    Simon, M.M.4
  • 14
    • 0031020230 scopus 로고    scopus 로고
    • Molecular characterization of a 6.6-kilodalton Borrelia burgdorferi outer membrane-associated lipoprotein (lp6.6) which appears to be downregulated during mammalian infection
    • Lahdenne, P., S.F. Porcella, K.E. Hagman, D.R. Akins, T.G. Popova, D.L. Cox, J.D. Radolf, and M.V. Norgard. 1997. Molecular characterization of a 6.6-kilodalton Borrelia burgdorferi outer membrane-associated lipoprotein (lp6.6) which appears to be downregulated during mammalian infection. Infect. Immun. 65:412-121.
    • (1997) Infect. Immun. , vol.65 , pp. 412-1121
    • Lahdenne, P.1    Porcella, S.F.2    Hagman, K.E.3    Akins, D.R.4    Popova, T.G.5    Cox, D.L.6    Radolf, J.D.7    Norgard, M.V.8
  • 15
    • 0026511987 scopus 로고
    • Environmental signals controlling expression of virulence determinants in bacteria
    • Mekalanos, J.J. 1992. Environmental signals controlling expression of virulence determinants in bacteria. J. Bacteriol. 174:1-7.
    • (1992) J. Bacteriol. , vol.174 , pp. 1-7
    • Mekalanos, J.J.1
  • 16
    • 0031034470 scopus 로고    scopus 로고
    • Regulation of bacterial virulence gene expression by the host environment
    • Guiney, D.G. 1997. Regulation of bacterial virulence gene expression by the host environment. J. Clin. Invest. 99:565-569.
    • (1997) J. Clin. Invest. , vol.99 , pp. 565-569
    • Guiney, D.G.1
  • 17
    • 0028828202 scopus 로고
    • Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi
    • Stevenson, B., T.G. Schwan, and P.A. Rosa. 1995. Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi. Infect. Immun. 63:4535-4539.
    • (1995) Infect. Immun. , vol.63 , pp. 4535-4539
    • Stevenson, B.1    Schwan, T.G.2    Rosa, P.A.3
  • 20
    • 0022999139 scopus 로고
    • Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness
    • Craft, J.E., D.K. Fischer, G.T. Shimamoto, and A.C. Steere. 1986. Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness. J. Clin. Invest. 78:934-939.
    • (1986) J. Clin. Invest. , vol.78 , pp. 934-939
    • Craft, J.E.1    Fischer, D.K.2    Shimamoto, G.T.3    Steere, A.C.4
  • 21
    • 0029036568 scopus 로고
    • Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi
    • Barthold, S.W., E. Fikrig, L.K. Bockenstedt, and D.H. Persing. 1995. Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi. Infect. Immun. 63:2255-2261.
    • (1995) Infect. Immun. , vol.63 , pp. 2255-2261
    • Barthold, S.W.1    Fikrig, E.2    Bockenstedt, L.K.3    Persing, D.H.4
  • 22
    • 0030741615 scopus 로고    scopus 로고
    • Protective and arthritis-resolving activity in sera of mice infected with Borrelia burgdorferi
    • Barthold, S.W., S.L. Feng, L.K. Bockenstedt, E. Fikrig, and K. Feen. 1997. Protective and arthritis-resolving activity in sera of mice infected with Borrelia burgdorferi. Clin. Infect. Dis. 25:S9-S17.
    • (1997) Clin. Infect. Dis. , vol.25
    • Barthold, S.W.1    Feng, S.L.2    Bockenstedt, L.K.3    Fikrig, E.4    Feen, K.5
  • 25
    • 0024619268 scopus 로고
    • Surface characteristics of Pseudomonas aeruginosa grown in a chamber implant model in mice and rats
    • Kelly, N.M., A. Bell, and R.E. Hancock. 1989. Surface characteristics of Pseudomonas aeruginosa grown in a chamber implant model in mice and rats. Infect. Immun. 57:344-350.
    • (1989) Infect. Immun. , vol.57 , pp. 344-350
    • Kelly, N.M.1    Bell, A.2    Hancock, R.E.3
  • 26
    • 0029058917 scopus 로고
    • Subcutaneous implanted chambers in different mouse strains as an animal model to study genetic stability during infection with Lyme disease Borrelia
    • Jonsson, M., T. Elmros, and S. Bergstrom. 1995. Subcutaneous implanted chambers in different mouse strains as an animal model to study genetic stability during infection with Lyme disease Borrelia. Microb. Pathog. 18: 109-114.
    • (1995) Microb. Pathog. , vol.18 , pp. 109-114
    • Jonsson, M.1    Elmros, T.2    Bergstrom, S.3
  • 27
    • 0028910384 scopus 로고
    • Studies on early events of Borrelia burgdorferi-induced cytokine production in immunodeficient SCID mice by using a tissue chamber model for acute inflammation
    • Hurtenbach, U., C. Museteanu, J. Gasser, U.E. Schaible, and M.M. Simon. 1995. Studies on early events of Borrelia burgdorferi-induced cytokine production in immunodeficient SCID mice by using a tissue chamber model for acute inflammation. Int. J. Exp. Pathol. 76:111-123.
    • (1995) Int. J. Exp. Pathol. , vol.76 , pp. 111-123
    • Hurtenbach, U.1    Museteanu, C.2    Gasser, J.3    Schaible, U.E.4    Simon, M.M.5
  • 29
    • 0021671855 scopus 로고
    • Isolation and cultivation of Lyme disease spirocheles
    • Barbour, A.G. 1984. Isolation and cultivation of Lyme disease spirocheles. Yale J. Biol. Med. 57:521-525.
    • (1984) Yale J. Biol. Med. , vol.57 , pp. 521-525
    • Barbour, A.G.1
  • 30
    • 0023806075 scopus 로고
    • Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
    • Smith, D.B., and K.S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene. 67:31-40.
    • (1988) Gene , vol.67 , pp. 31-40
    • Smith, D.B.1    Johnson, K.S.2
  • 31
    • 0024365376 scopus 로고
    • Ear punch biopsy method for detection and isolation of Borrelia burgdorferi from rodents
    • Sinsky, R.J., and J. Piesman. 1989. Ear punch biopsy method for detection and isolation of Borrelia burgdorferi from rodents. J. Clin. Microbiol. 27: 1723-1727.
    • (1989) J. Clin. Microbiol. , vol.27 , pp. 1723-1727
    • Sinsky, R.J.1    Piesman, J.2
  • 33
    • 0029950581 scopus 로고    scopus 로고
    • Borrelia burgdorferi supercoiled plasmids encode multiple tandem open reading frames and a lipoprotein gene family
    • Porcella, S.F., T.G. Popova, D.R. Akins, M. Li, J.D. Radolf, and M.V. Norgard. 1996. Borrelia burgdorferi supercoiled plasmids encode multiple tandem open reading frames and a lipoprotein gene family. J. Bacteriol. 178:3293-3307.
    • (1996) J. Bacteriol. , vol.178 , pp. 3293-3307
    • Porcella, S.F.1    Popova, T.G.2    Akins, D.R.3    Li, M.4    Radolf, J.D.5    Norgard, M.V.6
  • 34
    • 0026602904 scopus 로고
    • Analysis of the N-terminal region of the 47-kilodalton integral membrane lipoprotein of Treponema pallidum
    • Weigel, L.M., M.E. Brandt, and M.V. Norgard. 1992. Analysis of the N-terminal region of the 47-kilodalton integral membrane lipoprotein of Treponema pallidum. Infect. Immun. 60:1568-1576.
    • (1992) Infect. Immun. , vol.60 , pp. 1568-1576
    • Weigel, L.M.1    Brandt, M.E.2    Norgard, M.V.3
  • 36
    • 0026483757 scopus 로고
    • Purification and immunological characterization of a major low-molecular-weight lipoprotein from Borrelia burgdorferi
    • Katona, L.I., G. Beck, and G.S. Habicht. 1992. Purification and immunological characterization of a major low-molecular-weight lipoprotein from Borrelia burgdorferi. Infect. Immun. 60:4995-5003.
    • (1992) Infect. Immun. , vol.60 , pp. 4995-5003
    • Katona, L.I.1    Beck, G.2    Habicht, G.S.3
  • 37
    • 0022628817 scopus 로고
    • Monoclonal antibody selection and analysis of a recombinant DNA-derived surface immunogen of Treponema pallidium expressed in Escherichia coli
    • Swancutt, M.A., D.A. Twehous, and M.V. Norgard. 1986. Monoclonal antibody selection and analysis of a recombinant DNA-derived surface immunogen of Treponema pallidium expressed in Escherichia coli. Infect. Immun. 52: 110-119.
    • (1986) Infect. Immun. , vol.52 , pp. 110-119
    • Swancutt, M.A.1    Twehous, D.A.2    Norgard, M.V.3
  • 38
    • 0019800463 scopus 로고
    • Silver stain for proteins in polyacrylamide gels: A modified procedure with enhanced uniform sensitivity
    • Morrissey, J.H. 1981. Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. Anal. Biochem. 117: 307-310.
    • (1981) Anal. Biochem. , vol.117 , pp. 307-310
    • Morrissey, J.H.1
  • 39
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 40
    • 0017696571 scopus 로고
    • High-resolution two-dimensional electrophoresis of basic as well as acidic proteins
    • O'Farrell, P.Z., H.M. Goodman, and P.H. O'Farrell. 1977. High-resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell. 12: 1133-1142.
    • (1977) Cell , vol.12 , pp. 1133-1142
    • O'Farrell, P.Z.1    Goodman, H.M.2    O'Farrell, P.H.3
  • 41
    • 0021760092 scopus 로고
    • A comprehensive set of sequence analysis programs for the VAX
    • Devereux, J., P. Haeberli, and O. Smithies. 1984. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12:387-395.
    • (1984) Nucleic Acids Res. , vol.12 , pp. 387-395
    • Devereux, J.1    Haeberli, P.2    Smithies, O.3
  • 42
    • 0028072561 scopus 로고
    • The dipeptide permease of Escherichia coli closely resembles other bacterial transport systems and shows growth-phase-dependent expression
    • Abouhamad, W.N., and M.D. Manson. 1994. The dipeptide permease of Escherichia coli closely resembles other bacterial transport systems and shows growth-phase-dependent expression. Mol. Microbiol. 14:1077-1092.
    • (1994) Mol. Microbiol. , vol.14 , pp. 1077-1092
    • Abouhamad, W.N.1    Manson, M.D.2
  • 43
    • 0027258405 scopus 로고
    • Synthesis of the Escherichia coli K-12 nucleoid-associated DNA-binding protein H-NS is subjected to growth-phase eontrol and autoregulation
    • Dersch, P., K. Schmidt, and E. Bremer. 1993. Synthesis of the Escherichia coli K-12 nucleoid-associated DNA-binding protein H-NS is subjected to growth-phase eontrol and autoregulation. Mol. Microbiol. 8:875-889.
    • (1993) Mol. Microbiol. , vol.8 , pp. 875-889
    • Dersch, P.1    Schmidt, K.2    Bremer, E.3
  • 44
    • 0026608131 scopus 로고
    • Expression of extracellular phospholipase from Serratia liquefaciens is growth-phase-dependent, catabolite-repressed, and regulated by anaerobiosis
    • Givskov, M., and S. Molin. 1992. Expression of extracellular phospholipase from Serratia liquefaciens is growth-phase-dependent, catabolite-repressed, and regulated by anaerobiosis. Mol. Microbiol. 6:1363-1374.
    • (1992) Mol. Microbiol. , vol.6 , pp. 1363-1374
    • Givskov, M.1    Molin, S.2
  • 45
    • 0028149818 scopus 로고
    • Regulation of the Yersinia enterocolitica enterotoxin Yst gene. Influence of growth phase, temperature, osmolarity, pH, and bacterial host factors
    • Mikulskis, A.V., I. Delor, V.H. Thi, and G.R. Cornelis. 1994. Regulation of the Yersinia enterocolitica enterotoxin Yst gene. Influence of growth phase, temperature, osmolarity, pH, and bacterial host factors. Mol. Microbiol. 14: 905-915.
    • (1994) Mol. Microbiol. , vol.14 , pp. 905-915
    • Mikulskis, A.V.1    Delor, I.2    Thi, V.H.3    Cornelis, G.R.4
  • 49
    • 0026355962 scopus 로고
    • Mechanisms and biological effects of mismatch repair
    • Modrich, P. 1991. Mechanisms and biological effects of mismatch repair. Ann. Rev. Gen. 25:229-253.
    • (1991) Ann. Rev. Gen. , vol.25 , pp. 229-253
    • Modrich, P.1
  • 50
    • 0030860062 scopus 로고    scopus 로고
    • Characterization of cp18, a naturally truncated member of the cp32 family of Barrelia burgdorferi plasmids
    • Stevenson, B., S. Casjens, R. van Vugt, S.F. Porcella, K. Tilly, J.L. Bono, and P. Rosa. 1997. Characterization of cp18, a naturally truncated member of the cp32 family of Barrelia burgdorferi plasmids. J. Bacteriol. 179:4285-4291.
    • (1997) J. Bacteriol. , vol.179 , pp. 4285-4291
    • Stevenson, B.1    Casjens, S.2    Van Vugt, R.3    Porcella, S.F.4    Tilly, K.5    Bono, J.L.6    Rosa, P.7
  • 51
    • 0030763407 scopus 로고    scopus 로고
    • Probing bacterial gene expression within host cells
    • Valdivia, R.H., and S. Falkow. 1997. Probing bacterial gene expression within host cells. Trends Microbiol. 25:360-363.
    • (1997) Trends Microbiol. , vol.25 , pp. 360-363
    • Valdivia, R.H.1    Falkow, S.2
  • 52
    • 0028275230 scopus 로고
    • In vivo expression technology for selection of bacterial genes specifically induced in host tissues
    • Slauch, J.M., M.J. Mahan, and J.J. Mekalanos. 1994. In vivo expression technology for selection of bacterial genes specifically induced in host tissues. Meth. Enzymol. 235:481-192.
    • (1994) Meth. Enzymol. , vol.235 , pp. 481-1192
    • Slauch, J.M.1    Mahan, M.J.2    Mekalanos, J.J.3
  • 53
    • 0030989515 scopus 로고    scopus 로고
    • Acquired resistance to Borrelia burgdorferi in the rabbit. Comparison between outer surface protein A vaccine- and infection-derived immunity
    • Foley, D.M., Y.-P. Wang, X.-Y. Wu, D.R. Blanco, M.A. Lovett, and J.N. Miller. 1997. Acquired resistance to Borrelia burgdorferi in the rabbit. Comparison between outer surface protein A vaccine-and infection-derived immunity. J. Clin. Invest. 99:2030-2035.
    • (1997) J. Clin. Invest. , vol.99 , pp. 2030-2035
    • Foley, D.M.1    Wang, Y.-P.2    Wu, X.-Y.3    Blanco, D.R.4    Lovett, M.A.5    Miller, J.N.6
  • 54
    • 0021601421 scopus 로고
    • Peritoneal dialysis and loss of proteins: A review
    • Dulaney, J.T., and F.E. Hatch, Jr. 1984. Peritoneal dialysis and loss of proteins: a review, Kidney Int. 26:253-262.
    • (1984) Kidney Int. , vol.26 , pp. 253-262
    • Dulaney, J.T.1    Hatch Jr., F.E.2
  • 56
    • 0027934212 scopus 로고
    • Quuntitation of the Borrelia burgdorferi outer surface protein A in lxodes scapularis: Fluctuation during the tick life cycle, doubling times, and loss while feeding
    • Burkot, T.R., J. Piesman, and R.A. Wirtz. 1994. Quuntitation of the Borrelia burgdorferi outer surface protein A in lxodes scapularis: fluctuation during the tick life cycle, doubling times, and loss while feeding. J. Infect. Dis. 170:883-889.
    • (1994) J. Infect. Dis. , vol.170 , pp. 883-889
    • Burkot, T.R.1    Piesman, J.2    Wirtz, R.A.3
  • 57
    • 0028842880 scopus 로고
    • Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding
    • de Silva, A.M., and E. Fikrig. 1995. Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding. Am. J. Top. Med. Hyg. 53: 397-404.
    • (1995) Am. J. Top. Med. Hyg. , vol.53 , pp. 397-404
    • De Silva, A.M.1    Fikrig, E.2
  • 58
    • 0031012029 scopus 로고    scopus 로고
    • Homology throughout the multiple 32-kilobase circular plasmids present in Lyme disease spirochetes
    • Casjens, S., R. van Vugt, K. Tilly, P.A. Rosa, and B. Stevenson. 1997. Homology throughout the multiple 32-kilobase circular plasmids present in Lyme disease spirochetes. J. Bacteriol. 179:217-227.
    • (1997) J. Bacteriol. , vol.179 , pp. 217-227
    • Casjens, S.1    Van Vugt, R.2    Tilly, K.3    Rosa, P.A.4    Stevenson, B.5
  • 59
    • 10144264563 scopus 로고    scopus 로고
    • Molecular and evolutionary analyses of a variable series of genes in Borrelia burgdorferi that are related to ospE and ospF, constitute a gene family, and share a common upstream homology box
    • Marconi, R.T., S.Y. Sung, C.A. Hughes, and J.A. Carlyon. 1996. Molecular and evolutionary analyses of a variable series of genes in Borrelia burgdorferi that are related to ospE and ospF, constitute a gene family, and share a common upstream homology box. J. Bacteriol. 178:5615-5626.
    • (1996) J. Bacteriol. , vol.178 , pp. 5615-5626
    • Marconi, R.T.1    Sung, S.Y.2    Hughes, C.A.3    Carlyon, J.A.4
  • 60
    • 0027991355 scopus 로고
    • Molecular biology of the Borrelia, bacteria with linear replicons
    • Saint Girons, I., I.G. Old, and B.F. Davidson. 1944. Molecular biology of the Borrelia, bacteria with linear replicons. Microbiology. 140:1803-1816.
    • (1944) Microbiology , vol.140 , pp. 1803-1816
    • Saint Girons, I.1    Old, I.G.2    Davidson, B.F.3
  • 61
    • 0024726210 scopus 로고
    • The molecular biology of Borrelia
    • Barbour, A.G. 1989. The molecular biology of Borrelia. Rev. Infect. Dis. 11(Suppl. 6):S1470-S1474.
    • (1989) Rev. Infect. Dis. , vol.11 , Issue.6 SUPPL.
    • Barbour, A.G.1
  • 62
    • 0023753146 scopus 로고
    • Changes in infectivity and plasmid profile of the Lyme disease spirochete, Borrelia burgdorferi, as a result of in vitro cultivation
    • Schwan, T.G., W. Burgdorfer, and C.F. Garon. 1988. Changes in infectivity and plasmid profile of the Lyme disease spirochete, Borrelia burgdorferi, as a result of in vitro cultivation. Infect. Immun. 56:1831-1836.
    • (1988) Infect. Immun. , vol.56 , pp. 1831-1836
    • Schwan, T.G.1    Burgdorfer, W.2    Garon, C.F.3
  • 63
    • 0025986915 scopus 로고
    • Lyme disease assay which detects killed Borrelia burgdorferi
    • Callister, S.M., R.F. Schell, and S.D. Lovrich. 1991. Lyme disease assay which detects killed Borrelia burgdorferi. J. Clin. Microbiol. 29:1773-1776.
    • (1991) J. Clin. Microbiol. , vol.29 , pp. 1773-1776
    • Callister, S.M.1    Schell, R.F.2    Lovrich, S.D.3
  • 64
    • 0027207678 scopus 로고
    • OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection
    • Fikrig, E., S.W. Barthold, and R.A. Flavell. 1993. OspA vaccination of mice with established Borrelia burgdorferi infection alters disease but not infection. Infect. Immun. 61:2553-2557.
    • (1993) Infect. Immun. , vol.61 , pp. 2553-2557
    • Fikrig, E.1    Barthold, S.W.2    Flavell, R.A.3
  • 65
    • 0029962660 scopus 로고    scopus 로고
    • Borrelia burgdorferi DNA in the urine of treated patients with chronic Lyme disease symptoms. A PCR study of 97 cases
    • Bayer, M.E., L. Zhang, and M.H. Bayer. 1996. Borrelia burgdorferi DNA in the urine of treated patients with chronic Lyme disease symptoms. A PCR study of 97 cases. Infection. 24:347-353.
    • (1996) Infection , vol.24 , pp. 347-353
    • Bayer, M.E.1    Zhang, L.2    Bayer, M.H.3
  • 67
    • 0031060071 scopus 로고    scopus 로고
    • Persistence of Borrelia burgdorferi in experimentally infected dogs after antibiotic treatment
    • Straubinger, R.K., B.A. Summers, Y.-F. Chang, and M.J.G. Appel. 1997. Persistence of Borrelia burgdorferi in experimentally infected dogs after antibiotic treatment. J. Clin. Microbiol. 35:111-116.
    • (1997) J. Clin. Microbiol. , vol.35 , pp. 111-116
    • Straubinger, R.K.1    Summers, B.A.2    Chang, Y.-F.3    Appel, M.J.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.