Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior

Human Molecular Genetics

Volumn 24, Issue 5, 2015, Pages 1305-1321

  Baek, Jean Ha ^a   Schmidt, Eva ^a   Viceconte, Nikenza ^a   Strandgren, Charlotte ^a   Pernold, Karin ^b   Richard, Thibaud J C ^b   Van Leeuwen, Fred W ^c   Dantuma, Nico P ^b   Damberg, Peter ^b   Hultenby, Kjell ^b   Ulfhake, Brun ^b   Mugnaini, Enrico ^d   Rozell, Björn ^e   Eriksson, Maria ^a  

^a Karolinska Institute and Center for Innovative Medicine Department of Biosciences and Nutrition   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d NORTHWESTERN UNIVERSITY   (United States)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

LAMIN A; LAMIN C; PROGERIN; PROTEIN; UNCLASSIFIED DRUG; LAMIN B; LAMIN B1; LMNA PROTEIN, MOUSE; MESSENGER RNA;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BODY WEIGHT; BONE LENGTH; CELL NUCLEUS; CELL ULTRASTRUCTURE; CEREBELLUM; CONTROLLED STUDY; FEMALE; FRONTAL CORTEX; GENE EXPRESSION; GENE MUTATION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LONG TERM CARE; MALE; MOUSE; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OSTEOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROGERIA; STEM CELL; ANIMAL; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; GENETICS; IMAGE PROCESSING; METABOLISM; PREMATURE AGING; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

AGING; AGING, PREMATURE; ANIMALS; CELL DIFFERENTIATION; FEMALE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IMAGE PROCESSING, COMPUTER-ASSISTED; LAMIN TYPE A; LAMIN TYPE B; MALE; MICE; MICE, TRANSGENIC; NEUROGENESIS; NEURONS; RNA, MESSENGER; STEM CELLS;

EID: 84924455010     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddu541     Document Type: Article

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