Expression of the Hutchinson-Gilford progeria mutation during osteoblast development results in loss of osteocytes, irregular mineralization, and poor biomechanical properties

Journal of Biological Chemistry

Volumn 287, Issue 40, 2012, Pages 33512-33522

  Schmidt, Eva ^a   Nilsson, Ola ^a   Koskela, Antti ^b   Tuukkanen, Juha ^b   Ohlsson, Claes ^c   Rozell, Björn ^d   Eriksson, Maria ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF OULU   (Finland)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AGING PROCESS; BIOMECHANICAL PROPERTIES; BONE DISEASE; BONE MARROW; BONE STRUCTURE; CLINICAL FEATURES; DEVELOPMENT RESULTS; DNA DAMAGES; GENETIC DISORDERS; GROWTH RETARDATION; HISTOPATHOLOGICAL EXAMINATIONS; MOUSE MODELS; MULTIPLE FEATURES; MUTANT MICE; OSTEOBLAST DIFFERENTIATION; OSTEOCYTES; PREMATURE AGING; WNT SIGNALING;

BIOMECHANICS; BONE; COMPUTERIZED TOMOGRAPHY; DEFECTS; MAMMALS; MINERALOGY; TISSUE;

OSTEOBLASTS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CELL DIFFERENTIATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DENTIN; DNA DAMAGE; DOWN REGULATION; FEMALE; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; MALE; MINERALIZATION; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCYTE; POINT MUTATION; PRIORITY JOURNAL; PROGERIA; RNA EXTRACTION; WNT SIGNALING PATHWAY;

AGING; ANIMALS; BIOMECHANICS; BONE AND BONES; DNA DAMAGE; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NUCLEAR PROTEINS; OSTEOBLASTS; OSTEOCYTES; PROGERIA; PROTEIN PRECURSORS; SIGNAL TRANSDUCTION; WNT PROTEINS;

MUS;

EID: 84866939080     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.366450     Document Type: Article

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