IL-10/Janus kinase/signal transducer and activator of transcription 3 signaling dysregulates Bim expression in autoimmune lymphoproliferative syndrome

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 3, 2015, Pages 762-770

  Niss, Omar ^a   Sholl, Allyson ^b   Bleesing, Jack J ^a   Hildeman, David A ^b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

ABT 737; ALPS; apoptosis; Bcl 2 pathway; BH3 mimetic; Bim; double negative T cells; IL 10; T cell homeostasis

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; BIM PROTEIN; FLUOROCHROME; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 6; JANUS KINASE; PROTEIN BCL 2; RUXOLITINIB; STAT3 PROTEIN; ABT-737; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; BCL-2-LIKE PROTEIN 11; BCL2 PROTEIN, HUMAN; BCL2L1 PROTEIN, HUMAN; BIPHENYL DERIVATIVE; FAS ANTIGEN; FAS PROTEIN, HUMAN; IL10 PROTEIN, HUMAN; JANUS KINASE 1; MCL1 PROTEIN, HUMAN; MEMBRANE PROTEIN; NITROPHENOL; ONCOPROTEIN; PIPERAZINE DERIVATIVE; PROTEIN BCL X; PROTEIN MCL 1; STAT3 PROTEIN, HUMAN; SULFONAMIDE;

ADOLESCENT; ADULT; APOPTOSIS; ARTICLE; AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE NEGATIVE T CELL; FEMALE; FLOW CYTOMETRY; GENE MUTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; INFANT; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; MALE; NEUTROPHIL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SCHOOL CHILD; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; UPREGULATION; YOUNG ADULT; CASE CONTROL STUDY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MUTATION; PATHOLOGY; PRIMARY CELL CULTURE;

ADOLESCENT; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; APOPTOSIS REGULATORY PROTEINS; AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME; BCL-X PROTEIN; BIPHENYL COMPOUNDS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INFANT; INTERLEUKIN-10; JANUS KINASE 1; MALE; MEMBRANE PROTEINS; MUTATION; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NITROPHENOLS; PIPERAZINES; PRIMARY CELL CULTURE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SULFONAMIDES; T-LYMPHOCYTES;

EID: 84924409227     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.07.020     Document Type: Article

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