Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice

Lupus

Volumn 19, Issue 10, 2010, Pages 1171-1180

  Wang, S ^a   Yang, N ^a   Zhang, L ^a   Huang, B ^a   Tan, H ^a   Liang, Y ^a   Li, Y ^a   Yu, X ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

anti DNA antibodies; nephritis; systemic lupus erythematosus

Indexed keywords

COMPLEMENT COMPONENT C3; DOUBLE STRANDED DNA ANTIBODY; GAMMA INTERFERON; IMMUNOGLOBULIN G; JANUS KINASE 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCYTE CHEMOTACTIC PROTEIN 1; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; STAT1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HISTOLOGY; INFLAMMATORY CELL; KIDNEY FUNCTION; LUPUS ERYTHEMATOSUS NEPHRITIS; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEINURIA; SALIVARY GLAND; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, ANTINUCLEAR; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DNA; ENZYME INHIBITORS; FEMALE; INFLAMMATION; JANUS KINASE 2; JANUS KINASES; KIDNEY; LUPUS NEPHRITIS; MICE; MICE, INBRED MRL LPR; PHOSPHORYLATION; SALIVARY GLANDS; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; STAT1 TRANSCRIPTION FACTOR; TYRPHOSTINS;

EID: 77956256590     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/0961203310367660     Document Type: Article

References (40)

1. Adler S., Cohen A., Glassock R. Secondary glomerular diseases. In: Brenner B (ed.), The Kidney. Philadelphia, PA: Saunders ; 1996. p. 1498-1516.
2. Aringer M., Smolen JS Cytokine expression in lupus kidneys. Lupus 2005 ; 14: 13-18.
3. Uhm WS, Na K., Song GW, et al. Cytokine balance in kidney tissue from lupus nephritis patients. Rheumatology (Oxford) 2003 ; 42: 935-938.
4. Schwarting A., Wada T., Kinoshita K., Tesch G., Kelley VR IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) mice. J Immunol 1998 ; 161: 494-503.
5. Fan X., Wuthrich RP Upregulation of lymphoid and renal interferon-gamma mRNA in autoimmune MRL-Fas(lpr) mice with lupus nephritis. Inflammation 1997 ; 21: 105-112.
6. Carvalho-Pinto CE, Garcia MI, Mellado M., et al. Autocrine production of IFN-gamma by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice. J Immunol 2002 ; 169: 1058-1067.
7. Gough DJ, Levy DE, Johnstone RW, Clarke CJ IFNgamma signaling-does it mean JAK-STAT? Cytokine Growth Factor Rev 2008 ; 19: 383-394.
8. Darnell Jr JE STATs and gene regulation. Science 1997 ; 277: 1630-1635.
9. Imada K., Leonard WJ The Jak-STAT pathway. Mol Immunol 2000 ; 37: 1-11.
10. Durbin JE, Hackenmiller R., Simon MC, Levy DE Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 1996 ; 84: 443-450.
11. Meraz MA, White JM, Sheehan KC, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996 ; 84: 431-442.
12. Schindler C., Strehlow I. Cytokines and STAT signaling. Adv Pharmacol 2000 ; 47: 113-174.
13. Kisseleva T., Bhattacharya S., Braunstein J., Schindler CW Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 2002 ; 285: 1-24.
14. Gadina M., Hilton D., Johnston JA, et al. Signaling by type I and II cytokine receptors: ten years after. Curr Opin Immunol 2001 ; 13: 363-373.
15. Dong J., Wang QX, Zhou CY, Ma XF, Zhang YC Activation of the STAT1 signalling pathway in lupus nephritis in MRL/lpr mice. Lupus 2007 ; 16: 101-109.
16. Martinez-Lostao L., Ordi-Ros J., Balada E., et al. Activation of the signal transducer and activator of transcription-1 in diffuse proliferative lupus nephritis. Lupus 2007 ; 16: 483-488.
17. Luo C., Laaja P. Inhibitors of JAKs/STATs and the kinases: a possible new cluster of drugs. Drug Discov Today 2004 ; 9: 268-275.
18. Ghoreschi K., Laurence A., O'Shea JJ Selectivity and therapeutic inhibition of kinases: to be or not to be? Nat Immunol 2009 ; 10: 356-360.
19. Muraoka M., Hasegawa H., Kohno M., et al. IK cytokine ameliorates the progression of lupus nephritis in MRL/lpr mice. Arthritis Rheum 2006 ; 54: 3591-3600.
20. Yang N., Isbel NM, Nikolic-Paterson DJ, et al. Local macrophage proliferation in human glomerulonephritis. Kidney Int 1998 ; 54: 143-151.
21. Atkinson C., Qiao F., Song H., Gilkeson GS, Tomlinson S. Low-dose targeted complement inhibition protects against renal disease and other manifestations of autoimmune disease in MRL/lpr mice. J Immunol 2008 ; 180: 1231-1238.
22. Bao L., Haas M., Kraus DM, Hack BK, et al. Administration of a soluble recombinant complement c3 inhibitor protects against renal disease in MRL/lpr mice. J Am Soc Nephrol 2003 ; 14: 670-679.
23. Isenberg D., Smeenk R. Clinical laboratory assays for measuring anti-dsDNA antibodies Where are we now? Lupus 2002 ; 11: 797-800.
24. Segerer S., Nelson PJ, Schlondorff D. Chemokines, chemokine receptors, and renal disease: from basic science to pathophysiologic and therapeutic studies. J Am Soc Nephrol 2000 ; 11: 152-176.
25. Perez de Lema G., Maier H., Nieto E., et al. Chemokine expression precedes inflammatory cell infiltration and chemokine receptor and cytokine expression during the initiation of murine lupus nephritis. J Am Soc Nephrol 2001 ; 12: 1369-1382.
26. Wada T., Yokoyama H., Su SB, et al. Monitoring urinary levels of monocyte chemotactic and activating factor reflects disease activity of lupus nephritis. Kidney Int 1996 ; 49: 761-767.
27. Hasegawa H., Kohno M., Sasaki M., et al. Antagonist of monocyte chemoattractant protein 1 ameliorates the initiation and progression of lupus nephritis and renal vasculitis in MRL/lpr mice. Arthritis Rheum 2003 ; 48: 2555-2566.
28. Bian ZM, Elner VM, Yoshida A., Kunkel SL, Elner SG Signaling pathways for glycated human serum albumin-induced IL-8 and MCP-1 secretion in human RPE cells. Invest Ophthalmol Vis Sci 2001 ; 42: 1660-1668.
29. Burysek L., Syrovets T., Simmet T. The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and Janus kinase (JAK)/STAT signaling pathways. J Biol Chem 2002 ; 277: 33509-33517.
30. Kim OS, Park EJ, Joe EH, Jou I. JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells. J Biol Chem 2002 ; 277: 40594-40601.
31. Steimle V., Siegrist CA, Mottet A., Lisowska-Grospierre B., Mach B. Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA. Science 1994 ; 265: 106-109.
32. Yokoyama H., Takabatake T., Takaeda M., et al. Up-regulated MHC-class II expression and gamma-IFN and soluble IL-2R in lupus nephritis. Kidney Int 1992 ; 42: 755-763.
33. Wuthrich RP, Yui MA, Mazoujian G., Nabavi N., Glimcher LH, Kelley VE Enhanced MHC class II expression in renal proximal tubules precedes loss of renal function in MRL/lpr mice with lupus nephritis. Am J Pathol 1989 ; 134: 45-51.
34. Nagarajan UM, Bushey A., Boss JM Modulation of gene expression by the MHC class II transactivator. J Immunol 2002 ; 169: 5078-5088.
35. van den Elsen PJ, van der Stoep N., Vietor HE, Wilson L., van Zutphen M., Gobin SJ Lack of CIITA expression is central to the absence of antigen presentation functions of trophoblast cells and is caused by methylation of the IFN-gamma inducible promoter (PIV) of CIITA. Hum Immunol 2000 ; 61: 850-862.
36. Barbaro Ade L., Tosi G., Frumento G., et al. Block of Stat-1 activation in macrophages phagocytosing bacteria causes reduced transcription of CIITA and consequent impaired antigen presentation. Eur J Immunol 2002 ; 32: 1309-1318.
37. Lee SJ, Qin H., Benveniste EN The IFN-gamma-induced transcriptional program of the CIITA gene is inhibited by statins. Eur J Immunol 2008 ; 38: 2325-2336.
38. Kelley VE, Roths JB Interaction of mutant lpr gene with background strain influences renal disease. Clin Immunol Immunopathol 1985 ; 37: 220-229.
39. Bright JJ, Du C., Sriram S. Tyrphostin b42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis. J Immunol 1999 ; 162: 6255-6262.
40. Karonitsch T., Feierl E., Steiner CW, et al. Activation of the interferon-gamma signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells. Arthritis Rheum 2009 ; 60: 1463-1471.