Modeling of the Human Alveolar Rhabdomyosarcoma Pax3-Foxo1 Chromosome Translocation in Mouse Myoblasts Using CRISPR-Cas9 Nuclease

PLoS Genetics

Volumn 11, Issue 2, 2015, Pages 1-24

  Lagutina, Irina V ^a   Valentine, Virginia ^a   Picchione, Fabrizio ^a   Harwood, Frank ^a   Valentine, Marcus B ^a   Villarejo Balcells, Barbara ^b   Carvajal, Jaime J ^b,c   Grosveld, Gerard C ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c Universidad Pablo de Olavide   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CAS9 NUCLEASE; CRISPR ASSOCIATED PROTEIN; MESSENGER RNA; NUCLEASE; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR PAX3; UNCLASSIFIED DRUG; ONCOPROTEIN; PAIRED BOX TRANSCRIPTION FACTOR; PAX3-FOXO1A FUSION PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CHROMOSOME 1; CHROMOSOME 3; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; FLUORESCENCE IN SITU HYBRIDIZATION; FORELIMB; FUSION GENE; GENE EXPRESSION; GENE LOCUS; HINDLIMB; MOUSE; NONHUMAN; PAX3 FOXO1 FUSION GENE; RHABDOMYOSARCOMA; SYNTENY; ANIMAL; BIOSYNTHESIS; CRISPR CAS SYSTEM; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; GENETICS; HUMAN; METABOLISM; MYOBLAST; PATHOLOGY; TUMOR CELL LINE;

MUS;

ANIMALS; CELL LINE, TUMOR; CRISPR-CAS SYSTEMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; MYOBLASTS; ONCOGENE PROTEINS, FUSION; PAIRED BOX TRANSCRIPTION FACTORS; RHABDOMYOSARCOMA, ALVEOLAR; RNA, MESSENGER; TRANSLOCATION, GENETIC;

EID: 84924404064     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004951     Document Type: Article

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