Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

Nature Communications

Volumn 6, Issue , 2015, Pages

  Madhusudhan, Thati ^a   Wang, Hongjie ^a,b   Dong, Wei ^a   Ghosh, Sanchita ^a   Bock, Fabian ^a   Thangapandi, Veera Raghavan ^a   Ranjan, Satish ^a   Wolter, Juliane ^a   Kohli, Shrey ^a   Shahzad, Khurrum ^a,c   Heidel, Florian ^a   Krueger, Martin ^d   Schwenger, Vedat ^e   Moeller, Marcus J ^f   Kalinski, Thomas ^a   Reiser, Jochen ^g   Chavakis, Triantafyllos ^h   Isermann, Berend ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c UNIVERSITY OF HEALTH SCIENCES   (Pakistan)

^d UNIVERSITY OF LEIPZIG   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

^f UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^g RUSH UNIVERSITY   (United States)

^h DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE P85 ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE P85 BETA; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; ATF6 PROTEIN, MOUSE; DDIT3 PROTEIN, MOUSE; DNA BINDING PROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; REGULATORY FACTOR X TRANSCRIPTION FACTOR; STREPTOZOCIN; TRANSCRIPTION FACTOR; XBP1 PROTEIN, HUMAN; XBP1 PROTEIN, MOUSE;

ADAPTATION; CELL ORGANELLE; DIABETES; HOMEOSTASIS; HORMONE; PATHOLOGY; PROTEIN; RODENT; TRANSLOCATION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE EXACERBATION; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PODOCYTE; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DEFICIENCY; ENDOPLASMIC RETICULUM; EXPERIMENTAL DIABETES MELLITUS; FACTUAL DATABASE; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY;

MURINAE; MUS;

ACTIVATING TRANSCRIPTION FACTOR 6; ANIMALS; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; DATABASES, FACTUAL; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION; HUMANS; INSULIN; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PODOCYTES; RECEPTOR, INSULIN; REGULATORY FACTOR X TRANSCRIPTION FACTORS; SIGNAL TRANSDUCTION; STREPTOZOCIN; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; X-BOX BINDING PROTEIN 1;

EID: 84924371283     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7496     Document Type: Article

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